Gene Symbol | PABPN1 |
Entrez Gene ID | 282298 |
Full Name | poly(A) binding protein nuclear 1 |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
ORF » Species Summary » Bos taurus » PABPN1 cDNA ORF clone
Gene Symbol | PABPN1 |
Entrez Gene ID | 282298 |
Full Name | poly(A) binding protein nuclear 1 |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
mRNA | Protein | Name |
---|---|---|
XM_024997278.1 | XP_024853046.1 | polyadenylate-binding protein 2 isoform X1 |
NM_174569.2 | NP_776994.1 | polyadenylate-binding protein 2 |
Drosophila melanogaster (fruit fly) | Pabp2 | NP_724648.1 |
Caenorhabditis elegans (roundworm) | pabp-2 | NP_492504.1 |
Oryza sativa (rice) | Os06g0219600 | NP_001057163.1 |
Homo sapiens (human) | PABPN1 | NP_004634.1 |
Arabidopsis thaliana (thale cress) | AT5G65260 | NP_201329.1 |
Arabidopsis thaliana (thale cress) | AT5G10350 | NP_196597.1 |
Pan troglodytes (chimpanzee) | PABPN1 | XP_001162168.1 |
Canis lupus familiaris (dog) | PABPN1 | NP_001123909.2 |
Rattus norvegicus (Norway rat) | Pabpn1 | NP_001128480.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP005117 | XP_313998.3 |
Oryza sativa (rice) | Os02g0757900 | NP_001048174.1 |
Bos taurus (cattle) | PABPN1 | NP_776994.1 |
Mus musculus (house mouse) | Pabpn1 | NP_062275.1 |
Poly(A) tail length is controlled by the nuclear poly(A)-binding protein regulating the interaction between poly(A) polymerase and the cleavage and polyadenylation specificity factor.
K?hn U, G?ndel M, Knoth A, Kerwitz Y, R?del S, Wahle E
The Journal of biological chemistry284(34)22803-14(2009 Aug)
A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)
Promiscuous modification of the nuclear poly(A)-binding protein by multiple protein-arginine methyltransferases does not affect the aggregation behavior.
Fronz K, Otto S, K?lbel K, K?hn U, Friedrich H, Schierhorn A, Beck-Sickinger AG, Ostareck-Lederer A, Wahle E
The Journal of biological chemistry283(29)20408-20(2008 Jul)
Trinucleotide expansions leading to an extended poly-L-alanine segment in the poly (A) binding protein PABPN1 cause fibril formation.
Scheuermann T, Schulz B, Blume A, Wahle E, Rudolph R, Schwarz E
Protein science : a publication of the Protein Society12(12)2685-92(2003 Dec)
Stimulation of poly(A) polymerase through a direct interaction with the nuclear poly(A) binding protein allosterically regulated by RNA.
Kerwitz Y, K?hn U, Lilie H, Knoth A, Scheuermann T, Friedrich H, Schwarz E, Wahle E
The EMBO journal22(14)3705-14(2003 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
PABPN1 measures the length of the tail and is responsible for disrupting the CPSF-poly(A) polymerase interaction.
Title: Poly(A) tail length is controlled by the nuclear poly(A)-binding protein regulating the interaction between poly(A) polymerase and the cleavage and polyadenylation specificity factor.
C-terminal domain containing the methylated arginine residues is known to promote PAPBN1 self-association, and arginine methylation has been reported to inhibit self-association of an orthologous protein
Title: Promiscuous modification of the nuclear poly(A)-binding protein by multiple protein-arginine methyltransferases does not affect the aggregation behavior.
fibril formation from trinucleotide expansion
Title: Trinucleotide expansions leading to an extended poly-L-alanine segment in the poly (A) binding protein PABPN1 cause fibril formation.
The following PABPN1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PABPN1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OBa219412 | |
Clone ID Related Accession (Same CDS sequence) | XM_024997278.1 | |
Accession Version | XM_024997278.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 537bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-06 | |
Organism | Bos taurus(cattle) | |
Product | polyadenylate-binding protein 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037337.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGGAAG AAGCTGAGAA GCTAAAGGAG CTACAGAACG AGGTAGAGAA GCAGATGAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_024853046.1 |
CDS | 153..689 |
Translation |
Target ORF information:
Target ORF information:
|
XM_024997278.1 |
1 | ATGGAGGAAG AAGCTGAGAA GCTAAAGGAG CTACAGAACG AGGTAGAGAA GCAGATGAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OBa41429 | |
Clone ID Related Accession (Same CDS sequence) | NM_174569.2 | |
Accession Version | NM_174569.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 921bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-18 | |
Organism | Bos taurus(cattle) | |
Product | polyadenylate-binding protein 2 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X89969.1. On Jun 3, 2003 this sequence version replaced NM_174569.1. ##Evidence-Data-START## Transcript exon combination :: X89969.1, BC133558.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145413, SAMN03145419 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCGGCGG CGGCGGCGGC GGCAGCAGCA GCGGGGGCTG CGGGCGGTCG GGGCTCCGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_776994.1 |
CDS | 2096..3016 |
Translation |
Target ORF information:
Target ORF information:
|
NM_174569.2 |
1 | ATGGCGGCGG CGGCGGCGGC GGCAGCAGCA GCGGGGGCTG CGGGCGGTCG GGGCTCCGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Poly(A) tail length is controlled by the nuclear poly(A)-binding protein regulating the interaction between poly(A) polymerase and the cleavage and polyadenylation specificity factor. |
A whole-genome assembly of the domestic cow, Bos taurus. |
Promiscuous modification of the nuclear poly(A)-binding protein by multiple protein-arginine methyltransferases does not affect the aggregation behavior. |
Trinucleotide expansions leading to an extended poly-L-alanine segment in the poly (A) binding protein PABPN1 cause fibril formation. |
Stimulation of poly(A) polymerase through a direct interaction with the nuclear poly(A) binding protein allosterically regulated by RNA. |