Trpc2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Trpc2
Entrez Gene ID	64573
Full Name	transient receptor potential cation channel, subfamily C, member 2, pseudogene
Synonyms	Trrp2
General protein information	Preferred Names transient receptor potential cation channel, subfamily C, member 2, pseudogene Names short transient receptor potential channel 2 TRP-2 rTrp2 transient receptor protein 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q32

mRNA and Protein(s)

mRNA	Protein	Name
XM_008774632.2	XP_008772854.2	short transient receptor potential channel 2
XM_008759812.2	XP_008758034.1	short transient receptor potential channel 2
NM_022638.3	NP_072160.2	short transient receptor potential channel 2

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Trpc2	XP_006229964.1
Mus musculus (house mouse)	Trpc2	NP_001103367.1

Gene Ontology
Bibliography

Related articles in PubMed

Significance of the transient receptor potential canonical 2 (TRPC2) channel in the regulation of rat thyroid FRTL-5 cell proliferation, migration, adhesion and invasion.
Sukumaran P, L?f C, Pulli I, Kemppainen K, Viitanen T, T?rnquist K
Molecular and cellular endocrinology374(1-2)10-21(2013 Jul)

Functional coupling of TRPC2 cation channels and the calcium-activated anion channels in rat thyroid cells: implications for iodide homeostasis.
Viitanen TM, Sukumaran P, L?f C, T?rnquist K
Journal of cellular physiology228(4)814-23(2013 Apr)

Canonical transient receptor potential channel 2 (TRPC2) as a major regulator of calcium homeostasis in rat thyroid FRTL-5 cells: importance of protein kinase C ? (PKC?) and stromal interaction molecule 2 (STIM2).
Sukumaran P, L?f C, Kemppainen K, Kankaanp?? P, Pulli I, N?sman J, Viitanen T, T?rnquist K
The Journal of biological chemistry287(53)44345-60(2012 Dec)

Communication between the calcium and cAMP pathways regulate the expression of the TSH receptor: TRPC2 in the center of action.
L?f C, Sukumaran P, Viitanen T, Vainio M, Kemppainen K, Pulli I, N?sman J, Kukkonen JP, T?rnquist K
Molecular endocrinology (Baltimore, Md.)26(12)2046-57(2012 Dec)

The TRPC2 channel forms protein-protein interactions with Homer and RTP in the rat vomeronasal organ.
Mast TG, Brann JH, Fadool DA
BMC neuroscience1161(2010 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TRPC2 is an important regulator of rat thyroid cell function.
Title: Significance of the transient receptor potential canonical 2 (TRPC2) channel in the regulation of rat thyroid FRTL-5 cell proliferation, migration, adhesion and invasion.

Ca(2+) entry via TRPC2 contributes to CaCC activation.
Title: Functional coupling of TRPC2 cation channels and the calcium-activated anion channels in rat thyroid cells: implications for iodide homeostasis.

TRPC2, by regulating STIM2, PKC expression, and SERCA activity, regulates calcium homeostasis in thyroid cells.
Title: Canonical transient receptor potential channel 2 (TRPC2) as a major regulator of calcium homeostasis in rat thyroid FRTL-5 cells: importance of protein kinase C ? (PKC?) and stromal interaction molecule 2 (STIM2).

findings show that TRPC2 is important for posttranslational processing and secretion of thyroglobulin
Title: Communication between the calcium and cAMP pathways regulate the expression of the TSH receptor: TRPC2 in the center of action.

TRPC2 expression and channel activity is regulated by chaperone- and scaffolding-associated proteins, which could modulate the transduction of chemosignals.
Title: The TRPC2 channel forms protein-protein interactions with Homer and RTP in the rat vomeronasal organ.

The following Trpc2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Trpc2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa43612	NM_022638.3 Latest version!	Rattus norvegicus transient receptor potential cation channel subfamily C member 2 (Trpc2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Trpc2 ( NM_022638.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_072160.2 Rattus norvegicus transient receptor potential cation channel subfamily C member 2 (Trpc2), mRNA.

Price & Availability↑

CloneID	ORa43612
Clone ID Related Accession (Same CDS sequence)	NM_022638.3
Accession Version	NM_022638.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2664bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-19
Organism	Rattus norvegicus(Norway rat)
Product	short transient receptor potential channel 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07004912.1. On Oct 3, 2019 this sequence version replaced NM_022638.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AF136401.1 [ECO:0000332] ##Evidence-Data-END##

ATGGATCCCC TTTCGCCCAA CTGGACTGAG ATTGTGAACA AAAAGCTCAA ATTCCCCCCA 
ACACTGCTGC GTGCTATCCA GGAGGGCCAG CTGGGTCTCG TGCAGCAGCT GCTGGAATCA 
GGCTCCGATC CCTCGGGTGC TGGGCCAGGT GGTCCTCTGC GGAATGTGGA AGAGTCTGAG 
GACCGCTCCT GGAGGGAAGC CCTTAATCTG GCCATCCGCC TGGGCCACGA GGTCATCACT 
GATGTTCTGC TGGCCAATGT CAAGTTTGAC TTCCGGCAGA TCCACGAAGC CCTGCTAGTG 
GCTGTGGACA CAAACCAGCC AGCGGTAGTG CGTCGTCTGT TAGCTCGGCT GGAACGGGAG 
AAAGGTCGAA AAGTAGACAC CAAGTCTTTC TCTTTAGCCT TCTTTGACTC ATCAATCGAT 
GGCTCCCGCT TTGCCCCTGG TGTTACTCCA CTCACACTGG CCTGCCAGAA GGACCTGTAT 
GAGATTGCCC AGCTGCTTAT GGACCAGGGC CACACTATTG CTCGGCCCCA CCCAGTTTCC 
TGTGCCTGCC TCGAGTGCAG CAATGCGCGC CGATATGACC TGCTGAAGTT CTCACTATCC 
CGAATCAACA CCTACCGGGG CATTGCTAGC AGGGCTCACC TCTCGCTGGC CAGTGAGGAT 
GCCATGCTGG CGGCCTTTCA GCTCAGCCGG GAGCTCAGGC GCCTTGCACG GAAGGAGCCT 
GAGTTTAAGC CTCAGTACAT TGCCCTGGAG TCTCTCTGCC AGGACTATGG CTTTGAGTTG 
CTGGGCATGT GCCGGAATCA GAGTGAGGTC ACTGCAGTGC TCAATGACCT GGGCGAGGAT 
AGTGAGACTG AGCCTGAGGC TGAGGGCCTG GGCCAGGCCT TTGAGGAGGG CATCCCTAAC 
CTGGCAAGAC TGCGGTTGGC TGTCAACTAC AACCAGAAAC AGTTTGTAGC ACACCCCATC 
TGCCAGCAAG TGCTGTCTTC CATTTGGTGT GGGAACCTGG CTGGCTGGCG CGGGAGCACC 
ACCATCTGGA AGCTCTTTGT GGCCTTCCTC ATCTTCCTCA CCATGCCCTT CCTCTGCATT 
GGCTACTGGC TGGCGCCCAA GTCCCGGCTG GGCCGCCTGC TGAAGATCCC AGTGTTGAAG 
TTCCTGCTCC ATTCTGCCTC CTATCTGTGG TTCCTGATCT TCTTGCTGGG AGAGTCTCTG 
GTCATGGAGA CTCAGCTGAG CACCTTCAAA GGCCGCAGTC AGAGTGTCTG GGAGACTTCT 
CTGCATATGA TTTGGGTCAC AGGCTTTCTG TGGTTTGAGT GTAAGGAGGT GTGGATCGAG 
GGCTTGCGAA GCTACCTCCT GGACTGGTGG AACTTCCTGG ACGTGGTCAT CCTGTCTCTG 
TACCTGGCAT CCTTTGCACT GCGCCTCCTC CTGGCTGGAC TTGCCTACAT GCACTGCCGG 
GACGCCTCAG ACAGCAGCAC CTGCCGATAC TTCACCACAG CTGAGCGAAG TGAGTGGCGC 
ACAGAGGACC CCCAGTTCCT GGCCGAGGTG CTCTTTGCTG TCACGAGCAT GCTCAGTTTC 
ACCCGATTGG CGTATATTCT GCCAGCTCAC GAATCATTGG GCACTCTGCA GATCTCCATT 
GGCAAGATGA TTGACGACAT GATCCGGTTC ATGTTCATCC TCATGATCAT CCTGACTGCC 
TTCCTCTGCG GCCTCAACAA CATCTATGTG CCCTACCAGG AGACGGAGAA GCTGGGCAAT 
TTCAACGAAA CGTTCCAGTT CCTCTTCTGG ACCATGTTTG GCATGGAAGA GCACTCTGTG 
GTGGACATGC CCCAGTTCCT GGTGCCTGAG TTCGTGGGCC GGGCCATGTA CGGCATCTTT 
ACCATCGTCA TGGTGATTGT GCTACTCAAC ATGCTCATCG CCATGATCAC CAACTCCTTC 
CAGAAGATCG AGGACGATGC TGATGTAGAG TGGAAGTTTG CTCGCTCCAA GCTCTACCTG 
TCCTACTTCC GAGAGGGTCT GACGCTGCCT GTGCCTTTTA ACATCCTGCC ATCCCCAAAG 
GCTGCCTTCT ACCTTCTCAG GAGGATTTTC CGGTTCATTT GCTGTGGCTC CTCCTGTTGC 
AAAGCCAAGA AGTCGGACTA TCCCCCAATC CCGACCTTTA CCAACCCTGG GGCAAGGGCG 
GGGCCTGGGG AAGGAGAACA TGTGTCCTAC CGCCTTCGAG TCATCAAGGC TCTGGTGCAG 
CGCTACATAG AGACTGCCCG GCGCGAGTTC GAGGAGACCC GTCGGAAAGA TCTGGGCAAC 
AGACTGACAG AGCTGACCAA GACTGTGTCT CGACTGCAAA GCGAGGTGGC CAGTGTGCAG 
AAGACTGTGG CAGCGGGAGG GGCGCTGCGG CCTCCGGATG GCGCCAGCAT CCTCAGTCGG 
TACATCACCC GAGTGCGCAA CAGCTTCCAG AACCTGGGCC CCCCTGCCCC TGACACCCCC 
GCAGAGCTGA CGATGCCTGG GATTGTGGAG ACCGAAGTCT CCTTAGAAGA TAGCCTTGAT 
GCTACAGGAG AGGCTGGGAC TCCAGCTTCT GGAGAGTCCA GCTCTTCCTC CTCGGCCCAT 
GTGCTGGTAC ACAGGGAGCA AGAAGCAGAG GGGGCAGGGG ACTTGCCCCT GGGGGAAGAT 
CTGGAGACCA AGGGCGAGTC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_072160.2
CDS	53..2716
Translation	MDPLSPNWTEIVNKKLKFPPTLLRAIQEGQLGLVQQLLESGSDPSGAGPGGPLRNVEESEDRSWREALNLAIRLGHEVITDVLLANVKFDFRQIHEALLVAVDTNQPAVVRRLLARLEREKGRKVDTKSFSLAFFDSSIDGSRFAPGVTPLTLACQKDLYEIAQLLMDQGHTIARPHPVSCACLECSNARRYDLLKFSLSRINTYRGIASRAHLSLASEDAMLAAFQLSRELRRLARKEPEFKPQYIALESLCQDYGFELLGMCRNQSEVTAVLNDLGEDSETEPEAEGLGQAFEEGIPNLARLRLAVNYNQKQFVAHPICQQVLSSIWCGNLAGWRGSTTIWKLFVAFLIFLTMPFLCIGYWLAPKSRLGRLLKIPVLKFLLHSASYLWFLIFLLGESLVMETQLSTFKGRSQSVWETSLHMIWVTGFLWFECKEVWIEGLRSYLLDWWNFLDVVILSLYLASFALRLLLAGLAYMHCRDASDSSTCRYFTTAERSEWRTEDPQFLAEVLFAVTSMLSFTRLAYILPAHESLGTLQISIGKMIDDMIRFMFILMIILTAFLCGLNNIYVPYQETEKLGNFNETFQFLFWTMFGMEEHSVVDMPQFLVPEFVGRAMYGIFTIVMVIVLLNMLIAMITNSFQKIEDDADVEWKFARSKLYLSYFREGLTLPVPFNILPSPKAAFYLLRRIFRFICCGSSCCKAKKSDYPPIPTFTNPGARAGPGEGEHVSYRLRVIKALVQRYIETARREFEETRRKDLGNRLTELTKTVSRLQSEVASVQKTVAAGGALRPPDGASILSRYITRVRNSFQNLGPPAPDTPAELTMPGIVETEVSLEDSLDATGEAGTPASGESSSSSSAHVLVHREQEAEGAGDLPLGEDLETKGES

Target ORF information:

RefSeq Version	NM_022638.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus transient receptor potential cation channel subfamily C member 2 (Trpc2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022638.3

ORF Insert Sequence:

ATGGATCCCC TTTCGCCCAA CTGGACTGAG ATTGTGAACA AAAAGCTCAA ATTCCCCCCA 
ACACTGCTGC GTGCTATCCA GGAGGGCCAG CTGGGTCTCG TGCAGCAGCT GCTGGAATCA 
GGCTCCGATC CCTCGGGTGC TGGGCCAGGT GGTCCTCTGC GGAATGTGGA AGAGTCTGAG 
GACCGCTCCT GGAGGGAAGC CCTTAATCTG GCCATCCGCC TGGGCCACGA GGTCATCACT 
GATGTTCTGC TGGCCAATGT CAAGTTTGAC TTCCGGCAGA TCCACGAAGC CCTGCTAGTG 
GCTGTGGACA CAAACCAGCC AGCGGTAGTG CGTCGTCTGT TAGCTCGGCT GGAACGGGAG 
AAAGGTCGAA AAGTAGACAC CAAGTCTTTC TCTTTAGCCT TCTTTGACTC ATCAATCGAT 
GGCTCCCGCT TTGCCCCTGG TGTTACTCCA CTCACACTGG CCTGCCAGAA GGACCTGTAT 
GAGATTGCCC AGCTGCTTAT GGACCAGGGC CACACTATTG CTCGGCCCCA CCCAGTTTCC 
TGTGCCTGCC TCGAGTGCAG CAATGCGCGC CGATATGACC TGCTGAAGTT CTCACTATCC 
CGAATCAACA CCTACCGGGG CATTGCTAGC AGGGCTCACC TCTCGCTGGC CAGTGAGGAT 
GCCATGCTGG CGGCCTTTCA GCTCAGCCGG GAGCTCAGGC GCCTTGCACG GAAGGAGCCT 
GAGTTTAAGC CTCAGTACAT TGCCCTGGAG TCTCTCTGCC AGGACTATGG CTTTGAGTTG 
CTGGGCATGT GCCGGAATCA GAGTGAGGTC ACTGCAGTGC TCAATGACCT GGGCGAGGAT 
AGTGAGACTG AGCCTGAGGC TGAGGGCCTG GGCCAGGCCT TTGAGGAGGG CATCCCTAAC 
CTGGCAAGAC TGCGGTTGGC TGTCAACTAC AACCAGAAAC AGTTTGTAGC ACACCCCATC 
TGCCAGCAAG TGCTGTCTTC CATTTGGTGT GGGAACCTGG CTGGCTGGCG CGGGAGCACC 
ACCATCTGGA AGCTCTTTGT GGCCTTCCTC ATCTTCCTCA CCATGCCCTT CCTCTGCATT 
GGCTACTGGC TGGCGCCCAA GTCCCGGCTG GGCCGCCTGC TGAAGATCCC AGTGTTGAAG 
TTCCTGCTCC ATTCTGCCTC CTATCTGTGG TTCCTGATCT TCTTGCTGGG AGAGTCTCTG 
GTCATGGAGA CTCAGCTGAG CACCTTCAAA GGCCGCAGTC AGAGTGTCTG GGAGACTTCT 
CTGCATATGA TTTGGGTCAC AGGCTTTCTG TGGTTTGAGT GTAAGGAGGT GTGGATCGAG 
GGCTTGCGAA GCTACCTCCT GGACTGGTGG AACTTCCTGG ACGTGGTCAT CCTGTCTCTG 
TACCTGGCAT CCTTTGCACT GCGCCTCCTC CTGGCTGGAC TTGCCTACAT GCACTGCCGG 
GACGCCTCAG ACAGCAGCAC CTGCCGATAC TTCACCACAG CTGAGCGAAG TGAGTGGCGC 
ACAGAGGACC CCCAGTTCCT GGCCGAGGTG CTCTTTGCTG TCACGAGCAT GCTCAGTTTC 
ACCCGATTGG CGTATATTCT GCCAGCTCAC GAATCATTGG GCACTCTGCA GATCTCCATT 
GGCAAGATGA TTGACGACAT GATCCGGTTC ATGTTCATCC TCATGATCAT CCTGACTGCC 
TTCCTCTGCG GCCTCAACAA CATCTATGTG CCCTACCAGG AGACGGAGAA GCTGGGCAAT 
TTCAACGAAA CGTTCCAGTT CCTCTTCTGG ACCATGTTTG GCATGGAAGA GCACTCTGTG 
GTGGACATGC CCCAGTTCCT GGTGCCTGAG TTCGTGGGCC GGGCCATGTA CGGCATCTTT 
ACCATCGTCA TGGTGATTGT GCTACTCAAC ATGCTCATCG CCATGATCAC CAACTCCTTC 
CAGAAGATCG AGGACGATGC TGATGTAGAG TGGAAGTTTG CTCGCTCCAA GCTCTACCTG 
TCCTACTTCC GAGAGGGTCT GACGCTGCCT GTGCCTTTTA ACATCCTGCC ATCCCCAAAG 
GCTGCCTTCT ACCTTCTCAG GAGGATTTTC CGGTTCATTT GCTGTGGCTC CTCCTGTTGC 
AAAGCCAAGA AGTCGGACTA TCCCCCAATC CCGACCTTTA CCAACCCTGG GGCAAGGGCG 
GGGCCTGGGG AAGGAGAACA TGTGTCCTAC CGCCTTCGAG TCATCAAGGC TCTGGTGCAG 
CGCTACATAG AGACTGCCCG GCGCGAGTTC GAGGAGACCC GTCGGAAAGA TCTGGGCAAC 
AGACTGACAG AGCTGACCAA GACTGTGTCT CGACTGCAAA GCGAGGTGGC CAGTGTGCAG 
AAGACTGTGG CAGCGGGAGG GGCGCTGCGG CCTCCGGATG GCGCCAGCAT CCTCAGTCGG 
TACATCACCC GAGTGCGCAA CAGCTTCCAG AACCTGGGCC CCCCTGCCCC TGACACCCCC 
GCAGAGCTGA CGATGCCTGG GATTGTGGAG ACCGAAGTCT CCTTAGAAGA TAGCCTTGAT 
GCTACAGGAG AGGCTGGGAC TCCAGCTTCT GGAGAGTCCA GCTCTTCCTC CTCGGCCCAT 
GTGCTGGTAC ACAGGGAGCA AGAAGCAGAG GGGGCAGGGG ACTTGCCCCT GGGGGAAGAT 
CTGGAGACCA AGGGCGAGTC CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Significance of the transient receptor potential canonical 2 (TRPC2) channel in the regulation of rat thyroid FRTL-5 cell proliferation, migration, adhesion and invasion.
Molecular and cellular endocrinology374(1-2)10-21(2013 Jul)
Sukumaran P,L?f C,Pulli I,Kemppainen K,Viitanen T,T?rnquist K

Functional coupling of TRPC2 cation channels and the calcium-activated anion channels in rat thyroid cells: implications for iodide homeostasis.
Journal of cellular physiology228(4)814-23(2013 Apr)
Viitanen TM,Sukumaran P,L?f C,T?rnquist K

Canonical transient receptor potential channel 2 (TRPC2) as a major regulator of calcium homeostasis in rat thyroid FRTL-5 cells: importance of protein kinase C ? (PKC?) and stromal interaction molecule 2 (STIM2).
The Journal of biological chemistry287(53)44345-60(2012 Dec)
Sukumaran P,L?f C,Kemppainen K,Kankaanp?? P,Pulli I,N?sman J,Viitanen T,T?rnquist K

Communication between the calcium and cAMP pathways regulate the expression of the TSH receptor: TRPC2 in the center of action.
Molecular endocrinology (Baltimore, Md.)26(12)2046-57(2012 Dec)
L?f C,Sukumaran P,Viitanen T,Vainio M,Kemppainen K,Pulli I,N?sman J,Kukkonen JP,T?rnquist K

The TRPC2 channel forms protein-protein interactions with Homer and RTP in the rat vomeronasal organ.
BMC neuroscience1161(2010 May)
Mast TG,Brann JH,Fadool DA

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Trpc2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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