Lrrn3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lrrn3
Entrez Gene ID	81514
Full Name	leucine rich repeat neuronal 3
Synonyms	Nlrr3
General protein information	Preferred Names leucine rich repeat neuronal 3 Names leucine-rich repeat neuronal protein 3 NLRR-3 leucine rich repeat protein 3, neuronal neuronal leucine-rich repeat protein 3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q21
Summary	acts to facilitate increased EGF induced phosphorylation of MAPK; may play a role in internalization of EGF via clathrin-coated vesicles [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_030856.1	NP_110483.1	leucine-rich repeat neuronal protein 3 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LRRN3	XP_527861.1
	LOC701932	XP_002808410.1
Canis lupus familiaris (dog)	LRRN3	XP_005628792.1
Mus musculus (house mouse)	Lrrn3	NP_001258637.1
Gallus gallus (chicken)	LRRN3	XP_001232594.1
Homo sapiens (human)	LRRN3	NP_001093128.1
Rattus norvegicus (Norway rat)	Lrrn3	NP_110483.1
Xenopus tropicalis (tropical clawed frog)	lrrn3	NP_001072526.1
Bos taurus (cattle)	LRRN3	XP_002686856.1
Danio rerio (zebrafish)	LOC100535105	XP_003201600.1

Gene Ontology
Bibliography

Related articles in PubMed

Novel candidate genes for impaired nephron development in a rat model with inherited nephron deficit and albuminuria.
Herlan L, Schulz A, Schulte L, Schulz H, H?bner N, Kreutz R
Clinical and experimental pharmacology & physiology42(10)1051-8(2015 Oct)

Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins.
Um JW, Pramanik G, Ko JS, Song MY, Lee D, Kim H, Park KS, S?dhof TC, Tabuchi K, Ko J
Cell reports6(6)1096-1109(2014 Mar)

[Role of LRRN3 in the cerebellum postnatal development in rats].
Yang J, Li F, Qiu L, Luo X, Huang H
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences36(5)424-9(2011 May)

Mapping the microtubule binding regions of calponin.
Fattoum A, Roustan C, Smyczynski C, Der Terrossian E, Kassab R
Biochemistry42(5)1274-82(2003 Feb)

Neuronal leucine-rich repeat protein-3 amplifies MAPK activation by epidermal growth factor through a carboxyl-terminal region containing endocytosis motifs.
Fukamachi K, Matsuoka Y, Ohno H, Hamaguchi T, Tsuda H
The Journal of biological chemistry277(46)43549-52(2002 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

LRRN3 plays an important role in postnatal cerebellum development.
Title: [Role of LRRN3 in the cerebellum postnatal development in rats].

NLRR-3 potentiates Ras-MAPK signaling by facilitating internalization of EGF in clathrin-coated vesicles
Title: Neuronal leucine-rich repeat protein-3 amplifies MAPK activation by epidermal growth factor through a carboxyl-terminal region containing endocytosis motifs.

rNLRR-3 gene expression is regulated mainly through the Ras-MAPK signaling pathway in fibroblasts
Title: Rat neuronal leucine-rich repeat protein-3: cloning and regulation of the gene expression.

The following Lrrn3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lrrn3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07209	NM_030856.1 Latest version!	Rattus norvegicus leucine rich repeat neuronal 3 (Lrrn3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lrrn3 ( NM_030856.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_110483.1 Rattus norvegicus leucine rich repeat neuronal 3 (Lrrn3), mRNA.

Price & Availability↑

CloneID	ORa07209
Clone ID Related Accession (Same CDS sequence)	NM_030856.1
Accession Version	NM_030856.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2124bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Rattus norvegicus(Norway rat)
Product	leucine-rich repeat neuronal protein 3 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF291437.1. On Dec 17, 2003 this sequence version replaced XM_346765.1. ##Evidence-Data-START## Transcript exon combination :: AF291437.1, FQ133124.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAAGGACG CACCACTCCA AATCCACGTG CTACTTGGCC TGGCTATCAC CGCACTCGTA 
CAAGCCGGAG ATAAAAAAGT GGATTGCCCC CAGTTATGTA CATGTGAGAT CAGGCCTTGG 
TTCACTCCCA GATCCATCTA TATGGAAGCA TCGACAGTGG ACTGTAATGA TTTAGGGCTT 
TTAAACTTCC CGGCCAGATT GCCTGCAGAC ACACAGATTT TGCTCCTGCA GACTAACAAT 
ATTGCAAGAA TTGAACATTC CACAGACTTT CCAGTAAACC TTACTGGCCT GGACTTATCT 
CAGAACAATT TATCTTCGGT CACTAATATT AATGTACAAA AGATGTCCCA GCTTCTTTCT 
GTATACCTAG AGGAAAACAA GCTAACGGAG CTGCCTGAAA AGTGTCTGTA TGGACTGAGT 
AACTTGCAGG AGCTTTACGT CAATCACAAC TTGCTGTCTG CCATCTCTCC CGGAGCCTTC 
GTTGGCCTAC ATAACCTTCT TCGACTTCAT CTCAACTCAA ACAGACTGCA GATGATCAAC 
AGTAAGTGGT TTGAGGCTCT TCCTAATCTT GAGATTCTGA TGCTCGGGGA CAACCCCATC 
CTCAGAATCA AGGACATGAA CTTTCAGCCT CTTCTCAAGC TCCGCAGCCT GGTTATCGCT 
GGCATAAACC TCACAGAAGT ACCAGATGAT GCCTTGGTTG GACTGGAAAA CCTGGAAAGC 
ATCTCTTTTT ATGATAATAG GCTTAATAAG GTACCCCAGG TTGCTCTTCA AAAGGCTGTC 
AACCTCAAGT TTTTGGATCT AAATAAAAAC CCTATTAACA GAATACGAAG GGGTGATTTT 
AGCAATATGC TACACTTGAA GGAGTTGGGG ATAAACAATA TGCCTGAACT TGTCTCCATT 
GACAGTCTCG CTGTGGATAA CTTGCCAGAT TTGAGAAAAA TAGAAGCTAC TAACAACCCC 
AGGTTGTCTT ACATTCACCC TAATGCATTT TTCAGACTCC CAAAGCTAGA ATCTCTCATG 
CTGAACAGCA ATGCCCTCAG TGCCCTCTAC CATGGTACCA TAGAGTCTTT GCCAAACCTC 
AAGGAAATCA GCATACACAG CAATCCCATC CGGTGTGACT GTGTAATCCG CTGGATTAAC 
ATGAACAAAA CCAACATTCG GTTTATGGAA CCAGATTCTC TGTTCTGTGT GGACCCACCT 
GAATTCCAAG GCCAGAATGT TCGACAAGTG CATTTCAGGG ATATGATGGA AATCTGCCTC 
CCTCTTATAG CTCCTGAGAG CTTTCCTTCC ATCCTGGATG TAGAAGCTGA CAGCTATGTG 
TCGCTTCACT GCAGAGCCAC TGCAGAACCC CAGCCTGAAA TCTACTGGAT CACACCTTCT 
GGTAAAAGAC TATTGCCAAA CACTCTGAGA GAGAAGTTCT ATGTTCATTC TGAAGGCACA 
CTAGACATAA GAGGCATAAC CCCAAAGGAA GGTGGGTTGT ACACCTGCAT AGCTACTAAC 
CTAGTCGGTG CTGACTTGAA GTCTATTATG ATCAAAGTGG GAGGTTTTGT TCCTCAGGAT 
AACAACGGGT CATTGAATAT TAAAATAAGA GATATCCGGG CCAATTCTGT TCTGGTGTCT 
TGGAAAGCAA ACTCTAAAAT TCTCAAATCC AGTGTTAAGT GGACAGCCTT TGTTAAGACT 
GAAGACTCCC AGGCTGCCCA AAGTGCTCGA ATACCATCTG ATGTCAAGGT ATACAATCTT 
ACTCATCTGA AACCTTCTAC TGAGTACAAA ATTTGTATTG ATATTCCCAC CATCTATCAG 
AAAAGCAGAA AACAATGTGT GAATGTGACC ACGAAAAGTC TGGAGCATGA CGGAAAAGAA 
AATGGAAAGA GTCACACAGT ATTTGTGGCC TGCGTTGGAG GTCTTCTGGG GATCATTGGT 
GTAATGTGTC TTTTCGGCTG TGTCTCACAA GAAGGGAACT GTGAGAATGA ACACAGCTAT 
ACTGTGAACC ACTGTCACAA GCCAACCTTG GCATTCAGTG AGCTTTACCC TCCTCTAATC 
AACCTCTGGG AGTCCAGCAA AGAAAAACCG GCATCGTTGG AAGTAAAAGC AACTGCTATA 
GGTGTGCCGA CAAGTATGTC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_110483.1
CDS	693..2816
Translation	MKDAPLQIHVLLGLAITALVQAGDKKVDCPQLCTCEIRPWFTPRSIYMEASTVDCNDLGLLNFPARLPADTQILLLQTNNIARIEHSTDFPVNLTGLDLSQNNLSSVTNINVQKMSQLLSVYLEENKLTELPEKCLYGLSNLQELYVNHNLLSAISPGAFVGLHNLLRLHLNSNRLQMINSKWFEALPNLEILMLGDNPILRIKDMNFQPLLKLRSLVIAGINLTEVPDDALVGLENLESISFYDNRLNKVPQVALQKAVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELVSIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCVIRWINMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLPLIAPESFPSILDVEADSYVSLHCRATAEPQPEIYWITPSGKRLLPNTLREKFYVHSEGTLDIRGITPKEGGLYTCIATNLVGADLKSIMIKVGGFVPQDNNGSLNIKIRDIRANSVLVSWKANSKILKSSVKWTAFVKTEDSQAAQSARIPSDVKVYNLTHLKPSTEYKICIDIPTIYQKSRKQCVNVTTKSLEHDGKENGKSHTVFVACVGGLLGIIGVMCLFGCVSQEGNCENEHSYTVNHCHKPTLAFSELYPPLINLWESSKEKPASLEVKATAIGVPTSMS

Target ORF information:

RefSeq Version	NM_030856.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus leucine rich repeat neuronal 3 (Lrrn3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030856.1

ORF Insert Sequence:

ATGAAGGACG CACCACTCCA AATCCACGTG CTACTTGGCC TGGCTATCAC CGCACTCGTA 
CAAGCCGGAG ATAAAAAAGT GGATTGCCCC CAGTTATGTA CATGTGAGAT CAGGCCTTGG 
TTCACTCCCA GATCCATCTA TATGGAAGCA TCGACAGTGG ACTGTAATGA TTTAGGGCTT 
TTAAACTTCC CGGCCAGATT GCCTGCAGAC ACACAGATTT TGCTCCTGCA GACTAACAAT 
ATTGCAAGAA TTGAACATTC CACAGACTTT CCAGTAAACC TTACTGGCCT GGACTTATCT 
CAGAACAATT TATCTTCGGT CACTAATATT AATGTACAAA AGATGTCCCA GCTTCTTTCT 
GTATACCTAG AGGAAAACAA GCTAACGGAG CTGCCTGAAA AGTGTCTGTA TGGACTGAGT 
AACTTGCAGG AGCTTTACGT CAATCACAAC TTGCTGTCTG CCATCTCTCC CGGAGCCTTC 
GTTGGCCTAC ATAACCTTCT TCGACTTCAT CTCAACTCAA ACAGACTGCA GATGATCAAC 
AGTAAGTGGT TTGAGGCTCT TCCTAATCTT GAGATTCTGA TGCTCGGGGA CAACCCCATC 
CTCAGAATCA AGGACATGAA CTTTCAGCCT CTTCTCAAGC TCCGCAGCCT GGTTATCGCT 
GGCATAAACC TCACAGAAGT ACCAGATGAT GCCTTGGTTG GACTGGAAAA CCTGGAAAGC 
ATCTCTTTTT ATGATAATAG GCTTAATAAG GTACCCCAGG TTGCTCTTCA AAAGGCTGTC 
AACCTCAAGT TTTTGGATCT AAATAAAAAC CCTATTAACA GAATACGAAG GGGTGATTTT 
AGCAATATGC TACACTTGAA GGAGTTGGGG ATAAACAATA TGCCTGAACT TGTCTCCATT 
GACAGTCTCG CTGTGGATAA CTTGCCAGAT TTGAGAAAAA TAGAAGCTAC TAACAACCCC 
AGGTTGTCTT ACATTCACCC TAATGCATTT TTCAGACTCC CAAAGCTAGA ATCTCTCATG 
CTGAACAGCA ATGCCCTCAG TGCCCTCTAC CATGGTACCA TAGAGTCTTT GCCAAACCTC 
AAGGAAATCA GCATACACAG CAATCCCATC CGGTGTGACT GTGTAATCCG CTGGATTAAC 
ATGAACAAAA CCAACATTCG GTTTATGGAA CCAGATTCTC TGTTCTGTGT GGACCCACCT 
GAATTCCAAG GCCAGAATGT TCGACAAGTG CATTTCAGGG ATATGATGGA AATCTGCCTC 
CCTCTTATAG CTCCTGAGAG CTTTCCTTCC ATCCTGGATG TAGAAGCTGA CAGCTATGTG 
TCGCTTCACT GCAGAGCCAC TGCAGAACCC CAGCCTGAAA TCTACTGGAT CACACCTTCT 
GGTAAAAGAC TATTGCCAAA CACTCTGAGA GAGAAGTTCT ATGTTCATTC TGAAGGCACA 
CTAGACATAA GAGGCATAAC CCCAAAGGAA GGTGGGTTGT ACACCTGCAT AGCTACTAAC 
CTAGTCGGTG CTGACTTGAA GTCTATTATG ATCAAAGTGG GAGGTTTTGT TCCTCAGGAT 
AACAACGGGT CATTGAATAT TAAAATAAGA GATATCCGGG CCAATTCTGT TCTGGTGTCT 
TGGAAAGCAA ACTCTAAAAT TCTCAAATCC AGTGTTAAGT GGACAGCCTT TGTTAAGACT 
GAAGACTCCC AGGCTGCCCA AAGTGCTCGA ATACCATCTG ATGTCAAGGT ATACAATCTT 
ACTCATCTGA AACCTTCTAC TGAGTACAAA ATTTGTATTG ATATTCCCAC CATCTATCAG 
AAAAGCAGAA AACAATGTGT GAATGTGACC ACGAAAAGTC TGGAGCATGA CGGAAAAGAA 
AATGGAAAGA GTCACACAGT ATTTGTGGCC TGCGTTGGAG GTCTTCTGGG GATCATTGGT 
GTAATGTGTC TTTTCGGCTG TGTCTCACAA GAAGGGAACT GTGAGAATGA ACACAGCTAT 
ACTGTGAACC ACTGTCACAA GCCAACCTTG GCATTCAGTG AGCTTTACCC TCCTCTAATC 
AACCTCTGGG AGTCCAGCAA AGAAAAACCG GCATCGTTGG AAGTAAAAGC AACTGCTATA 
GGTGTGCCGA CAAGTATGTC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Novel candidate genes for impaired nephron development in a rat model with inherited nephron deficit and albuminuria.
Clinical and experimental pharmacology & physiology42(10)1051-8(2015 Oct)
Herlan L,Schulz A,Schulte L,Schulz H,H?bner N,Kreutz R

Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins.
Cell reports6(6)1096-1109(2014 Mar)
Um JW,Pramanik G,Ko JS,Song MY,Lee D,Kim H,Park KS,S?dhof TC,Tabuchi K,Ko J

[Role of LRRN3 in the cerebellum postnatal development in rats].
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences36(5)424-9(2011 May)
Yang J,Li F,Qiu L,Luo X,Huang H

Mapping the microtubule binding regions of calponin.
Biochemistry42(5)1274-82(2003 Feb)
Fattoum A,Roustan C,Smyczynski C,Der Terrossian E,Kassab R

Neuronal leucine-rich repeat protein-3 amplifies MAPK activation by epidermal growth factor through a carboxyl-terminal region containing endocytosis motifs.
The Journal of biological chemistry277(46)43549-52(2002 Nov)
Fukamachi K,Matsuoka Y,Ohno H,Hamaguchi T,Tsuda H

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Lrrn3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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