Gene Symbol | SEC61A1 |
Entrez Gene ID | 404006 |
Full Name | Sec61 translocon alpha 1 subunit |
Gene Type | protein-coding |
Organism | Canis lupus familiaris(dog) |
ORF » Species Summary » Canis lupus familiaris » SEC61A1 cDNA ORF clone
Gene Symbol | SEC61A1 |
Entrez Gene ID | 404006 |
Full Name | Sec61 translocon alpha 1 subunit |
Gene Type | protein-coding |
Organism | Canis lupus familiaris(dog) |
mRNA | Protein | Name |
---|---|---|
NM_001003315.1 | NP_001003315.1 | protein transport protein Sec61 subunit alpha isoform 1 |
Pan troglodytes (chimpanzee) | SEC61A1 | XP_003310030.1 |
Danio rerio (zebrafish) | sec61a1 | NP_705945.1 |
Danio rerio (zebrafish) | sec61al2 | NP_963871.1 |
Kluyveromyces lactis | KLLA0E01145g | XP_454000.1 |
Bos taurus (cattle) | SEC61A1 | NP_001035594.1 |
Gallus gallus (chicken) | SEC61A1 | XP_414364.3 |
Saccharomyces cerevisiae (baker's yeast) | SEC61 | NP_013482.1 |
Eremothecium gossypii | AGOS_AFR596W | NP_986143.1 |
Oryza sativa (rice) | Os09g0347700 | NP_001062945.1 |
Homo sapiens (human) | SEC61A1 | NP_037468.1 |
Rattus norvegicus (Norway rat) | Sec61a1 | NP_954865.1 |
Schizosaccharomyces pombe (fission yeast) | sec61 | NP_595226.1 |
Arabidopsis thaliana (thale cress) | AT1G29310 | NP_174225.2 |
Xenopus tropicalis (tropical clawed frog) | sec61a1 | NP_001004801.1 |
Canis lupus familiaris (dog) | SEC61A1 | NP_001003315.1 |
Mus musculus (house mouse) | Sec61a1 | NP_058602.1 |
Neurospora crassa | NCU08897 | XP_958835.1 |
Arabidopsis thaliana (thale cress) | AT2G34250 | NP_180972.1 |
Oryza sativa (rice) | Os03g0213100 | NP_001049359.1 |
SEC61A1 | XP_002798757.1 | |
Magnaporthe oryzae (rice blast fungus) | MGG_04856 | XP_003712335.1 |
Calmodulin regulation of the calcium-leak channel Sec61 is unique to vertebrates.
Harsman A, Kopp A, Wagner R, Zimmermann R, Jung M
Channels (Austin, Tex.)5(4)293-8(2011 Jul-Aug)
Interaction of calmodulin with Sec61? limits Ca2+ leakage from the endoplasmic reticulum.
Erdmann F, Sch?uble N, Lang S, Jung M, Honigmann A, Ahmad M, Dudek J, Benedix J, Harsman A, Kopp A, Helms V, Cavali? A, Wagner R, Zimmermann R
The EMBO journal30(1)17-31(2011 Jan)
Control of translocation through the Sec61 translocon by nascent polypeptide structure within the ribosome.
Daniel CJ, Conti B, Johnson AE, Skach WR
The Journal of biological chemistry283(30)20864-73(2008 Jul)
A complex of chaperones and disulfide isomerases occludes the cytosolic face of the translocation protein Sec61p and affects translocation of the prion protein.
Stockton JD, Merkert MC, Kellaris KV
Biochemistry42(44)12821-34(2003 Nov)
A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation.
G?rlich D, Prehn S, Hartmann E, Kalies KU, Rapoport TA
Cell71(3)489-503(1992 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
CaM binding to the cytosolic N-terminus of Sec61alpha is involved in limiting Ca(2+)-leakage from the ER in C. familiaris but not S. cerevisiae.
Title: Calmodulin regulation of the calcium-leak channel Sec61 is unique to vertebrates.
Calmodulin binds to a conserved motif of the Sec61 alpha subunit in a calcium-dependent and sequence-specific manner.
Title: Interaction of calmodulin with Sec61? limits Ca2+ leakage from the endoplasmic reticulum.
The following SEC61A1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SEC61A1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCe00155 | |
Clone ID Related Accession (Same CDS sequence) | NM_001003315.1 | |
Accession Version | NM_001003315.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1431bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-22 | |
Organism | Canis lupus familiaris(dog) | |
Product | protein transport protein Sec61 subunit alpha isoform 1 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M96629.1. ##Evidence-Data-START## Transcript exon combination :: M96629.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103936001, SAMEA103936002 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCGATCA AATTTCTGGA AGTTATCAAG CCTTTCTGTG TCATCCTGCC AGAGATTCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001003315.1 |
CDS | 103..1533 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001003315.1 |
1 | ATGGCGATCA AATTTCTGGA AGTTATCAAG CCTTTCTGTG TCATCCTGCC AGAGATTCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Calmodulin regulation of the calcium-leak channel Sec61 is unique to vertebrates. |
Interaction of calmodulin with Sec61? limits Ca2+ leakage from the endoplasmic reticulum. |
Control of translocation through the Sec61 translocon by nascent polypeptide structure within the ribosome. |
A complex of chaperones and disulfide isomerases occludes the cytosolic face of the translocation protein Sec61p and affects translocation of the prion protein. |
A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation. |