PLA2G4B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PLA2G4B
Entrez Gene ID	100137049
Full Name	phospholipase A2 group IVB
Synonyms	HsT16992,cPLA2-beta
General protein information	Preferred Names phospholipase A2 group IVB Names cytosolic phospholipase A2 beta phospholipase A2, group IVB (cytosolic)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q15.1
Summary	This gene encodes a member of the cytosolic phospholipase A2 protein family. Phospholipase A2 enzymes hydrolyze the sn-2 bond of phospholipids, releasing lysophospholipids and fatty acids. This enzyme may be associated with mitochondria and early endosomes. Most tissues also express read-through transcripts from the upstream gene into this gene, some of which may encode fusion proteins combining the N-terminus of the upstream gene including its JmjC domain with the almost complete coding region of this gene, including the C2 and cytoplasmic phospholipase A2 domains. [provided by RefSeq, Jul 2008].
Disorder MIM:	606088

mRNA and Protein(s)

mRNA	Protein	Name
NM_001114633.1	NP_001108105.1	cytosolic phospholipase A2 beta

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PLA2G4B	NP_001191165.1
Rattus norvegicus (Norway rat)	Pla2g4b	NP_001101234.2
Gallus gallus (chicken)	PLA2G4B	XP_004941702.1
Homo sapiens (human)	PLA2G4B	NP_001108105.1
Mus musculus (house mouse)	Pla2g4b	NP_663353.3
Pan troglodytes (chimpanzee)	PLA2G4B	XP_001157544.1
Bos taurus (cattle)	PLA2G4B	NP_001108129.1

Gene Ontology
Bibliography

Related articles in PubMed

A novel read-through transcript JMJD7-PLA2G4B regulates head and neck squamous cell carcinoma cell proliferation and survival.
Cheng Y, Wang Y, Li J, Chang I, Wang CY
Oncotarget8(2)1972-1982(2017 Jan)

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S,
Diabetes care33(10)2250-3(2010 Oct)

Cooperation of TLR2 with MyD88, PI3K, and Rac1 in lipoteichoic acid-induced cPLA2/COX-2-dependent airway inflammatory responses.
Lee IT, Lee CW, Tung WH, Wang SW, Lin CC, Shu JC, Yang CM
The American journal of pathology176(4)1671-84(2010 Apr)

Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.
Segat L, Brand?o LA, Guimar?es RL, Pontillo A, Athanasakis E, de Oliveira RM, Arraes LC, de Lima Filho JL, Crovella S
Vaccine28(10)2201-6(2010 Mar)

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, , ,
American journal of human genetics85(5)628-42(2009 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

TLR2 cooperates with MyD88, PI3K, and Rac1 in lipoteichoic acid-induced cPLA2/COX-2-dependent airway inflammatory responses
Title: Cooperation of TLR2 with MyD88, PI3K, and Rac1 in lipoteichoic acid-induced cPLA2/COX-2-dependent airway inflammatory responses.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

The following PLA2G4B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PLA2G4B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu31631	NM_001114633.1 Latest version!	Homo sapiens phospholipase A2 group IVB (PLA2G4B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$394.50-$552.30 $789.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PLA2G4B ( NM_001114633.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001108105.1 Homo sapiens phospholipase A2 group IVB (PLA2G4B), mRNA.

Price & Availability↑

CloneID	OHu31631
Clone ID Related Accession (Same CDS sequence)	NM_001114633.1
Accession Version	NM_001114633.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2346bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Homo sapiens(human)
Product	cytosolic phospholipase A2 beta
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK310651.1, DA250544.1, CA488226.1, BF372565.1, CU447449.1, BM982475.1 and BQ004235.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK299419.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2145893 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGCTGTGG CAGAGGTGTC CAGGACCTGC CTGCTCACGG TTCGTGTCCT GCAGGCCCAT 
CGCCTACCCT CTAAGGACCT AGTGACCCCC TCTGACTGCT ACGTGACTCT CTGGCTGCCC 
ACGGCCTGCA GCCACAGGCT CCAGACACGC ACGGTCAAGA ACAGCAGTAG CCCTGTCTGG 
AACCAGAGCT TTCACTTCAG GATCCACAGG CAGCTCAAGA ATGTCATGGA ACTGAAAGTC 
TTTGACCAGG ACCTGGTGAC CGGAGATGAC CCTGTGTTGT CAGTACTGTT TGATGCGGGG 
ACTCTGCGGG CTGGGGAGTT CCGGCGCGAG AGCTTCTCAC TGAGCCCTCA GGGTGAGGGG 
CGCCTGGAAG TTGAATTTCG CCTGCAGAGT CTGGCTGACC GTGGCGAGTG GCTCGTCAGC 
AATGGCGTTC TGGTGGCCCG GGAGCTCTCC TGCTTGCACG TTCAACTGGA GGAGACAGGA 
GACCAGAAGT CCTCAGAGCA CAGAGTTCAG CTTGTGGTTC CTGGGTCCTG TGAGGGTCCG 
CAGGAGGCCT CTGTGGGCAC TGGCACCTTC CGCTTCCACT GCCCAGCCTG CTGGGAGCAG 
GAGCTGAGTA TTCGCCTGCA GGATGCCCCC GAGGAGCAAC TAAAGGCGCC ACTGAGTGCC 
CTGCCCTCTG GTCAAGTGGT GAGGCTTGTC TTCCCCACGT CCCAGGAGCC CCTGATGAGA 
GTGGAGCTGA AAAAAGAAGC AGGACTGAGG GAGCTGGCCG TGCGACTGGG CTTCGGGCCC 
TGTGCAGAGG AGCAGGCCTT CCTGAGCAGG AGGAAGCAGG TGGTGGCCGC GGCCTTGAGG 
CAGGCCCTGC AGCTGGACGG AGACCTGCAG GAGGATGAGA TCCCAGTGGT AGCTATTATG 
GCCACTGGTG GTGGGATCCG GGCAATGACT TCCCTGTATG GGCAGCTGGC TGGCCTGAAG 
GAGCTGGGCC TCTTGGATTG CGTCTCCTAC ATCACCGGGG CCTCGGGCTC CACCTGGGCC 
TTGGCCAACC TTTATGAGGA CCCAGAGTGG TCTCAGAAGG ACCTGGCAGG GCCCACTGAG 
TTGCTGAAGA CCCAGGTGAC CAAGAACAAG CTGGGTGTGC TGGCCCCCAG CCAGCTGCAG 
CGGTACCGGC AGGAGCTGGC CGAGCGTGCC CGCTTGGGCT ACCCAAGCTG CTTCACCAAC 
CTGTGGGCCC TCATCAACGA GGCGCTGCTG CATGATGAGC CCCATGATCA CAAGCTCTCA 
GATCAACGGG AGGCCCTGAG TCATGGCCAG AACCCTCTGC CCATCTACTG TGCCCTCAAC 
ACCAAAGGGC AGAGCCTGAC CACTTTTGAA TTTGGGGAGT GGTGCGAGTT CTCTCCCTAC 
GAGGTCGGCT TCCCCAAGTA CGGGGCCTTC ATCCCCTCTG AGCTCTTTGG CTCCGAGTTC 
TTTATGGGGC AGCTGATGAA GAGGCTTCCT GAGTCCCGCA TCTGCTTCTT AGAAGGTATC 
TGGAGCAACC TGTATGCAGC CAACCTCCAG GACAGCTTAT ACTGGGCCTC AGAGCCCAGC 
CAGTTCTGGG ACCGCTGGGT CAGGAACCAG GCCAACCTGG ACAAGGAGCA GGTCCCCCTT 
CTGAAGATAG AAGAACCACC CTCAACAGCC GGCAGGATAG CTGAGTTTTT CACCGATCTT 
CTGACGTGGC GTCCACTGGC CCAGGCCACA CATAATTTCC TGCGTGGCCT CCATTTCCAC 
AAAGACTACT TTCAGCATCC TCACTTCTCC ACATGGAAAG CTACCACTCT GGATGGGCTC 
CCCAACCAGC TGACACCCTC GGAGCCCCAC CTGTGCCTGC TGGATGTTGG CTACCTCATC 
AATACCAGCT GCCTGCCCCT CCTGCAGCCC ACTCGGGACG TGGACCTCAT CCTGTCATTG 
GACTACAACC TCCACGGAGC CTTCCAGCAG TTGCAGCTCC TGGGCCGGTT CTGCCAGGAG 
CAGGGGATCC CGTTCCCACC CATCTCGCCC AGCCCCGAAG AGCAGCTCCA GCCTCGGGAG 
TGCCACACCT TCTCCGACCC CACCTGCCCC GGAGCCCCTG CGGTGCTGCA CTTTCCTCTG 
GTCAGCGACT CCTTCCGGGA GTACTCGGCC CCTGGGGTCC GGCGGACACC CGAGGAGGCG 
GCAGCTGGGG AGGTGAACCT GTCTTCATCG GACTCTCCCT ACCACTACAC GAAGGTGACC 
TACAGCCAGG AGGACGTGGA CAAGCTGCTG CACCTGACAC ATTACAATGT CTGCAACAAC 
CAGGAGCAGC TGCTGGAGGC TCTGCGCCAG GCAGTGCAGC GGAGGCGGCA GCGCAGGCCC 
CACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001108105.1
CDS	102..2447
Translation	MAVAEVSRTCLLTVRVLQAHRLPSKDLVTPSDCYVTLWLPTACSHRLQTRTVKNSSSPVWNQSFHFRIHRQLKNVMELKVFDQDLVTGDDPVLSVLFDAGTLRAGEFRRESFSLSPQGEGRLEVEFRLQSLADRGEWLVSNGVLVARELSCLHVQLEETGDQKSSEHRVQLVVPGSCEGPQEASVGTGTFRFHCPACWEQELSIRLQDAPEEQLKAPLSALPSGQVVRLVFPTSQEPLMRVELKKEAGLRELAVRLGFGPCAEEQAFLSRRKQVVAAALRQALQLDGDLQEDEIPVVAIMATGGGIRAMTSLYGQLAGLKELGLLDCVSYITGASGSTWALANLYEDPEWSQKDLAGPTELLKTQVTKNKLGVLAPSQLQRYRQELAERARLGYPSCFTNLWALINEALLHDEPHDHKLSDQREALSHGQNPLPIYCALNTKGQSLTTFEFGEWCEFSPYEVGFPKYGAFIPSELFGSEFFMGQLMKRLPESRICFLEGIWSNLYAANLQDSLYWASEPSQFWDRWVRNQANLDKEQVPLLKIEEPPSTAGRIAEFFTDLLTWRPLAQATHNFLRGLHFHKDYFQHPHFSTWKATTLDGLPNQLTPSEPHLCLLDVGYLINTSCLPLLQPTRDVDLILSLDYNLHGAFQQLQLLGRFCQEQGIPFPPISPSPEEQLQPRECHTFSDPTCPGAPAVLHFPLVSDSFREYSAPGVRRTPEEAAAGEVNLSSSDSPYHYTKVTYSQEDVDKLLHLTHYNVCNNQEQLLEALRQAVQRRRQRRPH

Target ORF information:

RefSeq Version	NM_001114633.1
Organism	Homo sapiens(human)
Definition	Homo sapiens phospholipase A2 group IVB (PLA2G4B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001114633.1

ORF Insert Sequence:

ATGGCTGTGG CAGAGGTGTC CAGGACCTGC CTGCTCACGG TTCGTGTCCT GCAGGCCCAT 
CGCCTACCCT CTAAGGACCT AGTGACCCCC TCTGACTGCT ACGTGACTCT CTGGCTGCCC 
ACGGCCTGCA GCCACAGGCT CCAGACACGC ACGGTCAAGA ACAGCAGTAG CCCTGTCTGG 
AACCAGAGCT TTCACTTCAG GATCCACAGG CAGCTCAAGA ATGTCATGGA ACTGAAAGTC 
TTTGACCAGG ACCTGGTGAC CGGAGATGAC CCTGTGTTGT CAGTACTGTT TGATGCGGGG 
ACTCTGCGGG CTGGGGAGTT CCGGCGCGAG AGCTTCTCAC TGAGCCCTCA GGGTGAGGGG 
CGCCTGGAAG TTGAATTTCG CCTGCAGAGT CTGGCTGACC GTGGCGAGTG GCTCGTCAGC 
AATGGCGTTC TGGTGGCCCG GGAGCTCTCC TGCTTGCACG TTCAACTGGA GGAGACAGGA 
GACCAGAAGT CCTCAGAGCA CAGAGTTCAG CTTGTGGTTC CTGGGTCCTG TGAGGGTCCG 
CAGGAGGCCT CTGTGGGCAC TGGCACCTTC CGCTTCCACT GCCCAGCCTG CTGGGAGCAG 
GAGCTGAGTA TTCGCCTGCA GGATGCCCCC GAGGAGCAAC TAAAGGCGCC ACTGAGTGCC 
CTGCCCTCTG GTCAAGTGGT GAGGCTTGTC TTCCCCACGT CCCAGGAGCC CCTGATGAGA 
GTGGAGCTGA AAAAAGAAGC AGGACTGAGG GAGCTGGCCG TGCGACTGGG CTTCGGGCCC 
TGTGCAGAGG AGCAGGCCTT CCTGAGCAGG AGGAAGCAGG TGGTGGCCGC GGCCTTGAGG 
CAGGCCCTGC AGCTGGACGG AGACCTGCAG GAGGATGAGA TCCCAGTGGT AGCTATTATG 
GCCACTGGTG GTGGGATCCG GGCAATGACT TCCCTGTATG GGCAGCTGGC TGGCCTGAAG 
GAGCTGGGCC TCTTGGATTG CGTCTCCTAC ATCACCGGGG CCTCGGGCTC CACCTGGGCC 
TTGGCCAACC TTTATGAGGA CCCAGAGTGG TCTCAGAAGG ACCTGGCAGG GCCCACTGAG 
TTGCTGAAGA CCCAGGTGAC CAAGAACAAG CTGGGTGTGC TGGCCCCCAG CCAGCTGCAG 
CGGTACCGGC AGGAGCTGGC CGAGCGTGCC CGCTTGGGCT ACCCAAGCTG CTTCACCAAC 
CTGTGGGCCC TCATCAACGA GGCGCTGCTG CATGATGAGC CCCATGATCA CAAGCTCTCA 
GATCAACGGG AGGCCCTGAG TCATGGCCAG AACCCTCTGC CCATCTACTG TGCCCTCAAC 
ACCAAAGGGC AGAGCCTGAC CACTTTTGAA TTTGGGGAGT GGTGCGAGTT CTCTCCCTAC 
GAGGTCGGCT TCCCCAAGTA CGGGGCCTTC ATCCCCTCTG AGCTCTTTGG CTCCGAGTTC 
TTTATGGGGC AGCTGATGAA GAGGCTTCCT GAGTCCCGCA TCTGCTTCTT AGAAGGTATC 
TGGAGCAACC TGTATGCAGC CAACCTCCAG GACAGCTTAT ACTGGGCCTC AGAGCCCAGC 
CAGTTCTGGG ACCGCTGGGT CAGGAACCAG GCCAACCTGG ACAAGGAGCA GGTCCCCCTT 
CTGAAGATAG AAGAACCACC CTCAACAGCC GGCAGGATAG CTGAGTTTTT CACCGATCTT 
CTGACGTGGC GTCCACTGGC CCAGGCCACA CATAATTTCC TGCGTGGCCT CCATTTCCAC 
AAAGACTACT TTCAGCATCC TCACTTCTCC ACATGGAAAG CTACCACTCT GGATGGGCTC 
CCCAACCAGC TGACACCCTC GGAGCCCCAC CTGTGCCTGC TGGATGTTGG CTACCTCATC 
AATACCAGCT GCCTGCCCCT CCTGCAGCCC ACTCGGGACG TGGACCTCAT CCTGTCATTG 
GACTACAACC TCCACGGAGC CTTCCAGCAG TTGCAGCTCC TGGGCCGGTT CTGCCAGGAG 
CAGGGGATCC CGTTCCCACC CATCTCGCCC AGCCCCGAAG AGCAGCTCCA GCCTCGGGAG 
TGCCACACCT TCTCCGACCC CACCTGCCCC GGAGCCCCTG CGGTGCTGCA CTTTCCTCTG 
GTCAGCGACT CCTTCCGGGA GTACTCGGCC CCTGGGGTCC GGCGGACACC CGAGGAGGCG 
GCAGCTGGGG AGGTGAACCT GTCTTCATCG GACTCTCCCT ACCACTACAC GAAGGTGACC 
TACAGCCAGG AGGACGTGGA CAAGCTGCTG CACCTGACAC ATTACAATGT CTGCAACAAC 
CAGGAGCAGC TGCTGGAGGC TCTGCGCCAG GCAGTGCAGC GGAGGCGGCA GCGCAGGCCC 
CACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A novel read-through transcript JMJD7-PLA2G4B regulates head and neck squamous cell carcinoma cell proliferation and survival.
Oncotarget8(2)1972-1982(2017 Jan)
Cheng Y,Wang Y,Li J,Chang I,Wang CY

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Diabetes care33(10)2250-3(2010 Oct)
Bailey SD,Xie C,Do R,Montpetit A,Diaz R,Mohan V,Keavney B,Yusuf S,Gerstein HC,Engert JC,Anand S,

Cooperation of TLR2 with MyD88, PI3K, and Rac1 in lipoteichoic acid-induced cPLA2/COX-2-dependent airway inflammatory responses.
The American journal of pathology176(4)1671-84(2010 Apr)
Lee IT,Lee CW,Tung WH,Wang SW,Lin CC,Shu JC,Yang CM

Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.
Vaccine28(10)2201-6(2010 Mar)
Segat L,Brand?o LA,Guimar?es RL,Pontillo A,Athanasakis E,de Oliveira RM,Arraes LC,de Lima Filho JL,Crovella S

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
American journal of human genetics85(5)628-42(2009 Nov)
Talmud PJ,Drenos F,Shah S,Shah T,Palmen J,Verzilli C,Gaunt TR,Pallas J,Lovering R,Li K,Casas JP,Sofat R,Kumari M,Rodriguez S,Johnson T,Newhouse SJ,Dominiczak A,Samani NJ,Caulfield M,Sever P,Stanton A,Shields DC,Padmanabhan S,Melander O,Hastie C,Delles C,Ebrahim S,Marmot MG,Smith GD,Lawlor DA,Munroe PB,Day IN,Kivimaki M,Whittaker J,Humphries SE,Hingorani AD,,,

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PLA2G4B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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