Sec61a1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sec61a1
Entrez Gene ID	53421
Full Name	Sec61 alpha 1 subunit (S. cerevisiae)
Synonyms	AA408394,AA410007,Sec61a
General protein information	Preferred Names Sec61 alpha 1 subunit (S. cerevisiae) Names protein transport protein Sec61 subunit alpha isoform 1 SEC61, alpha subunit protein transport protein Sec61 subunit alpha sec61 alpha-1 transport protein sec61 alpha subunit
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6\|6 D1

mRNA and Protein(s)

mRNA	Protein	Name
NM_016906.4	NP_058602.1	protein transport protein Sec61 subunit alpha isoform 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	SEC61A1	XP_003310030.1
Danio rerio (zebrafish)	sec61a1	NP_705945.1
Danio rerio (zebrafish)	sec61al2	NP_963871.1
Kluyveromyces lactis	KLLA0E01145g	XP_454000.1
Bos taurus (cattle)	SEC61A1	NP_001035594.1
Gallus gallus (chicken)	SEC61A1	XP_414364.3
Saccharomyces cerevisiae (baker's yeast)	SEC61	NP_013482.1
Eremothecium gossypii	AGOS_AFR596W	NP_986143.1
Oryza sativa (rice)	Os09g0347700	NP_001062945.1
Homo sapiens (human)	SEC61A1	NP_037468.1
Rattus norvegicus (Norway rat)	Sec61a1	NP_954865.1
Schizosaccharomyces pombe (fission yeast)	sec61	NP_595226.1
Arabidopsis thaliana (thale cress)	AT1G29310	NP_174225.2
Xenopus tropicalis (tropical clawed frog)	sec61a1	NP_001004801.1
Canis lupus familiaris (dog)	SEC61A1	NP_001003315.1
Mus musculus (house mouse)	Sec61a1	NP_058602.1
Neurospora crassa	NCU08897	XP_958835.1
Arabidopsis thaliana (thale cress)	AT2G34250	NP_180972.1
Oryza sativa (rice)	Os03g0213100	NP_001049359.1
	SEC61A1	XP_002798757.1
Magnaporthe oryzae (rice blast fungus)	MGG_04856	XP_003712335.1

Gene Ontology
Bibliography

Related articles in PubMed

Sec61 blockade by mycolactone inhibits antigen cross-presentation independently of endosome-to-cytosol export.
Grotzke JE, Kozik P, Morel JD, Impens F, Pietrosemoli N, Cresswell P, Amigorena S, Demangel C
Proceedings of the National Academy of Sciences of the United States of America114(29)E5910-E5919(2017 Jul)

Heterozygous Loss-of-Function SEC61A1 Mutations Cause Autosomal-Dominant Tubulo-Interstitial and Glomerulocystic Kidney Disease with Anemia.
Bolar NA, Golzio C, ?ivn? M, Hayot G, Van Hemelrijk C, Schepers D, Vandeweyer G, Hoischen A, Huyghe JR, Raes A, Matthys E, Sys E, Azou M, Gubler MC, Praet M, Van Camp G, McFadden K, Pediaditakis I, P?istoupilov? A, Hoda?ov? K, Vyle?al P, Hartmannov? H, Str?neck? V, H?lkov? H, Bare?ov? V, Jedli?kov? I, Sovov? J, Hn?zda A, Kidd K, Bleyer AJ, Spong RS, Vande Walle J, Mortier G, Brunner H, Van Laer L, Kmoch S, Katsanis N, Loeys BL
American journal of human genetics99(1)174-87(2016 Jul)

Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation.
Jadhav B, McKenna M, Johnson N, High S, Sinning I, Pool MR
Nature communications610133(2015 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interaction of ribosomes and Sec62 with the core Sec61 translocon is mutually exclusive.
Title: Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation.

SEC61A1 gene silencing inhibits co- and post-translational transport of presecretory proteins into endoplasmic reticulum.
Title: Different effects of Sec61?, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells.

Diabetes can bemapped to a point mutation in the Sec61a1 gene that encodes a His to Tyr substitution at amino acid 344.
Title: A point mutation in Sec61alpha1 leads to diabetes and hepatosteatosis in mice.

The following Sec61a1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sec61a1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu10702	NM_016906.4 Latest version!	Mus musculus Sec61 alpha 1 subunit (S. cerevisiae) (Sec61a1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sec61a1 ( NM_016906.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_058602.1 Mus musculus Sec61 alpha 1 subunit (S. cerevisiae) (Sec61a1), mRNA.

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CloneID	OMu10702
Clone ID Related Accession (Same CDS sequence)	NM_016906.4
Accession Version	NM_016906.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1431bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-10
Organism	Mus musculus(house mouse)
Product	protein transport protein Sec61 subunit alpha isoform 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC154038.1. On Apr 28, 2007 this sequence version replaced NM_016906.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK088473.1, BC003707.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134, SAMN01164135 [ECO:0000348] ##Evidence-Data-END##

ATGGCGATCA AATTTCTGGA AGTCATCAAG CCATTCTGTG TCATCTTGCC GGAAATTCAG 
AAGCCAGAGA GAAAGATTCA GTTTAAGGAG AAAGTTCTGT GGACAGCCAT CACCCTCTTC 
ATCTTCTTAG TATGCTGTCA GATCCCCCTG TTTGGCATCA TGTCTTCAGA CTCAGCTGAC 
CCGTTCTACT GGATGCGAGT GATTCTGGCC TCTAACAGAG GTACCTTAAT GGAGCTGGGC 
ATCTCTCCTA TTGTCACCTC CGGTCTTATC ATGCAGCTCT TAGCTGGTGC CAAGATAATT 
GAAGTTGGGG ACACCCCGAA AGACCGAGCT CTCTTCAATG GAGCCCAGAA GTTGTTTGGA 
ATGATCATTA CTATCGGTCA GTCCATTGTG TATGTGATGA CGGGCATGTA CGGGGACCCT 
TCGGAGATGG GTGCTGGAAT CTGCCTGCTG ATCACCATTC AGCTCTTTGT TGCTGGCTTA 
ATTGTCCTAC TTTTGGATGA ACTTCTGCAA AAAGGGTACG GCTTGGGCTC TGGCATTTCT 
CTCTTCATTG CGACTAACAT CTGTGAGACC ATTGTGTGGA AGGCATTCAG CCCCACCACT 
GTCAACACTG GCCGAGGGAT GGAATTCGAA GGCGCCATCA TAGCGCTATT CCACCTGCTG 
GCCACCCGCA CAGACAAGGT CCGAGCCCTT CGAGAGGCAT TCTACCGCCA GAACCTCCCC 
AACCTCATGA ACCTGATTGC CACCATCTTC GTCTTTGCCG TTGTCATCTA TTTCCAGGGC 
TTCCGAGTGG ACCTTCCAAT CAAGTCGGCG CGTTACCGAG GCCAGTACAA CACCTATCCC 
ATCAAGCTCT TCTACACCTC CAACATCCCC ATCATCTTGC AGTCTGCTCT GGTGTCCAAC 
CTGTATGTCA TCTCCCAGAT GCTGTCAGCA CGCTTCAGTG GCAACCTGCT GGTTAGCCTG 
CTGGGCACCT GGTCGGATAC ATCATCTGGG GGCCCAGCCC GAGCTTACCC CGTTGGTGGC 
CTGTGTTACT ACCTGTCTCC TCCGGAATCG TTCGGCTCAG TGCTGGAGGA CCCTGTCCAT 
GCGGTCGTGT ACATCGTGTT CATGCTGGGC TCCTGTGCAT TCTTCTCCAA AACATGGATC 
GAAGTCTCAG GTTCTTCTGC CAAAGATGTT GCAAAGCAGC TGAAGGAGCA GCAGATGGTG 
ATGAGGGGCC ACAGGGAGAC CTCCATGGTG CATGAGCTCA ACCGGTACAT CCCCACAGCC 
GCAGCCTTTG GTGGGCTGTG CATTGGGGCC CTCTCTGTCC TGGCTGACTT CCTGGGTGCT 
ATCGGGTCTG GAACTGGGAT CCTGCTTGCG GTCACCATCA TCTACCAGTA CTTTGAGATC 
TTCGTCAAGG AACAGAGCGA GGTGGGCAGC ATGGGAGCCC TTCTCTTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058602.1
CDS	109..1539
Translation	MAIKFLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMIITIGQSIVYVMTGMYGDPSEMGAGICLLITIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTVNTGRGMEFEGAIIALFHLLATRTDKVRALREAFYRQNLPNLMNLIATIFVFAVVIYFQGFRVDLPIKSARYRGQYNTYPIKLFYTSNIPIILQSALVSNLYVISQMLSARFSGNLLVSLLGTWSDTSSGGPARAYPVGGLCYYLSPPESFGSVLEDPVHAVVYIVFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPTAAAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQSEVGSMGALLF

Target ORF information:

RefSeq Version	NM_016906.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus Sec61 alpha 1 subunit (S. cerevisiae) (Sec61a1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016906.4

ORF Insert Sequence:

ATGGCGATCA AATTTCTGGA AGTCATCAAG CCATTCTGTG TCATCTTGCC GGAAATTCAG 
AAGCCAGAGA GAAAGATTCA GTTTAAGGAG AAAGTTCTGT GGACAGCCAT CACCCTCTTC 
ATCTTCTTAG TATGCTGTCA GATCCCCCTG TTTGGCATCA TGTCTTCAGA CTCAGCTGAC 
CCGTTCTACT GGATGCGAGT GATTCTGGCC TCTAACAGAG GTACCTTAAT GGAGCTGGGC 
ATCTCTCCTA TTGTCACCTC CGGTCTTATC ATGCAGCTCT TAGCTGGTGC CAAGATAATT 
GAAGTTGGGG ACACCCCGAA AGACCGAGCT CTCTTCAATG GAGCCCAGAA GTTGTTTGGA 
ATGATCATTA CTATCGGTCA GTCCATTGTG TATGTGATGA CGGGCATGTA CGGGGACCCT 
TCGGAGATGG GTGCTGGAAT CTGCCTGCTG ATCACCATTC AGCTCTTTGT TGCTGGCTTA 
ATTGTCCTAC TTTTGGATGA ACTTCTGCAA AAAGGGTACG GCTTGGGCTC TGGCATTTCT 
CTCTTCATTG CGACTAACAT CTGTGAGACC ATTGTGTGGA AGGCATTCAG CCCCACCACT 
GTCAACACTG GCCGAGGGAT GGAATTCGAA GGCGCCATCA TAGCGCTATT CCACCTGCTG 
GCCACCCGCA CAGACAAGGT CCGAGCCCTT CGAGAGGCAT TCTACCGCCA GAACCTCCCC 
AACCTCATGA ACCTGATTGC CACCATCTTC GTCTTTGCCG TTGTCATCTA TTTCCAGGGC 
TTCCGAGTGG ACCTTCCAAT CAAGTCGGCG CGTTACCGAG GCCAGTACAA CACCTATCCC 
ATCAAGCTCT TCTACACCTC CAACATCCCC ATCATCTTGC AGTCTGCTCT GGTGTCCAAC 
CTGTATGTCA TCTCCCAGAT GCTGTCAGCA CGCTTCAGTG GCAACCTGCT GGTTAGCCTG 
CTGGGCACCT GGTCGGATAC ATCATCTGGG GGCCCAGCCC GAGCTTACCC CGTTGGTGGC 
CTGTGTTACT ACCTGTCTCC TCCGGAATCG TTCGGCTCAG TGCTGGAGGA CCCTGTCCAT 
GCGGTCGTGT ACATCGTGTT CATGCTGGGC TCCTGTGCAT TCTTCTCCAA AACATGGATC 
GAAGTCTCAG GTTCTTCTGC CAAAGATGTT GCAAAGCAGC TGAAGGAGCA GCAGATGGTG 
ATGAGGGGCC ACAGGGAGAC CTCCATGGTG CATGAGCTCA ACCGGTACAT CCCCACAGCC 
GCAGCCTTTG GTGGGCTGTG CATTGGGGCC CTCTCTGTCC TGGCTGACTT CCTGGGTGCT 
ATCGGGTCTG GAACTGGGAT CCTGCTTGCG GTCACCATCA TCTACCAGTA CTTTGAGATC 
TTCGTCAAGG AACAGAGCGA GGTGGGCAGC ATGGGAGCCC TTCTCTTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Sec61 blockade by mycolactone inhibits antigen cross-presentation independently of endosome-to-cytosol export.
Proceedings of the National Academy of Sciences of the United States of America114(29)E5910-E5919(2017 Jul)
Grotzke JE,Kozik P,Morel JD,Impens F,Pietrosemoli N,Cresswell P,Amigorena S,Demangel C

Heterozygous Loss-of-Function SEC61A1 Mutations Cause Autosomal-Dominant Tubulo-Interstitial and Glomerulocystic Kidney Disease with Anemia.
American journal of human genetics99(1)174-87(2016 Jul)
Bolar NA,Golzio C,?ivn? M,Hayot G,Van Hemelrijk C,Schepers D,Vandeweyer G,Hoischen A,Huyghe JR,Raes A,Matthys E,Sys E,Azou M,Gubler MC,Praet M,Van Camp G,McFadden K,Pediaditakis I,P?istoupilov? A,Hoda?ov? K,Vyle?al P,Hartmannov? H,Str?neck? V,H?lkov? H,Bare?ov? V,Jedli?kov? I,Sovov? J,Hn?zda A,Kidd K,Bleyer AJ,Spong RS,Vande Walle J,Mortier G,Brunner H,Van Laer L,Kmoch S,Katsanis N,Loeys BL

Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation.
Nature communications610133(2015 Dec)
Jadhav B,McKenna M,Johnson N,High S,Sinning I,Pool MR

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Sec61a1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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