Hnmt cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hnmt
Entrez Gene ID	81676
Full Name	histamine N-methyltransferase
General protein information	Preferred Names histamine N-methyltransferase Names histamine N-methyltransferase HMT
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3p13
Summary	catalyzes the conversion of S-adenosyl-L-methionine and histamine to S-adenosyl-L-homocysteine and N(T) methylhistamine [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031044.3	NP_112306.1	histamine N-methyltransferase

Pathways from BioSystems

Homologies

Homo sapiens (human)	HNMT	NP_008826.1
Pan troglodytes (chimpanzee)	HNMT	XP_001156140.1
Canis lupus familiaris (dog)	HNMT	XP_533340.1
Rattus norvegicus (Norway rat)	Hnmt	NP_112306.1
Gallus gallus (chicken)	HNMT	NP_001264802.1
	HNMT	XP_001094746.1
Bos taurus (cattle)	HNMT	NP_001030511.1
Xenopus tropicalis (tropical clawed frog)	hnmt	NP_001072355.1
Mus musculus (house mouse)	Hnmt	NP_536710.1
Danio rerio (zebrafish)	hnmt	NP_001003636.1

Gene Ontology
Bibliography

Related articles in PubMed

Mutations in the histamine N-methyltransferase gene, HNMT, are associated with nonsyndromic autosomal recessive intellectual disability.
Heidari A, Tongsook C, Najafipour R, Musante L, Vasli N, Garshasbi M, Hu H, Mittal K, McNaughton AJ, Sritharan K, Hudson M, Stehr H, Talebi S, Moradi M, Darvish H, Arshad Rafiq M, Mozhdehipanah H, Rashidinejad A, Samiei S, Ghadami M, Windpassinger C, Gillessen-Kaesbach G, Tzschach A, Ahmed I, Mikhailov A, Stavropoulos DJ, Carter MT, Keshavarz S, Ayub M, Najmabadi H, Liu X, Ropers HH, Macheroux P, Vincent JB
Human molecular genetics24(20)5697-710(2015 Oct)

High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy.
Hasson SA, Kane LA, Yamano K, Huang CH, Sliter DA, Buehler E, Wang C, Heman-Ackah SM, Hessa T, Guha R, Martin SE, Youle RJ
Nature504(7479)291-5(2013 Dec)

Functional increase of brain histaminergic signaling in Huntington's disease.
van Wamelen DJ, Shan L, Aziz NA, Anink JJ, Bao AM, Roos RA, Swaab DF
Brain pathology (Zurich, Switzerland)21(4)419-27(2011 Jul)

No association between histamine N-methyltransferase functional polymorphism Thr105Ile and Alzheimer's disease.
Marasovi?-?u?njara I, Palada V, Marinovi?-Terzi? I, Mimica N, Marin J, Muck-Seler D, Mustapi? M, Prese?ki P, Pivac N, Folnegovi?-?malc V, Marinovi?-?urin J, Terzi? J
Neuroscience letters489(2)119-21(2011 Feb)

Reduction of the infarct size by simultaneous administration of L-histidine and diphenhydramine in ischaemic rat brains.
Adachi N, Liu K, Ninomiya K, Matsuoka E, Motoki A, Irisawa Y, Nishibori M
Resuscitation82(2)219-21(2011 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Genomic structure of the rat and mouse histamine N-methyltransferase gene
Title: Genomic structure of the rat and mouse histamine N-methyltransferase gene.

The following Hnmt gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hnmt cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07451	NM_031044.3 Latest version!	Rattus norvegicus histamine N-methyltransferase (Hnmt), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hnmt ( NM_031044.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_112306.1 Rattus norvegicus histamine N-methyltransferase (Hnmt), mRNA.

Price & Availability↑

CloneID	ORa07451
Clone ID Related Accession (Same CDS sequence)	NM_031044.3
Accession Version	NM_031044.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 888bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Rattus norvegicus(Norway rat)
Product	histamine N-methyltransferase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D10693.1. On Jun 10, 2007 this sequence version replaced NM_031044.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D10693.1, BC087635.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN02642775 [ECO:0000348] ##Evidence-Data-END##

ATGGCATCTT TCATGAGGAG CTTATTTTCT GACCACAGCA GATATGTTGA ATCTTTTCGG 
AGATTTCTAA ATAATTCAAC GGAACACCAG TGCATGCAGG AATTCATGGA TAAGAAGCTT 
CCAGGCATAA TAGCAAGGAT TGGAGAAACA AAAGCAGAAA TTAAGATTCT GAGTATAGGC 
GGAGGTGCAG GTGAAATTGA CCTTCAGATT CTCTCCAAAG TCCAGGCTCA GTACCCAGGA 
ATCTGTATTA ACAATGAAGT TGTAGAGCCA AATGCCGAAC AAATTGTCAA GTACAAAGAG 
CTTGTAGCAA AGACATCAAA CATGGAGAAC ATAAAATTTG CTTGGCATAA GGAGACATCA 
TCTGAATATC AAAAACGTGT AGTGGAAGAA GACGAAGAAC CTCCAAAGTG GGACTTTATT 
CATATGATTC AGATGCTATA TTATGTAAAG GATATCCCAG CCACCCTGAA ATTCTTCCAC 
GGTCTCTTAG CTGCCAATGC TAAAATTCTC ATTATTCTTG TGTCAGGAAC TAGTGGCTGG 
GAAAAGCTAT GGAAAAAATA TGGATTCCGC CTACCCAGGG ATGACCTCTG CCAGTATGTC 
ACATCTTCTG ATCTTGCTCA GATACTGGAC GACCTGGGTA TTAAGTATGA ATGTTACGAC 
CTTTTGTCCA CTATGGACAT AACAGACTGT TTTATTGATG GTAATGAAAA TGGAGACCTG 
CTTTGGGATT TTTTGACAGA AACCTGCAAC TTTATCAAAA CAGCACCACT GGACCTCAAA 
GAGGAAATTA TGAAAGATCT TCAAGAGCCT GAATTTAGTG TTAAGAAAGA GGGGAAGGTA 
CTTTTCAACA ACAATCTGAG TTTTATAGTG GTTGAGGCAA ATGTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112306.1
CDS	9..896
Translation	MASFMRSLFSDHSRYVESFRRFLNNSTEHQCMQEFMDKKLPGIIARIGETKAEIKILSIGGGAGEIDLQILSKVQAQYPGICINNEVVEPNAEQIVKYKELVAKTSNMENIKFAWHKETSSEYQKRVVEEDEEPPKWDFIHMIQMLYYVKDIPATLKFFHGLLAANAKILIILVSGTSGWEKLWKKYGFRLPRDDLCQYVTSSDLAQILDDLGIKYECYDLLSTMDITDCFIDGNENGDLLWDFLTETCNFIKTAPLDLKEEIMKDLQEPEFSVKKEGKVLFNNNLSFIVVEANV

Target ORF information:

RefSeq Version	NM_031044.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus histamine N-methyltransferase (Hnmt), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031044.3

ORF Insert Sequence:

ATGGCATCTT TCATGAGGAG CTTATTTTCT GACCACAGCA GATATGTTGA ATCTTTTCGG 
AGATTTCTAA ATAATTCAAC GGAACACCAG TGCATGCAGG AATTCATGGA TAAGAAGCTT 
CCAGGCATAA TAGCAAGGAT TGGAGAAACA AAAGCAGAAA TTAAGATTCT GAGTATAGGC 
GGAGGTGCAG GTGAAATTGA CCTTCAGATT CTCTCCAAAG TCCAGGCTCA GTACCCAGGA 
ATCTGTATTA ACAATGAAGT TGTAGAGCCA AATGCCGAAC AAATTGTCAA GTACAAAGAG 
CTTGTAGCAA AGACATCAAA CATGGAGAAC ATAAAATTTG CTTGGCATAA GGAGACATCA 
TCTGAATATC AAAAACGTGT AGTGGAAGAA GACGAAGAAC CTCCAAAGTG GGACTTTATT 
CATATGATTC AGATGCTATA TTATGTAAAG GATATCCCAG CCACCCTGAA ATTCTTCCAC 
GGTCTCTTAG CTGCCAATGC TAAAATTCTC ATTATTCTTG TGTCAGGAAC TAGTGGCTGG 
GAAAAGCTAT GGAAAAAATA TGGATTCCGC CTACCCAGGG ATGACCTCTG CCAGTATGTC 
ACATCTTCTG ATCTTGCTCA GATACTGGAC GACCTGGGTA TTAAGTATGA ATGTTACGAC 
CTTTTGTCCA CTATGGACAT AACAGACTGT TTTATTGATG GTAATGAAAA TGGAGACCTG 
CTTTGGGATT TTTTGACAGA AACCTGCAAC TTTATCAAAA CAGCACCACT GGACCTCAAA 
GAGGAAATTA TGAAAGATCT TCAAGAGCCT GAATTTAGTG TTAAGAAAGA GGGGAAGGTA 
CTTTTCAACA ACAATCTGAG TTTTATAGTG GTTGAGGCAA ATGTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mutations in the histamine N-methyltransferase gene, HNMT, are associated with nonsyndromic autosomal recessive intellectual disability.
Human molecular genetics24(20)5697-710(2015 Oct)
Heidari A,Tongsook C,Najafipour R,Musante L,Vasli N,Garshasbi M,Hu H,Mittal K,McNaughton AJ,Sritharan K,Hudson M,Stehr H,Talebi S,Moradi M,Darvish H,Arshad Rafiq M,Mozhdehipanah H,Rashidinejad A,Samiei S,Ghadami M,Windpassinger C,Gillessen-Kaesbach G,Tzschach A,Ahmed I,Mikhailov A,Stavropoulos DJ,Carter MT,Keshavarz S,Ayub M,Najmabadi H,Liu X,Ropers HH,Macheroux P,Vincent JB

High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy.
Nature504(7479)291-5(2013 Dec)
Hasson SA,Kane LA,Yamano K,Huang CH,Sliter DA,Buehler E,Wang C,Heman-Ackah SM,Hessa T,Guha R,Martin SE,Youle RJ

Functional increase of brain histaminergic signaling in Huntington's disease.
Brain pathology (Zurich, Switzerland)21(4)419-27(2011 Jul)
van Wamelen DJ,Shan L,Aziz NA,Anink JJ,Bao AM,Roos RA,Swaab DF

No association between histamine N-methyltransferase functional polymorphism Thr105Ile and Alzheimer's disease.
Neuroscience letters489(2)119-21(2011 Feb)
Marasovi?-?u?njara I,Palada V,Marinovi?-Terzi? I,Mimica N,Marin J,Muck-Seler D,Mustapi? M,Prese?ki P,Pivac N,Folnegovi?-?malc V,Marinovi?-?urin J,Terzi? J

Reduction of the infarct size by simultaneous administration of L-histidine and diphenhydramine in ischaemic rat brains.
Resuscitation82(2)219-21(2011 Feb)
Adachi N,Liu K,Ninomiya K,Matsuoka E,Motoki A,Irisawa Y,Nishibori M

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Hnmt cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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