Selenoh cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Selenoh
Entrez Gene ID	72657
Full Name	selenoprotein H
Synonyms	2700094K13Rik,Selh
General protein information	Preferred Names selenoprotein H Names selenoprotein H
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2\|2 D
Summary	This gene encodes a nucleolar protein, which belongs to the SelWTH family. It functions as an oxidoreductase, and has been shown to protect neurons against UVB-induced damage by inhibiting apoptotic cell death pathways, promote mitochondrial biogenesis and mitochondrial function, and suppress cellular senescence through genome maintenance and redox regulation. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001033166.3	NP_001028338.1	selenoprotein H
NM_001033166.2	NP_001028338.1	selenoprotein H
NM_001037279.1	NP_001032356.1	selenoprotein H
NM_001037279.2	NP_001032356.1	selenoprotein H

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	C11H11orf31	NP_001140163.1
	C14H11orf31	NP_001152973.1
Bos taurus (cattle)	C15H11orf31	NP_001157564.1
Mus musculus (house mouse)	2700094K13Rik	NP_001028338.1
Gallus gallus (chicken)	LOC100858006	NP_001264794.1
Canis lupus familiaris (dog)	C18H11orf31	NP_001157978.1
Homo sapiens (human)	C11orf31	NP_734467.1
Rattus norvegicus (Norway rat)	RGD1563348	NP_001108411.1
Danio rerio (zebrafish)	seph	NP_835234.2

Gene Ontology
Bibliography

Related articles in PubMed

Selenoprotein Gene Nomenclature.
Gladyshev VN, Arn?r ES, Berry MJ, Brigelius-Floh? R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Floh? L, Green FR, Guig? R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, K?hrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonovi? M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y
The Journal of biological chemistry291(46)24036-24040(2016 Nov)

SelT, SelW, SelH, and Rdx12: genomics and molecular insights into the functions of selenoproteins of a novel thioredoxin-like family.
Dikiy A, Novoselov SV, Fomenko DE, Sengupta A, Carlson BA, Cerny RL, Ginalski K, Grishin NV, Hatfield DL, Gladyshev VN
Biochemistry46(23)6871-82(2007 Jun)

Selenoprotein H is a nucleolar thioredoxin-like protein with a unique expression pattern.
Novoselov SV, Kryukov GV, Xu XM, Carlson BA, Hatfield DL, Gladyshev VN
The Journal of biological chemistry282(16)11960-8(2007 Apr)

Characterization of mammalian selenoproteomes.
Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guig? R, Gladyshev VN
Science (New York, N.Y.)300(5624)1439-43(2003 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Selenoh gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Selenoh cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu18781	NM_001033166.3 Latest version!	Mus musculus selenoprotein H (Selenoh), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu18781	NM_001037279.2 Latest version!	Mus musculus selenoprotein H (Selenoh), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OMu18781	NM_001033166.2	Mus musculus RIKEN cDNA 2700094K13 gene (2700094K13Rik), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu18781	NM_001037279.1	Mus musculus RIKEN cDNA 2700094K13 gene (2700094K13Rik), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Selenoh ( NM_001033166.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001028338.1 Mus musculus selenoprotein H (Selenoh), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu18781
Clone ID Related Accession (Same CDS sequence)	NM_001033166.3 , NM_001033166.2 , NM_001037279.1 , NM_001037279.2
Accession Version	NM_001033166.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 351bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-24
Organism	Mus musculus(house mouse)
Product	selenoprotein H
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY239096.1, BC056177.1 and AV508490.1. On Mar 18, 2016 this sequence version replaced NM_001033166.2. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: BC056177.1, SRR1660819.207428.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134, SAMN01164135 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: PMID: 17337453 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCCCCC ACGGAAGAAA GCGTAAGGCG GGGGCCGCGC CTATGGAGAC GGTGGACAAG 
CGCGAGAAAC TGGCGGAGGG CGCGACCGTG GTCATTGAGC ATTGTACGAG CTGACGCGTG 
TACGGCCGCC ATGCTGCTGC CTTGAGCCAG GCTCTGCAAC TGGAGGCCCC AGAGCTACCT 
GTGCAAGTGA ACCCGTCCAA ACCGCGGAGG GGCAGCTTCG AGGTGACGCT GCTGCGCTCG 
GACAACAGCC GTGTTGAACT CTGGACTGGT ATTAAGAAGG GCCCTCCACG AAAGCTCAAA 
TTTCCTGAGC CTCAAGAGGT GGTTGAAGAA TTGAAGAAGT ACCTTTCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001028338.1
CDS	123..473
Translation	MAPHGRKRKAGAAPMETVDKREKLAEGATVVIEHCTS*RVYGRHAAALSQALQLEAPELPVQVNPSKPRRGSFEVTLLRSDNSRVELWTGIKKGPPRKLKFPEPQEVVEELKKYLS

Target ORF information:

RefSeq Version	NM_001033166.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus selenoprotein H (Selenoh), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001033166.3

ORF Insert Sequence:

ATGGCCCCCC ACGGAAGAAA GCGTAAGGCG GGGGCCGCGC CTATGGAGAC GGTGGACAAG 
CGCGAGAAAC TGGCGGAGGG CGCGACCGTG GTCATTGAGC ATTGTACGAG CTGACGCGTG 
TACGGCCGCC ATGCTGCTGC CTTGAGCCAG GCTCTGCAAC TGGAGGCCCC AGAGCTACCT 
GTGCAAGTGA ACCCGTCCAA ACCGCGGAGG GGCAGCTTCG AGGTGACGCT GCTGCGCTCG 
GACAACAGCC GTGTTGAACT CTGGACTGGT ATTAAGAAGG GCCCTCCACG AAAGCTCAAA 
TTTCCTGAGC CTCAAGAGGT GGTTGAAGAA TTGAAGAAGT ACCTTTCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Selenoh ( NM_001033166.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001028338.1 Mus musculus RIKEN cDNA 2700094K13 gene (2700094K13Rik), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu18781
Clone ID Related Accession (Same CDS sequence)	NM_001033166.3 , NM_001033166.2 , NM_001037279.1 , NM_001037279.2
Accession Version	NM_001033166.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 351bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-07-09
Organism	Mus musculus(House mouse)
Product	selenoprotein H
Comment

ATGGCCCCCC ACGGAAGAAA GCGTAAGGCG GGGGCCGCGC CTATGGAGAC GGTGGACAAG 
CGCGAGAAAC TGGCGGAGGG CGCGACCGTG GTCATTGAGC ATTGTACGAG CTGACGCGTG 
TACGGCCGCC ATGCTGCTGC CTTGAGCCAG GCTCTGCAAC TGGAGGCCCC AGAGCTACCT 
GTGCAAGTGA ACCCGTCCAA ACCGCGGAGG GGCAGCTTCG AGGTGACGCT GCTGCGCTCG 
GACAACAGCC GTGTTGAACT CTGGACTGGT ATTAAGAAGG GCCCTCCACG AAAGCTCAAA 
TTTCCTGAGC CTCAAGAGGT GGTTGAAGAA TTGAAGAAGT ACCTTTCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001028338.1
Translation	MAPHGRKRKAGAAPMETVDKREKLAEGATVVIEHCTS*RVYGRHAAALSQALQLEAPELPVQVNPSKPRRGSFEVTLLRSDNSRVELWTGIKKGPPRKLKFPEPQEVVEELKKYLS

Target ORF information:

RefSeq Version	NM_001033166.2
Organism	Mus musculus(House mouse)
Definition	Mus musculus RIKEN cDNA 2700094K13 gene (2700094K13Rik), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001033166.2

ORF Insert Sequence:

ATGGCCCCCC ACGGAAGAAA GCGTAAGGCG GGGGCCGCGC CTATGGAGAC GGTGGACAAG 
CGCGAGAAAC TGGCGGAGGG CGCGACCGTG GTCATTGAGC ATTGTACGAG CTGACGCGTG 
TACGGCCGCC ATGCTGCTGC CTTGAGCCAG GCTCTGCAAC TGGAGGCCCC AGAGCTACCT 
GTGCAAGTGA ACCCGTCCAA ACCGCGGAGG GGCAGCTTCG AGGTGACGCT GCTGCGCTCG 
GACAACAGCC GTGTTGAACT CTGGACTGGT ATTAAGAAGG GCCCTCCACG AAAGCTCAAA 
TTTCCTGAGC CTCAAGAGGT GGTTGAAGAA TTGAAGAAGT ACCTTTCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Selenoh ( NM_001037279.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001032356.1 Mus musculus RIKEN cDNA 2700094K13 gene (2700094K13Rik), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu18781
Clone ID Related Accession (Same CDS sequence)	NM_001033166.3 , NM_001033166.2 , NM_001037279.1 , NM_001037279.2
Accession Version	NM_001037279.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 351bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-07-09
Organism	Mus musculus(House mouse)
Product	selenoprotein H
Comment

ATGGCCCCCC ACGGAAGAAA GCGTAAGGCG GGGGCCGCGC CTATGGAGAC GGTGGACAAG 
CGCGAGAAAC TGGCGGAGGG CGCGACCGTG GTCATTGAGC ATTGTACGAG CTGACGCGTG 
TACGGCCGCC ATGCTGCTGC CTTGAGCCAG GCTCTGCAAC TGGAGGCCCC AGAGCTACCT 
GTGCAAGTGA ACCCGTCCAA ACCGCGGAGG GGCAGCTTCG AGGTGACGCT GCTGCGCTCG 
GACAACAGCC GTGTTGAACT CTGGACTGGT ATTAAGAAGG GCCCTCCACG AAAGCTCAAA 
TTTCCTGAGC CTCAAGAGGT GGTTGAAGAA TTGAAGAAGT ACCTTTCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001032356.1
Translation	MAPHGRKRKAGAAPMETVDKREKLAEGATVVIEHCTS*RVYGRHAAALSQALQLEAPELPVQVNPSKPRRGSFEVTLLRSDNSRVELWTGIKKGPPRKLKFPEPQEVVEELKKYLS

Target ORF information:

RefSeq Version	NM_001037279.1
Organism	Mus musculus(House mouse)
Definition	Mus musculus RIKEN cDNA 2700094K13 gene (2700094K13Rik), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001037279.1

ORF Insert Sequence:

ATGGCCCCCC ACGGAAGAAA GCGTAAGGCG GGGGCCGCGC CTATGGAGAC GGTGGACAAG 
CGCGAGAAAC TGGCGGAGGG CGCGACCGTG GTCATTGAGC ATTGTACGAG CTGACGCGTG 
TACGGCCGCC ATGCTGCTGC CTTGAGCCAG GCTCTGCAAC TGGAGGCCCC AGAGCTACCT 
GTGCAAGTGA ACCCGTCCAA ACCGCGGAGG GGCAGCTTCG AGGTGACGCT GCTGCGCTCG 
GACAACAGCC GTGTTGAACT CTGGACTGGT ATTAAGAAGG GCCCTCCACG AAAGCTCAAA 
TTTCCTGAGC CTCAAGAGGT GGTTGAAGAA TTGAAGAAGT ACCTTTCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Selenoh ( NM_001037279.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001032356.1 Mus musculus selenoprotein H (Selenoh), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu18781
Clone ID Related Accession (Same CDS sequence)	NM_001033166.3 , NM_001033166.2 , NM_001037279.1 , NM_001037279.2
Accession Version	NM_001037279.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 351bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-24
Organism	Mus musculus(house mouse)
Product	selenoprotein H
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY239096.1, AK012609.1 and AV508490.1. On Mar 18, 2016 this sequence version replaced NM_001037279.1. Transcript Variant: This variant (2) uses an alternate donor splice site at the penultimate exon in the 3' non-coding region compared to variant 1. Variants 1 and 2 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: CB203508.1, CA319070.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164138, SAMN01164142 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: PMID: 17337453 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCCCCC ACGGAAGAAA GCGTAAGGCG GGGGCCGCGC CTATGGAGAC GGTGGACAAG 
CGCGAGAAAC TGGCGGAGGG CGCGACCGTG GTCATTGAGC ATTGTACGAG CTGACGCGTG 
TACGGCCGCC ATGCTGCTGC CTTGAGCCAG GCTCTGCAAC TGGAGGCCCC AGAGCTACCT 
GTGCAAGTGA ACCCGTCCAA ACCGCGGAGG GGCAGCTTCG AGGTGACGCT GCTGCGCTCG 
GACAACAGCC GTGTTGAACT CTGGACTGGT ATTAAGAAGG GCCCTCCACG AAAGCTCAAA 
TTTCCTGAGC CTCAAGAGGT GGTTGAAGAA TTGAAGAAGT ACCTTTCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001032356.1
CDS	123..473
Translation	MAPHGRKRKAGAAPMETVDKREKLAEGATVVIEHCTS*RVYGRHAAALSQALQLEAPELPVQVNPSKPRRGSFEVTLLRSDNSRVELWTGIKKGPPRKLKFPEPQEVVEELKKYLS

Target ORF information:

RefSeq Version	NM_001037279.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus selenoprotein H (Selenoh), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001037279.2

ORF Insert Sequence:

ATGGCCCCCC ACGGAAGAAA GCGTAAGGCG GGGGCCGCGC CTATGGAGAC GGTGGACAAG 
CGCGAGAAAC TGGCGGAGGG CGCGACCGTG GTCATTGAGC ATTGTACGAG CTGACGCGTG 
TACGGCCGCC ATGCTGCTGC CTTGAGCCAG GCTCTGCAAC TGGAGGCCCC AGAGCTACCT 
GTGCAAGTGA ACCCGTCCAA ACCGCGGAGG GGCAGCTTCG AGGTGACGCT GCTGCGCTCG 
GACAACAGCC GTGTTGAACT CTGGACTGGT ATTAAGAAGG GCCCTCCACG AAAGCTCAAA 
TTTCCTGAGC CTCAAGAGGT GGTTGAAGAA TTGAAGAAGT ACCTTTCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Selenoprotein Gene Nomenclature.
The Journal of biological chemistry291(46)24036-24040(2016 Nov)
Gladyshev VN,Arn?r ES,Berry MJ,Brigelius-Floh? R,Bruford EA,Burk RF,Carlson BA,Castellano S,Chavatte L,Conrad M,Copeland PR,Diamond AM,Driscoll DM,Ferreiro A,Floh? L,Green FR,Guig? R,Handy DE,Hatfield DL,Hesketh J,Hoffmann PR,Holmgren A,Hondal RJ,Howard MT,Huang K,Kim HY,Kim IY,K?hrle J,Krol A,Kryukov GV,Lee BJ,Lee BC,Lei XG,Liu Q,Lescure A,Lobanov AV,Loscalzo J,Maiorino M,Mariotti M,Sandeep Prabhu K,Rayman MP,Rozovsky S,Salinas G,Schmidt EE,Schomburg L,Schweizer U,Simonovi? M,Sunde RA,Tsuji PA,Tweedie S,Ursini F,Whanger PD,Zhang Y

SelT, SelW, SelH, and Rdx12: genomics and molecular insights into the functions of selenoproteins of a novel thioredoxin-like family.
Biochemistry46(23)6871-82(2007 Jun)
Dikiy A,Novoselov SV,Fomenko DE,Sengupta A,Carlson BA,Cerny RL,Ginalski K,Grishin NV,Hatfield DL,Gladyshev VN

Selenoprotein H is a nucleolar thioredoxin-like protein with a unique expression pattern.
The Journal of biological chemistry282(16)11960-8(2007 Apr)
Novoselov SV,Kryukov GV,Xu XM,Carlson BA,Hatfield DL,Gladyshev VN

Characterization of mammalian selenoproteomes.
Science (New York, N.Y.)300(5624)1439-43(2003 May)
Kryukov GV,Castellano S,Novoselov SV,Lobanov AV,Zehtab O,Guig? R,Gladyshev VN

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Selenoh cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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