Pabp2 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pabp2
Entrez Gene ID	35788
Full Name	CG2163 gene product from transcript CG2163-RA
Synonyms	CG2163,Dmel\CG2163,PABP2,PABPN1,ROX2,Rox2,dpabII,pAbp2,pabp2,rox2
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 2R Map Location: 44B3-44B3

mRNA and Protein(s)

mRNA	Protein	Name
NM_165589.3	NP_724648.1	Pabp2, isoform B
NM_057554.4	NP_476902.1	Pabp2, isoform A

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	Pabp2	NP_724648.1
Caenorhabditis elegans (roundworm)	pabp-2	NP_492504.1
Oryza sativa (rice)	Os06g0219600	NP_001057163.1
Homo sapiens (human)	PABPN1	NP_004634.1
Arabidopsis thaliana (thale cress)	AT5G65260	NP_201329.1
Arabidopsis thaliana (thale cress)	AT5G10350	NP_196597.1
Pan troglodytes (chimpanzee)	PABPN1	XP_001162168.1
Canis lupus familiaris (dog)	PABPN1	NP_001123909.2
Rattus norvegicus (Norway rat)	Pabpn1	NP_001128480.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005117	XP_313998.3
Oryza sativa (rice)	Os02g0757900	NP_001048174.1
Bos taurus (cattle)	PABPN1	NP_776994.1
Mus musculus (house mouse)	Pabpn1	NP_062275.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the first step of the cleavage and polyadenylation reaction, mRNA cleavage, is affected in muscles expressing alanine-expanded PABPN1. We propose that impaired cleavage is an early defect in Oculopharyngeal muscular dystrophy.
Title: Mitochondrial dysfunction reveals the role of mRNA poly(A) tail regulation in oculopharyngeal muscular dystrophy pathogenesis.

Results suggest that oculopharyngeal muscular dystrophy does not result from polyalanine toxicity, but from an intrinsic
Title: A Drosophila model of oculopharyngeal muscular dystrophy reveals intrinsic toxicity of PABPN1.

Results identify the poly(A) binding protein PABP2 as a regulator of maternal mRNA poly(A) tail length and highlight the importance of this mode of translational control.
Title: An essential cytoplasmic function for the nuclear poly(A) binding protein, PABP2, in poly(A) tail length control and early development in Drosophila.

The following Pabp2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pabp2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa09259	NM_165589.3 Latest version!	Drosophila melanogaster Pabp2, transcript variant B (Pabp2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OFa09259	NM_057554.4 Latest version!	Drosophila melanogaster Pabp2, transcript variant A (Pabp2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pabp2 ( NM_165589.3 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_724648.1 Drosophila melanogaster Pabp2, transcript variant B (Pabp2), mRNA.

Price & Availability↑

CloneID	OFa09259
Clone ID Related Accession (Same CDS sequence)	NM_165589.3 , NM_057554.4
Accession Version	NM_165589.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 675bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	Pabp2, isoform B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033778). On Jul 15, 2014 this sequence version replaced NM_165589.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGGCCGATG AAGATATCAC ATTGAACGAG GATCAGCTCC TGGAGTCATT GGAGGAGACG 
AACGGGGAGC AAGAGACTGA GATCGCCACA GAGGTCGAGG AGGAGGGCAG CATGCAAATC 
GACCCGGAAC TGGAGGCCAT AAAGGCTCGA GTCAAGGAGA TGGAAGAGGA GGCCGAGAAG 
ATAAAGCAGA TGCAGTCGGA GGTGGACAAA CAAATGGCCG GTGGGTCTAC CACCGGCTTG 
GCCACAGTCC CGCTTTCTCT TGAGGAGAAG CAGGAAATCG ACACGCGGTC CGTCTACGTG 
GGCAATGTGG ACTACGGCGC ATCGGCCGAG GAACTGGAGG CCCACTTCCA CGGATGCGGC 
ACAATCAACC GAGTAACCAT ACTCTGCAAC AAGGCTGACG GGCACCCCAA GGGATTCGCA 
TACATTGAGT TTGGTTCCAA GGAGTTTGTC GAGACGGCAT TGGCCATGAA CGAAACCCTC 
TTCCGAGGGC GTCAAATAAA GGTAATGTCG AAGCGCACAA ACCGCCCTGG ACTCTCCACC 
ACAAACCGTT TCGCACGCGG CAGCTTCCGG GGTCGAGGAG CCCGTGTCTC CCGGGCGTGC 
TGTCACTCCA CCTTCCGAGG CGCCCGAAGA GCTATGGGTT ACCGTGGTCG CGCCAATTAC 
TACGCTCCTT ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_724648.1
CDS	407..1081
Translation	MADEDITLNEDQLLESLEETNGEQETEIATEVEEEGSMQIDPELEAIKARVKEMEEEAEKIKQMQSEVDKQMAGGSTTGLATVPLSLEEKQEIDTRSVYVGNVDYGASAEELEAHFHGCGTINRVTILCNKADGHPKGFAYIEFGSKEFVETALAMNETLFRGRQIKVMSKRTNRPGLSTTNRFARGSFRGRGARVSRACCHSTFRGARRAMGYRGRANYYAPY

Target ORF information:

RefSeq Version	NM_165589.3
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster Pabp2, transcript variant B (Pabp2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_165589.3

ORF Insert Sequence:

ATGGCCGATG AAGATATCAC ATTGAACGAG GATCAGCTCC TGGAGTCATT GGAGGAGACG 
AACGGGGAGC AAGAGACTGA GATCGCCACA GAGGTCGAGG AGGAGGGCAG CATGCAAATC 
GACCCGGAAC TGGAGGCCAT AAAGGCTCGA GTCAAGGAGA TGGAAGAGGA GGCCGAGAAG 
ATAAAGCAGA TGCAGTCGGA GGTGGACAAA CAAATGGCCG GTGGGTCTAC CACCGGCTTG 
GCCACAGTCC CGCTTTCTCT TGAGGAGAAG CAGGAAATCG ACACGCGGTC CGTCTACGTG 
GGCAATGTGG ACTACGGCGC ATCGGCCGAG GAACTGGAGG CCCACTTCCA CGGATGCGGC 
ACAATCAACC GAGTAACCAT ACTCTGCAAC AAGGCTGACG GGCACCCCAA GGGATTCGCA 
TACATTGAGT TTGGTTCCAA GGAGTTTGTC GAGACGGCAT TGGCCATGAA CGAAACCCTC 
TTCCGAGGGC GTCAAATAAA GGTAATGTCG AAGCGCACAA ACCGCCCTGG ACTCTCCACC 
ACAAACCGTT TCGCACGCGG CAGCTTCCGG GGTCGAGGAG CCCGTGTCTC CCGGGCGTGC 
TGTCACTCCA CCTTCCGAGG CGCCCGAAGA GCTATGGGTT ACCGTGGTCG CGCCAATTAC 
TACGCTCCTT ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pabp2 ( NM_057554.4 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_476902.1 Drosophila melanogaster Pabp2, transcript variant A (Pabp2), mRNA.

Price & Availability↑

CloneID	OFa09259
Clone ID Related Accession (Same CDS sequence)	NM_165589.3 , NM_057554.4
Accession Version	NM_057554.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 675bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	Pabp2, isoform A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033778). On Jul 15, 2014 this sequence version replaced NM_057554.3. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGGCCGATG AAGATATCAC ATTGAACGAG GATCAGCTCC TGGAGTCATT GGAGGAGACG 
AACGGGGAGC AAGAGACTGA GATCGCCACA GAGGTCGAGG AGGAGGGCAG CATGCAAATC 
GACCCGGAAC TGGAGGCCAT AAAGGCTCGA GTCAAGGAGA TGGAAGAGGA GGCCGAGAAG 
ATAAAGCAGA TGCAGTCGGA GGTGGACAAA CAAATGGCCG GTGGGTCTAC CACCGGCTTG 
GCCACAGTCC CGCTTTCTCT TGAGGAGAAG CAGGAAATCG ACACGCGGTC CGTCTACGTG 
GGCAATGTGG ACTACGGCGC ATCGGCCGAG GAACTGGAGG CCCACTTCCA CGGATGCGGC 
ACAATCAACC GAGTAACCAT ACTCTGCAAC AAGGCTGACG GGCACCCCAA GGGATTCGCA 
TACATTGAGT TTGGTTCCAA GGAGTTTGTC GAGACGGCAT TGGCCATGAA CGAAACCCTC 
TTCCGAGGGC GTCAAATAAA GGTAATGTCG AAGCGCACAA ACCGCCCTGG ACTCTCCACC 
ACAAACCGTT TCGCACGCGG CAGCTTCCGG GGTCGAGGAG CCCGTGTCTC CCGGGCGTGC 
TGTCACTCCA CCTTCCGAGG CGCCCGAAGA GCTATGGGTT ACCGTGGTCG CGCCAATTAC 
TACGCTCCTT ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_476902.1
CDS	407..1081
Translation	MADEDITLNEDQLLESLEETNGEQETEIATEVEEEGSMQIDPELEAIKARVKEMEEEAEKIKQMQSEVDKQMAGGSTTGLATVPLSLEEKQEIDTRSVYVGNVDYGASAEELEAHFHGCGTINRVTILCNKADGHPKGFAYIEFGSKEFVETALAMNETLFRGRQIKVMSKRTNRPGLSTTNRFARGSFRGRGARVSRACCHSTFRGARRAMGYRGRANYYAPY

Target ORF information:

RefSeq Version	NM_057554.4
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster Pabp2, transcript variant A (Pabp2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_057554.4

ORF Insert Sequence:

ATGGCCGATG AAGATATCAC ATTGAACGAG GATCAGCTCC TGGAGTCATT GGAGGAGACG 
AACGGGGAGC AAGAGACTGA GATCGCCACA GAGGTCGAGG AGGAGGGCAG CATGCAAATC 
GACCCGGAAC TGGAGGCCAT AAAGGCTCGA GTCAAGGAGA TGGAAGAGGA GGCCGAGAAG 
ATAAAGCAGA TGCAGTCGGA GGTGGACAAA CAAATGGCCG GTGGGTCTAC CACCGGCTTG 
GCCACAGTCC CGCTTTCTCT TGAGGAGAAG CAGGAAATCG ACACGCGGTC CGTCTACGTG 
GGCAATGTGG ACTACGGCGC ATCGGCCGAG GAACTGGAGG CCCACTTCCA CGGATGCGGC 
ACAATCAACC GAGTAACCAT ACTCTGCAAC AAGGCTGACG GGCACCCCAA GGGATTCGCA 
TACATTGAGT TTGGTTCCAA GGAGTTTGTC GAGACGGCAT TGGCCATGAA CGAAACCCTC 
TTCCGAGGGC GTCAAATAAA GGTAATGTCG AAGCGCACAA ACCGCCCTGG ACTCTCCACC 
ACAAACCGTT TCGCACGCGG CAGCTTCCGG GGTCGAGGAG CCCGTGTCTC CCGGGCGTGC 
TGTCACTCCA CCTTCCGAGG CGCCCGAAGA GCTATGGGTT ACCGTGGTCG CGCCAATTAC 
TACGCTCCTT ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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Pabp2 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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