Prokr1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Prokr1
Entrez Gene ID	192648
Full Name	prokineticin receptor 1
Synonyms	Gpr73
General protein information	Preferred Names prokineticin receptor 1 Names prokineticin receptor 1 G protein-coupled receptor 73 G protein-coupled receptor ZAQ PK-R1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q34
Summary	G protein-coupled receptor for prokineticin [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006236821.3	XP_006236883.1	prokineticin receptor 1 isoform X1
NM_138977.1	NP_620433.1	prokineticin receptor 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	PROKR1	NP_620414.1
Danio rerio (zebrafish)	prokr1a	NP_001166877.1
Pan troglodytes (chimpanzee)	PROKR1	XP_515526.3
Bos taurus (cattle)	PROKR1	NP_776755.1
Canis lupus familiaris (dog)	PROKR1	XP_538526.2
	PROKR1	XP_001094867.1
Mus musculus (house mouse)	Prokr1	NP_067356.2
Rattus norvegicus (Norway rat)	Prokr1	NP_620433.1

Gene Ontology
Bibliography

Related articles in PubMed

Involvement of Prokineticin 2 and Prokineticin Receptor 1 in Lipopolysaccharide-Induced Testitis in Rats.
Chen B, Yu L, Wang J, Li C, Zhao K, Zhang H
Inflammation39(2)534-42(2016 Apr)

Changes in the responsiveness of hypothalamic PK2 and PKR1 gene expression to fasting in developing male rats.
Iwasa T, Matsuzaki T, Tungalagsuvd A, Munkhzaya M, Kawami T, Yamasaki M, Murakami M, Kato T, Kuwahara A, Yasui T, Irahara M
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience3887-90(2014 Nov)

The prokineticin receptor-1 (GPR73) promotes cardiomyocyte survival and angiogenesis.
Urayama K, Guilini C, Messaddeq N, Hu K, Steenman M, Kurose H, Ert G, Nebigil CG
FASEB journal : official publication of the Federation of American Societies for Experimental Biology21(11)2980-93(2007 Sep)

Fine mapping of radiation susceptibility and gene expression analysis of LEC congenic rat lines.
Tsuji AB, Sugyo A, Ogiu T, Sagara M, Kimura T, Ishikawa A, Sudo H, Ohtsuki M, Aburatani H, Imai T, Harada YN
Genomics86(3)271-9(2005 Sep)

Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors.
Masuda Y, Takatsu Y, Terao Y, Kumano S, Ishibashi Y, Suenaga M, Abe M, Fukusumi S, Watanabe T, Shintani Y, Yamada T, Hinuma S, Inatomi N, Ohtaki T, Onda H, Fujino M
Biochemical and biophysical research communications293(1)396-402(2002 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Given one of the cognate receptors of prokineticin 2, prokineticin receptor 1 (PKR1) was significantly upregulated in orchitis as discussed in the current study, it is very likely that PK2/PKR1 signaling contribute to the development of inflammation-related testicular diseases.
Title: Involvement of Prokineticin 2 and Prokineticin Receptor 1 in Lipopolysaccharide-Induced Testitis in Rats.

These results indicate that Prokr1 is sensitive to nutritional status in male rats and that this sensitivity has already been established by the early neonatal period.
Title: Changes in the responsiveness of hypothalamic PK2 and PKR1 gene expression to fasting in developing male rats.

The following Prokr1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Prokr1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02056	NM_138977.1 Latest version!	Rattus norvegicus prokineticin receptor 1 (Prokr1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa02056	XM_006236821.3 Latest version!	Rattus norvegicus prokineticin receptor 1 (Prokr1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Prokr1 ( NM_138977.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_620433.1 Rattus norvegicus prokineticin receptor 1 (Prokr1), mRNA.

Price & Availability↑

CloneID	ORa02056
Clone ID Related Accession (Same CDS sequence)	XM_006236821.3 , NM_138977.1
Accession Version	NM_138977.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1182bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Rattus norvegicus(Norway rat)
Product	prokineticin receptor 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY089974.1. ##Evidence-Data-START## Transcript exon combination :: AB158419.1, AB158420.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689597, SAMEA2689603 [ECO:0000348] ##Evidence-Data-END##

ATGGAGACCA CTGTGGGGAC CCTGGGCGAG AATACCACAA ACACTTTCAC CGACTTCTTT 
TCTGCACGTG ATGGCAGTGG AGCCGAAACC TCCCCCTTGC CATTCACTTT CAGCTATGGT 
GACTATGACA TGCCCTCGGA TGAAGAGGAG GATGTGACCA ACTCTCGGAC TTTCTTTGCT 
GCCAAGATTG TCATTGGCAT GGCTTTGGTG GGCATCATGC TGGTGTGTGG CATCGGCAAC 
TTCATCTTCA TCACTGCGCT GGCCCGCTAC AAAAAGCTTC GCAACCTCAC CAACCTGCTT 
ATCGCCAACC TGGCCATTTC GGACTTCCTG GTAGCCATCG TGTGCTGCCC CTTTGAGATG 
GACTACTATG TGGTACGCCA GCTCTCCTGG GAGCACGGCC ATGTCCTGTG CGCCTCCGTC 
AACTACTTGC GCACCGTCTC CCTCTACGTG TCCACTAACG CCCTACTGGC CATTGCCATT 
GACAGGTATC TGGCCATTGT GCACCCGCTG AGACCGCGGA TGAAGTGTCA AACGGCTGCA 
GGCCTGATCT TCCTGGTGTG GTCTGTGTCC ATCCTCATCG CCATCCCAGC CGCCTACTTC 
ACCACTGAGA CGGTGTTGGT CATCGTGGAA AGCCAGGAGA AGATCTTCTG CGGCCAGATC 
TGGCCGGTGG ATCAGCAGTT CTACTACAGG TCCTATTTCC TTTTGGTCTT CGGCCTCGAG 
TTCGTGGGTC CTGTAATCGC CATGACCCTG TGCTATGCCA GGGTGTCCCG AGAGCTCTGG 
TTCAAGGCGG TGCCCGGCTT CCAGACAGAG CAGATCCGCC GGAGGCTGCG CTGTCGCCGA 
CGGACGGTAC TGGGGCTCGT GTGCGTCCTT TCCGCCTATG TGCTGTGCTG GGCTCCCTTC 
TATGGCTTCA CCATCGTGCG TGACTTCTTC CCCTCCGTGT TTGTGAAAGA GAAGCACTAC 
CTCACCGCCT TTTATGTGGT GGAGTGCATC GCCATGAGCA ACAGTATGAT CAATACGCTG 
TGCTTTGTGA CTGTCAGGAA TAACACCAGT AAGTACCTCA AGAGGATCCT GCGGCTCCAG 
TGGAGGGCCT CTCCTAGCGG GAGCAAGGCC AGCGCTGACC TCGACCTCAG GACCACGGGG 
ATTCCTGCCA CGGAGGAGGT GGACTGCATC CGACTGAAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_620433.1
CDS	1..1182
Translation	METTVGTLGENTTNTFTDFFSARDGSGAETSPLPFTFSYGDYDMPSDEEEDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFIFITALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTAAGLIFLVWSVSILIAIPAAYFTTETVLVIVESQEKIFCGQIWPVDQQFYYRSYFLLVFGLEFVGPVIAMTLCYARVSRELWFKAVPGFQTEQIRRRLRCRRRTVLGLVCVLSAYVLCWAPFYGFTIVRDFFPSVFVKEKHYLTAFYVVECIAMSNSMINTLCFVTVRNNTSKYLKRILRLQWRASPSGSKASADLDLRTTGIPATEEVDCIRLK

Target ORF information:

RefSeq Version	NM_138977.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus prokineticin receptor 1 (Prokr1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138977.1

ORF Insert Sequence:

ATGGAGACCA CTGTGGGGAC CCTGGGCGAG AATACCACAA ACACTTTCAC CGACTTCTTT 
TCTGCACGTG ATGGCAGTGG AGCCGAAACC TCCCCCTTGC CATTCACTTT CAGCTATGGT 
GACTATGACA TGCCCTCGGA TGAAGAGGAG GATGTGACCA ACTCTCGGAC TTTCTTTGCT 
GCCAAGATTG TCATTGGCAT GGCTTTGGTG GGCATCATGC TGGTGTGTGG CATCGGCAAC 
TTCATCTTCA TCACTGCGCT GGCCCGCTAC AAAAAGCTTC GCAACCTCAC CAACCTGCTT 
ATCGCCAACC TGGCCATTTC GGACTTCCTG GTAGCCATCG TGTGCTGCCC CTTTGAGATG 
GACTACTATG TGGTACGCCA GCTCTCCTGG GAGCACGGCC ATGTCCTGTG CGCCTCCGTC 
AACTACTTGC GCACCGTCTC CCTCTACGTG TCCACTAACG CCCTACTGGC CATTGCCATT 
GACAGGTATC TGGCCATTGT GCACCCGCTG AGACCGCGGA TGAAGTGTCA AACGGCTGCA 
GGCCTGATCT TCCTGGTGTG GTCTGTGTCC ATCCTCATCG CCATCCCAGC CGCCTACTTC 
ACCACTGAGA CGGTGTTGGT CATCGTGGAA AGCCAGGAGA AGATCTTCTG CGGCCAGATC 
TGGCCGGTGG ATCAGCAGTT CTACTACAGG TCCTATTTCC TTTTGGTCTT CGGCCTCGAG 
TTCGTGGGTC CTGTAATCGC CATGACCCTG TGCTATGCCA GGGTGTCCCG AGAGCTCTGG 
TTCAAGGCGG TGCCCGGCTT CCAGACAGAG CAGATCCGCC GGAGGCTGCG CTGTCGCCGA 
CGGACGGTAC TGGGGCTCGT GTGCGTCCTT TCCGCCTATG TGCTGTGCTG GGCTCCCTTC 
TATGGCTTCA CCATCGTGCG TGACTTCTTC CCCTCCGTGT TTGTGAAAGA GAAGCACTAC 
CTCACCGCCT TTTATGTGGT GGAGTGCATC GCCATGAGCA ACAGTATGAT CAATACGCTG 
TGCTTTGTGA CTGTCAGGAA TAACACCAGT AAGTACCTCA AGAGGATCCT GCGGCTCCAG 
TGGAGGGCCT CTCCTAGCGG GAGCAAGGCC AGCGCTGACC TCGACCTCAG GACCACGGGG 
ATTCCTGCCA CGGAGGAGGT GGACTGCATC CGACTGAAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Prokr1 ( XM_006236821.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006236883.1 Rattus norvegicus prokineticin receptor 1 (Prokr1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa02056
Clone ID Related Accession (Same CDS sequence)	XM_006236821.3 , NM_138977.1
Accession Version	XM_006236821.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1182bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	prokineticin receptor 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006236821.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGACCA CTGTGGGGAC CCTGGGCGAG AATACCACAA ACACTTTCAC CGACTTCTTT 
TCTGCACGTG ATGGCAGTGG AGCCGAAACC TCCCCCTTGC CATTCACTTT CAGCTATGGT 
GACTATGACA TGCCCTCGGA TGAAGAGGAG GATGTGACCA ACTCTCGGAC TTTCTTTGCT 
GCCAAGATTG TCATTGGCAT GGCTTTGGTG GGCATCATGC TGGTGTGTGG CATCGGCAAC 
TTCATCTTCA TCACTGCGCT GGCCCGCTAC AAAAAGCTTC GCAACCTCAC CAACCTGCTT 
ATCGCCAACC TGGCCATTTC GGACTTCCTG GTAGCCATCG TGTGCTGCCC CTTTGAGATG 
GACTACTATG TGGTACGCCA GCTCTCCTGG GAGCACGGCC ATGTCCTGTG CGCCTCCGTC 
AACTACTTGC GCACCGTCTC CCTCTACGTG TCCACTAACG CCCTACTGGC CATTGCCATT 
GACAGGTATC TGGCCATTGT GCACCCGCTG AGACCGCGGA TGAAGTGTCA AACGGCTGCA 
GGCCTGATCT TCCTGGTGTG GTCTGTGTCC ATCCTCATCG CCATCCCAGC CGCCTACTTC 
ACCACTGAGA CGGTGTTGGT CATCGTGGAA AGCCAGGAGA AGATCTTCTG CGGCCAGATC 
TGGCCGGTGG ATCAGCAGTT CTACTACAGG TCCTATTTCC TTTTGGTCTT CGGCCTCGAG 
TTCGTGGGTC CTGTAATCGC CATGACCCTG TGCTATGCCA GGGTGTCCCG AGAGCTCTGG 
TTCAAGGCGG TGCCCGGCTT CCAGACAGAG CAGATCCGCC GGAGGCTGCG CTGTCGCCGA 
CGGACGGTAC TGGGGCTCGT GTGCGTCCTT TCCGCCTATG TGCTGTGCTG GGCTCCCTTC 
TATGGCTTCA CCATCGTGCG TGACTTCTTC CCCTCCGTGT TTGTGAAAGA GAAGCACTAC 
CTCACCGCCT TTTATGTGGT GGAGTGCATC GCCATGAGCA ACAGTATGAT CAATACGCTG 
TGCTTTGTGA CTGTCAGGAA TAACACCAGT AAGTACCTCA AGAGGATCCT GCGGCTCCAG 
TGGAGGGCCT CTCCTAGCGG GAGCAAGGCC AGCGCTGACC TCGACCTCAG GACCACGGGG 
ATTCCTGCCA CGGAGGAGGT GGACTGCATC CGACTGAAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006236883.1
CDS	323..1504
Translation	METTVGTLGENTTNTFTDFFSARDGSGAETSPLPFTFSYGDYDMPSDEEEDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFIFITALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTAAGLIFLVWSVSILIAIPAAYFTTETVLVIVESQEKIFCGQIWPVDQQFYYRSYFLLVFGLEFVGPVIAMTLCYARVSRELWFKAVPGFQTEQIRRRLRCRRRTVLGLVCVLSAYVLCWAPFYGFTIVRDFFPSVFVKEKHYLTAFYVVECIAMSNSMINTLCFVTVRNNTSKYLKRILRLQWRASPSGSKASADLDLRTTGIPATEEVDCIRLK

Target ORF information:

RefSeq Version	XM_006236821.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus prokineticin receptor 1 (Prokr1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006236821.3

ORF Insert Sequence:

ATGGAGACCA CTGTGGGGAC CCTGGGCGAG AATACCACAA ACACTTTCAC CGACTTCTTT 
TCTGCACGTG ATGGCAGTGG AGCCGAAACC TCCCCCTTGC CATTCACTTT CAGCTATGGT 
GACTATGACA TGCCCTCGGA TGAAGAGGAG GATGTGACCA ACTCTCGGAC TTTCTTTGCT 
GCCAAGATTG TCATTGGCAT GGCTTTGGTG GGCATCATGC TGGTGTGTGG CATCGGCAAC 
TTCATCTTCA TCACTGCGCT GGCCCGCTAC AAAAAGCTTC GCAACCTCAC CAACCTGCTT 
ATCGCCAACC TGGCCATTTC GGACTTCCTG GTAGCCATCG TGTGCTGCCC CTTTGAGATG 
GACTACTATG TGGTACGCCA GCTCTCCTGG GAGCACGGCC ATGTCCTGTG CGCCTCCGTC 
AACTACTTGC GCACCGTCTC CCTCTACGTG TCCACTAACG CCCTACTGGC CATTGCCATT 
GACAGGTATC TGGCCATTGT GCACCCGCTG AGACCGCGGA TGAAGTGTCA AACGGCTGCA 
GGCCTGATCT TCCTGGTGTG GTCTGTGTCC ATCCTCATCG CCATCCCAGC CGCCTACTTC 
ACCACTGAGA CGGTGTTGGT CATCGTGGAA AGCCAGGAGA AGATCTTCTG CGGCCAGATC 
TGGCCGGTGG ATCAGCAGTT CTACTACAGG TCCTATTTCC TTTTGGTCTT CGGCCTCGAG 
TTCGTGGGTC CTGTAATCGC CATGACCCTG TGCTATGCCA GGGTGTCCCG AGAGCTCTGG 
TTCAAGGCGG TGCCCGGCTT CCAGACAGAG CAGATCCGCC GGAGGCTGCG CTGTCGCCGA 
CGGACGGTAC TGGGGCTCGT GTGCGTCCTT TCCGCCTATG TGCTGTGCTG GGCTCCCTTC 
TATGGCTTCA CCATCGTGCG TGACTTCTTC CCCTCCGTGT TTGTGAAAGA GAAGCACTAC 
CTCACCGCCT TTTATGTGGT GGAGTGCATC GCCATGAGCA ACAGTATGAT CAATACGCTG 
TGCTTTGTGA CTGTCAGGAA TAACACCAGT AAGTACCTCA AGAGGATCCT GCGGCTCCAG 
TGGAGGGCCT CTCCTAGCGG GAGCAAGGCC AGCGCTGACC TCGACCTCAG GACCACGGGG 
ATTCCTGCCA CGGAGGAGGT GGACTGCATC CGACTGAAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Involvement of Prokineticin 2 and Prokineticin Receptor 1 in Lipopolysaccharide-Induced Testitis in Rats.
Inflammation39(2)534-42(2016 Apr)
Chen B,Yu L,Wang J,Li C,Zhao K,Zhang H

Changes in the responsiveness of hypothalamic PK2 and PKR1 gene expression to fasting in developing male rats.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience3887-90(2014 Nov)
Iwasa T,Matsuzaki T,Tungalagsuvd A,Munkhzaya M,Kawami T,Yamasaki M,Murakami M,Kato T,Kuwahara A,Yasui T,Irahara M

The prokineticin receptor-1 (GPR73) promotes cardiomyocyte survival and angiogenesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology21(11)2980-93(2007 Sep)
Urayama K,Guilini C,Messaddeq N,Hu K,Steenman M,Kurose H,Ert G,Nebigil CG

Fine mapping of radiation susceptibility and gene expression analysis of LEC congenic rat lines.
Genomics86(3)271-9(2005 Sep)
Tsuji AB,Sugyo A,Ogiu T,Sagara M,Kimura T,Ishikawa A,Sudo H,Ohtsuki M,Aburatani H,Imai T,Harada YN

Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors.
Biochemical and biophysical research communications293(1)396-402(2002 Apr)
Masuda Y,Takatsu Y,Terao Y,Kumano S,Ishibashi Y,Suenaga M,Abe M,Fukusumi S,Watanabe T,Shintani Y,Yamada T,Hinuma S,Inatomi N,Ohtaki T,Onda H,Fujino M

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Prokr1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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