Maged1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Maged1
Entrez Gene ID	84469
Full Name	MAGE family member D1
Synonyms	Nrage
General protein information	Preferred Names MAGE family member D1 Names melanoma-associated antigen D1 MAGE-D1 antigen SNERG-1 melanoma antigen, family D, 1 neurotrophin receptor-interacting MAGE homolog sertoli cell necdin-related gene protein 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: X Map Location: Xq22
Summary	interacts with the p75 neurotrophin receptor; involved in mediating nerve growth factor-dependent apoptosis via a JNK-dependent pathway [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053409.2	NP_445861.1	melanoma-associated antigen D1

Pathways from BioSystems

Homologies

	LOC696658	XP_002808576.1
Mus musculus (house mouse)	Maged1	NP_062765.1
Rattus norvegicus (Norway rat)	Maged1	NP_445861.1
Canis lupus familiaris (dog)	MAGED1	XP_005641419.1
Bos taurus (cattle)	MAGED1	NP_001039590.2
Homo sapiens (human)	MAGED1	NP_001005333.1
Pan troglodytes (chimpanzee)	MAGED1	XP_003317513.1

Gene Ontology
Bibliography

Related articles in PubMed

The ubiquitin ligase Praja1 reduces NRAGE expression and inhibits neuronal differentiation of PC12 cells.
Teuber J, Mueller B, Fukabori R, Lang D, Albrecht A, Stork O
PloS one8(5)e63067(2013)

Dlxin-1, a MAGE family protein, induces accelerated neurite outgrowth and cell survival by enhanced and early activation of MEK and Akt signalling pathways in PC12 cells.
Reddy EM, Chettiar ST, Kaur N, Shepal V, Shiras A
Experimental cell research316(14)2220-36(2010 Aug)

Interaction of MAGED1 with nuclear receptors affects circadian clock function.
Wang X, Tang J, Xing L, Shi G, Ruan H, Gu X, Liu Z, Wu X, Gao X, Xu Y
The EMBO journal29(8)1389-400(2010 Apr)

NRAGE: a potential rheostat during branching morphogenesis.
Nikopoulos GN, Martins JF, Adams TL, Karaczyn A, Adams D, Vary C, Oxburgh L, Verdi JM
Mechanisms of development126(5-6)337-49(2009 May-Jun)

UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE.
Williams ME, Strickland P, Watanabe K, Hinck L
The Journal of biological chemistry278(19)17483-90(2003 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Praja1, through ubiquitination and degradation of NRAGE, inhibits neuronal differentiation.
Title: The ubiquitin ligase Praja1 reduces NRAGE expression and inhibits neuronal differentiation of PC12 cells.

effects on neuritogenesis are promoted through interactions of Dlxin-1 with the neurotrophin receptor TrkA
Title: Dlxin-1, a MAGE family protein, induces accelerated neurite outgrowth and cell survival by enhanced and early activation of MEK and Akt signalling pathways in PC12 cells.

The results are consistent with an important role for NRAGE in p75(NTR) signaling, as all cells that expressed p75(NTR) also expressed NRAGE. The wider distribution of NRAGE expression suggests that NRAGE may also participate in other signaling processes.
Title: Co-expression of the P75 neurotrophin receptor and neurotrophin receptor-interacting melanoma antigen homolog in the mature rat brain.

identification of NRAGE as a p75NTR interactor capable of inducing caspase activation and cell death through a JNK-dependent mitochondrial apoptotic pathway
Title: NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway.

The following Maged1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Maged1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12895	NM_053409.2 Latest version!	Rattus norvegicus MAGE family member D1 (Maged1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Maged1 ( NM_053409.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_445861.1 Rattus norvegicus MAGE family member D1 (Maged1), mRNA.

Price & Availability↑

CloneID	ORa12895
Clone ID Related Accession (Same CDS sequence)	NM_053409.2
Accession Version	NM_053409.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2328bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	melanoma-associated antigen D1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC081756.1. On Jun 10, 2007 this sequence version replaced NM_053409.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC081756.1, AF217964.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCTCAGA AACCGGACGG CGGTGCAGGC CTCCGCGGCT TCCAGGCAGA GGCCTCTGTA 
GAAGACAGCG CCTTGCTTGT GCAGACCTTG ATGGAAGCCA TCCAGATCTC CGAGGCTCCG 
CCCACCAGCC AGGCCACAGC AGCTGCCAGT GGGCCGAATG CTAGTCCCCA GAGTTCACAG 
CCCCCAACTG CCAATGAGAA GGCTGATACT GAGGTTTCAG CAGCTGCTGC CAGGCCTAAG 
ACAGGCTTTA AGGCCCAGAA TACCACCACA AAGGGGCCAA ATGATTACTC TCAGGCACGT 
AATGCCAAGG AGATGCCCAA GAATCAGCCT AAGGTGGCCT TTAAGTCACA GAATGCCACC 
TCTAAAGGTC CACATGCTGC CTCTGATTTT TCCCATGCAG CATCCACAGG CAAATCAGCA 
GCTAAAAAGT CTGAAATGGC CTTTAAGGGT CAGAATACCA CTACTAAGGC TGGCCCCAGT 
GCCACCTACA ATTTCACTCA GTCTCCCAGT GCCAATGAGA TGACCAACAA CCAGCCTAAG 
ACAGCTAAGG CTTGGAATGA CACCACTAAG ATCCCTGGAG CTGATGCCCA GACCCAGAAT 
GTAAACCAGG CCAAAATGGC TGACGTAGGG ACCAGTGCAG GTATCTCTGA AACTGACGGT 
GCAGCAGCCC AGACCTCAGC AGATGGCTCC CAGGCTCAGA ATGTGGAGTC CCGGACTATA 
ATTCGGGGCA AGAGGACCCG CAAGATTAAT AACTTGAATG TGGAAGAGAA CAGCAATGGG 
GACCAAAGGC GTGCCTCGCT GGCTTCCGGG AACTGGAGGT CTGCTCCGGT TCCAGTAACC 
ACTCAGAACC CACCTGGCGC ACCCCCTAAT GTGCTGTGGC AGACACCACT GGCTTGGCAG 
AACCCATCAG GCTGGCAAAA CCAGACAGCC AGGCAGACCC CACCAGCACG TCAGAGTCCC 
CCAGCTAGGC AGACACCATC AGCTTGGCAG AACCCCGTTG CATGGCAGAA TCCAGTGATC 
TGGCCTAACC CAGTGATCTG GCAGAATCCA GTGATCTGGC CAAACCCCAT TGTCTGGCCT 
GGCCCAATTG TCTGGCCAAA CCCAATGGCC TGGCAGAGTA CACCTGGATG GCAGAGCCCA 
CCCAGTTGGC AGGCTCCACC TAGTTGGCAG AGCCCTCAAG ATTGGCAAGG CCCTCCAGAT 
TGGCAGTTAC CACCTGACTG GTCAATGCCT CCTGACTGGT CCTTTCCCTC TGACTGGCCT 
TTTCCACCTG ACTGGATCCC TGCCGACTGG CCAATTCCAC CCGACTGGCA GAACTTACGA 
CCCTCACCTA ATCTGAGATC CTCCCCCAAC TCTCGTGCCT CACAGAACCA GGGTCCTCCA 
CAGCCCCGAG ATGTGGCCCT TCTTCAGGAA AGAGCAAATA AGCTGGTCAA GTACTTGATG 
CTTAAAGACT ACACGAAGGT GCCCATCAAG CGCTCAGAAA TGCTGAGAGA TATCATCCGA 
GAATACACTG ATGTTTATCC AGAAATCATT GAACGCGCAT GCTTTGTCCT GGAGAAGAAA 
TTTGGAATCC AGCTCAAGGA AATCGACAAA GAAGAGCATC TGTATATCCT CATCAGTACC 
CCTGAATCCC TGGCTGGCAT ACTGGGAACG ACCAAAGACA CACCGAAGCT AGGCCTCCTC 
TTAGTGATTC TGGGCATTAT CTTCATGAAT GGCAACCGTG CCACTGAGGC CGTCCTCTGG 
GAAGCACTGC GCAAGATGGG ACTACGTCCT GGGGTCAGAC ATCCCCTCCT TGGCGATCTG 
AGGAAACTTC TTACTTACGA GTTTGTAAAG CAGAAATACC TGGACTACAG ACGAGTGCCC 
AACAGCAACC CTCCTGAGTA TGAGTTCCTC TGGGGCCTCC GCTCCTACCA TGAGACTAGC 
AAGATGAAAG TGCTGAGATT CATTGCAGAG GTTCAGAAGA GAGACCCTCG TGACTGGACT 
GCACAGTTCA TGGAAGCTGC AGATGAAGCC TTGGATGCTC TGGATGCTGC TGCAGCTGAG 
GCAGAGGCCC GGGCCGAAGC AAGAAACCGC ATGGGGATTG GAGACGAGGC TGTGTCTGGG 
CCCTGGAGCT GGGATGACAT TGAGTTTGAG CTGCTGACCT GGGATGAGGA AGGAGATTTT 
GGAGATCCTT GGTCCAGGAT CCCCTTTACC TTCTGGGCCA GATACCACCA GAATGCCCGC 
TCCAGGTTTC CCCAGGCCTT TACCGGCCCC ATCATTGGCC CCAGCGGCAC TGCCACCGCC 
AACTTCGCCG CCAACTTCGG TGCCATTGGC TTCTTCTGGG TTGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_445861.1
CDS	131..2458
Translation	MAQKPDGGAGLRGFQAEASVEDSALLVQTLMEAIQISEAPPTSQATAAASGPNASPQSSQPPTANEKADTEVSAAAARPKTGFKAQNTTTKGPNDYSQARNAKEMPKNQPKVAFKSQNATSKGPHAASDFSHAASTGKSAAKKSEMAFKGQNTTTKAGPSATYNFTQSPSANEMTNNQPKTAKAWNDTTKIPGADAQTQNVNQAKMADVGTSAGISETDGAAAQTSADGSQAQNVESRTIIRGKRTRKINNLNVEENSNGDQRRASLASGNWRSAPVPVTTQNPPGAPPNVLWQTPLAWQNPSGWQNQTARQTPPARQSPPARQTPSAWQNPVAWQNPVIWPNPVIWQNPVIWPNPIVWPGPIVWPNPMAWQSTPGWQSPPSWQAPPSWQSPQDWQGPPDWQLPPDWSMPPDWSFPSDWPFPPDWIPADWPIPPDWQNLRPSPNLRSSPNSRASQNQGPPQPRDVALLQERANKLVKYLMLKDYTKVPIKRSEMLRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYILISTPESLAGILGTTKDTPKLGLLLVILGIIFMNGNRATEAVLWEALRKMGLRPGVRHPLLGDLRKLLTYEFVKQKYLDYRRVPNSNPPEYEFLWGLRSYHETSKMKVLRFIAEVQKRDPRDWTAQFMEAADEALDALDAAAAEAEARAEARNRMGIGDEAVSGPWSWDDIEFELLTWDEEGDFGDPWSRIPFTFWARYHQNARSRFPQAFTGPIIGPSGTATANFAANFGAIGFFWVE

Target ORF information:

RefSeq Version	NM_053409.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus MAGE family member D1 (Maged1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053409.2

ORF Insert Sequence:

ATGGCTCAGA AACCGGACGG CGGTGCAGGC CTCCGCGGCT TCCAGGCAGA GGCCTCTGTA 
GAAGACAGCG CCTTGCTTGT GCAGACCTTG ATGGAAGCCA TCCAGATCTC CGAGGCTCCG 
CCCACCAGCC AGGCCACAGC AGCTGCCAGT GGGCCGAATG CTAGTCCCCA GAGTTCACAG 
CCCCCAACTG CCAATGAGAA GGCTGATACT GAGGTTTCAG CAGCTGCTGC CAGGCCTAAG 
ACAGGCTTTA AGGCCCAGAA TACCACCACA AAGGGGCCAA ATGATTACTC TCAGGCACGT 
AATGCCAAGG AGATGCCCAA GAATCAGCCT AAGGTGGCCT TTAAGTCACA GAATGCCACC 
TCTAAAGGTC CACATGCTGC CTCTGATTTT TCCCATGCAG CATCCACAGG CAAATCAGCA 
GCTAAAAAGT CTGAAATGGC CTTTAAGGGT CAGAATACCA CTACTAAGGC TGGCCCCAGT 
GCCACCTACA ATTTCACTCA GTCTCCCAGT GCCAATGAGA TGACCAACAA CCAGCCTAAG 
ACAGCTAAGG CTTGGAATGA CACCACTAAG ATCCCTGGAG CTGATGCCCA GACCCAGAAT 
GTAAACCAGG CCAAAATGGC TGACGTAGGG ACCAGTGCAG GTATCTCTGA AACTGACGGT 
GCAGCAGCCC AGACCTCAGC AGATGGCTCC CAGGCTCAGA ATGTGGAGTC CCGGACTATA 
ATTCGGGGCA AGAGGACCCG CAAGATTAAT AACTTGAATG TGGAAGAGAA CAGCAATGGG 
GACCAAAGGC GTGCCTCGCT GGCTTCCGGG AACTGGAGGT CTGCTCCGGT TCCAGTAACC 
ACTCAGAACC CACCTGGCGC ACCCCCTAAT GTGCTGTGGC AGACACCACT GGCTTGGCAG 
AACCCATCAG GCTGGCAAAA CCAGACAGCC AGGCAGACCC CACCAGCACG TCAGAGTCCC 
CCAGCTAGGC AGACACCATC AGCTTGGCAG AACCCCGTTG CATGGCAGAA TCCAGTGATC 
TGGCCTAACC CAGTGATCTG GCAGAATCCA GTGATCTGGC CAAACCCCAT TGTCTGGCCT 
GGCCCAATTG TCTGGCCAAA CCCAATGGCC TGGCAGAGTA CACCTGGATG GCAGAGCCCA 
CCCAGTTGGC AGGCTCCACC TAGTTGGCAG AGCCCTCAAG ATTGGCAAGG CCCTCCAGAT 
TGGCAGTTAC CACCTGACTG GTCAATGCCT CCTGACTGGT CCTTTCCCTC TGACTGGCCT 
TTTCCACCTG ACTGGATCCC TGCCGACTGG CCAATTCCAC CCGACTGGCA GAACTTACGA 
CCCTCACCTA ATCTGAGATC CTCCCCCAAC TCTCGTGCCT CACAGAACCA GGGTCCTCCA 
CAGCCCCGAG ATGTGGCCCT TCTTCAGGAA AGAGCAAATA AGCTGGTCAA GTACTTGATG 
CTTAAAGACT ACACGAAGGT GCCCATCAAG CGCTCAGAAA TGCTGAGAGA TATCATCCGA 
GAATACACTG ATGTTTATCC AGAAATCATT GAACGCGCAT GCTTTGTCCT GGAGAAGAAA 
TTTGGAATCC AGCTCAAGGA AATCGACAAA GAAGAGCATC TGTATATCCT CATCAGTACC 
CCTGAATCCC TGGCTGGCAT ACTGGGAACG ACCAAAGACA CACCGAAGCT AGGCCTCCTC 
TTAGTGATTC TGGGCATTAT CTTCATGAAT GGCAACCGTG CCACTGAGGC CGTCCTCTGG 
GAAGCACTGC GCAAGATGGG ACTACGTCCT GGGGTCAGAC ATCCCCTCCT TGGCGATCTG 
AGGAAACTTC TTACTTACGA GTTTGTAAAG CAGAAATACC TGGACTACAG ACGAGTGCCC 
AACAGCAACC CTCCTGAGTA TGAGTTCCTC TGGGGCCTCC GCTCCTACCA TGAGACTAGC 
AAGATGAAAG TGCTGAGATT CATTGCAGAG GTTCAGAAGA GAGACCCTCG TGACTGGACT 
GCACAGTTCA TGGAAGCTGC AGATGAAGCC TTGGATGCTC TGGATGCTGC TGCAGCTGAG 
GCAGAGGCCC GGGCCGAAGC AAGAAACCGC ATGGGGATTG GAGACGAGGC TGTGTCTGGG 
CCCTGGAGCT GGGATGACAT TGAGTTTGAG CTGCTGACCT GGGATGAGGA AGGAGATTTT 
GGAGATCCTT GGTCCAGGAT CCCCTTTACC TTCTGGGCCA GATACCACCA GAATGCCCGC 
TCCAGGTTTC CCCAGGCCTT TACCGGCCCC ATCATTGGCC CCAGCGGCAC TGCCACCGCC 
AACTTCGCCG CCAACTTCGG TGCCATTGGC TTCTTCTGGG TTGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The ubiquitin ligase Praja1 reduces NRAGE expression and inhibits neuronal differentiation of PC12 cells.
PloS one8(5)e63067(2013)
Teuber J,Mueller B,Fukabori R,Lang D,Albrecht A,Stork O

Dlxin-1, a MAGE family protein, induces accelerated neurite outgrowth and cell survival by enhanced and early activation of MEK and Akt signalling pathways in PC12 cells.
Experimental cell research316(14)2220-36(2010 Aug)
Reddy EM,Chettiar ST,Kaur N,Shepal V,Shiras A

Interaction of MAGED1 with nuclear receptors affects circadian clock function.
The EMBO journal29(8)1389-400(2010 Apr)
Wang X,Tang J,Xing L,Shi G,Ruan H,Gu X,Liu Z,Wu X,Gao X,Xu Y

NRAGE: a potential rheostat during branching morphogenesis.
Mechanisms of development126(5-6)337-49(2009 May-Jun)
Nikopoulos GN,Martins JF,Adams TL,Karaczyn A,Adams D,Vary C,Oxburgh L,Verdi JM

UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE.
The Journal of biological chemistry278(19)17483-90(2003 May)
Williams ME,Strickland P,Watanabe K,Hinck L

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Maged1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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