Selenoh cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Selenoh
Entrez Gene ID	502642
Full Name	selenoprotein H
Synonyms	RGD1563348,Selh
General protein information	Preferred Names selenoprotein H Names selenoprotein H
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q24
Summary	This gene encodes a nucleolar protein, which belongs to the SelWTH family. It functions as an oxidoreductase, and has been shown to protect neurons against UVB-induced damage by inhibiting apoptotic cell death pathways, promote mitochondrial biogenesis and mitochondrial function, and suppress cellular senescence through genome maintenance and redox regulation. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001114939.2	NP_001108411.1	selenoprotein H
NM_001321292.1	NP_001308221.1	selenoprotein H

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	C11H11orf31	NP_001140163.1
	C14H11orf31	NP_001152973.1
Bos taurus (cattle)	C15H11orf31	NP_001157564.1
Mus musculus (house mouse)	2700094K13Rik	NP_001028338.1
Gallus gallus (chicken)	LOC100858006	NP_001264794.1
Canis lupus familiaris (dog)	C18H11orf31	NP_001157978.1
Homo sapiens (human)	C11orf31	NP_734467.1
Rattus norvegicus (Norway rat)	RGD1563348	NP_001108411.1
Danio rerio (zebrafish)	seph	NP_835234.2

Gene Ontology
Bibliography

Related articles in PubMed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

Characterization of mammalian selenoproteomes.
Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guig? R, Gladyshev VN
Science (New York, N.Y.)300(5624)1439-43(2003 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Selenoh gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Selenoh cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01137	NM_001114939.2 Latest version!	Rattus norvegicus selenoprotein H (Selenoh), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa01137	NM_001321292.1 Latest version!	Rattus norvegicus selenoprotein H (Selenoh), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Selenoh ( NM_001114939.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001108411.1 Rattus norvegicus selenoprotein H (Selenoh), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ORa01137
Clone ID Related Accession (Same CDS sequence)	NM_001114939.2 , NM_001321292.1
Accession Version	NM_001114939.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 351bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-31
Organism	Rattus norvegicus(Norway rat)
Product	selenoprotein H
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from FQ144408.1 and BQ781777.1. On Mar 18, 2016 this sequence version replaced NM_001114939.1. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: FQ144408.1, BI285703.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCCCTC TCGGAAGAAA GCGTAAGGCC GGGGCCGCGC CTATCGAGTC GGCGGACAAG 
CGCGAGAAAC TGGCGGAGGG CGCGGCCGTG GTCATTGAGC ATTGTACGAG CTGACGTGTC 
TACGGCCGCC ATGCTGCTGC CCTGAGCCAG GCTCTGCAAC TGGAGGCCCC AGAGATATCT 
GTGCAAGTGA ACCGGTCCAA GCCGCGGAGG GGCAGCTTCG AAGTGACGCT GCTGCGCCCG 
GACAACAGTC GTGTTGAACT CTGGACTGGT ATTAAGAAGG GCCCTCCACG AAAGCTCAAA 
TTTCCTGAGC CTCAAGAGAT GGTTGAAGAA TTGAAGAAGT ACCTTTCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001108411.1
CDS	118..468
Translation	MAPLGRKRKAGAAPIESADKREKLAEGAAVVIEHCTS*RVYGRHAAALSQALQLEAPEISVQVNRSKPRRGSFEVTLLRPDNSRVELWTGIKKGPPRKLKFPEPQEMVEELKKYLS

Target ORF information:

RefSeq Version	NM_001114939.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus selenoprotein H (Selenoh), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001114939.2

ORF Insert Sequence:

ATGGCCCCTC TCGGAAGAAA GCGTAAGGCC GGGGCCGCGC CTATCGAGTC GGCGGACAAG 
CGCGAGAAAC TGGCGGAGGG CGCGGCCGTG GTCATTGAGC ATTGTACGAG CTGACGTGTC 
TACGGCCGCC ATGCTGCTGC CCTGAGCCAG GCTCTGCAAC TGGAGGCCCC AGAGATATCT 
GTGCAAGTGA ACCGGTCCAA GCCGCGGAGG GGCAGCTTCG AAGTGACGCT GCTGCGCCCG 
GACAACAGTC GTGTTGAACT CTGGACTGGT ATTAAGAAGG GCCCTCCACG AAAGCTCAAA 
TTTCCTGAGC CTCAAGAGAT GGTTGAAGAA TTGAAGAAGT ACCTTTCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Selenoh ( NM_001321292.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001308221.1 Rattus norvegicus selenoprotein H (Selenoh), transcript variant 2, mRNA.

Price & Availability↑

CloneID	ORa01137
Clone ID Related Accession (Same CDS sequence)	NM_001114939.2 , NM_001321292.1
Accession Version	NM_001321292.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 351bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-31
Organism	Rattus norvegicus(Norway rat)
Product	selenoprotein H
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from FQ144408.1, BQ204240.1 and BQ781777.1. Transcript Variant: This variant (2) uses an alternate donor splice site at the penultimate exon in the 3' non-coding region compared to variant 1. Variants 1 and 2 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: CN542322.1, BQ204240.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906355, SAMN01906356 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCCCTC TCGGAAGAAA GCGTAAGGCC GGGGCCGCGC CTATCGAGTC GGCGGACAAG 
CGCGAGAAAC TGGCGGAGGG CGCGGCCGTG GTCATTGAGC ATTGTACGAG CTGACGTGTC 
TACGGCCGCC ATGCTGCTGC CCTGAGCCAG GCTCTGCAAC TGGAGGCCCC AGAGATATCT 
GTGCAAGTGA ACCGGTCCAA GCCGCGGAGG GGCAGCTTCG AAGTGACGCT GCTGCGCCCG 
GACAACAGTC GTGTTGAACT CTGGACTGGT ATTAAGAAGG GCCCTCCACG AAAGCTCAAA 
TTTCCTGAGC CTCAAGAGAT GGTTGAAGAA TTGAAGAAGT ACCTTTCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001308221.1
CDS	118..468
Translation	MAPLGRKRKAGAAPIESADKREKLAEGAAVVIEHCTS*RVYGRHAAALSQALQLEAPEISVQVNRSKPRRGSFEVTLLRPDNSRVELWTGIKKGPPRKLKFPEPQEMVEELKKYLS

Target ORF information:

RefSeq Version	NM_001321292.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus selenoprotein H (Selenoh), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001321292.1

ORF Insert Sequence:

ATGGCCCCTC TCGGAAGAAA GCGTAAGGCC GGGGCCGCGC CTATCGAGTC GGCGGACAAG 
CGCGAGAAAC TGGCGGAGGG CGCGGCCGTG GTCATTGAGC ATTGTACGAG CTGACGTGTC 
TACGGCCGCC ATGCTGCTGC CCTGAGCCAG GCTCTGCAAC TGGAGGCCCC AGAGATATCT 
GTGCAAGTGA ACCGGTCCAA GCCGCGGAGG GGCAGCTTCG AAGTGACGCT GCTGCGCCCG 
GACAACAGTC GTGTTGAACT CTGGACTGGT ATTAAGAAGG GCCCTCCACG AAAGCTCAAA 
TTTCCTGAGC CTCAAGAGAT GGTTGAAGAA TTGAAGAAGT ACCTTTCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

Characterization of mammalian selenoproteomes.
Science (New York, N.Y.)300(5624)1439-43(2003 May)
Kryukov GV,Castellano S,Novoselov SV,Lobanov AV,Zehtab O,Guig? R,Gladyshev VN

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Selenoh cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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