Gene Symbol | gcs-1 |
Entrez Gene ID | 174438 |
Full Name | Glutamate--cysteine ligase |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
ORF » Species Summary » Caenorhabditis elegans » gcs-1 cDNA ORF clone
Gene Symbol | gcs-1 |
Entrez Gene ID | 174438 |
Full Name | Glutamate--cysteine ligase |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
mRNA | Protein | Name |
---|---|---|
NM_063526.5 | NP_495927.2 | Glutamate--cysteine ligase |
NM_063526.6 | NP_495927.2 | Glutamate--cysteine ligase |
Rattus norvegicus (Norway rat) | Gclc | NP_036947.1 |
Saccharomyces cerevisiae (baker's yeast) | GSH1 | NP_012434.1 |
Kluyveromyces lactis | KLLA0F14058g | XP_455711.1 |
Schizosaccharomyces pombe (fission yeast) | gcs1 | NP_593031.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_07317 | XP_003715549.1 |
Pan troglodytes (chimpanzee) | GCLC | XP_001155930.1 |
GCLC | XP_001108943.1 | |
Danio rerio (zebrafish) | gclc | NP_954971.2 |
Drosophila melanogaster (fruit fly) | Gclc | NP_525005.2 |
Caenorhabditis elegans (roundworm) | gcs-1 | NP_495927.2 |
Canis lupus familiaris (dog) | GCLC | XP_852845.1 |
Bos taurus (cattle) | GCLC | NP_001077143.1 |
Mus musculus (house mouse) | Gclc | NP_034425.1 |
Gallus gallus (chicken) | GCLC | XP_419910.3 |
Eremothecium gossypii | AGOS_AFR086C | NP_985633.1 |
Neurospora crassa | NCU01157 | XP_961523.1 |
Xenopus tropicalis (tropical clawed frog) | gclc | NP_001072803.1 |
Homo sapiens (human) | GCLC | NP_001489.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP001512 | XP_321610.3 |
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
only 1mM DEM caused upregulation of egl-1, a gene controlled by a p53-orthologue, CEP-1.we suppressed GSH biosynthesis in worms by attenuating g-glutamylcysteine synthetase (gcs-1) expression through RNAi.gcs-1 knockdown commencing right after hatching impaired nematode stress resistance and rendered young adult worms prone to vulval ruptures during egg-laying.
Title: Non-linear impact of glutathione depletion on C. elegans life span and stress resistance.
PMK-1 phosphorylates SKN-1, leading to its accumulation in intestine nuclei, where SKN-1 activates transcription of gcs-1.
Title: The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response.
The following gcs-1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the gcs-1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCa337567 | |
Clone ID Related Accession (Same CDS sequence) | NM_063526.5 , NM_063526.6 | |
Accession Version | NM_063526.5 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1965bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | Glutamate--cysteine ligase | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003280). On Jun 26, 2012 this sequence version replaced NM_063526.4. COMPLETENESS: incomplete on both ends. |
1 | ATGGGTCTTT TGACGAAAGG TAGTCCGTTG ACGTGGGCAG AAACCGTACC GCACATTGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_495927.2 |
CDS | 1..1965 |
Translation |
Target ORF information:
Target ORF information:
|
NM_063526.5 |
1 | ATGGGTCTTT TGACGAAAGG TAGTCCGTTG ACGTGGGCAG AAACCGTACC GCACATTGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa337567 | |
Clone ID Related Accession (Same CDS sequence) | NM_063526.5 , NM_063526.6 | |
Accession Version | NM_063526.6 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1965bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Glutamate--cysteine ligase | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003280). On Sep 4, 2019 this sequence version replaced NM_063526.5. |
1 | ATGGGTCTTT TGACGAAAGG TAGTCCGTTG ACGTGGGCAG AAACCGTACC GCACATTGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_495927.2 |
CDS | 2..1966 |
Translation |
Target ORF information:
Target ORF information:
|
NM_063526.6 |
1 | ATGGGTCTTT TGACGAAAGG TAGTCCGTTG ACGTGGGCAG AAACCGTACC GCACATTGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Genome sequence of the nematode C. elegans: a platform for investigating biology. |