Gene Symbol | selenoh |
Entrez Gene ID | 347743 |
Full Name | selenoprotein H |
Synonyms | cb697,selh,seph,wu:fa11g07,wu:fb23d03 |
General protein information |
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Gene Type | protein-coding |
Organism | Danio rerio(zebrafish) |
Summary | This gene encodes a nucleolar protein, which belongs to the SelWTH family. It functions as an oxidoreductase; and in mammals, it has been shown to protect neurons against UVB-induced damage, promote mitochondrial biogenesis, and suppress cellular senescence. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Aug 2017]. |