Gene Symbol | MGE1 |
Entrez Gene ID | 854407 |
Full Name | Mge1p |
Synonyms | YGE1 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » MGE1 cDNA ORF clone
Gene Symbol | MGE1 |
Entrez Gene ID | 854407 |
Full Name | Mge1p |
Synonyms | YGE1 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001183651.3 | NP_014875.3 | Mge1p |
Homo sapiens (human) | GRPEL1 | NP_079472.1 |
Pan troglodytes (chimpanzee) | GRPEL1 | XP_526517.2 |
Saccharomyces cerevisiae (baker's yeast) | MGE1 | NP_014875.3 |
Kluyveromyces lactis | KLLA0D07326g | XP_453388.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_03214 | XP_003716765.1 |
Oryza sativa (rice) | Os08g0338700 | NP_001061586.1 |
Oryza sativa (rice) | Os09g0284400 | NP_001062776.1 |
Rattus norvegicus (Norway rat) | Grpel1 | NP_077813.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP011150 | XP_309497.4 |
Neurospora crassa | NCU01516 | XP_956965.1 |
Danio rerio (zebrafish) | grpel1 | NP_001032461.1 |
Schizosaccharomyces pombe (fission yeast) | mge1 | NP_596677.1 |
Mus musculus (house mouse) | Grpel1 | NP_077798.1 |
Gallus gallus (chicken) | GRPEL1 | NP_001006458.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP012770 | XP_307508.3 |
GRPEL1 | XP_001091412.1 | |
Canis lupus familiaris (dog) | GRPEL1 | XP_545902.4 |
Bos taurus (cattle) | GRPEL1 | NP_001029673.1 |
Drosophila melanogaster (fruit fly) | Roe1 | NP_610886.2 |
Caenorhabditis elegans (roundworm) | C34C12.8 | NP_497713.1 |
Xenopus tropicalis (tropical clawed frog) | grpel1 | NP_001016179.1 |
The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.
Dujon B, Albermann K, Aldea M, Alexandraki D, Ansorge W, Arino J, Benes V, Bohn C, Bolotin-Fukuhara M, Bordonn? R, Boyer J, Camasses A, Casamayor A, Casas C, Ch?ret G, Cziepluch C, Daignan-Fornier B, Dang DV, de Haan M, Delius H, Durand P, Fairhead C, Feldmann H, Gaillon L, Kleine K
Nature387(6632 Suppl)98-102(1997 May)
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Data show that the Mge1 H167L mutant has increased thermal stability compared to that of wild-type Mge1 and also augments Hsp70-mediated protein refolding activity.
Title: A Single Point Mutation in Mitochondrial Hsp70 Cochaperone Mge1 Gains Thermal Stability and Resistance.
Mge1 is regulated by Mxr2. Mxr2 selectively reduces methionine sulfoxide at position 155 of Mge1 and restores the activity of Mge1 both in vitro and in vivo.
Title: Methionine sulfoxide reductase 2 reversibly regulates Mge1, a cochaperone of mitochondrial Hsp70, during oxidative stress.
The nucleotide-exchange factor Mge1 did not induce ADP release, as expected, but rather facilitated binding of ATP.
Title: Real-time observation of the conformational dynamics of mitochondrial Hsp70 by spFRET.
results show an oxidative stress-dependent decrease in Mge1 dimer formation accompanied by a concomitant decrease in Mge1-Hsp70 complex formation; study suggests Mge1 acts as a novel oxidative sensor of mitochondria to regulate mitochondrial protein import and folding
Title: Mge1, a nucleotide exchange factor of Hsp70, acts as an oxidative sensor to regulate mitochondrial Hsp70 function.
Mge1p can act as a thermosensor for the mitochondrial Hsp70 system, regulating the nucleotide exchange rates under heat shock
Title: Thermal adaptation of the yeast mitochondrial Hsp70 system is regulated by the reversible unfolding of its nucleotide exchange factor.
The following MGE1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MGE1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi03528 | |
Clone ID Related Accession (Same CDS sequence) | NM_001183651.3 | |
Accession Version | NM_001183651.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 687bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | Mge1p | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001147). On Jul 30, 2012 this sequence version replaced NM_001183651.2. ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGAGAGCTT TTTCAGCAGC CACCGTTAGG GCCACAACTA GGAAGTCGTT CATCCCAATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_014875.3 |
CDS | 1..687 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001183651.3 |
1 | ATGAGAGCTT TTTCAGCAGC CACCGTTAGG GCCACAACTA GGAAGTCGTT CATCCCAATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XV. |
Life with 6000 genes. |