PABPN1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PABPN1
Entrez Gene ID	8106
Full Name	poly(A) binding protein nuclear 1
Synonyms	OPMD,PAB2,PABII,PABP-2,PABP2
General protein information	Preferred Names poly(A) binding protein nuclear 1 Names polyadenylate-binding protein 2 poly(A) binding protein 2 poly(A) binding protein II
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q11.2
Summary	This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene. [provided by RefSeq, Dec 2010].
Disorder MIM:	602279
Disorder Html:	Oculopharyngeal muscular dystrophy, 164300 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001360551.2	NP_001347480.1	polyadenylate-binding protein 2 isoform 2
NM_004643.3	NP_004634.1	polyadenylate-binding protein 2 isoform 1
NM_001360551.1	NP_001347480.1	polyadenylate-binding protein 2 isoform 2
NM_001360552.1	NP_001347481.1	polyadenylate-binding protein 2 isoform 3

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	Pabp2	NP_724648.1
Caenorhabditis elegans (roundworm)	pabp-2	NP_492504.1
Oryza sativa (rice)	Os06g0219600	NP_001057163.1
Homo sapiens (human)	PABPN1	NP_004634.1
Arabidopsis thaliana (thale cress)	AT5G65260	NP_201329.1
Arabidopsis thaliana (thale cress)	AT5G10350	NP_196597.1
Pan troglodytes (chimpanzee)	PABPN1	XP_001162168.1
Canis lupus familiaris (dog)	PABPN1	NP_001123909.2
Rattus norvegicus (Norway rat)	Pabpn1	NP_001128480.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005117	XP_313998.3
Oryza sativa (rice)	Os02g0757900	NP_001048174.1
Bos taurus (cattle)	PABPN1	NP_776994.1
Mus musculus (house mouse)	Pabpn1	NP_062275.1

Gene Ontology
Bibliography

Related articles in PubMed

Nuclear poly(A)-binding protein 1 is an ATM target and essential for DNA double-strand break repair.
Gavish-Izakson M, Velpula BB, Elkon R, Prados-Carvajal R, Barnabas GD, Ugalde AP, Agami R, Geiger T, Huertas P, Ziv Y, Shiloh Y
Nucleic acids research(2017 Dec)

Comprehensive Characterization of Alternative Polyadenylation in Human Cancer.
Xiang Y, Ye Y, Lou Y, Yang Y, Cai C, Zhang Z, Mills T, Chen NY, Kim Y, Muge Ozguc F, Diao L, Karmouty-Quintana H, Xia Y, Kellems RE, Chen Z, Blackburn MR, Yoo SH, Shyu AB, Mills GB, Han L
Journal of the National Cancer Institute(2017 Nov)

The nuclear poly(A) binding protein of mammals, but not of fission yeast, participates in mRNA polyadenylation.
K?hn U, Buschmann J, Wahle E
RNA (New York, N.Y.)23(4)473-482(2017 04)

Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1.
Abdelmohsen K, Panda AC, Munk R, Grammatikakis I, Dudekula DB, De S, Kim J, Noh JH, Kim KM, Martindale JL, Gorospe M
RNA biology14(3)361-369(2017 03)

Regulated Intron Retention and Nuclear Pre-mRNA Decay Contribute to PABPN1 Autoregulation.
Bergeron D, Pal G, Beaulieu YB, Chabot B, Bachand F
Molecular and cellular biology35(14)2503-17(2015 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Whereas PABPN1 strongly increases the activity of its cognate poly(A) polymerase in vitro, Pab2 was unable to stimulate Pla1 to any significant extent.
Title: The nuclear poly(A) binding protein of mammals, but not of fission yeast, participates in mRNA polyadenylation.

We propose that the extensive binding of CircPABPN1 to HuR prevents HuR binding to PABPN1 mRNA and lowers PABPN1 translation, providing the first example of competition between a circRNA and its cognate mRNA for an RBP that affects translation.
Title: Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1.

The purpose of this study was to characterize the type of PABPN1 expanded alleles in a large cohort of Oculopharyngeal muscular dystrophy individuals from Mexico.
Title: Characterization of

Large cohort study demonstrated that in heterozygous and homozygous patients with oculopharyngeal muscular dystrophy, the mean age at diagnosis and the severity of the clinical symptoms correlate to the number of PABPN1 (GCN) repeats. Homozygous patients showed the worse phenotype, suggesting a gene-dose effect in addition to the repeat number expansion.
Title: Correlation between PABPN1 genotype and disease severity in oculopharyngeal muscular dystrophy.

The described is the mRNA degradation poly(A) tail exosome targeting (PAXT) connection, which comprises the ZFC3H1 Zn-knuckle protein as a central link between MTR4 and the nuclear poly(A)-binding protein PABPN1.
Title: Identification of a Nuclear Exosome Decay Pathway for Processed Transcripts.

The following PABPN1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PABPN1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22259	NM_004643.3 Latest version!	Homo sapiens poly(A) binding protein nuclear 1 (PABPN1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu106933	NM_001360552.1 Latest version!	Homo sapiens poly(A) binding protein nuclear 1 (PABPN1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu107072	NM_001360551.2 Latest version!	Homo sapiens poly(A) binding protein nuclear 1 (PABPN1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu107072	NM_001360551.1	Homo sapiens poly(A) binding protein nuclear 1 (PABPN1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PABPN1 ( NM_004643.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004634.1 Homo sapiens poly(A) binding protein nuclear 1 (PABPN1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22259
Clone ID Related Accession (Same CDS sequence)	NM_004643.3
Accession Version	NM_004643.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 921bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-30
Organism	Homo sapiens(human)
Product	polyadenylate-binding protein 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL049829.4, BI830835.1, BC010939.1 and BM979311.1. This sequence is a reference standard in the RefSeqGene project. On Dec 23, 2010 this sequence version replaced NM_004643.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.332773.1, SRR1163655.418336.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGG CGGCGGCGGC GGCAGCAGCA GCGGGGGCTG CGGGCGGTCG GGGCTCCGGG 
CCGGGGCGGC GGCGCCATCT TGTGCCCGGG GCCGGTGGGG AGGCCGGGGA GGGGGCCCCG 
GGGGGCGCAG GGGACTACGG GAACGGCCTG GAGTCTGAGG AACTGGAGCC TGAGGAGCTG 
CTGCTGGAGC CCGAGCCGGA GCCCGAGCCC GAAGAGGAGC CGCCCCGGCC CCGCGCCCCC 
CCGGGAGCTC CGGGCCCTGG GCCTGGTTCG GGAGCCCCCG GCAGCCAAGA GGAGGAGGAG 
GAGCCGGGAC TGGTCGAGGG TGACCCGGGG GACGGCGCCA TTGAGGACCC GGAGCTGGAA 
GCTATCAAAG CTCGAGTCAG GGAGATGGAG GAAGAAGCTG AGAAGCTAAA GGAGCTACAG 
AACGAGGTAG AGAAGCAGAT GAATATGAGT CCACCTCCAG GCAATGCTGG CCCGGTGATC 
ATGTCCATTG AGGAGAAGAT GGAGGCTGAT GCCCGTTCCA TCTATGTTGG CAATGTGGAC 
TATGGTGCAA CAGCAGAAGA GCTGGAAGCT CACTTTCATG GCTGTGGTTC AGTCAACCGT 
GTTACCATAC TGTGTGACAA ATTTAGTGGC CATCCCAAAG GGTTTGCGTA TATAGAGTTC 
TCAGACAAAG AGTCAGTGAG GACTTCCTTG GCCTTAGATG AGTCCCTATT TAGAGGAAGG 
CAAATCAAGG TGATCCCAAA ACGAACCAAC AGACCAGGCA TCAGCACAAC AGACCGGGGT 
TTTCCACGAG CCCGCTACCG CGCCCGGACC ACCAACTACA ACAGCTCCCG CTCTCGATTC 
TACAGTGGTT TTAACAGCAG GCCCCGGGGT CGCGTCTACA GGGGCCGGGC TAGAGCGACA 
TCATGGTATT CCCCTTACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004634.1
CDS	1283..2203
Translation	MAAAAAAAAAAGAAGGRGSGPGRRRHLVPGAGGEAGEGAPGGAGDYGNGLESEELEPEELLLEPEPEPEPEEEPPRPRAPPGAPGPGPGSGAPGSQEEEEEPGLVEGDPGDGAIEDPELEAIKARVREMEEEAEKLKELQNEVEKQMNMSPPPGNAGPVIMSIEEKMEADARSIYVGNVDYGATAEELEAHFHGCGSVNRVTILCDKFSGHPKGFAYIEFSDKESVRTSLALDESLFRGRQIKVIPKRTNRPGISTTDRGFPRARYRARTTNYNSSRSRFYSGFNSRPRGRVYRGRARATSWYSPY

Target ORF information:

RefSeq Version	NM_004643.3
Organism	Homo sapiens(human)
Definition	Homo sapiens poly(A) binding protein nuclear 1 (PABPN1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004643.3

ORF Insert Sequence:

ATGGCGGCGG CGGCGGCGGC GGCAGCAGCA GCGGGGGCTG CGGGCGGTCG GGGCTCCGGG 
CCGGGGCGGC GGCGCCATCT TGTGCCCGGG GCCGGTGGGG AGGCCGGGGA GGGGGCCCCG 
GGGGGCGCAG GGGACTACGG GAACGGCCTG GAGTCTGAGG AACTGGAGCC TGAGGAGCTG 
CTGCTGGAGC CCGAGCCGGA GCCCGAGCCC GAAGAGGAGC CGCCCCGGCC CCGCGCCCCC 
CCGGGAGCTC CGGGCCCTGG GCCTGGTTCG GGAGCCCCCG GCAGCCAAGA GGAGGAGGAG 
GAGCCGGGAC TGGTCGAGGG TGACCCGGGG GACGGCGCCA TTGAGGACCC GGAGCTGGAA 
GCTATCAAAG CTCGAGTCAG GGAGATGGAG GAAGAAGCTG AGAAGCTAAA GGAGCTACAG 
AACGAGGTAG AGAAGCAGAT GAATATGAGT CCACCTCCAG GCAATGCTGG CCCGGTGATC 
ATGTCCATTG AGGAGAAGAT GGAGGCTGAT GCCCGTTCCA TCTATGTTGG CAATGTGGAC 
TATGGTGCAA CAGCAGAAGA GCTGGAAGCT CACTTTCATG GCTGTGGTTC AGTCAACCGT 
GTTACCATAC TGTGTGACAA ATTTAGTGGC CATCCCAAAG GGTTTGCGTA TATAGAGTTC 
TCAGACAAAG AGTCAGTGAG GACTTCCTTG GCCTTAGATG AGTCCCTATT TAGAGGAAGG 
CAAATCAAGG TGATCCCAAA ACGAACCAAC AGACCAGGCA TCAGCACAAC AGACCGGGGT 
TTTCCACGAG CCCGCTACCG CGCCCGGACC ACCAACTACA ACAGCTCCCG CTCTCGATTC 
TACAGTGGTT TTAACAGCAG GCCCCGGGGT CGCGTCTACA GGGGCCGGGC TAGAGCGACA 
TCATGGTATT CCCCTTACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PABPN1 ( NM_001360552.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001347481.1 Homo sapiens poly(A) binding protein nuclear 1 (PABPN1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu106933
Clone ID Related Accession (Same CDS sequence)	NM_001360552.1
Accession Version	NM_001360552.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 537bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-30
Organism	Homo sapiens(human)
Product	polyadenylate-binding protein 2 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL049829.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX326046.1, SRR1163655.54639.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGAAG AAGCTGAGAA GCTAAAGGAG CTACAGAACG AGGTAGAGAA GCAGATGAAT 
ATGAGTCCAC CTCCAGGCAA TGCTGGCCCG GTGATCATGT CCATTGAGGA GAAGATGGAG 
GCTGATGCCC GTTCCATCTA TGTTGGCAAT GTGGACTATG GTGCAACAGC AGAAGAGCTG 
GAAGCTCACT TTCATGGCTG TGGTTCAGTC AACCGTGTTA CCATACTGTG TGACAAATTT 
AGTGGCCATC CCAAAGGGTT TGCGTATATA GAGTTCTCAG ACAAAGAGTC AGTGAGGACT 
TCCTTGGCCT TAGATGAGTC CCTATTTAGA GGAAGGCAAA TCAAGGTGAT CCCAAAACGA 
ACCAACAGAC CAGGCATCAG CACAACAGAC CGGGGTTTTC CACGAGCCCG CTACCGCGCC 
CGGACCACCA ACTACAACAG CTCCCGCTCT CGATTCTACA GTGGTTTTAA CAGCAGGCCC 
CGGGGTCGCG TCTACAGGGG CCGGGCTAGA GCGACATCAT GGTATTCCCC TTACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001347481.1
CDS	209..745
Translation	MEEEAEKLKELQNEVEKQMNMSPPPGNAGPVIMSIEEKMEADARSIYVGNVDYGATAEELEAHFHGCGSVNRVTILCDKFSGHPKGFAYIEFSDKESVRTSLALDESLFRGRQIKVIPKRTNRPGISTTDRGFPRARYRARTTNYNSSRSRFYSGFNSRPRGRVYRGRARATSWYSPY

Target ORF information:

RefSeq Version	NM_001360552.1
Organism	Homo sapiens(human)
Definition	Homo sapiens poly(A) binding protein nuclear 1 (PABPN1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001360552.1

ORF Insert Sequence:

ATGGAGGAAG AAGCTGAGAA GCTAAAGGAG CTACAGAACG AGGTAGAGAA GCAGATGAAT 
ATGAGTCCAC CTCCAGGCAA TGCTGGCCCG GTGATCATGT CCATTGAGGA GAAGATGGAG 
GCTGATGCCC GTTCCATCTA TGTTGGCAAT GTGGACTATG GTGCAACAGC AGAAGAGCTG 
GAAGCTCACT TTCATGGCTG TGGTTCAGTC AACCGTGTTA CCATACTGTG TGACAAATTT 
AGTGGCCATC CCAAAGGGTT TGCGTATATA GAGTTCTCAG ACAAAGAGTC AGTGAGGACT 
TCCTTGGCCT TAGATGAGTC CCTATTTAGA GGAAGGCAAA TCAAGGTGAT CCCAAAACGA 
ACCAACAGAC CAGGCATCAG CACAACAGAC CGGGGTTTTC CACGAGCCCG CTACCGCGCC 
CGGACCACCA ACTACAACAG CTCCCGCTCT CGATTCTACA GTGGTTTTAA CAGCAGGCCC 
CGGGGTCGCG TCTACAGGGG CCGGGCTAGA GCGACATCAT GGTATTCCCC TTACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PABPN1 ( NM_001360551.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001347480.1 Homo sapiens poly(A) binding protein nuclear 1 (PABPN1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu107072
Clone ID Related Accession (Same CDS sequence)	NM_001360551.2 , NM_001360551.1
Accession Version	NM_001360551.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 891bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-30
Organism	Homo sapiens(human)
Product	polyadenylate-binding protein 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG496896.1, BX247976.1, AL049829.4 and BM979311.1. On Jun 2, 2019 this sequence version replaced NM_001360551.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX247976.1, SRR3476690.784894.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGG CGGCGGCGGC GGCAGCAGCA GCGGGGGCTG CGGGCGGTCG GGGCTCCGGG 
CCGGGGCGGC GGCGCCATCT TGTGCCCGGG GCCGGTGGGG AGGCCGGGGA GGGGGCCCCG 
GGGGGCGCAG GGGACTACGG GAACGGCCTG GAGTCTGAGG AACTGGAGCC TGAGGAGCTG 
CTGCTGGAGC CCGAGCCGGA GCCCGAGCCC GAAGAGGAGC CGCCCCGGCC CCGCGCCCCC 
CCGGGAGCTC CGGGCCCTGG GCCTGGTTCG GGAGCCCCCG GCAGCCAAGA GGAGGAGGAG 
GAGCCGGGAC TGGTCGAGGG TGACCCGGGG GACGGCGCCA TTGAGGACCC GGAGCTGGAA 
GCTATCAAAG CTCGAGTCAG GGAGATGGAG GAAGAAGCTG AGAAGCTAAA GGAGCTACAG 
AACGAGGTAG AGAAGCAGAT GAATATGAGT CCACCTCCAG GCAATGCTGG CCCGGTGATC 
ATGTCCATTG AGGAGAAGAT GGAGGCTGAT GCCCGTTCCA TCTATGTTGG CAATGTGGAC 
TATGGTGCAA CAGCAGAAGA GCTGGAAGCT CACTTTCATG GCTGTGGTTC AGTCAACCGT 
GTTACCATAC TGTGTGACAA ATTTAGTGGC CATCCCAAAG GGTTTGCGTA TATAGAGTTC 
TCAGACAAAG AGTCAGTGAG GACTTCCTTG GCCTTAGATG AGTCCCTATT TAGAGGAAGG 
CAAATCAAGG TGATCCCAAA ACGAACCAAC AGACCAGGCA TCAGCACAAC AGACCGGGGT 
TTTCCACGAG CCCGCTACCG CGCCCGGACC ACCAACTACA ACAGCTCCCG CTCTCGATTC 
TACAGTGGTT TTAACAGCAG GCCCCGGGGT CGCGTCTACA GGTCAGGATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001347480.1
CDS	14..904
Translation	MAAAAAAAAAAGAAGGRGSGPGRRRHLVPGAGGEAGEGAPGGAGDYGNGLESEELEPEELLLEPEPEPEPEEEPPRPRAPPGAPGPGPGSGAPGSQEEEEEPGLVEGDPGDGAIEDPELEAIKARVREMEEEAEKLKELQNEVEKQMNMSPPPGNAGPVIMSIEEKMEADARSIYVGNVDYGATAEELEAHFHGCGSVNRVTILCDKFSGHPKGFAYIEFSDKESVRTSLALDESLFRGRQIKVIPKRTNRPGISTTDRGFPRARYRARTTNYNSSRSRFYSGFNSRPRGRVYRSG

Target ORF information:

RefSeq Version	NM_001360551.2
Organism	Homo sapiens(human)
Definition	Homo sapiens poly(A) binding protein nuclear 1 (PABPN1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001360551.2

ORF Insert Sequence:

ATGGCGGCGG CGGCGGCGGC GGCAGCAGCA GCGGGGGCTG CGGGCGGTCG GGGCTCCGGG 
CCGGGGCGGC GGCGCCATCT TGTGCCCGGG GCCGGTGGGG AGGCCGGGGA GGGGGCCCCG 
GGGGGCGCAG GGGACTACGG GAACGGCCTG GAGTCTGAGG AACTGGAGCC TGAGGAGCTG 
CTGCTGGAGC CCGAGCCGGA GCCCGAGCCC GAAGAGGAGC CGCCCCGGCC CCGCGCCCCC 
CCGGGAGCTC CGGGCCCTGG GCCTGGTTCG GGAGCCCCCG GCAGCCAAGA GGAGGAGGAG 
GAGCCGGGAC TGGTCGAGGG TGACCCGGGG GACGGCGCCA TTGAGGACCC GGAGCTGGAA 
GCTATCAAAG CTCGAGTCAG GGAGATGGAG GAAGAAGCTG AGAAGCTAAA GGAGCTACAG 
AACGAGGTAG AGAAGCAGAT GAATATGAGT CCACCTCCAG GCAATGCTGG CCCGGTGATC 
ATGTCCATTG AGGAGAAGAT GGAGGCTGAT GCCCGTTCCA TCTATGTTGG CAATGTGGAC 
TATGGTGCAA CAGCAGAAGA GCTGGAAGCT CACTTTCATG GCTGTGGTTC AGTCAACCGT 
GTTACCATAC TGTGTGACAA ATTTAGTGGC CATCCCAAAG GGTTTGCGTA TATAGAGTTC 
TCAGACAAAG AGTCAGTGAG GACTTCCTTG GCCTTAGATG AGTCCCTATT TAGAGGAAGG 
CAAATCAAGG TGATCCCAAA ACGAACCAAC AGACCAGGCA TCAGCACAAC AGACCGGGGT 
TTTCCACGAG CCCGCTACCG CGCCCGGACC ACCAACTACA ACAGCTCCCG CTCTCGATTC 
TACAGTGGTT TTAACAGCAG GCCCCGGGGT CGCGTCTACA GGTCAGGATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PABPN1 ( NM_001360551.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001347480.1 Homo sapiens poly(A) binding protein nuclear 1 (PABPN1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu107072
Clone ID Related Accession (Same CDS sequence)	NM_001360551.2 , NM_001360551.1
Accession Version	NM_001360551.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 891bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-03-03
Organism	Homo sapiens(human)
Product	polyadenylate-binding protein 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG496896.1, BX247976.1, AL049829.4 and BM979311.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX247976.1, SRR1163655.546569.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGG CGGCGGCGGC GGCAGCAGCA GCGGGGGCTG CGGGCGGTCG GGGCTCCGGG 
CCGGGGCGGC GGCGCCATCT TGTGCCCGGG GCCGGTGGGG AGGCCGGGGA GGGGGCCCCG 
GGGGGCGCAG GGGACTACGG GAACGGCCTG GAGTCTGAGG AACTGGAGCC TGAGGAGCTG 
CTGCTGGAGC CCGAGCCGGA GCCCGAGCCC GAAGAGGAGC CGCCCCGGCC CCGCGCCCCC 
CCGGGAGCTC CGGGCCCTGG GCCTGGTTCG GGAGCCCCCG GCAGCCAAGA GGAGGAGGAG 
GAGCCGGGAC TGGTCGAGGG TGACCCGGGG GACGGCGCCA TTGAGGACCC GGAGCTGGAA 
GCTATCAAAG CTCGAGTCAG GGAGATGGAG GAAGAAGCTG AGAAGCTAAA GGAGCTACAG 
AACGAGGTAG AGAAGCAGAT GAATATGAGT CCACCTCCAG GCAATGCTGG CCCGGTGATC 
ATGTCCATTG AGGAGAAGAT GGAGGCTGAT GCCCGTTCCA TCTATGTTGG CAATGTGGAC 
TATGGTGCAA CAGCAGAAGA GCTGGAAGCT CACTTTCATG GCTGTGGTTC AGTCAACCGT 
GTTACCATAC TGTGTGACAA ATTTAGTGGC CATCCCAAAG GGTTTGCGTA TATAGAGTTC 
TCAGACAAAG AGTCAGTGAG GACTTCCTTG GCCTTAGATG AGTCCCTATT TAGAGGAAGG 
CAAATCAAGG TGATCCCAAA ACGAACCAAC AGACCAGGCA TCAGCACAAC AGACCGGGGT 
TTTCCACGAG CCCGCTACCG CGCCCGGACC ACCAACTACA ACAGCTCCCG CTCTCGATTC 
TACAGTGGTT TTAACAGCAG GCCCCGGGGT CGCGTCTACA GGTCAGGATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001347480.1
CDS	14..904
Translation	MAAAAAAAAAAGAAGGRGSGPGRRRHLVPGAGGEAGEGAPGGAGDYGNGLESEELEPEELLLEPEPEPEPEEEPPRPRAPPGAPGPGPGSGAPGSQEEEEEPGLVEGDPGDGAIEDPELEAIKARVREMEEEAEKLKELQNEVEKQMNMSPPPGNAGPVIMSIEEKMEADARSIYVGNVDYGATAEELEAHFHGCGSVNRVTILCDKFSGHPKGFAYIEFSDKESVRTSLALDESLFRGRQIKVIPKRTNRPGISTTDRGFPRARYRARTTNYNSSRSRFYSGFNSRPRGRVYRSG

Target ORF information:

RefSeq Version	NM_001360551.1
Organism	Homo sapiens(human)
Definition	Homo sapiens poly(A) binding protein nuclear 1 (PABPN1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001360551.1

ORF Insert Sequence:

ATGGCGGCGG CGGCGGCGGC GGCAGCAGCA GCGGGGGCTG CGGGCGGTCG GGGCTCCGGG 
CCGGGGCGGC GGCGCCATCT TGTGCCCGGG GCCGGTGGGG AGGCCGGGGA GGGGGCCCCG 
GGGGGCGCAG GGGACTACGG GAACGGCCTG GAGTCTGAGG AACTGGAGCC TGAGGAGCTG 
CTGCTGGAGC CCGAGCCGGA GCCCGAGCCC GAAGAGGAGC CGCCCCGGCC CCGCGCCCCC 
CCGGGAGCTC CGGGCCCTGG GCCTGGTTCG GGAGCCCCCG GCAGCCAAGA GGAGGAGGAG 
GAGCCGGGAC TGGTCGAGGG TGACCCGGGG GACGGCGCCA TTGAGGACCC GGAGCTGGAA 
GCTATCAAAG CTCGAGTCAG GGAGATGGAG GAAGAAGCTG AGAAGCTAAA GGAGCTACAG 
AACGAGGTAG AGAAGCAGAT GAATATGAGT CCACCTCCAG GCAATGCTGG CCCGGTGATC 
ATGTCCATTG AGGAGAAGAT GGAGGCTGAT GCCCGTTCCA TCTATGTTGG CAATGTGGAC 
TATGGTGCAA CAGCAGAAGA GCTGGAAGCT CACTTTCATG GCTGTGGTTC AGTCAACCGT 
GTTACCATAC TGTGTGACAA ATTTAGTGGC CATCCCAAAG GGTTTGCGTA TATAGAGTTC 
TCAGACAAAG AGTCAGTGAG GACTTCCTTG GCCTTAGATG AGTCCCTATT TAGAGGAAGG 
CAAATCAAGG TGATCCCAAA ACGAACCAAC AGACCAGGCA TCAGCACAAC AGACCGGGGT 
TTTCCACGAG CCCGCTACCG CGCCCGGACC ACCAACTACA ACAGCTCCCG CTCTCGATTC 
TACAGTGGTT TTAACAGCAG GCCCCGGGGT CGCGTCTACA GGTCAGGATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Nuclear poly(A)-binding protein 1 is an ATM target and essential for DNA double-strand break repair.
Nucleic acids research(2017 Dec)
Gavish-Izakson M,Velpula BB,Elkon R,Prados-Carvajal R,Barnabas GD,Ugalde AP,Agami R,Geiger T,Huertas P,Ziv Y,Shiloh Y

Comprehensive Characterization of Alternative Polyadenylation in Human Cancer.
Journal of the National Cancer Institute(2017 Nov)
Xiang Y,Ye Y,Lou Y,Yang Y,Cai C,Zhang Z,Mills T,Chen NY,Kim Y,Muge Ozguc F,Diao L,Karmouty-Quintana H,Xia Y,Kellems RE,Chen Z,Blackburn MR,Yoo SH,Shyu AB,Mills GB,Han L

The nuclear poly(A) binding protein of mammals, but not of fission yeast, participates in mRNA polyadenylation.
RNA (New York, N.Y.)23(4)473-482(2017 04)
K?hn U,Buschmann J,Wahle E

Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1.
RNA biology14(3)361-369(2017 03)
Abdelmohsen K,Panda AC,Munk R,Grammatikakis I,Dudekula DB,De S,Kim J,Noh JH,Kim KM,Martindale JL,Gorospe M

Regulated Intron Retention and Nuclear Pre-mRNA Decay Contribute to PABPN1 Autoregulation.
Molecular and cellular biology35(14)2503-17(2015 Jul)
Bergeron D,Pal G,Beaulieu YB,Chabot B,Bachand F

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PABPN1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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