CLCN1 cDNA ORF clone, Canis lupus familiaris(dog)

Gene
Clones
gRNAs

Summary

Gene Symbol	CLCN1
Entrez Gene ID	403723
Full Name	chloride voltage-gated channel 1
General protein information	Preferred Names chloride voltage-gated channel 1 Names chloride channel protein 1 chloride channel 1, skeletal muscle (Thomsen disease, autosomal dominant) chloride channel protein, skeletal muscle clC-1 skeletal muscle chloride channel 1 skeletal muscle chloride channel ClC-1
Gene Type	protein-coding
Organism	Canis lupus familiaris(dog)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001003124.2	NP_001003124.1	chloride channel protein 1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Clcn1	NP_038519.1
Gallus gallus (chicken)	CLCN1	XP_004938180.1
Danio rerio (zebrafish)	LOC567478	XP_695866.4
	CLCN1	XP_001092282.1
Danio rerio (zebrafish)	clcn1a	NP_001076379.1
Homo sapiens (human)	CLCN1	NP_000074.2
Pan troglodytes (chimpanzee)	CLCN1	XP_527935.2
Canis lupus familiaris (dog)	CLCN1	NP_001003124.1
Bos taurus (cattle)	CLCN1	NP_001137343.1
Rattus norvegicus (Norway rat)	Clcn1	NP_037279.1

Gene Ontology
Bibliography

Related articles in PubMed

A missense mutation in canine C1C-1 causes recessive myotonia congenita in the dog.
Rhodes TH, Vite CH, Giger U, Patterson DF, Fahlke C, George AL Jr
FEBS letters456(1)54-8(1999 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following CLCN1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CLCN1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OCe00278	NM_001003124.2 Latest version!	Canis lupus familiaris chloride voltage-gated channel 1 (CLCN1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$510.30 $729.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CLCN1 ( NM_001003124.2 ) cDNA ORF clone, Canis lupus familiaris(dog) -> NP_001003124.1 Canis lupus familiaris chloride voltage-gated channel 1 (CLCN1), mRNA.

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CloneID	OCe00278
Clone ID Related Accession (Same CDS sequence)	NM_001003124.2
Accession Version	NM_001003124.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2931bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Canis lupus familiaris(dog)
Product	chloride channel protein 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF162445.2. On Aug 30, 2012 this sequence version replaced NM_001003124.1. ##Evidence-Data-START## Transcript exon combination :: AF162445.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00013600, SAMN00991610 [ECO:0000348] ##Evidence-Data-END##

ATGCAGCCAT CCCAGTCCCT GCGGCGTGGG GGCGAGCAGA GCTGGTGGGG TAGTGCTCCC 
CAGTACCAGT ACATGCCTTT TGAACACTGC ACCAGCTACG GACTGCCCTC CGAGAATGGA 
GCCCTTCAAC ACAGGCTCCA CAGGGATGCA GGCCTCCGCG CCAACACCCG CCCCACACAG 
ATCTATGGCC ATTACAAACA GCAATTCTCA GACAAGGAGC AGGACACAGG GATGTCCAAG 
AAGATGGGCT CCAGTGAAAG CATGGACAGC AAGGATGAGG ATCACTATTC TAAATGTCAA 
GGCTGTGTCC GCCGCCTGGG ACACGTGGTG AGAAGAAAGT TAGGAGAAGA CTGGATCTTT 
CTGGTGCTCC TGGGACTGCT TATGGCCCTG GTTAGCTGGA GCATGGATTA TGTCAGTGCC 
AAAAGCCTTC AGGCCTACAA GTGGAGCTAC TACCAGATGC AGCCCAACCT GCCTCTGCAG 
TACCTGGTCT GGGTCACCTT CCCGCTAACT CTCATCCTCT TCAGCGCCGT CTTTTGCCAC 
CTCATCTCTC CCCAGGCTGT TGGCTCTGGG ATCCCTGAAA TGAAGACAAT ACTCCGTGGA 
GTCATCCTGA AGGAATATCT CACCCTCAAG GCCTTTGTGG CCAAGGTTGT GGCCCTGACT 
GCGGGGCTGG GCAGTGGCAT TCCTGTGGGG AAGGAGGGCC CTTTCGTCCA CATTGCCAGC 
ATCTGTGCTG CGGTCCTCAG CAAGTTTATG TCCATGTTCT GTGGGGTCTA TGAGCAGCCA 
TACTATTACA CTGACATGCT GACGGTGGGC TGTGCTGTAG GAGTTGGCTG TTGTTTTGGG 
ACGCCACTTG GAGGAGTGTT GTTCAGCATC GAGGTCACCT CTACATACTT TGCTGTGCGG 
AACTACTGGC GAGGATTCTT TGCAGCCACG TTCAGTGCCT TTGTTTTCCG CGTGCTGGCC 
GTGTGGAACA AGGACGCTGT CACCATCACT GCTCTCTTCA GAACCAATTT CCGAATGGAT 
TTCCCCTTTG ACCTGCAGGA ACTCCCAGCC TTCGCCATCA TCGGGATTTG CTGTGGCTTC 
CTGGGAGCCG TGTTTGTGTA CCTGCATCGC CAAGTCATGC TCGGTGTCCG AAAGCACAAG 
GCCCTCAGCC AATTTCTGGC GAAGCACCGC CTGCTGTATC CTGGAATAGT TACCTTCATC 
ATTGCCTCAT TCACCTTTCC GCCAGGAATA GGCCAATTCA TGGCTGGAGA GTTGATGCCT 
CGTGAAGCCA TCAGCACCCT ATTCGACAAT AACACATGGG TAAAGCATGT GGGTGACCCT 
GAAAGCCTGG GCCGGTCAGC TGTGTGGATC CACCCACGGG TCAACGTGAT CATCATCATC 
TTCCTCTTCT TTATCATGAA GTTCTGGATG TCCATCGTGG CCACCACTAT GCCTATACCC 
TGCGGAGGCT TCATGCCTGT GTTTGTGCTA GGAGCTGCAT TTGGGAGGCT GGTAGGAGAG 
ATCATGGCCA TGCTATTCCC TGATGGTATC CTATTTGATG ACATCATCTA CAAGATCCTA 
CCTGGAGGCT ATGCGGTAAT TGGGGCAGCA GCGCTGACCG GTGCAGTATC CCACACAGTC 
TCCACAGCTG TGATTTGCTT CGAATTAACG GGTCAGATTG CCCACATCCT GCCCATGATG 
GTGGCTGTCA TCTTGGCCAA CATGGTGGCT CAGAGCCTGC AGCCCTCCCT CTATGACAGC 
ATCATCCAGG TCAAGAAGCT ACCCTACTTG CCTGACCTTG GTTGGAACCA GCTCAGCAAA 
TTTACCATAT TTGTTGAGGA CATCATGGTT CGTGATGTGA AGTTTGTTTC AGCTACTTGC 
ACATACGGGG AATTGCGAAC CCTGCTCCAG ACCACCACAG TCAAGACTTT ACCACTGGTT 
GATTCTAAAG ATTCTATGAT CCTGCTGGGC TCCGTGGAGC GCTCAGAGCT ACAGTCCCTC 
CTGCAGCGCC ACTTGGGCCC TGAGCGGAGG CTGCGGGTGG CCCAGGACAT GGCCAGGAAG 
TTGTCTGAGC TGCCCTACGA TGGGAAGGGA CACCAAGGCA TCTCACCCGA GGGCCGAAGG 
GAGTCCTTTG CCTTTGTGGA TGAGGATGAA GATGAGGACC TCTCTGGGAA GCCCGAGCTG 
CCTCCTCTTC CTCCTCCTCA CCCCTTACCA TCTGCCCCAT TGTCCTCTGA AGAGTCCAAT 
GGGCCCCTGC CCAGCCACAA ACAGCAGCCA GAAGCACCGG AGCCTGCAGA TCAAAGACCC 
TCTGTCTTTC GGTCCCTGCT GCGCTGCTTA CTTGGCAGAC CTCGCCCCAC GAAGAAGAAA 
ACAACCCAGG AGTCAATGGA TTTAGTGGAC AACATGTCAC CTGAAGAGAT CGAGGCCTGG 
GAACAGGAGC AGCTGAGCCA GCCTGTCTGT TTTGACTACT GCTGCATCGA CCAATCCCCC 
TTCCAGCTGG TGGAGCAGAC GTCCCTGCAC AAGACCCACA CGCTCTTCTC GCTCCTTGGC 
CTCCACCTTG CCTATGTGAC CAGCATGGGG AAGCTCAGGG GCGTGCTGGC ATTGGAGGAG 
CTGCAGAAGG CCATCGAGGG GCACACCAAG TCTGGGGTGC AGCTCCGCCC TCCCCTGGCC 
AGCTTCCGGA GCACGACTTC CACTCGGAAG AATCCGGGAG GCCCACCCCC TCCCACCGAG 
GCCTGGAGTC TGCCTGAGGA TGGAACTGGG GCTCCTGCCT CCCCAGAGCC CCCCGCACCC 
TCCCCCTCCC CAGCTCCCTT GCTCTCTGAG GCTCCAGCCA AAGTGGAGGG TGAGCTGGAG 
GAGCTGGAGC TGGGAGAGAG TCCAGGGCTG GAGGAGGAGC TCGCTGACAT CCTGCAGGGC 
CCAAGTCTGC GATCCACGGA TGAGGAGGAC GAGGACGAGC TGATTCTTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001003124.1
CDS	92..3022
Translation	MQPSQSLRRGGEQSWWGSAPQYQYMPFEHCTSYGLPSENGALQHRLHRDAGLRANTRPTQIYGHYKQQFSDKEQDTGMSKKMGSSESMDSKDEDHYSKCQGCVRRLGHVVRRKLGEDWIFLVLLGLLMALVSWSMDYVSAKSLQAYKWSYYQMQPNLPLQYLVWVTFPLTLILFSAVFCHLISPQAVGSGIPEMKTILRGVILKEYLTLKAFVAKVVALTAGLGSGIPVGKEGPFVHIASICAAVLSKFMSMFCGVYEQPYYYTDMLTVGCAVGVGCCFGTPLGGVLFSIEVTSTYFAVRNYWRGFFAATFSAFVFRVLAVWNKDAVTITALFRTNFRMDFPFDLQELPAFAIIGICCGFLGAVFVYLHRQVMLGVRKHKALSQFLAKHRLLYPGIVTFIIASFTFPPGIGQFMAGELMPREAISTLFDNNTWVKHVGDPESLGRSAVWIHPRVNVIIIIFLFFIMKFWMSIVATTMPIPCGGFMPVFVLGAAFGRLVGEIMAMLFPDGILFDDIIYKILPGGYAVIGAAALTGAVSHTVSTAVICFELTGQIAHILPMMVAVILANMVAQSLQPSLYDSIIQVKKLPYLPDLGWNQLSKFTIFVEDIMVRDVKFVSATCTYGELRTLLQTTTVKTLPLVDSKDSMILLGSVERSELQSLLQRHLGPERRLRVAQDMARKLSELPYDGKGHQGISPEGRRESFAFVDEDEDEDLSGKPELPPLPPPHPLPSAPLSSEESNGPLPSHKQQPEAPEPADQRPSVFRSLLRCLLGRPRPTKKKTTQESMDLVDNMSPEEIEAWEQEQLSQPVCFDYCCIDQSPFQLVEQTSLHKTHTLFSLLGLHLAYVTSMGKLRGVLALEELQKAIEGHTKSGVQLRPPLASFRSTTSTRKNPGGPPPPTEAWSLPEDGTGAPASPEPPAPSPSPAPLLSEAPAKVEGELEELELGESPGLEEELADILQGPSLRSTDEEDEDELIL

Target ORF information:

RefSeq Version	NM_001003124.2
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris chloride voltage-gated channel 1 (CLCN1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001003124.2

ORF Insert Sequence:

ATGCAGCCAT CCCAGTCCCT GCGGCGTGGG GGCGAGCAGA GCTGGTGGGG TAGTGCTCCC 
CAGTACCAGT ACATGCCTTT TGAACACTGC ACCAGCTACG GACTGCCCTC CGAGAATGGA 
GCCCTTCAAC ACAGGCTCCA CAGGGATGCA GGCCTCCGCG CCAACACCCG CCCCACACAG 
ATCTATGGCC ATTACAAACA GCAATTCTCA GACAAGGAGC AGGACACAGG GATGTCCAAG 
AAGATGGGCT CCAGTGAAAG CATGGACAGC AAGGATGAGG ATCACTATTC TAAATGTCAA 
GGCTGTGTCC GCCGCCTGGG ACACGTGGTG AGAAGAAAGT TAGGAGAAGA CTGGATCTTT 
CTGGTGCTCC TGGGACTGCT TATGGCCCTG GTTAGCTGGA GCATGGATTA TGTCAGTGCC 
AAAAGCCTTC AGGCCTACAA GTGGAGCTAC TACCAGATGC AGCCCAACCT GCCTCTGCAG 
TACCTGGTCT GGGTCACCTT CCCGCTAACT CTCATCCTCT TCAGCGCCGT CTTTTGCCAC 
CTCATCTCTC CCCAGGCTGT TGGCTCTGGG ATCCCTGAAA TGAAGACAAT ACTCCGTGGA 
GTCATCCTGA AGGAATATCT CACCCTCAAG GCCTTTGTGG CCAAGGTTGT GGCCCTGACT 
GCGGGGCTGG GCAGTGGCAT TCCTGTGGGG AAGGAGGGCC CTTTCGTCCA CATTGCCAGC 
ATCTGTGCTG CGGTCCTCAG CAAGTTTATG TCCATGTTCT GTGGGGTCTA TGAGCAGCCA 
TACTATTACA CTGACATGCT GACGGTGGGC TGTGCTGTAG GAGTTGGCTG TTGTTTTGGG 
ACGCCACTTG GAGGAGTGTT GTTCAGCATC GAGGTCACCT CTACATACTT TGCTGTGCGG 
AACTACTGGC GAGGATTCTT TGCAGCCACG TTCAGTGCCT TTGTTTTCCG CGTGCTGGCC 
GTGTGGAACA AGGACGCTGT CACCATCACT GCTCTCTTCA GAACCAATTT CCGAATGGAT 
TTCCCCTTTG ACCTGCAGGA ACTCCCAGCC TTCGCCATCA TCGGGATTTG CTGTGGCTTC 
CTGGGAGCCG TGTTTGTGTA CCTGCATCGC CAAGTCATGC TCGGTGTCCG AAAGCACAAG 
GCCCTCAGCC AATTTCTGGC GAAGCACCGC CTGCTGTATC CTGGAATAGT TACCTTCATC 
ATTGCCTCAT TCACCTTTCC GCCAGGAATA GGCCAATTCA TGGCTGGAGA GTTGATGCCT 
CGTGAAGCCA TCAGCACCCT ATTCGACAAT AACACATGGG TAAAGCATGT GGGTGACCCT 
GAAAGCCTGG GCCGGTCAGC TGTGTGGATC CACCCACGGG TCAACGTGAT CATCATCATC 
TTCCTCTTCT TTATCATGAA GTTCTGGATG TCCATCGTGG CCACCACTAT GCCTATACCC 
TGCGGAGGCT TCATGCCTGT GTTTGTGCTA GGAGCTGCAT TTGGGAGGCT GGTAGGAGAG 
ATCATGGCCA TGCTATTCCC TGATGGTATC CTATTTGATG ACATCATCTA CAAGATCCTA 
CCTGGAGGCT ATGCGGTAAT TGGGGCAGCA GCGCTGACCG GTGCAGTATC CCACACAGTC 
TCCACAGCTG TGATTTGCTT CGAATTAACG GGTCAGATTG CCCACATCCT GCCCATGATG 
GTGGCTGTCA TCTTGGCCAA CATGGTGGCT CAGAGCCTGC AGCCCTCCCT CTATGACAGC 
ATCATCCAGG TCAAGAAGCT ACCCTACTTG CCTGACCTTG GTTGGAACCA GCTCAGCAAA 
TTTACCATAT TTGTTGAGGA CATCATGGTT CGTGATGTGA AGTTTGTTTC AGCTACTTGC 
ACATACGGGG AATTGCGAAC CCTGCTCCAG ACCACCACAG TCAAGACTTT ACCACTGGTT 
GATTCTAAAG ATTCTATGAT CCTGCTGGGC TCCGTGGAGC GCTCAGAGCT ACAGTCCCTC 
CTGCAGCGCC ACTTGGGCCC TGAGCGGAGG CTGCGGGTGG CCCAGGACAT GGCCAGGAAG 
TTGTCTGAGC TGCCCTACGA TGGGAAGGGA CACCAAGGCA TCTCACCCGA GGGCCGAAGG 
GAGTCCTTTG CCTTTGTGGA TGAGGATGAA GATGAGGACC TCTCTGGGAA GCCCGAGCTG 
CCTCCTCTTC CTCCTCCTCA CCCCTTACCA TCTGCCCCAT TGTCCTCTGA AGAGTCCAAT 
GGGCCCCTGC CCAGCCACAA ACAGCAGCCA GAAGCACCGG AGCCTGCAGA TCAAAGACCC 
TCTGTCTTTC GGTCCCTGCT GCGCTGCTTA CTTGGCAGAC CTCGCCCCAC GAAGAAGAAA 
ACAACCCAGG AGTCAATGGA TTTAGTGGAC AACATGTCAC CTGAAGAGAT CGAGGCCTGG 
GAACAGGAGC AGCTGAGCCA GCCTGTCTGT TTTGACTACT GCTGCATCGA CCAATCCCCC 
TTCCAGCTGG TGGAGCAGAC GTCCCTGCAC AAGACCCACA CGCTCTTCTC GCTCCTTGGC 
CTCCACCTTG CCTATGTGAC CAGCATGGGG AAGCTCAGGG GCGTGCTGGC ATTGGAGGAG 
CTGCAGAAGG CCATCGAGGG GCACACCAAG TCTGGGGTGC AGCTCCGCCC TCCCCTGGCC 
AGCTTCCGGA GCACGACTTC CACTCGGAAG AATCCGGGAG GCCCACCCCC TCCCACCGAG 
GCCTGGAGTC TGCCTGAGGA TGGAACTGGG GCTCCTGCCT CCCCAGAGCC CCCCGCACCC 
TCCCCCTCCC CAGCTCCCTT GCTCTCTGAG GCTCCAGCCA AAGTGGAGGG TGAGCTGGAG 
GAGCTGGAGC TGGGAGAGAG TCCAGGGCTG GAGGAGGAGC TCGCTGACAT CCTGCAGGGC 
CCAAGTCTGC GATCCACGGA TGAGGAGGAC GAGGACGAGC TGATTCTTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A missense mutation in canine C1C-1 causes recessive myotonia congenita in the dog.
FEBS letters456(1)54-8(1999 Jul)
Rhodes TH,Vite CH,Giger U,Patterson DF,Fahlke C,George AL Jr

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CLCN1 cDNA ORF clone, Canis lupus familiaris(dog)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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