wrn-1 cDNA ORF clone, Caenorhabditis elegans

Gene
Clones
gRNAs

Summary

Gene Symbol	wrn-1
Entrez Gene ID	174081
Full Name	Probable Werner syndrome ATP-dependent helicase homolog 1
Gene Type	protein-coding
Organism	Caenorhabditis elegans

mRNA and Protein(s)

mRNA	Protein	Name
NM_062923.5	NP_495324.2	Probable Werner syndrome ATP-dependent helicase homolog 1
NM_062923.6	NP_495324.2	Probable Werner syndrome ATP-dependent helicase homolog 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	WRN	NP_000544.2
Mus musculus (house mouse)	Wrn	NP_035851.3
Bos taurus (cattle)	WRN	NP_001137329.2
Caenorhabditis elegans (roundworm)	wrn-1	NP_495324.2
Canis lupus familiaris (dog)	WRN	XP_539984.4
Gallus gallus (chicken)	WRN	XP_001235033.2
Xenopus tropicalis (tropical clawed frog)	wrn	XP_002939304.1
Pan troglodytes (chimpanzee)	WRN	XP_528104.2
	WRN	XP_001085031.1
Rattus norvegicus (Norway rat)	RGD1564788	XP_006253317.1
Danio rerio (zebrafish)	wrn	XP_697980.5
Oryza sativa (rice)	Os07g0681600	NP_001060655.1

Gene Ontology
Bibliography

Related articles in PubMed

Genome sequence of the nematode C. elegans: a platform for investigating biology.

Science (New York, N.Y.)282(5396)2012-8(1998 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

WRN-1 plays a conserved role in the resection of DSB ends and mediates checkpoint signaling, thereby influencing levels of RPA and RAD-51
Title: The Caenorhabditis elegans WRN helicase promotes double-strand DNA break repair by mediating end resection and checkpoint activation.

WRN-1 functions downstream of RPA-1 and upstream of CHK-1 in the DSB checkpoint pathway and is also required for the repair of DSB.
Title: The Caenorhabditis elegans Werner syndrome protein participates in DNA damage checkpoint and DNA repair in response to CPT-induced double-strand breaks.

analysis of physical and functional interactions of Caenorhabditis elegans WRN-1 helicase with RPA-1
Title: Physical and functional interactions of Caenorhabditis elegans WRN-1 helicase with RPA-1.

WRN-1 functions together with RPA-1 upstream of ATM and ATR to trigger cell cycle arrest in response to double-strand DNA breaks.
Title: The Caenorhabditis elegans Werner syndrome protein functions upstream of ATR and ATM in response to DNA replication inhibition and double-strand DNA breaks.

This protein is able to unwind DNA structures may improve the access for DNA repair and replication proteins that are important for preventing the accumulation of abnormal structures.
Title: Biochemical characterization of the WRN-1 RecQ helicase of Caenorhabditis elegans.

The following wrn-1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the wrn-1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OCa338984	NM_062923.6 Latest version!	Caenorhabditis elegans Probable Werner syndrome ATP-dependent helicase homolog 1 (wrn-1), partial mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00
View Old Accession Versions >>
OCa338984	NM_062923.5	Caenorhabditis elegans Probable Werner syndrome ATP-dependent helicase homolog 1 (wrn-1), partial mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$629.30 $899.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

wrn-1 ( NM_062923.5 ) cDNA ORF clone, Caenorhabditis elegans -> NP_495324.2 Caenorhabditis elegans Probable Werner syndrome ATP-dependent helicase homolog 1 (wrn-1), partial mRNA.

Price & Availability↑

CloneID	OCa338984
Clone ID Related Accession (Same CDS sequence)	NM_062923.5 , NM_062923.6
Accession Version	NM_062923.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3171bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-08
Organism	Caenorhabditis elegans
Product	Probable Werner syndrome ATP-dependent helicase homolog 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003280). On Jun 26, 2012 this sequence version replaced NM_062923.4. COMPLETENESS: incomplete on both ends.

ATGATAAGTG ATGATGACGA TCTACCATCT ACTCGCCCGG GATCTGTGAA TGAGGAATTA 
CCAGAAACCG AACCCGAAGA TAATGATGAG TTGCCTGAAA CAGAACCTGA AAGCGATTCC 
GATAAACCTA CCGTAACCTC GAATAAAACA GAAAACCAAG TTGCTGATGA AGATTATGAT 
TCATTCGACG ATTTTGTGCC CAGTCAAACA CACACAGCCT CCAAAATACC TGTAAAAAAT 
AAACGAGCCA AAAAGTGCAC TGTAGAATCT GATTCATCAT CTTCGGATGA TTCCGATCAA 
GGAGATGATT GTGAATTTAT CCCAGCTTGT GATGAGACAC AGGAAGTTCC GAAAATCAAA 
AGAGGATACA CTCTGAGAAC TCGAGCAAGT GTAAAGAACA AATGTGATGA TTCATGGGAT 
GATGGAATAG ACGAAGAAGA TGTCTCAAAA AGATCAGAAG ACACGTTAAA TGATTCATTT 
GTTGATCCTG AATTCATGGA TTCTGTTCTA GATAATCAAT TAACGATCAA AGGCAAAAAG 
CAATTTCTCG ATGATGGAGA GTTTTTCACA GACCGGAATG TTCCTCAGAT TGATGAAGCT 
ACAAAAATGA AGTGGGCATC AATGACGTCA CCTCCTCAAG AAGCTTTGAA CGCATTGAAC 
GAATTCTTCG GTCATAAAGG ATTCCGAGAA AAGCAGTGGG ATGTTGTCAG AAATGTTTTG 
GGAGGAAAAG ACCAATTTGT TCTTATGTCC ACTGGTTATG GTAAAAGTGT ATGTTATCAG 
CTACCATCAC TTCTTCTCAA TTCGATGACT GTCGTGGTAT CTCCATTAAT TTCATTGATG 
AATGATCAAG TAACTACATT GGTTTCTAAA GGTATTGATG CAGTGAAACT AGATGGACAT 
TCTACACAAA TTGAATGGGA TCAAGTTGCG AATAATATGC ACCGAATTAG GTTCATCTAC 
ATGTCACCTG AAATGGTTAC GAGCCAAAAG GGTTTGGAAT TATTAACTTC TTGCCGAAAA 
CATATCTCCC TCCTCGCTAT TGATGAAGCT CATTGTGTTT CTCAATGGGG ACACGACTTT 
CGAAACTCGT ACAGGCATCT CGCAGAAATT AGAAACCGAT CTGATCTATG CAATATTCCA 
ATGATTGCTC TTACCGCTAC TGCCACAGTT AGAGTTCGTG ATGACGTCAT TGCTAATTTA 
AGACTCCGCA AGCCATTAAT CACAACTACG TCGTTTGATA GAAAGAATCT CTACATTTCT 
GTGCATTCTT CAAAGGACAT GGCTGAAGAT TTAGGATTAT TCATGAAAAC CGATGAAGTT 
AAAGGAAGAC ACTTTGGTGG ACCTACTATT ATTTATTGCC AAACGAAACA AATGGTCGAT 
GATGTGAACT GTGTTTTGAG AAGAATCGGA GTTCGTTCTG CTCATTATCA CGCAGGACTC 
ACTAAAAATC AACGAGAAAA AGCACACACC GATTTTATGA GAGATAAGAT TACAACAATC 
GTTGCGACAG TTGCATTTGG TATGGGAATT GACAAACCCG ACGTTCGAAA TGTGATTCAT 
TACGGATGCC CGAACAATAT CGAATCATAT TATCAAGAAA TCGGAAGAGC TGGTCGAGAT 
GGATCTCCAA GTATTTGTCG TGTATTCTGG GCTCCGAAAG ATTTGAATAC TATAAAATTT 
AAACTTCGAA ATTCGCAGCA AAAAGAAGAA GTAGTTGAAA ATCTTACAAT GATGCTAAGA 
CAACTCGAGT TGGTTCTGAC AACCGTTGGA TGTAGAAGAT ACCAACTTCT GAAGCACTTT 
GACCCATCAT ACGCGAAACC TCCAACTATG CAAGCTGATT GTTGTGATAG ATGTACTGAA 
ATGCTCAATG GAAATCAAGA TTCATCATCC AGTATTGTTG ATGTTACAAC AGAATCGAAG 
TGGTTGTTTC AAGTTATTAA CGAAATGTAC AACGGGAAAA CTGGTATCGG AAAACCAATC 
GAATTTCTGA GGGGATCGAG TAAAGAAGAC TGGCGAATCA AGACCACATC TCAACAAAAA 
TTGTTTGGAA TTGGAAAACA TATTCCTGAT AAATGGTGGA AAGCACTTGC AGCATCACTT 
CGAATTGCTG GTTATCTTGG AGAAGTTAGG CTGATGCAAA TGAAATTTGG AAGTTGTATC 
ACTTTGTCCG AACTCGGGGA ACGATGGCTT TTGACTGGAA AAGAGATGAA AATCGATGCG 
ACACCGATTT TATTGCAAGG GAAGAAAGAA AAAGCCGCAC CTTCAACTGT CCCCGGAGCT 
TCAAGATCTC AGTCAACTAA ATCAAGTACA GAGATTCCAA CCAAGATTCT CGGAGCGAAT 
AAGATTCGTG AATACGAGCC TGCAAATGAA AACGAGCAGC TGATGAACTT GAAAAAGCAA 
GAAGTCACTG GTCTTCCAGA GAAGATTGAT CAACTGCGCT CTCGTCTTGA CGACATTCGT 
GTAGGAATTG CAAACATGCA TGAAGTAGCA CCATTCCAAA TTGTATCGAA TACTGTTCTT 
GATTGTTTTG CCAACTTGAG ACCTACCTCA GCCTCGAATC TCGAAATGAT TGATGGAATG 
TCGGCTCAGC AGAAATCTAG ATACGGAAAA CGATTTGTCG ATTGTGTTGT ACAATTTTCA 
AAGGAAACTG GCATTGCAAC AAACGTCAAT GCCAACGATA TGATACCCCC TGAACTTATT 
TCAAAAATGC AGAAAGTTCT CTCGGATGCG GTGAGAAGAG TATACACAGA GCATCTTATT 
TCGAGATCCA CTGCGAAAGA AGTGGCAACT GCTCGAGGAA TTAGTGAGGG TACTGTATAT 
TCATATCTCG CGATGGCGGT AGAAAAAGGA TTACCTCTTC ACTTAGACAA GTTAAATGTC 
TCCAGAAAGA ATATTGCAAT GGCTCTAAAT GCAGTTAGAG TACATTTAGG ATCAAATGTT 
GCCGTACTGA CACCATGGGT TGAAGCTATG GGAGTCGTAC CTGATTTTAA TCAGTTGAAA 
TTGATCCGGG CAATTCTTAT TTACGAATAT GGATTGGATA CGAGTGAGAA CCAAGAGAAG 
CCAGACATCC AATCTATGCC GTCCACTTCA AATCCATCCA CCATCAAAAC AGTTCCATCA 
ACACCTTCAT CCTCTCTCAG AGCTCCTCCA TTGAAGAAAT TCAAACTTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_495324.2
CDS	1..3171
Translation	MISDDDDLPSTRPGSVNEELPETEPEDNDELPETEPESDSDKPTVTSNKTENQVADEDYDSFDDFVPSQTHTASKIPVKNKRAKKCTVESDSSSSDDSDQGDDCEFIPACDETQEVPKIKRGYTLRTRASVKNKCDDSWDDGIDEEDVSKRSEDTLNDSFVDPEFMDSVLDNQLTIKGKKQFLDDGEFFTDRNVPQIDEATKMKWASMTSPPQEALNALNEFFGHKGFREKQWDVVRNVLGGKDQFVLMSTGYGKSVCYQLPSLLLNSMTVVVSPLISLMNDQVTTLVSKGIDAVKLDGHSTQIEWDQVANNMHRIRFIYMSPEMVTSQKGLELLTSCRKHISLLAIDEAHCVSQWGHDFRNSYRHLAEIRNRSDLCNIPMIALTATATVRVRDDVIANLRLRKPLITTTSFDRKNLYISVHSSKDMAEDLGLFMKTDEVKGRHFGGPTIIYCQTKQMVDDVNCVLRRIGVRSAHYHAGLTKNQREKAHTDFMRDKITTIVATVAFGMGIDKPDVRNVIHYGCPNNIESYYQEIGRAGRDGSPSICRVFWAPKDLNTIKFKLRNSQQKEEVVENLTMMLRQLELVLTTVGCRRYQLLKHFDPSYAKPPTMQADCCDRCTEMLNGNQDSSSSIVDVTTESKWLFQVINEMYNGKTGIGKPIEFLRGSSKEDWRIKTTSQQKLFGIGKHIPDKWWKALAASLRIAGYLGEVRLMQMKFGSCITLSELGERWLLTGKEMKIDATPILLQGKKEKAAPSTVPGASRSQSTKSSTEIPTKILGANKIREYEPANENEQLMNLKKQEVTGLPEKIDQLRSRLDDIRVGIANMHEVAPFQIVSNTVLDCFANLRPTSASNLEMIDGMSAQQKSRYGKRFVDCVVQFSKETGIATNVNANDMIPPELISKMQKVLSDAVRRVYTEHLISRSTAKEVATARGISEGTVYSYLAMAVEKGLPLHLDKLNVSRKNIAMALNAVRVHLGSNVAVLTPWVEAMGVVPDFNQLKLIRAILIYEYGLDTSENQEKPDIQSMPSTSNPSTIKTVPSTPSSSLRAPPLKKFKL

Target ORF information:

RefSeq Version	NM_062923.5
Organism	Caenorhabditis elegans
Definition	Caenorhabditis elegans Probable Werner syndrome ATP-dependent helicase homolog 1 (wrn-1), partial mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_062923.5

ORF Insert Sequence:

ATGATAAGTG ATGATGACGA TCTACCATCT ACTCGCCCGG GATCTGTGAA TGAGGAATTA 
CCAGAAACCG AACCCGAAGA TAATGATGAG TTGCCTGAAA CAGAACCTGA AAGCGATTCC 
GATAAACCTA CCGTAACCTC GAATAAAACA GAAAACCAAG TTGCTGATGA AGATTATGAT 
TCATTCGACG ATTTTGTGCC CAGTCAAACA CACACAGCCT CCAAAATACC TGTAAAAAAT 
AAACGAGCCA AAAAGTGCAC TGTAGAATCT GATTCATCAT CTTCGGATGA TTCCGATCAA 
GGAGATGATT GTGAATTTAT CCCAGCTTGT GATGAGACAC AGGAAGTTCC GAAAATCAAA 
AGAGGATACA CTCTGAGAAC TCGAGCAAGT GTAAAGAACA AATGTGATGA TTCATGGGAT 
GATGGAATAG ACGAAGAAGA TGTCTCAAAA AGATCAGAAG ACACGTTAAA TGATTCATTT 
GTTGATCCTG AATTCATGGA TTCTGTTCTA GATAATCAAT TAACGATCAA AGGCAAAAAG 
CAATTTCTCG ATGATGGAGA GTTTTTCACA GACCGGAATG TTCCTCAGAT TGATGAAGCT 
ACAAAAATGA AGTGGGCATC AATGACGTCA CCTCCTCAAG AAGCTTTGAA CGCATTGAAC 
GAATTCTTCG GTCATAAAGG ATTCCGAGAA AAGCAGTGGG ATGTTGTCAG AAATGTTTTG 
GGAGGAAAAG ACCAATTTGT TCTTATGTCC ACTGGTTATG GTAAAAGTGT ATGTTATCAG 
CTACCATCAC TTCTTCTCAA TTCGATGACT GTCGTGGTAT CTCCATTAAT TTCATTGATG 
AATGATCAAG TAACTACATT GGTTTCTAAA GGTATTGATG CAGTGAAACT AGATGGACAT 
TCTACACAAA TTGAATGGGA TCAAGTTGCG AATAATATGC ACCGAATTAG GTTCATCTAC 
ATGTCACCTG AAATGGTTAC GAGCCAAAAG GGTTTGGAAT TATTAACTTC TTGCCGAAAA 
CATATCTCCC TCCTCGCTAT TGATGAAGCT CATTGTGTTT CTCAATGGGG ACACGACTTT 
CGAAACTCGT ACAGGCATCT CGCAGAAATT AGAAACCGAT CTGATCTATG CAATATTCCA 
ATGATTGCTC TTACCGCTAC TGCCACAGTT AGAGTTCGTG ATGACGTCAT TGCTAATTTA 
AGACTCCGCA AGCCATTAAT CACAACTACG TCGTTTGATA GAAAGAATCT CTACATTTCT 
GTGCATTCTT CAAAGGACAT GGCTGAAGAT TTAGGATTAT TCATGAAAAC CGATGAAGTT 
AAAGGAAGAC ACTTTGGTGG ACCTACTATT ATTTATTGCC AAACGAAACA AATGGTCGAT 
GATGTGAACT GTGTTTTGAG AAGAATCGGA GTTCGTTCTG CTCATTATCA CGCAGGACTC 
ACTAAAAATC AACGAGAAAA AGCACACACC GATTTTATGA GAGATAAGAT TACAACAATC 
GTTGCGACAG TTGCATTTGG TATGGGAATT GACAAACCCG ACGTTCGAAA TGTGATTCAT 
TACGGATGCC CGAACAATAT CGAATCATAT TATCAAGAAA TCGGAAGAGC TGGTCGAGAT 
GGATCTCCAA GTATTTGTCG TGTATTCTGG GCTCCGAAAG ATTTGAATAC TATAAAATTT 
AAACTTCGAA ATTCGCAGCA AAAAGAAGAA GTAGTTGAAA ATCTTACAAT GATGCTAAGA 
CAACTCGAGT TGGTTCTGAC AACCGTTGGA TGTAGAAGAT ACCAACTTCT GAAGCACTTT 
GACCCATCAT ACGCGAAACC TCCAACTATG CAAGCTGATT GTTGTGATAG ATGTACTGAA 
ATGCTCAATG GAAATCAAGA TTCATCATCC AGTATTGTTG ATGTTACAAC AGAATCGAAG 
TGGTTGTTTC AAGTTATTAA CGAAATGTAC AACGGGAAAA CTGGTATCGG AAAACCAATC 
GAATTTCTGA GGGGATCGAG TAAAGAAGAC TGGCGAATCA AGACCACATC TCAACAAAAA 
TTGTTTGGAA TTGGAAAACA TATTCCTGAT AAATGGTGGA AAGCACTTGC AGCATCACTT 
CGAATTGCTG GTTATCTTGG AGAAGTTAGG CTGATGCAAA TGAAATTTGG AAGTTGTATC 
ACTTTGTCCG AACTCGGGGA ACGATGGCTT TTGACTGGAA AAGAGATGAA AATCGATGCG 
ACACCGATTT TATTGCAAGG GAAGAAAGAA AAAGCCGCAC CTTCAACTGT CCCCGGAGCT 
TCAAGATCTC AGTCAACTAA ATCAAGTACA GAGATTCCAA CCAAGATTCT CGGAGCGAAT 
AAGATTCGTG AATACGAGCC TGCAAATGAA AACGAGCAGC TGATGAACTT GAAAAAGCAA 
GAAGTCACTG GTCTTCCAGA GAAGATTGAT CAACTGCGCT CTCGTCTTGA CGACATTCGT 
GTAGGAATTG CAAACATGCA TGAAGTAGCA CCATTCCAAA TTGTATCGAA TACTGTTCTT 
GATTGTTTTG CCAACTTGAG ACCTACCTCA GCCTCGAATC TCGAAATGAT TGATGGAATG 
TCGGCTCAGC AGAAATCTAG ATACGGAAAA CGATTTGTCG ATTGTGTTGT ACAATTTTCA 
AAGGAAACTG GCATTGCAAC AAACGTCAAT GCCAACGATA TGATACCCCC TGAACTTATT 
TCAAAAATGC AGAAAGTTCT CTCGGATGCG GTGAGAAGAG TATACACAGA GCATCTTATT 
TCGAGATCCA CTGCGAAAGA AGTGGCAACT GCTCGAGGAA TTAGTGAGGG TACTGTATAT 
TCATATCTCG CGATGGCGGT AGAAAAAGGA TTACCTCTTC ACTTAGACAA GTTAAATGTC 
TCCAGAAAGA ATATTGCAAT GGCTCTAAAT GCAGTTAGAG TACATTTAGG ATCAAATGTT 
GCCGTACTGA CACCATGGGT TGAAGCTATG GGAGTCGTAC CTGATTTTAA TCAGTTGAAA 
TTGATCCGGG CAATTCTTAT TTACGAATAT GGATTGGATA CGAGTGAGAA CCAAGAGAAG 
CCAGACATCC AATCTATGCC GTCCACTTCA AATCCATCCA CCATCAAAAC AGTTCCATCA 
ACACCTTCAT CCTCTCTCAG AGCTCCTCCA TTGAAGAAAT TCAAACTTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

wrn-1 ( NM_062923.6 ) cDNA ORF clone, Caenorhabditis elegans -> NP_495324.2 Caenorhabditis elegans Probable Werner syndrome ATP-dependent helicase homolog 1 (wrn-1), partial mRNA.

Price & Availability↑

CloneID	OCa338984
Clone ID Related Accession (Same CDS sequence)	NM_062923.5 , NM_062923.6
Accession Version	NM_062923.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3171bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-17
Organism	Caenorhabditis elegans
Product	Probable Werner syndrome ATP-dependent helicase homolog 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003280). On Sep 4, 2019 this sequence version replaced NM_062923.5. COMPLETENESS: incomplete on the 5' end.

ATGATAAGTG ATGATGACGA TCTACCATCT ACTCGCCCGG GATCTGTGAA TGAGGAATTA 
CCAGAAACCG AACCCGAAGA TAATGATGAG TTGCCTGAAA CAGAACCTGA AAGCGATTCC 
GATAAACCTA CCGTAACCTC GAATAAAACA GAAAACCAAG TTGCTGATGA AGATTATGAT 
TCATTCGACG ATTTTGTGCC CAGTCAAACA CACACAGCCT CCAAAATACC TGTAAAAAAT 
AAACGAGCCA AAAAGTGCAC TGTAGAATCT GATTCATCAT CTTCGGATGA TTCCGATCAA 
GGAGATGATT GTGAATTTAT CCCAGCTTGT GATGAGACAC AGGAAGTTCC GAAAATCAAA 
AGAGGATACA CTCTGAGAAC TCGAGCAAGT GTAAAGAACA AATGTGATGA TTCATGGGAT 
GATGGAATAG ACGAAGAAGA TGTCTCAAAA AGATCAGAAG ACACGTTAAA TGATTCATTT 
GTTGATCCTG AATTCATGGA TTCTGTTCTA GATAATCAAT TAACGATCAA AGGCAAAAAG 
CAATTTCTCG ATGATGGAGA GTTTTTCACA GACCGGAATG TTCCTCAGAT TGATGAAGCT 
ACAAAAATGA AGTGGGCATC AATGACGTCA CCTCCTCAAG AAGCTTTGAA CGCATTGAAC 
GAATTCTTCG GTCATAAAGG ATTCCGAGAA AAGCAGTGGG ATGTTGTCAG AAATGTTTTG 
GGAGGAAAAG ACCAATTTGT TCTTATGTCC ACTGGTTATG GTAAAAGTGT ATGTTATCAG 
CTACCATCAC TTCTTCTCAA TTCGATGACT GTCGTGGTAT CTCCATTAAT TTCATTGATG 
AATGATCAAG TAACTACATT GGTTTCTAAA GGTATTGATG CAGTGAAACT AGATGGACAT 
TCTACACAAA TTGAATGGGA TCAAGTTGCG AATAATATGC ACCGAATTAG GTTCATCTAC 
ATGTCACCTG AAATGGTTAC GAGCCAAAAG GGTTTGGAAT TATTAACTTC TTGCCGAAAA 
CATATCTCCC TCCTCGCTAT TGATGAAGCT CATTGTGTTT CTCAATGGGG ACACGACTTT 
CGAAACTCGT ACAGGCATCT CGCAGAAATT AGAAACCGAT CTGATCTATG CAATATTCCA 
ATGATTGCTC TTACCGCTAC TGCCACAGTT AGAGTTCGTG ATGACGTCAT TGCTAATTTA 
AGACTCCGCA AGCCATTAAT CACAACTACG TCGTTTGATA GAAAGAATCT CTACATTTCT 
GTGCATTCTT CAAAGGACAT GGCTGAAGAT TTAGGATTAT TCATGAAAAC CGATGAAGTT 
AAAGGAAGAC ACTTTGGTGG ACCTACTATT ATTTATTGCC AAACGAAACA AATGGTCGAT 
GATGTGAACT GTGTTTTGAG AAGAATCGGA GTTCGTTCTG CTCATTATCA CGCAGGACTC 
ACTAAAAATC AACGAGAAAA AGCACACACC GATTTTATGA GAGATAAGAT TACAACAATC 
GTTGCGACAG TTGCATTTGG TATGGGAATT GACAAACCCG ACGTTCGAAA TGTGATTCAT 
TACGGATGCC CGAACAATAT CGAATCATAT TATCAAGAAA TCGGAAGAGC TGGTCGAGAT 
GGATCTCCAA GTATTTGTCG TGTATTCTGG GCTCCGAAAG ATTTGAATAC TATAAAATTT 
AAACTTCGAA ATTCGCAGCA AAAAGAAGAA GTAGTTGAAA ATCTTACAAT GATGCTAAGA 
CAACTCGAGT TGGTTCTGAC AACCGTTGGA TGTAGAAGAT ACCAACTTCT GAAGCACTTT 
GACCCATCAT ACGCGAAACC TCCAACTATG CAAGCTGATT GTTGTGATAG ATGTACTGAA 
ATGCTCAATG GAAATCAAGA TTCATCATCC AGTATTGTTG ATGTTACAAC AGAATCGAAG 
TGGTTGTTTC AAGTTATTAA CGAAATGTAC AACGGGAAAA CTGGTATCGG AAAACCAATC 
GAATTTCTGA GGGGATCGAG TAAAGAAGAC TGGCGAATCA AGACCACATC TCAACAAAAA 
TTGTTTGGAA TTGGAAAACA TATTCCTGAT AAATGGTGGA AAGCACTTGC AGCATCACTT 
CGAATTGCTG GTTATCTTGG AGAAGTTAGG CTGATGCAAA TGAAATTTGG AAGTTGTATC 
ACTTTGTCCG AACTCGGGGA ACGATGGCTT TTGACTGGAA AAGAGATGAA AATCGATGCG 
ACACCGATTT TATTGCAAGG GAAGAAAGAA AAAGCCGCAC CTTCAACTGT CCCCGGAGCT 
TCAAGATCTC AGTCAACTAA ATCAAGTACA GAGATTCCAA CCAAGATTCT CGGAGCGAAT 
AAGATTCGTG AATACGAGCC TGCAAATGAA AACGAGCAGC TGATGAACTT GAAAAAGCAA 
GAAGTCACTG GTCTTCCAGA GAAGATTGAT CAACTGCGCT CTCGTCTTGA CGACATTCGT 
GTAGGAATTG CAAACATGCA TGAAGTAGCA CCATTCCAAA TTGTATCGAA TACTGTTCTT 
GATTGTTTTG CCAACTTGAG ACCTACCTCA GCCTCGAATC TCGAAATGAT TGATGGAATG 
TCGGCTCAGC AGAAATCTAG ATACGGAAAA CGATTTGTCG ATTGTGTTGT ACAATTTTCA 
AAGGAAACTG GCATTGCAAC AAACGTCAAT GCCAACGATA TGATACCCCC TGAACTTATT 
TCAAAAATGC AGAAAGTTCT CTCGGATGCG GTGAGAAGAG TATACACAGA GCATCTTATT 
TCGAGATCCA CTGCGAAAGA AGTGGCAACT GCTCGAGGAA TTAGTGAGGG TACTGTATAT 
TCATATCTCG CGATGGCGGT AGAAAAAGGA TTACCTCTTC ACTTAGACAA GTTAAATGTC 
TCCAGAAAGA ATATTGCAAT GGCTCTAAAT GCAGTTAGAG TACATTTAGG ATCAAATGTT 
GCCGTACTGA CACCATGGGT TGAAGCTATG GGAGTCGTAC CTGATTTTAA TCAGTTGAAA 
TTGATCCGGG CAATTCTTAT TTACGAATAT GGATTGGATA CGAGTGAGAA CCAAGAGAAG 
CCAGACATCC AATCTATGCC GTCCACTTCA AATCCATCCA CCATCAAAAC AGTTCCATCA 
ACACCTTCAT CCTCTCTCAG AGCTCCTCCA TTGAAGAAAT TCAAACTTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_495324.2
CDS	1..3171
Translation	MISDDDDLPSTRPGSVNEELPETEPEDNDELPETEPESDSDKPTVTSNKTENQVADEDYDSFDDFVPSQTHTASKIPVKNKRAKKCTVESDSSSSDDSDQGDDCEFIPACDETQEVPKIKRGYTLRTRASVKNKCDDSWDDGIDEEDVSKRSEDTLNDSFVDPEFMDSVLDNQLTIKGKKQFLDDGEFFTDRNVPQIDEATKMKWASMTSPPQEALNALNEFFGHKGFREKQWDVVRNVLGGKDQFVLMSTGYGKSVCYQLPSLLLNSMTVVVSPLISLMNDQVTTLVSKGIDAVKLDGHSTQIEWDQVANNMHRIRFIYMSPEMVTSQKGLELLTSCRKHISLLAIDEAHCVSQWGHDFRNSYRHLAEIRNRSDLCNIPMIALTATATVRVRDDVIANLRLRKPLITTTSFDRKNLYISVHSSKDMAEDLGLFMKTDEVKGRHFGGPTIIYCQTKQMVDDVNCVLRRIGVRSAHYHAGLTKNQREKAHTDFMRDKITTIVATVAFGMGIDKPDVRNVIHYGCPNNIESYYQEIGRAGRDGSPSICRVFWAPKDLNTIKFKLRNSQQKEEVVENLTMMLRQLELVLTTVGCRRYQLLKHFDPSYAKPPTMQADCCDRCTEMLNGNQDSSSSIVDVTTESKWLFQVINEMYNGKTGIGKPIEFLRGSSKEDWRIKTTSQQKLFGIGKHIPDKWWKALAASLRIAGYLGEVRLMQMKFGSCITLSELGERWLLTGKEMKIDATPILLQGKKEKAAPSTVPGASRSQSTKSSTEIPTKILGANKIREYEPANENEQLMNLKKQEVTGLPEKIDQLRSRLDDIRVGIANMHEVAPFQIVSNTVLDCFANLRPTSASNLEMIDGMSAQQKSRYGKRFVDCVVQFSKETGIATNVNANDMIPPELISKMQKVLSDAVRRVYTEHLISRSTAKEVATARGISEGTVYSYLAMAVEKGLPLHLDKLNVSRKNIAMALNAVRVHLGSNVAVLTPWVEAMGVVPDFNQLKLIRAILIYEYGLDTSENQEKPDIQSMPSTSNPSTIKTVPSTPSSSLRAPPLKKFKL

Target ORF information:

RefSeq Version	NM_062923.6
Organism	Caenorhabditis elegans
Definition	Caenorhabditis elegans Probable Werner syndrome ATP-dependent helicase homolog 1 (wrn-1), partial mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_062923.6

ORF Insert Sequence:

ATGATAAGTG ATGATGACGA TCTACCATCT ACTCGCCCGG GATCTGTGAA TGAGGAATTA 
CCAGAAACCG AACCCGAAGA TAATGATGAG TTGCCTGAAA CAGAACCTGA AAGCGATTCC 
GATAAACCTA CCGTAACCTC GAATAAAACA GAAAACCAAG TTGCTGATGA AGATTATGAT 
TCATTCGACG ATTTTGTGCC CAGTCAAACA CACACAGCCT CCAAAATACC TGTAAAAAAT 
AAACGAGCCA AAAAGTGCAC TGTAGAATCT GATTCATCAT CTTCGGATGA TTCCGATCAA 
GGAGATGATT GTGAATTTAT CCCAGCTTGT GATGAGACAC AGGAAGTTCC GAAAATCAAA 
AGAGGATACA CTCTGAGAAC TCGAGCAAGT GTAAAGAACA AATGTGATGA TTCATGGGAT 
GATGGAATAG ACGAAGAAGA TGTCTCAAAA AGATCAGAAG ACACGTTAAA TGATTCATTT 
GTTGATCCTG AATTCATGGA TTCTGTTCTA GATAATCAAT TAACGATCAA AGGCAAAAAG 
CAATTTCTCG ATGATGGAGA GTTTTTCACA GACCGGAATG TTCCTCAGAT TGATGAAGCT 
ACAAAAATGA AGTGGGCATC AATGACGTCA CCTCCTCAAG AAGCTTTGAA CGCATTGAAC 
GAATTCTTCG GTCATAAAGG ATTCCGAGAA AAGCAGTGGG ATGTTGTCAG AAATGTTTTG 
GGAGGAAAAG ACCAATTTGT TCTTATGTCC ACTGGTTATG GTAAAAGTGT ATGTTATCAG 
CTACCATCAC TTCTTCTCAA TTCGATGACT GTCGTGGTAT CTCCATTAAT TTCATTGATG 
AATGATCAAG TAACTACATT GGTTTCTAAA GGTATTGATG CAGTGAAACT AGATGGACAT 
TCTACACAAA TTGAATGGGA TCAAGTTGCG AATAATATGC ACCGAATTAG GTTCATCTAC 
ATGTCACCTG AAATGGTTAC GAGCCAAAAG GGTTTGGAAT TATTAACTTC TTGCCGAAAA 
CATATCTCCC TCCTCGCTAT TGATGAAGCT CATTGTGTTT CTCAATGGGG ACACGACTTT 
CGAAACTCGT ACAGGCATCT CGCAGAAATT AGAAACCGAT CTGATCTATG CAATATTCCA 
ATGATTGCTC TTACCGCTAC TGCCACAGTT AGAGTTCGTG ATGACGTCAT TGCTAATTTA 
AGACTCCGCA AGCCATTAAT CACAACTACG TCGTTTGATA GAAAGAATCT CTACATTTCT 
GTGCATTCTT CAAAGGACAT GGCTGAAGAT TTAGGATTAT TCATGAAAAC CGATGAAGTT 
AAAGGAAGAC ACTTTGGTGG ACCTACTATT ATTTATTGCC AAACGAAACA AATGGTCGAT 
GATGTGAACT GTGTTTTGAG AAGAATCGGA GTTCGTTCTG CTCATTATCA CGCAGGACTC 
ACTAAAAATC AACGAGAAAA AGCACACACC GATTTTATGA GAGATAAGAT TACAACAATC 
GTTGCGACAG TTGCATTTGG TATGGGAATT GACAAACCCG ACGTTCGAAA TGTGATTCAT 
TACGGATGCC CGAACAATAT CGAATCATAT TATCAAGAAA TCGGAAGAGC TGGTCGAGAT 
GGATCTCCAA GTATTTGTCG TGTATTCTGG GCTCCGAAAG ATTTGAATAC TATAAAATTT 
AAACTTCGAA ATTCGCAGCA AAAAGAAGAA GTAGTTGAAA ATCTTACAAT GATGCTAAGA 
CAACTCGAGT TGGTTCTGAC AACCGTTGGA TGTAGAAGAT ACCAACTTCT GAAGCACTTT 
GACCCATCAT ACGCGAAACC TCCAACTATG CAAGCTGATT GTTGTGATAG ATGTACTGAA 
ATGCTCAATG GAAATCAAGA TTCATCATCC AGTATTGTTG ATGTTACAAC AGAATCGAAG 
TGGTTGTTTC AAGTTATTAA CGAAATGTAC AACGGGAAAA CTGGTATCGG AAAACCAATC 
GAATTTCTGA GGGGATCGAG TAAAGAAGAC TGGCGAATCA AGACCACATC TCAACAAAAA 
TTGTTTGGAA TTGGAAAACA TATTCCTGAT AAATGGTGGA AAGCACTTGC AGCATCACTT 
CGAATTGCTG GTTATCTTGG AGAAGTTAGG CTGATGCAAA TGAAATTTGG AAGTTGTATC 
ACTTTGTCCG AACTCGGGGA ACGATGGCTT TTGACTGGAA AAGAGATGAA AATCGATGCG 
ACACCGATTT TATTGCAAGG GAAGAAAGAA AAAGCCGCAC CTTCAACTGT CCCCGGAGCT 
TCAAGATCTC AGTCAACTAA ATCAAGTACA GAGATTCCAA CCAAGATTCT CGGAGCGAAT 
AAGATTCGTG AATACGAGCC TGCAAATGAA AACGAGCAGC TGATGAACTT GAAAAAGCAA 
GAAGTCACTG GTCTTCCAGA GAAGATTGAT CAACTGCGCT CTCGTCTTGA CGACATTCGT 
GTAGGAATTG CAAACATGCA TGAAGTAGCA CCATTCCAAA TTGTATCGAA TACTGTTCTT 
GATTGTTTTG CCAACTTGAG ACCTACCTCA GCCTCGAATC TCGAAATGAT TGATGGAATG 
TCGGCTCAGC AGAAATCTAG ATACGGAAAA CGATTTGTCG ATTGTGTTGT ACAATTTTCA 
AAGGAAACTG GCATTGCAAC AAACGTCAAT GCCAACGATA TGATACCCCC TGAACTTATT 
TCAAAAATGC AGAAAGTTCT CTCGGATGCG GTGAGAAGAG TATACACAGA GCATCTTATT 
TCGAGATCCA CTGCGAAAGA AGTGGCAACT GCTCGAGGAA TTAGTGAGGG TACTGTATAT 
TCATATCTCG CGATGGCGGT AGAAAAAGGA TTACCTCTTC ACTTAGACAA GTTAAATGTC 
TCCAGAAAGA ATATTGCAAT GGCTCTAAAT GCAGTTAGAG TACATTTAGG ATCAAATGTT 
GCCGTACTGA CACCATGGGT TGAAGCTATG GGAGTCGTAC CTGATTTTAA TCAGTTGAAA 
TTGATCCGGG CAATTCTTAT TTACGAATAT GGATTGGATA CGAGTGAGAA CCAAGAGAAG 
CCAGACATCC AATCTATGCC GTCCACTTCA AATCCATCCA CCATCAAAAC AGTTCCATCA 
ACACCTTCAT CCTCTCTCAG AGCTCCTCCA TTGAAGAAAT TCAAACTTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)

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wrn-1 cDNA ORF clone, Caenorhabditis elegans

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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