BUB1B-PAK6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	BUB1B-PAK6
Entrez Gene ID	106821730
Full Name	BUB1B-PAK6 readthrough
General protein information	Preferred Names BUB1B-PAK6 readthrough Names serine/threonine-protein kinase PAK 6
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q15.1
Summary	This gene represents readthrough transcription between the genes BUB1B (mitotic checkpoint serine/threonine-protein kinase BUB1 beta) and PAK6 (serine/threonine-protein kinase PAK 6). The protein encoded by the readthrough transcripts is the same as the product of the downstream gene (PAK6). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001128629.2	NP_001122101.1	serine/threonine-protein kinase PAK 6
NM_001128629.3	NP_001122101.1	serine/threonine-protein kinase PAK 6
NM_001128628.2	NP_001122100.1	serine/threonine-protein kinase PAK 6

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

p21-Activated kinase 6 (PAK6) inhibits prostate cancer growth via phosphorylation of androgen receptor and tumorigenic E3 ligase murine double minute-2 (Mdm2).
Liu T, Li Y, Gu H, Zhu G, Li J, Cao L, Li F
The Journal of biological chemistry288(5)3359-69(2013 Feb)

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
Comuzzie AG, Cole SA, Laston SL, Voruganti VS, Haack K, Gibbs RA, Butte NF
PloS one7(12)e51954(2012)

Pak6 protein kinase is a novel effector of an atypical Rho family GTPase Chp/RhoV.
Shepelev MV, Korobko IV
Biochemistry. Biokhimiia77(1)26-32(2012 Jan)

Group I p21-activated kinases regulate thyroid cancer cell migration and are overexpressed and activated in thyroid cancer invasion.
McCarty SK, Saji M, Zhang X, Jarjoura D, Fusco A, Vasko VV, Ringel MD
Endocrine-related cancer17(4)989-99(2010 Dec)

The emerging importance of group II PAKs.
Wells CM, Jones GE
The Biochemical journal425(3)465-73(2010 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following BUB1B-PAK6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BUB1B-PAK6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu00400	NM_001128629.3 Latest version!	Homo sapiens BUB1B-PAK6 readthrough (BUB1B-PAK6), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu00400	NM_001128628.2 Latest version!	Homo sapiens BUB1B-PAK6 readthrough (BUB1B-PAK6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu00400	NM_001128629.2	Homo sapiens BUB1B-PAK6 readthrough (BUB1B-PAK6), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

BUB1B-PAK6 ( NM_001128629.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001122101.1 Homo sapiens BUB1B-PAK6 readthrough (BUB1B-PAK6), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu00400
Clone ID Related Accession (Same CDS sequence)	NM_001128629.2 , NM_001128629.3 , NM_001128628.2
Accession Version	NM_001128629.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2046bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-15
Organism	Homo sapiens(human)
Product	serine/threonine-protein kinase PAK 6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK315817.1, BC035596.1, AK131522.1 and AK026592.1. On Mar 1, 2013 this sequence version replaced NM_001128629.1. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: AK315817.1, SRR1803614.195102.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## readthrough transcript :: includes exons from GeneID 701, 56924 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTTCCGCA AGAAAAAGAA GAAACGCCCT GAGATCTCAG CGCCACAGAA CTTCCAGCAC 
CGTGTCCACA CCTCCTTCGA CCCCAAAGAA GGCAAGTTTG TGGGCCTCCC CCCACAATGG 
CAGAACATCC TGGACACACT GCGGCGCCCC AAGCCCGTGG TGGACCCTTC GCGAATCACA 
CGGGTGCAGC TCCAGCCCAT GAAGACAGTG GTGCGGGGCA GCGCGATGCC TGTGGATGGC 
TACATCTCGG GGCTGCTCAA CGACATCCAG AAGTTGTCAG TCATCAGCTC CAACACCCTG 
CGTGGCCGCA GCCCCACCAG CCGGCGGCGG GCACAGTCCC TGGGGCTGCT GGGGGATGAG 
CACTGGGCCA CCGACCCAGA CATGTACCTC CAGAGCCCCC AGTCTGAGCG CACTGACCCC 
CACGGCCTCT ACCTCAGCTG CAACGGGGGC ACACCAGCAG GCCACAAGCA GATGCCGTGG 
CCCGAGCCAC AGAGCCCACG GGTCCTGCCC AATGGGCTGG CTGCAAAGGC ACAGTCCCTG 
GGCCCCGCCG AGTTTCAGGG TGCCTCGCAG CGCTGTCTGC AGCTGGGTGC CTGCCTGCAG 
AGCTCCCCAC CAGGAGCCTC GCCCCCCACG GGCACCAATA GGCATGGAAT GAAGGCTGCC 
AAGCATGGCT CTGAGGAGGC CCGGCCACAG TCCTGCCTGG TGGGCTCAGC CACAGGCAGG 
CCAGGTGGGG AAGGCAGCCC TAGCCCTAAG ACCCGGGAGA GCAGCCTGAA GCGCAGGCTA 
TTCCGAAGCA TGTTCCTGTC CACTGCTGCC ACAGCCCCTC CAAGCAGCAG CAAGCCAGGC 
CCTCCACCAC AGAGCAAGCC CAACTCCTCT TTCCGACCGC CGCAGAAAGA CAACCCCCCA 
AGCCTGGTGG CCAAGGCCCA GTCCTTGCCC TCGGACCAGC CGGTGGGGAC CTTCAGCCCT 
CTGACCACTT CGGATACCAG CAGCCCCCAG AAGTCCCTCC GCACAGCCCC GGCCACAGGC 
CAGCTTCCAG GCCGGTCTTC CCCAGCGGGA TCCCCCCGCA CCTGGCACGC CCAGATCAGC 
ACCAGCAACC TGTACCTGCC CCAGGACCCC ACGGTTGCCA AGGGTGCCCT GGCTGGTGAG 
GACACAGGTG TTGTGACACA TGAGCAGTTC AAGGCTGCGC TCAGGATGGT GGTGGACCAG 
GGTGACCCCC GGCTGCTGCT GGACAGCTAC GTGAAGATTG GCGAGGGCTC CACCGGCATC 
GTCTGCTTGG CCCGGGAGAA GCACTCGGGC CGCCAGGTGG CCGTCAAGAT GATGGACCTC 
AGGAAGCAGC AGCGCAGGGA GCTGCTCTTC AACGAGGTGG TGATCATGCG GGACTACCAG 
CACTTCAACG TGGTGGAGAT GTACAAGAGC TACCTGGTGG GCGAGGAGCT GTGGGTGCTC 
ATGGAGTTCC TGCAGGGAGG AGCCCTCACA GACATCGTCT CCCAAGTCAG GCTGAATGAG 
GAGCAGATTG CCACTGTGTG TGAGGCTGTG CTGCAGGCCC TGGCCTACCT GCATGCTCAG 
GGTGTCATCC ACCGGGACAT CAAGAGTGAC TCCATCCTGC TGACCCTCGA TGGCAGGGTG 
AAGCTCTCGG ACTTCGGATT CTGTGCTCAG ATCAGCAAAG ACGTCCCTAA GAGGAAGTCC 
CTGGTGGGAA CCCCCTACTG GATGGCTCCT GAAGTGATCT CCAGGTCTTT GTATGCCACT 
GAGGTGGATA TCTGGTCTCT GGGCATCATG GTGATTGAGA TGGTAGATGG GGAGCCACCG 
TACTTCAGTG ACTCCCCAGT GCAAGCCATG AAGAGGCTCC GGGACAGCCC CCCACCCAAG 
CTGAAAAACT CTCACAAGGT CTCCCCAGTG CTGCGAGACT TCCTGGAGCG GATGCTGGTG 
CGGGACCCCC AAGAGAGAGC CACAGCCCAG GAGCTCCTAG ACCACCCCTT CCTGCTGCAG 
ACAGGGCTAC CTGAGTGCCT GGTGCCCCTG ATCCAGCTCT ACCGAAAGCA GACCTCCACC 
TGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001122101.1
CDS	358..2403
Translation	MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRITRVQLQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDEHWATDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSLGPAEFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGRPGGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLIQLYRKQTSTC

Target ORF information:

RefSeq Version	NM_001128629.2
Organism	Homo sapiens(human)
Definition	Homo sapiens BUB1B-PAK6 readthrough (BUB1B-PAK6), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001128629.2

ORF Insert Sequence:

ATGTTCCGCA AGAAAAAGAA GAAACGCCCT GAGATCTCAG CGCCACAGAA CTTCCAGCAC 
CGTGTCCACA CCTCCTTCGA CCCCAAAGAA GGCAAGTTTG TGGGCCTCCC CCCACAATGG 
CAGAACATCC TGGACACACT GCGGCGCCCC AAGCCCGTGG TGGACCCTTC GCGAATCACA 
CGGGTGCAGC TCCAGCCCAT GAAGACAGTG GTGCGGGGCA GCGCGATGCC TGTGGATGGC 
TACATCTCGG GGCTGCTCAA CGACATCCAG AAGTTGTCAG TCATCAGCTC CAACACCCTG 
CGTGGCCGCA GCCCCACCAG CCGGCGGCGG GCACAGTCCC TGGGGCTGCT GGGGGATGAG 
CACTGGGCCA CCGACCCAGA CATGTACCTC CAGAGCCCCC AGTCTGAGCG CACTGACCCC 
CACGGCCTCT ACCTCAGCTG CAACGGGGGC ACACCAGCAG GCCACAAGCA GATGCCGTGG 
CCCGAGCCAC AGAGCCCACG GGTCCTGCCC AATGGGCTGG CTGCAAAGGC ACAGTCCCTG 
GGCCCCGCCG AGTTTCAGGG TGCCTCGCAG CGCTGTCTGC AGCTGGGTGC CTGCCTGCAG 
AGCTCCCCAC CAGGAGCCTC GCCCCCCACG GGCACCAATA GGCATGGAAT GAAGGCTGCC 
AAGCATGGCT CTGAGGAGGC CCGGCCACAG TCCTGCCTGG TGGGCTCAGC CACAGGCAGG 
CCAGGTGGGG AAGGCAGCCC TAGCCCTAAG ACCCGGGAGA GCAGCCTGAA GCGCAGGCTA 
TTCCGAAGCA TGTTCCTGTC CACTGCTGCC ACAGCCCCTC CAAGCAGCAG CAAGCCAGGC 
CCTCCACCAC AGAGCAAGCC CAACTCCTCT TTCCGACCGC CGCAGAAAGA CAACCCCCCA 
AGCCTGGTGG CCAAGGCCCA GTCCTTGCCC TCGGACCAGC CGGTGGGGAC CTTCAGCCCT 
CTGACCACTT CGGATACCAG CAGCCCCCAG AAGTCCCTCC GCACAGCCCC GGCCACAGGC 
CAGCTTCCAG GCCGGTCTTC CCCAGCGGGA TCCCCCCGCA CCTGGCACGC CCAGATCAGC 
ACCAGCAACC TGTACCTGCC CCAGGACCCC ACGGTTGCCA AGGGTGCCCT GGCTGGTGAG 
GACACAGGTG TTGTGACACA TGAGCAGTTC AAGGCTGCGC TCAGGATGGT GGTGGACCAG 
GGTGACCCCC GGCTGCTGCT GGACAGCTAC GTGAAGATTG GCGAGGGCTC CACCGGCATC 
GTCTGCTTGG CCCGGGAGAA GCACTCGGGC CGCCAGGTGG CCGTCAAGAT GATGGACCTC 
AGGAAGCAGC AGCGCAGGGA GCTGCTCTTC AACGAGGTGG TGATCATGCG GGACTACCAG 
CACTTCAACG TGGTGGAGAT GTACAAGAGC TACCTGGTGG GCGAGGAGCT GTGGGTGCTC 
ATGGAGTTCC TGCAGGGAGG AGCCCTCACA GACATCGTCT CCCAAGTCAG GCTGAATGAG 
GAGCAGATTG CCACTGTGTG TGAGGCTGTG CTGCAGGCCC TGGCCTACCT GCATGCTCAG 
GGTGTCATCC ACCGGGACAT CAAGAGTGAC TCCATCCTGC TGACCCTCGA TGGCAGGGTG 
AAGCTCTCGG ACTTCGGATT CTGTGCTCAG ATCAGCAAAG ACGTCCCTAA GAGGAAGTCC 
CTGGTGGGAA CCCCCTACTG GATGGCTCCT GAAGTGATCT CCAGGTCTTT GTATGCCACT 
GAGGTGGATA TCTGGTCTCT GGGCATCATG GTGATTGAGA TGGTAGATGG GGAGCCACCG 
TACTTCAGTG ACTCCCCAGT GCAAGCCATG AAGAGGCTCC GGGACAGCCC CCCACCCAAG 
CTGAAAAACT CTCACAAGGT CTCCCCAGTG CTGCGAGACT TCCTGGAGCG GATGCTGGTG 
CGGGACCCCC AAGAGAGAGC CACAGCCCAG GAGCTCCTAG ACCACCCCTT CCTGCTGCAG 
ACAGGGCTAC CTGAGTGCCT GGTGCCCCTG ATCCAGCTCT ACCGAAAGCA GACCTCCACC 
TGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BUB1B-PAK6 ( NM_001128629.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001122101.1 Homo sapiens BUB1B-PAK6 readthrough (BUB1B-PAK6), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu00400
Clone ID Related Accession (Same CDS sequence)	NM_001128629.2 , NM_001128629.3 , NM_001128628.2
Accession Version	NM_001128629.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2046bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-01
Organism	Homo sapiens(human)
Product	serine/threonine-protein kinase PAK 6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK315817.1, BC035596.1, AK131522.1 and AK026592.1. On Jun 2, 2019 this sequence version replaced NM_001128629.2. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: AK315817.1, SRR1803614.195102.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## readthrough transcript :: includes exons from GeneID 701, 56924 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTTCCGCA AGAAAAAGAA GAAACGCCCT GAGATCTCAG CGCCACAGAA CTTCCAGCAC 
CGTGTCCACA CCTCCTTCGA CCCCAAAGAA GGCAAGTTTG TGGGCCTCCC CCCACAATGG 
CAGAACATCC TGGACACACT GCGGCGCCCC AAGCCCGTGG TGGACCCTTC GCGAATCACA 
CGGGTGCAGC TCCAGCCCAT GAAGACAGTG GTGCGGGGCA GCGCGATGCC TGTGGATGGC 
TACATCTCGG GGCTGCTCAA CGACATCCAG AAGTTGTCAG TCATCAGCTC CAACACCCTG 
CGTGGCCGCA GCCCCACCAG CCGGCGGCGG GCACAGTCCC TGGGGCTGCT GGGGGATGAG 
CACTGGGCCA CCGACCCAGA CATGTACCTC CAGAGCCCCC AGTCTGAGCG CACTGACCCC 
CACGGCCTCT ACCTCAGCTG CAACGGGGGC ACACCAGCAG GCCACAAGCA GATGCCGTGG 
CCCGAGCCAC AGAGCCCACG GGTCCTGCCC AATGGGCTGG CTGCAAAGGC ACAGTCCCTG 
GGCCCCGCCG AGTTTCAGGG TGCCTCGCAG CGCTGTCTGC AGCTGGGTGC CTGCCTGCAG 
AGCTCCCCAC CAGGAGCCTC GCCCCCCACG GGCACCAATA GGCATGGAAT GAAGGCTGCC 
AAGCATGGCT CTGAGGAGGC CCGGCCACAG TCCTGCCTGG TGGGCTCAGC CACAGGCAGG 
CCAGGTGGGG AAGGCAGCCC TAGCCCTAAG ACCCGGGAGA GCAGCCTGAA GCGCAGGCTA 
TTCCGAAGCA TGTTCCTGTC CACTGCTGCC ACAGCCCCTC CAAGCAGCAG CAAGCCAGGC 
CCTCCACCAC AGAGCAAGCC CAACTCCTCT TTCCGACCGC CGCAGAAAGA CAACCCCCCA 
AGCCTGGTGG CCAAGGCCCA GTCCTTGCCC TCGGACCAGC CGGTGGGGAC CTTCAGCCCT 
CTGACCACTT CGGATACCAG CAGCCCCCAG AAGTCCCTCC GCACAGCCCC GGCCACAGGC 
CAGCTTCCAG GCCGGTCTTC CCCAGCGGGA TCCCCCCGCA CCTGGCACGC CCAGATCAGC 
ACCAGCAACC TGTACCTGCC CCAGGACCCC ACGGTTGCCA AGGGTGCCCT GGCTGGTGAG 
GACACAGGTG TTGTGACACA TGAGCAGTTC AAGGCTGCGC TCAGGATGGT GGTGGACCAG 
GGTGACCCCC GGCTGCTGCT GGACAGCTAC GTGAAGATTG GCGAGGGCTC CACCGGCATC 
GTCTGCTTGG CCCGGGAGAA GCACTCGGGC CGCCAGGTGG CCGTCAAGAT GATGGACCTC 
AGGAAGCAGC AGCGCAGGGA GCTGCTCTTC AACGAGGTGG TGATCATGCG GGACTACCAG 
CACTTCAACG TGGTGGAGAT GTACAAGAGC TACCTGGTGG GCGAGGAGCT GTGGGTGCTC 
ATGGAGTTCC TGCAGGGAGG AGCCCTCACA GACATCGTCT CCCAAGTCAG GCTGAATGAG 
GAGCAGATTG CCACTGTGTG TGAGGCTGTG CTGCAGGCCC TGGCCTACCT GCATGCTCAG 
GGTGTCATCC ACCGGGACAT CAAGAGTGAC TCCATCCTGC TGACCCTCGA TGGCAGGGTG 
AAGCTCTCGG ACTTCGGATT CTGTGCTCAG ATCAGCAAAG ACGTCCCTAA GAGGAAGTCC 
CTGGTGGGAA CCCCCTACTG GATGGCTCCT GAAGTGATCT CCAGGTCTTT GTATGCCACT 
GAGGTGGATA TCTGGTCTCT GGGCATCATG GTGATTGAGA TGGTAGATGG GGAGCCACCG 
TACTTCAGTG ACTCCCCAGT GCAAGCCATG AAGAGGCTCC GGGACAGCCC CCCACCCAAG 
CTGAAAAACT CTCACAAGGT CTCCCCAGTG CTGCGAGACT TCCTGGAGCG GATGCTGGTG 
CGGGACCCCC AAGAGAGAGC CACAGCCCAG GAGCTCCTAG ACCACCCCTT CCTGCTGCAG 
ACAGGGCTAC CTGAGTGCCT GGTGCCCCTG ATCCAGCTCT ACCGAAAGCA GACCTCCACC 
TGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001122101.1
CDS	358..2403
Translation	MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRITRVQLQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDEHWATDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSLGPAEFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGRPGGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLIQLYRKQTSTC

Target ORF information:

RefSeq Version	NM_001128629.3
Organism	Homo sapiens(human)
Definition	Homo sapiens BUB1B-PAK6 readthrough (BUB1B-PAK6), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001128629.3

ORF Insert Sequence:

ATGTTCCGCA AGAAAAAGAA GAAACGCCCT GAGATCTCAG CGCCACAGAA CTTCCAGCAC 
CGTGTCCACA CCTCCTTCGA CCCCAAAGAA GGCAAGTTTG TGGGCCTCCC CCCACAATGG 
CAGAACATCC TGGACACACT GCGGCGCCCC AAGCCCGTGG TGGACCCTTC GCGAATCACA 
CGGGTGCAGC TCCAGCCCAT GAAGACAGTG GTGCGGGGCA GCGCGATGCC TGTGGATGGC 
TACATCTCGG GGCTGCTCAA CGACATCCAG AAGTTGTCAG TCATCAGCTC CAACACCCTG 
CGTGGCCGCA GCCCCACCAG CCGGCGGCGG GCACAGTCCC TGGGGCTGCT GGGGGATGAG 
CACTGGGCCA CCGACCCAGA CATGTACCTC CAGAGCCCCC AGTCTGAGCG CACTGACCCC 
CACGGCCTCT ACCTCAGCTG CAACGGGGGC ACACCAGCAG GCCACAAGCA GATGCCGTGG 
CCCGAGCCAC AGAGCCCACG GGTCCTGCCC AATGGGCTGG CTGCAAAGGC ACAGTCCCTG 
GGCCCCGCCG AGTTTCAGGG TGCCTCGCAG CGCTGTCTGC AGCTGGGTGC CTGCCTGCAG 
AGCTCCCCAC CAGGAGCCTC GCCCCCCACG GGCACCAATA GGCATGGAAT GAAGGCTGCC 
AAGCATGGCT CTGAGGAGGC CCGGCCACAG TCCTGCCTGG TGGGCTCAGC CACAGGCAGG 
CCAGGTGGGG AAGGCAGCCC TAGCCCTAAG ACCCGGGAGA GCAGCCTGAA GCGCAGGCTA 
TTCCGAAGCA TGTTCCTGTC CACTGCTGCC ACAGCCCCTC CAAGCAGCAG CAAGCCAGGC 
CCTCCACCAC AGAGCAAGCC CAACTCCTCT TTCCGACCGC CGCAGAAAGA CAACCCCCCA 
AGCCTGGTGG CCAAGGCCCA GTCCTTGCCC TCGGACCAGC CGGTGGGGAC CTTCAGCCCT 
CTGACCACTT CGGATACCAG CAGCCCCCAG AAGTCCCTCC GCACAGCCCC GGCCACAGGC 
CAGCTTCCAG GCCGGTCTTC CCCAGCGGGA TCCCCCCGCA CCTGGCACGC CCAGATCAGC 
ACCAGCAACC TGTACCTGCC CCAGGACCCC ACGGTTGCCA AGGGTGCCCT GGCTGGTGAG 
GACACAGGTG TTGTGACACA TGAGCAGTTC AAGGCTGCGC TCAGGATGGT GGTGGACCAG 
GGTGACCCCC GGCTGCTGCT GGACAGCTAC GTGAAGATTG GCGAGGGCTC CACCGGCATC 
GTCTGCTTGG CCCGGGAGAA GCACTCGGGC CGCCAGGTGG CCGTCAAGAT GATGGACCTC 
AGGAAGCAGC AGCGCAGGGA GCTGCTCTTC AACGAGGTGG TGATCATGCG GGACTACCAG 
CACTTCAACG TGGTGGAGAT GTACAAGAGC TACCTGGTGG GCGAGGAGCT GTGGGTGCTC 
ATGGAGTTCC TGCAGGGAGG AGCCCTCACA GACATCGTCT CCCAAGTCAG GCTGAATGAG 
GAGCAGATTG CCACTGTGTG TGAGGCTGTG CTGCAGGCCC TGGCCTACCT GCATGCTCAG 
GGTGTCATCC ACCGGGACAT CAAGAGTGAC TCCATCCTGC TGACCCTCGA TGGCAGGGTG 
AAGCTCTCGG ACTTCGGATT CTGTGCTCAG ATCAGCAAAG ACGTCCCTAA GAGGAAGTCC 
CTGGTGGGAA CCCCCTACTG GATGGCTCCT GAAGTGATCT CCAGGTCTTT GTATGCCACT 
GAGGTGGATA TCTGGTCTCT GGGCATCATG GTGATTGAGA TGGTAGATGG GGAGCCACCG 
TACTTCAGTG ACTCCCCAGT GCAAGCCATG AAGAGGCTCC GGGACAGCCC CCCACCCAAG 
CTGAAAAACT CTCACAAGGT CTCCCCAGTG CTGCGAGACT TCCTGGAGCG GATGCTGGTG 
CGGGACCCCC AAGAGAGAGC CACAGCCCAG GAGCTCCTAG ACCACCCCTT CCTGCTGCAG 
ACAGGGCTAC CTGAGTGCCT GGTGCCCCTG ATCCAGCTCT ACCGAAAGCA GACCTCCACC 
TGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BUB1B-PAK6 ( NM_001128628.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001122100.1 Homo sapiens BUB1B-PAK6 readthrough (BUB1B-PAK6), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu00400
Clone ID Related Accession (Same CDS sequence)	NM_001128629.2 , NM_001128629.3 , NM_001128628.2
Accession Version	NM_001128628.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2046bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-15
Organism	Homo sapiens(human)
Product	serine/threonine-protein kinase PAK 6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA414215.1, AK290227.1, BC035596.1, AK131522.1 and AK026592.1. This sequence is a reference standard in the RefSeqGene project. On Mar 1, 2013 this sequence version replaced NM_001128628.1. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.52203.1, SRR1660807.30271.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154665, SAMN03465403 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## readthrough transcript :: includes exons from GeneID 701, 56924 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTTCCGCA AGAAAAAGAA GAAACGCCCT GAGATCTCAG CGCCACAGAA CTTCCAGCAC 
CGTGTCCACA CCTCCTTCGA CCCCAAAGAA GGCAAGTTTG TGGGCCTCCC CCCACAATGG 
CAGAACATCC TGGACACACT GCGGCGCCCC AAGCCCGTGG TGGACCCTTC GCGAATCACA 
CGGGTGCAGC TCCAGCCCAT GAAGACAGTG GTGCGGGGCA GCGCGATGCC TGTGGATGGC 
TACATCTCGG GGCTGCTCAA CGACATCCAG AAGTTGTCAG TCATCAGCTC CAACACCCTG 
CGTGGCCGCA GCCCCACCAG CCGGCGGCGG GCACAGTCCC TGGGGCTGCT GGGGGATGAG 
CACTGGGCCA CCGACCCAGA CATGTACCTC CAGAGCCCCC AGTCTGAGCG CACTGACCCC 
CACGGCCTCT ACCTCAGCTG CAACGGGGGC ACACCAGCAG GCCACAAGCA GATGCCGTGG 
CCCGAGCCAC AGAGCCCACG GGTCCTGCCC AATGGGCTGG CTGCAAAGGC ACAGTCCCTG 
GGCCCCGCCG AGTTTCAGGG TGCCTCGCAG CGCTGTCTGC AGCTGGGTGC CTGCCTGCAG 
AGCTCCCCAC CAGGAGCCTC GCCCCCCACG GGCACCAATA GGCATGGAAT GAAGGCTGCC 
AAGCATGGCT CTGAGGAGGC CCGGCCACAG TCCTGCCTGG TGGGCTCAGC CACAGGCAGG 
CCAGGTGGGG AAGGCAGCCC TAGCCCTAAG ACCCGGGAGA GCAGCCTGAA GCGCAGGCTA 
TTCCGAAGCA TGTTCCTGTC CACTGCTGCC ACAGCCCCTC CAAGCAGCAG CAAGCCAGGC 
CCTCCACCAC AGAGCAAGCC CAACTCCTCT TTCCGACCGC CGCAGAAAGA CAACCCCCCA 
AGCCTGGTGG CCAAGGCCCA GTCCTTGCCC TCGGACCAGC CGGTGGGGAC CTTCAGCCCT 
CTGACCACTT CGGATACCAG CAGCCCCCAG AAGTCCCTCC GCACAGCCCC GGCCACAGGC 
CAGCTTCCAG GCCGGTCTTC CCCAGCGGGA TCCCCCCGCA CCTGGCACGC CCAGATCAGC 
ACCAGCAACC TGTACCTGCC CCAGGACCCC ACGGTTGCCA AGGGTGCCCT GGCTGGTGAG 
GACACAGGTG TTGTGACACA TGAGCAGTTC AAGGCTGCGC TCAGGATGGT GGTGGACCAG 
GGTGACCCCC GGCTGCTGCT GGACAGCTAC GTGAAGATTG GCGAGGGCTC CACCGGCATC 
GTCTGCTTGG CCCGGGAGAA GCACTCGGGC CGCCAGGTGG CCGTCAAGAT GATGGACCTC 
AGGAAGCAGC AGCGCAGGGA GCTGCTCTTC AACGAGGTGG TGATCATGCG GGACTACCAG 
CACTTCAACG TGGTGGAGAT GTACAAGAGC TACCTGGTGG GCGAGGAGCT GTGGGTGCTC 
ATGGAGTTCC TGCAGGGAGG AGCCCTCACA GACATCGTCT CCCAAGTCAG GCTGAATGAG 
GAGCAGATTG CCACTGTGTG TGAGGCTGTG CTGCAGGCCC TGGCCTACCT GCATGCTCAG 
GGTGTCATCC ACCGGGACAT CAAGAGTGAC TCCATCCTGC TGACCCTCGA TGGCAGGGTG 
AAGCTCTCGG ACTTCGGATT CTGTGCTCAG ATCAGCAAAG ACGTCCCTAA GAGGAAGTCC 
CTGGTGGGAA CCCCCTACTG GATGGCTCCT GAAGTGATCT CCAGGTCTTT GTATGCCACT 
GAGGTGGATA TCTGGTCTCT GGGCATCATG GTGATTGAGA TGGTAGATGG GGAGCCACCG 
TACTTCAGTG ACTCCCCAGT GCAAGCCATG AAGAGGCTCC GGGACAGCCC CCCACCCAAG 
CTGAAAAACT CTCACAAGGT CTCCCCAGTG CTGCGAGACT TCCTGGAGCG GATGCTGGTG 
CGGGACCCCC AAGAGAGAGC CACAGCCCAG GAGCTCCTAG ACCACCCCTT CCTGCTGCAG 
ACAGGGCTAC CTGAGTGCCT GGTGCCCCTG ATCCAGCTCT ACCGAAAGCA GACCTCCACC 
TGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001122100.1
CDS	441..2486
Translation	MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRITRVQLQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDEHWATDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSLGPAEFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGRPGGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLIQLYRKQTSTC

Target ORF information:

RefSeq Version	NM_001128628.2
Organism	Homo sapiens(human)
Definition	Homo sapiens BUB1B-PAK6 readthrough (BUB1B-PAK6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001128628.2

ORF Insert Sequence:

ATGTTCCGCA AGAAAAAGAA GAAACGCCCT GAGATCTCAG CGCCACAGAA CTTCCAGCAC 
CGTGTCCACA CCTCCTTCGA CCCCAAAGAA GGCAAGTTTG TGGGCCTCCC CCCACAATGG 
CAGAACATCC TGGACACACT GCGGCGCCCC AAGCCCGTGG TGGACCCTTC GCGAATCACA 
CGGGTGCAGC TCCAGCCCAT GAAGACAGTG GTGCGGGGCA GCGCGATGCC TGTGGATGGC 
TACATCTCGG GGCTGCTCAA CGACATCCAG AAGTTGTCAG TCATCAGCTC CAACACCCTG 
CGTGGCCGCA GCCCCACCAG CCGGCGGCGG GCACAGTCCC TGGGGCTGCT GGGGGATGAG 
CACTGGGCCA CCGACCCAGA CATGTACCTC CAGAGCCCCC AGTCTGAGCG CACTGACCCC 
CACGGCCTCT ACCTCAGCTG CAACGGGGGC ACACCAGCAG GCCACAAGCA GATGCCGTGG 
CCCGAGCCAC AGAGCCCACG GGTCCTGCCC AATGGGCTGG CTGCAAAGGC ACAGTCCCTG 
GGCCCCGCCG AGTTTCAGGG TGCCTCGCAG CGCTGTCTGC AGCTGGGTGC CTGCCTGCAG 
AGCTCCCCAC CAGGAGCCTC GCCCCCCACG GGCACCAATA GGCATGGAAT GAAGGCTGCC 
AAGCATGGCT CTGAGGAGGC CCGGCCACAG TCCTGCCTGG TGGGCTCAGC CACAGGCAGG 
CCAGGTGGGG AAGGCAGCCC TAGCCCTAAG ACCCGGGAGA GCAGCCTGAA GCGCAGGCTA 
TTCCGAAGCA TGTTCCTGTC CACTGCTGCC ACAGCCCCTC CAAGCAGCAG CAAGCCAGGC 
CCTCCACCAC AGAGCAAGCC CAACTCCTCT TTCCGACCGC CGCAGAAAGA CAACCCCCCA 
AGCCTGGTGG CCAAGGCCCA GTCCTTGCCC TCGGACCAGC CGGTGGGGAC CTTCAGCCCT 
CTGACCACTT CGGATACCAG CAGCCCCCAG AAGTCCCTCC GCACAGCCCC GGCCACAGGC 
CAGCTTCCAG GCCGGTCTTC CCCAGCGGGA TCCCCCCGCA CCTGGCACGC CCAGATCAGC 
ACCAGCAACC TGTACCTGCC CCAGGACCCC ACGGTTGCCA AGGGTGCCCT GGCTGGTGAG 
GACACAGGTG TTGTGACACA TGAGCAGTTC AAGGCTGCGC TCAGGATGGT GGTGGACCAG 
GGTGACCCCC GGCTGCTGCT GGACAGCTAC GTGAAGATTG GCGAGGGCTC CACCGGCATC 
GTCTGCTTGG CCCGGGAGAA GCACTCGGGC CGCCAGGTGG CCGTCAAGAT GATGGACCTC 
AGGAAGCAGC AGCGCAGGGA GCTGCTCTTC AACGAGGTGG TGATCATGCG GGACTACCAG 
CACTTCAACG TGGTGGAGAT GTACAAGAGC TACCTGGTGG GCGAGGAGCT GTGGGTGCTC 
ATGGAGTTCC TGCAGGGAGG AGCCCTCACA GACATCGTCT CCCAAGTCAG GCTGAATGAG 
GAGCAGATTG CCACTGTGTG TGAGGCTGTG CTGCAGGCCC TGGCCTACCT GCATGCTCAG 
GGTGTCATCC ACCGGGACAT CAAGAGTGAC TCCATCCTGC TGACCCTCGA TGGCAGGGTG 
AAGCTCTCGG ACTTCGGATT CTGTGCTCAG ATCAGCAAAG ACGTCCCTAA GAGGAAGTCC 
CTGGTGGGAA CCCCCTACTG GATGGCTCCT GAAGTGATCT CCAGGTCTTT GTATGCCACT 
GAGGTGGATA TCTGGTCTCT GGGCATCATG GTGATTGAGA TGGTAGATGG GGAGCCACCG 
TACTTCAGTG ACTCCCCAGT GCAAGCCATG AAGAGGCTCC GGGACAGCCC CCCACCCAAG 
CTGAAAAACT CTCACAAGGT CTCCCCAGTG CTGCGAGACT TCCTGGAGCG GATGCTGGTG 
CGGGACCCCC AAGAGAGAGC CACAGCCCAG GAGCTCCTAG ACCACCCCTT CCTGCTGCAG 
ACAGGGCTAC CTGAGTGCCT GGTGCCCCTG ATCCAGCTCT ACCGAAAGCA GACCTCCACC 
TGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

p21-Activated kinase 6 (PAK6) inhibits prostate cancer growth via phosphorylation of androgen receptor and tumorigenic E3 ligase murine double minute-2 (Mdm2).
The Journal of biological chemistry288(5)3359-69(2013 Feb)
Liu T,Li Y,Gu H,Zhu G,Li J,Cao L,Li F

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
PloS one7(12)e51954(2012)
Comuzzie AG,Cole SA,Laston SL,Voruganti VS,Haack K,Gibbs RA,Butte NF

Pak6 protein kinase is a novel effector of an atypical Rho family GTPase Chp/RhoV.
Biochemistry. Biokhimiia77(1)26-32(2012 Jan)
Shepelev MV,Korobko IV

Group I p21-activated kinases regulate thyroid cancer cell migration and are overexpressed and activated in thyroid cancer invasion.
Endocrine-related cancer17(4)989-99(2010 Dec)
McCarty SK,Saji M,Zhang X,Jarjoura D,Fusco A,Vasko VV,Ringel MD

The emerging importance of group II PAKs.
The Biochemical journal425(3)465-73(2010 Jan)
Wells CM,Jones GE

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BUB1B-PAK6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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