Furin cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Furin
Entrez Gene ID	54281
Full Name	furin (paired basic amino acid cleaving enzyme)
Synonyms	Pace,Pcsk3
General protein information	Preferred Names furin (paired basic amino acid cleaving enzyme) Names furin Paired basic amino acid cleaving enzyme (furin) Proprotein convertase subtilisin/kexin type 3 (paired basic amino acid cleaving enzyme, furin, membrane associated receptor protein) dibasic-processing enzyme paired basic amino acid residue-cleaving enzyme prohormone convertase 3 proprotein convertase subtilisin/kexin type3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q31
Summary	may be one of several enzymes involved in the proteolytic processing of extracellular superoxide dismutase (EC-SOD) [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_008759556.1	XP_008757778.1	furin isoform X1
XM_008759555.2	XP_008757777.1	furin isoform X1
NM_019331.1	NP_062204.1	furin precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	FURIN	XP_510596.2
Rattus norvegicus (Norway rat)	Furin	NP_062204.1
Caenorhabditis elegans (roundworm)	kpc-1	NP_492974.2
Mus musculus (house mouse)	Furin	NP_001074923.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001330	XP_321814.4
Homo sapiens (human)	FURIN	NP_002560.1
Canis lupus familiaris (dog)	FURIN	XP_850069.2
Bos taurus (cattle)	FURIN	NP_776561.1
Danio rerio (zebrafish)	furinb	NP_001038574.2
Xenopus tropicalis (tropical clawed frog)	furin	XP_004912697.1
	FURIN	XP_001094068.1
Gallus gallus (chicken)	FURIN	NP_990046.1
Danio rerio (zebrafish)	furina	NP_001038571.1

Gene Ontology
Bibliography

Related articles in PubMed

Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes.
Essalmani R, Susan-Resiga D, Chamberland A, Asselin MC, Canuel M, Constam D, Creemers JW, Day R, Gauthier D, Prat A, Seidah NG
The Journal of biological chemistry288(37)26410-8(2013 Sep)

Proprotein convertases play an important role in regulating PKGI endoproteolytic cleavage and nuclear transport.
Kato S, Zhang R, Roberts JD Jr
American journal of physiology. Lung cellular and molecular physiology305(2)L130-40(2013 Jul)

Proprotein convertase furin regulates apoptosis and proliferation of granulosa cells in the rat ovary.
Yang X, Wang Q, Gao Z, Zhou Z, Peng S, Chang WL, Lin HY, Zhang W, Wang H
PloS one8(2)e50479(2013)

In vivo evidence that furin from hepatocytes inactivates PCSK9.
Essalmani R, Susan-Resiga D, Chamberland A, Abifadel M, Creemers JW, Boileau C, Seidah NG, Prat A
The Journal of biological chemistry286(6)4257-63(2011 Feb)

E-selectin ligand-1 regulates growth plate homeostasis in mice by inhibiting the intracellular processing and secretion of mature TGF-beta.
Yang T, Mendoza-Londono R, Lu H, Tao J, Li K, Keller B, Jiang MM, Shah R, Chen Y, Bertin TK, Engin F, Dabovic B, Rifkin DB, Hicks J, Jamrich M, Beaudet AL, Lee B
The Journal of clinical investigation120(7)2474-85(2010 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

overexpression of PCs, furin and PC5, but not PC7, which are all expressed in SMC, increase PKGI cleavage in a dose-dependent manner
Title: Proprotein convertases play an important role in regulating PKGI endoproteolytic cleavage and nuclear transport.

these data suggest that furin may play an important role in regulating apoptosis and proliferation of granulosa cells.
Title: Proprotein convertase furin regulates apoptosis and proliferation of granulosa cells in the rat ovary.

upregulated during the preovulatory period, which results in activation of proteinases associated with the breakdown of the follicular wall during ovulation
Title: Ovarian furin (proprotein convertase subtilisin/kexin type3): expression, localization, and potential role in ovulation in the rat.

integrin bidirectional signalling is critically controlled by furin
Title: Integrin cleavage regulates bidirectional signalling in vascular smooth muscle cells.

Disturbances of the MT1-MMP/furin interaction must account for a lack in extracellular matrix remodeling, increased deposition of glomerular basement membrane material, and loss of glomerular filtration integrity in diabetic glomerulopathy.
Title: Expression and localization of MT1-MMP and furin in the glomerular wall of short- and long-term diabetic rats.

The following Furin gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Furin cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa04441	NM_019331.1 Latest version!	Rattus norvegicus furin (paired basic amino acid cleaving enzyme) (Furin), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
ORa43416	XM_008759556.1 Latest version!	Rattus norvegicus furin (paired basic amino acid cleaving enzyme) (Furin), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
ORa43416	XM_008759555.2 Latest version!	Rattus norvegicus furin (paired basic amino acid cleaving enzyme) (Furin), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Furin ( NM_019331.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_062204.1 Rattus norvegicus furin (paired basic amino acid cleaving enzyme) (Furin), mRNA.

Price & Availability↑

CloneID	ORa04441
Clone ID Related Accession (Same CDS sequence)	NM_019331.1
Accession Version	NM_019331.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2382bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	furin precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X55660.1. On Jan 12, 2005 this sequence version replaced XM_346546.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X55660.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGAGCTGA GACCCTGGTT GCTATGGGTG GTAGCAGCAG CAGGAGCCTT GGTCCTGCTA 
GCAGCTGAAG CTCGCGGCCA GAAGATCTTC ACCAACACGT GGGCTGTGCA CATTTCTGGA 
GGCCCAGCTG TGGCTGATAG TGTGGCACGG AAGCATGGGT TCCACAACCT GGGCCAGATC 
TTCGGTGACT ATTACCACTT CTGGCACAGA GCAGTGACAA AGCGGTCCCT GTCGCCTCAC 
CGCCCGCGGC ACAGCCGGCT ACAGAGGGTG CCTCAAGTGA AGTGGCTGGA GCAGCAGGTA 
GCCAAGCAAA GGGCCAAGAG GGACGTGTAT CAGGAGCCCA CAGACCCCAA GTTCCCTCAG 
CAGTGGTACC TGTCTGGGGT CACTCAGCGA GACCTGAATG TGAAGGAAGC CTGGGCCCAG 
GGCTTCACAG GGCGTGGCAT TGTGGTCTCC ATCCTGGATG ACGGCATTGA AAAGAACCAT 
CCTGACTTGG CAGGCAATTA TGACCCGGGA GCCAGCTTTG ATGTCAATGA CCAGGACCCT 
GACCCACAGC CTCGGTACAC GCAGATGAAT GACAACAGGC ACGGCACTCG GTGTGCCGGG 
GAAGTGGCAG CGGTGGCCAA CAATGGTGTC TGTGGTGTAG GTGTAGCTTA CAATGCCCGG 
ATTGGAGGGG TGCGTATGTT GGATGGCGAG GTGACTGACG CGGTAGAGGC ACGTTCGCTG 
GGCCTGAATC CCAACCACAT CCACATCTAC AGCGCCAGCT GGGGCCCCGA GGACGACGGC 
AAGACCGTGG ATGGGCCAGC CCGGCTCGCC GAGGAGGCCT TCTTTCGGGG AGTTAGCCAG 
GGCCGCGGAG GGCTGGGCTC CATCTTTGTC TGGGCCTCAG GGAATGGGGG CCGGGAACAT 
GACAGCTGTA ACTGTGACGG CTACACCAAC AGTATCTACA CGCTGTCCAT CAGCAGTGCC 
ACACAATTCG GCAACGTGCC CTGGTACAGT GAGGCCTGCT CCTCCACACT GGCCACCACC 
TACAGCAGTG GCAACCAGAA TGAGAAGCAG ATTGTGACAA CTGACTTGAG GCAGAAGTGC 
ACTGAGTCTC ACACAGGCAC CTCAGCCTCC GCCCCTTTGG CAGCTGGTAT CATTGCTCTC 
ACCCTGGAGG CCAACAAGAA CCTCACCTGG CGGGACATGC AGCACCTGGT GGTGCAGACC 
TCAAAGCCAG CACATCTCAA CGCTAACGAT TGGGCCACCA ATGGCGTGGG CCGGAAAGTG 
AGCCATTCCT ATGGCTACGG GCTGTTGGAT GCAGGTGCCA TGGTGGCCCT GGCCCAGAAC 
TGGACAACAG TGGCCCCCCA GCGGAAGTGC ATCATTGAAA TCCTGGCAGA GCCCAAGGAC 
ATTGGCAAAC GGCTAGAGGT GCGCAAGACC GTGACAGCGT GCCTGGGTGA GCCCAACCAC 
ATCTCCAGAC TGGAACACGT TCAGGCACGG CTCACCCTGT CTTACAATCG CCGTGGTGAC 
CTGGCTATCC ACCTCATCAG CCCCATGGGC ACCCGTTCCA CCCTATTAGC TGCCAGACCA 
CATGACTACT CTGCTGATGG ATTTAATGAC TGGGCTTTCA TGACAACTCA TTCCTGGGAT 
GAGGACCCCT CTGGCGAGTG GGTCCTAGAG ATTGAAAATA CCAGCGAGGC CAACAACTAT 
GGGACGCTGA CCAAGTTCAC TCTCGTCCTA TATGGCACAG CCTCTGAGGG TCTCTCTGCA 
CCTCCAGAGA GCAGCGGCTG CAAGACCCTC ACATCCAGCC AGGCCTGCGT GGTGTGTGAG 
GAAGGTTTCT CACTGCACCA GAAAAGCTGT GTCCAGCGTT GCCCACCAGG CTTCACACCC 
CAAGTCCTTG ATACACACTA CAGCACTGAG AATGATGTGG AGATCATCCG TGCCAGCGTC 
TGCACCCCCT GCCACGCCTC ATGTGCCACT TGCCAGGGCC CAGCTCCCAC AGACTGCCTC 
AGCTGCCCCA GCCATGCCTC CCTGGACCCT GTGGAGCAAA CCTGCTCCCG GCAAAGCCAG 
AGCAGCCGAG AGTCCCGACC TCAGCAGCCA CCTCCCGCAC TGCGCCCAGA GGTGGAAGTG 
GAGCCCCGGT TGCGGGCTGG GCTGGCCTCT CACCTGCCGG AGGTCCTGGC CGGCCTCAGC 
TGCCTTATCA TCGCTCTCAT CTTTGGCATC GTCTTCCTCT TCCTGCATCG GTGTTCAGGC 
TTCAGCTTCC GGGGAGTGAA AGTGTACACC ATGGACCGTG GCCTCATCTC CTACAAGGGG 
CTGCCTCCTG AGGCCTGGCA GGAGGAGTGC CCATCTGACT CAGAAGAGGA TGAGGGCCGG 
GGCGAGAGGA CCGCCTTTAT CAAAGACCAG AGCGCCCTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062204.1
CDS	444..2825
Translation	MELRPWLLWVVAAAGALVLLAAEARGQKIFTNTWAVHISGGPAVADSVARKHGFHNLGQIFGDYYHFWHRAVTKRSLSPHRPRHSRLQRVPQVKWLEQQVAKQRAKRDVYQEPTDPKFPQQWYLSGVTQRDLNVKEAWAQGFTGRGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIEILAEPKDIGKRLEVRKTVTACLGEPNHISRLEHVQARLTLSYNRRGDLAIHLISPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTASEGLSAPPESSGCKTLTSSQACVVCEEGFSLHQKSCVQRCPPGFTPQVLDTHYSTENDVEIIRASVCTPCHASCATCQGPAPTDCLSCPSHASLDPVEQTCSRQSQSSRESRPQQPPPALRPEVEVEPRLRAGLASHLPEVLAGLSCLIIALIFGIVFLFLHRCSGFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEEDEGRGERTAFIKDQSAL

Target ORF information:

RefSeq Version	NM_019331.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus furin (paired basic amino acid cleaving enzyme) (Furin), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019331.1

ORF Insert Sequence:

ATGGAGCTGA GACCCTGGTT GCTATGGGTG GTAGCAGCAG CAGGAGCCTT GGTCCTGCTA 
GCAGCTGAAG CTCGCGGCCA GAAGATCTTC ACCAACACGT GGGCTGTGCA CATTTCTGGA 
GGCCCAGCTG TGGCTGATAG TGTGGCACGG AAGCATGGGT TCCACAACCT GGGCCAGATC 
TTCGGTGACT ATTACCACTT CTGGCACAGA GCAGTGACAA AGCGGTCCCT GTCGCCTCAC 
CGCCCGCGGC ACAGCCGGCT ACAGAGGGTG CCTCAAGTGA AGTGGCTGGA GCAGCAGGTA 
GCCAAGCAAA GGGCCAAGAG GGACGTGTAT CAGGAGCCCA CAGACCCCAA GTTCCCTCAG 
CAGTGGTACC TGTCTGGGGT CACTCAGCGA GACCTGAATG TGAAGGAAGC CTGGGCCCAG 
GGCTTCACAG GGCGTGGCAT TGTGGTCTCC ATCCTGGATG ACGGCATTGA AAAGAACCAT 
CCTGACTTGG CAGGCAATTA TGACCCGGGA GCCAGCTTTG ATGTCAATGA CCAGGACCCT 
GACCCACAGC CTCGGTACAC GCAGATGAAT GACAACAGGC ACGGCACTCG GTGTGCCGGG 
GAAGTGGCAG CGGTGGCCAA CAATGGTGTC TGTGGTGTAG GTGTAGCTTA CAATGCCCGG 
ATTGGAGGGG TGCGTATGTT GGATGGCGAG GTGACTGACG CGGTAGAGGC ACGTTCGCTG 
GGCCTGAATC CCAACCACAT CCACATCTAC AGCGCCAGCT GGGGCCCCGA GGACGACGGC 
AAGACCGTGG ATGGGCCAGC CCGGCTCGCC GAGGAGGCCT TCTTTCGGGG AGTTAGCCAG 
GGCCGCGGAG GGCTGGGCTC CATCTTTGTC TGGGCCTCAG GGAATGGGGG CCGGGAACAT 
GACAGCTGTA ACTGTGACGG CTACACCAAC AGTATCTACA CGCTGTCCAT CAGCAGTGCC 
ACACAATTCG GCAACGTGCC CTGGTACAGT GAGGCCTGCT CCTCCACACT GGCCACCACC 
TACAGCAGTG GCAACCAGAA TGAGAAGCAG ATTGTGACAA CTGACTTGAG GCAGAAGTGC 
ACTGAGTCTC ACACAGGCAC CTCAGCCTCC GCCCCTTTGG CAGCTGGTAT CATTGCTCTC 
ACCCTGGAGG CCAACAAGAA CCTCACCTGG CGGGACATGC AGCACCTGGT GGTGCAGACC 
TCAAAGCCAG CACATCTCAA CGCTAACGAT TGGGCCACCA ATGGCGTGGG CCGGAAAGTG 
AGCCATTCCT ATGGCTACGG GCTGTTGGAT GCAGGTGCCA TGGTGGCCCT GGCCCAGAAC 
TGGACAACAG TGGCCCCCCA GCGGAAGTGC ATCATTGAAA TCCTGGCAGA GCCCAAGGAC 
ATTGGCAAAC GGCTAGAGGT GCGCAAGACC GTGACAGCGT GCCTGGGTGA GCCCAACCAC 
ATCTCCAGAC TGGAACACGT TCAGGCACGG CTCACCCTGT CTTACAATCG CCGTGGTGAC 
CTGGCTATCC ACCTCATCAG CCCCATGGGC ACCCGTTCCA CCCTATTAGC TGCCAGACCA 
CATGACTACT CTGCTGATGG ATTTAATGAC TGGGCTTTCA TGACAACTCA TTCCTGGGAT 
GAGGACCCCT CTGGCGAGTG GGTCCTAGAG ATTGAAAATA CCAGCGAGGC CAACAACTAT 
GGGACGCTGA CCAAGTTCAC TCTCGTCCTA TATGGCACAG CCTCTGAGGG TCTCTCTGCA 
CCTCCAGAGA GCAGCGGCTG CAAGACCCTC ACATCCAGCC AGGCCTGCGT GGTGTGTGAG 
GAAGGTTTCT CACTGCACCA GAAAAGCTGT GTCCAGCGTT GCCCACCAGG CTTCACACCC 
CAAGTCCTTG ATACACACTA CAGCACTGAG AATGATGTGG AGATCATCCG TGCCAGCGTC 
TGCACCCCCT GCCACGCCTC ATGTGCCACT TGCCAGGGCC CAGCTCCCAC AGACTGCCTC 
AGCTGCCCCA GCCATGCCTC CCTGGACCCT GTGGAGCAAA CCTGCTCCCG GCAAAGCCAG 
AGCAGCCGAG AGTCCCGACC TCAGCAGCCA CCTCCCGCAC TGCGCCCAGA GGTGGAAGTG 
GAGCCCCGGT TGCGGGCTGG GCTGGCCTCT CACCTGCCGG AGGTCCTGGC CGGCCTCAGC 
TGCCTTATCA TCGCTCTCAT CTTTGGCATC GTCTTCCTCT TCCTGCATCG GTGTTCAGGC 
TTCAGCTTCC GGGGAGTGAA AGTGTACACC ATGGACCGTG GCCTCATCTC CTACAAGGGG 
CTGCCTCCTG AGGCCTGGCA GGAGGAGTGC CCATCTGACT CAGAAGAGGA TGAGGGCCGG 
GGCGAGAGGA CCGCCTTTAT CAAAGACCAG AGCGCCCTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Furin ( XM_008759556.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008757778.1 Rattus norvegicus furin (paired basic amino acid cleaving enzyme) (Furin), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa43416
Clone ID Related Accession (Same CDS sequence)	XM_008759556.1 , XM_008759555.2
Accession Version	XM_008759556.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2382bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	furin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCTGA GACCCTGGTT GCTATGGGTG GTAGCAGCAG CAGGAGCCTT GGTCCTGCTA 
GCAGCTGAAG CTCGCGGCCA GAAGATCTTC ACCAACACGT GGGCTGTGCA CATTTCTGGA 
GGCCCAGCTG TGGCTGATAG TGTGGCACGG AAGCATGGGT TCCACAACCT GGGCCAGATC 
TTCGGTGACT ATTACCACTT CTGGCACAGA GCAGTGACAA AGCGGTCCCT GTCGCCTCAC 
CGCCCGCGGC ACAGCCGGCT ACAGAGGGAG CCTCAAGTGA AGTGGCTGGA GCAGCAGGTA 
GCCAAGCAAA GGGCCAAGAG GGACGTGTAT CAGGAGCCCA CAGACCCCAA GTTCCCTCAG 
CAGTGGTACC TGTCTGGGGT CACTCAGCGA GACCTGAATG TGAAGGAAGC CTGGGCCCAG 
GGCTTCACAG GGCGTGGCAT TGTGGTCTCC ATCCTGGATG ACGGCATTGA AAAGAACCAT 
CCTGACTTGG CAGGCAATTA TGACCCGGGA GCCAGCTTTG ATGTCAATGA CCAGGACCCT 
GACCCACAGC CTCGGTACAC GCAGATGAAT GACAACAGGC ACGGCACTCG GTGTGCCGGG 
GAAGTGGCAG CGGTGGCCAA CAATGGTGTC TGTGGTGTAG GTGTAGCTTA CAATGCCCGG 
ATTGGAGGGG TGCGTATGTT GGATGGCGAG GTGACTGACG CGGTAGAGGC ACGTTCGCTG 
GGCCTGAATC CCAACCACAT CCACATCTAC AGCGCCAGCT GGGGCCCCGA GGACGACGGC 
AAGACCGTGG ATGGGCCAGC CCGGCTCGCC GAGGAGGCCT TCTTTCGGGG AGTTAGCCAG 
GGCCGCGGAG GGCTGGGCTC CATCTTTGTC TGGGCCTCAG GGAACGGGGG CCGGGAACAT 
GACAGCTGTA ACTGTGACGG CTACACCAAC AGCATCTACA CGCTGTCCAT CAGCAGTGCC 
ACACAATTCG GCAACGTGCC CTGGTACAGT GAGGCCTGCT CCTCCACACT GGCCACCACC 
TACAGCAGTG GCAACCAGAA TGAGAAGCAG ATTGTGACAA CTGACCTGAG GCAGAAGTGC 
ACTGAGTCTC ACACAGGCAC CTCAGCCTCC GCCCCTTTGG CAGCTGGTAT CATTGCTCTC 
ACCCTGGAGG CCAACAAGAA CCTCACCTGG CGGGACATGC AGCACCTGGT GGTGCAGACC 
TCAAAGCCAG CACATCTCAA CGCTAACGAT TGGGCCACCA ATGGCGTGGG CCGGAAAGTG 
AGCCATTCCT ATGGCTACGG GCTGTTGGAT GCAGGTGCCA TGGTGGCCCT GGCCCAGAAC 
TGGACAACAG TGGCCCCCCA GCGGAAGTGC ATCATTGAAA TCCTGGCAGA GCCCAAGGAC 
ATTGGCAAAC GGCTAGAGGT GCGCAAGACC GTGACAGCGT GCCTGGGTGA GCCCAACCAC 
ATCTCCAGAC TGGAACACGT TCAGGCACGG CTCACCCTGT CTTACAATCG CCGTGGTGAC 
CTGGCTATCC ACCTCATCAG CCCCATGGGC ACCCGTTCCA CCCTATTAGC TGCCAGACCA 
CATGACTACT CTGCTGATGG ATTTAATGAC TGGGCTTTCA TGACAACTCA TTCCTGGGAT 
GAGGACCCCT CTGGCGAGTG GGTCCTAGAG ATTGAAAATA CCAGCGAGGC CAACAACTAT 
GGGACGCTGA CCAAGTTCAC TCTCGTCCTA TATGGCACAG CCTCTGAGGG TCTCTCTGCA 
CCTCCAGAGA GCAGCGGCTG CAAGACCCTC ACATCCAGCC AGGCCTGCGT GGTGTGTGAG 
GAAGGTTTCT CACTGCACCA GAAAAGCTGT GTCCAGCGTT GCCCACCAGG CTTCACACCC 
CAAGTCCTTG ATACACACTA CAGCACTGAG AATGATGTGG AGATCATCCG TGCCAGTGTC 
TGCACCCCCT GCCACGCCTC ATGTGCCACT TGCCAGGGCC CAGCTCCCAC AGACTGCCTC 
AGCTGCCCCA GCCATGCCTC CCTGGACCCT GTGGAGCAAA CCTGCTCCCG GCAAAGCCAG 
AGCAGCCGAG AGTCCCGACC TCAGCAGCCA CCTCCCGCAC TGCGCCCAGA GGTGGAAGTG 
GAGCCCCGGT TGCGGGCTGG GCTGGCCTCT CACCTGCCGG AGGTCCTGGC CGGCCTCAGC 
TGCCTTATCA TCGCTCTCAT CTTTGGCATC GTCTTCCTCT TCCTGCATCG GTGTTCAGGC 
TTCAGCTTCC GGGGAGTGAA AGTGTACACC ATGGACCGTG GCCTCATCTC CTACAAGGGG 
CTGCCTCCTG AGGCCTGGCA GGAGGAGTGC CCATCTGACT CAGAAGAGGA TGAGGGCCGG 
GGCGAGAGGA CCGCCTTTAT CAAAGACCAG AGCGCCCTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008757778.1
CDS	375..2756
Translation	MELRPWLLWVVAAAGALVLLAAEARGQKIFTNTWAVHISGGPAVADSVARKHGFHNLGQIFGDYYHFWHRAVTKRSLSPHRPRHSRLQREPQVKWLEQQVAKQRAKRDVYQEPTDPKFPQQWYLSGVTQRDLNVKEAWAQGFTGRGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIEILAEPKDIGKRLEVRKTVTACLGEPNHISRLEHVQARLTLSYNRRGDLAIHLISPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTASEGLSAPPESSGCKTLTSSQACVVCEEGFSLHQKSCVQRCPPGFTPQVLDTHYSTENDVEIIRASVCTPCHASCATCQGPAPTDCLSCPSHASLDPVEQTCSRQSQSSRESRPQQPPPALRPEVEVEPRLRAGLASHLPEVLAGLSCLIIALIFGIVFLFLHRCSGFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEEDEGRGERTAFIKDQSAL

Target ORF information:

RefSeq Version	XM_008759556.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus furin (paired basic amino acid cleaving enzyme) (Furin), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008759556.1

ORF Insert Sequence:

ATGGAGCTGA GACCCTGGTT GCTATGGGTG GTAGCAGCAG CAGGAGCCTT GGTCCTGCTA 
GCAGCTGAAG CTCGCGGCCA GAAGATCTTC ACCAACACGT GGGCTGTGCA CATTTCTGGA 
GGCCCAGCTG TGGCTGATAG TGTGGCACGG AAGCATGGGT TCCACAACCT GGGCCAGATC 
TTCGGTGACT ATTACCACTT CTGGCACAGA GCAGTGACAA AGCGGTCCCT GTCGCCTCAC 
CGCCCGCGGC ACAGCCGGCT ACAGAGGGAG CCTCAAGTGA AGTGGCTGGA GCAGCAGGTA 
GCCAAGCAAA GGGCCAAGAG GGACGTGTAT CAGGAGCCCA CAGACCCCAA GTTCCCTCAG 
CAGTGGTACC TGTCTGGGGT CACTCAGCGA GACCTGAATG TGAAGGAAGC CTGGGCCCAG 
GGCTTCACAG GGCGTGGCAT TGTGGTCTCC ATCCTGGATG ACGGCATTGA AAAGAACCAT 
CCTGACTTGG CAGGCAATTA TGACCCGGGA GCCAGCTTTG ATGTCAATGA CCAGGACCCT 
GACCCACAGC CTCGGTACAC GCAGATGAAT GACAACAGGC ACGGCACTCG GTGTGCCGGG 
GAAGTGGCAG CGGTGGCCAA CAATGGTGTC TGTGGTGTAG GTGTAGCTTA CAATGCCCGG 
ATTGGAGGGG TGCGTATGTT GGATGGCGAG GTGACTGACG CGGTAGAGGC ACGTTCGCTG 
GGCCTGAATC CCAACCACAT CCACATCTAC AGCGCCAGCT GGGGCCCCGA GGACGACGGC 
AAGACCGTGG ATGGGCCAGC CCGGCTCGCC GAGGAGGCCT TCTTTCGGGG AGTTAGCCAG 
GGCCGCGGAG GGCTGGGCTC CATCTTTGTC TGGGCCTCAG GGAACGGGGG CCGGGAACAT 
GACAGCTGTA ACTGTGACGG CTACACCAAC AGCATCTACA CGCTGTCCAT CAGCAGTGCC 
ACACAATTCG GCAACGTGCC CTGGTACAGT GAGGCCTGCT CCTCCACACT GGCCACCACC 
TACAGCAGTG GCAACCAGAA TGAGAAGCAG ATTGTGACAA CTGACCTGAG GCAGAAGTGC 
ACTGAGTCTC ACACAGGCAC CTCAGCCTCC GCCCCTTTGG CAGCTGGTAT CATTGCTCTC 
ACCCTGGAGG CCAACAAGAA CCTCACCTGG CGGGACATGC AGCACCTGGT GGTGCAGACC 
TCAAAGCCAG CACATCTCAA CGCTAACGAT TGGGCCACCA ATGGCGTGGG CCGGAAAGTG 
AGCCATTCCT ATGGCTACGG GCTGTTGGAT GCAGGTGCCA TGGTGGCCCT GGCCCAGAAC 
TGGACAACAG TGGCCCCCCA GCGGAAGTGC ATCATTGAAA TCCTGGCAGA GCCCAAGGAC 
ATTGGCAAAC GGCTAGAGGT GCGCAAGACC GTGACAGCGT GCCTGGGTGA GCCCAACCAC 
ATCTCCAGAC TGGAACACGT TCAGGCACGG CTCACCCTGT CTTACAATCG CCGTGGTGAC 
CTGGCTATCC ACCTCATCAG CCCCATGGGC ACCCGTTCCA CCCTATTAGC TGCCAGACCA 
CATGACTACT CTGCTGATGG ATTTAATGAC TGGGCTTTCA TGACAACTCA TTCCTGGGAT 
GAGGACCCCT CTGGCGAGTG GGTCCTAGAG ATTGAAAATA CCAGCGAGGC CAACAACTAT 
GGGACGCTGA CCAAGTTCAC TCTCGTCCTA TATGGCACAG CCTCTGAGGG TCTCTCTGCA 
CCTCCAGAGA GCAGCGGCTG CAAGACCCTC ACATCCAGCC AGGCCTGCGT GGTGTGTGAG 
GAAGGTTTCT CACTGCACCA GAAAAGCTGT GTCCAGCGTT GCCCACCAGG CTTCACACCC 
CAAGTCCTTG ATACACACTA CAGCACTGAG AATGATGTGG AGATCATCCG TGCCAGTGTC 
TGCACCCCCT GCCACGCCTC ATGTGCCACT TGCCAGGGCC CAGCTCCCAC AGACTGCCTC 
AGCTGCCCCA GCCATGCCTC CCTGGACCCT GTGGAGCAAA CCTGCTCCCG GCAAAGCCAG 
AGCAGCCGAG AGTCCCGACC TCAGCAGCCA CCTCCCGCAC TGCGCCCAGA GGTGGAAGTG 
GAGCCCCGGT TGCGGGCTGG GCTGGCCTCT CACCTGCCGG AGGTCCTGGC CGGCCTCAGC 
TGCCTTATCA TCGCTCTCAT CTTTGGCATC GTCTTCCTCT TCCTGCATCG GTGTTCAGGC 
TTCAGCTTCC GGGGAGTGAA AGTGTACACC ATGGACCGTG GCCTCATCTC CTACAAGGGG 
CTGCCTCCTG AGGCCTGGCA GGAGGAGTGC CCATCTGACT CAGAAGAGGA TGAGGGCCGG 
GGCGAGAGGA CCGCCTTTAT CAAAGACCAG AGCGCCCTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Furin ( XM_008759555.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008757777.1 Rattus norvegicus furin (paired basic amino acid cleaving enzyme) (Furin), transcript variant X1, mRNA.

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CloneID	ORa43416
Clone ID Related Accession (Same CDS sequence)	XM_008759556.1 , XM_008759555.2
Accession Version	XM_008759555.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2382bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	furin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008759555.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCTGA GACCCTGGTT GCTATGGGTG GTAGCAGCAG CAGGAGCCTT GGTCCTGCTA 
GCAGCTGAAG CTCGCGGCCA GAAGATCTTC ACCAACACGT GGGCTGTGCA CATTTCTGGA 
GGCCCAGCTG TGGCTGATAG TGTGGCACGG AAGCATGGGT TCCACAACCT GGGCCAGATC 
TTCGGTGACT ATTACCACTT CTGGCACAGA GCAGTGACAA AGCGGTCCCT GTCGCCTCAC 
CGCCCGCGGC ACAGCCGGCT ACAGAGGGAG CCTCAAGTGA AGTGGCTGGA GCAGCAGGTA 
GCCAAGCAAA GGGCCAAGAG GGACGTGTAT CAGGAGCCCA CAGACCCCAA GTTCCCTCAG 
CAGTGGTACC TGTCTGGGGT CACTCAGCGA GACCTGAATG TGAAGGAAGC CTGGGCCCAG 
GGCTTCACAG GGCGTGGCAT TGTGGTCTCC ATCCTGGATG ACGGCATTGA AAAGAACCAT 
CCTGACTTGG CAGGCAATTA TGACCCGGGA GCCAGCTTTG ATGTCAATGA CCAGGACCCT 
GACCCACAGC CTCGGTACAC GCAGATGAAT GACAACAGGC ACGGCACTCG GTGTGCCGGG 
GAAGTGGCAG CGGTGGCCAA CAATGGTGTC TGTGGTGTAG GTGTAGCTTA CAATGCCCGG 
ATTGGAGGGG TGCGTATGTT GGATGGCGAG GTGACTGACG CGGTAGAGGC ACGTTCGCTG 
GGCCTGAATC CCAACCACAT CCACATCTAC AGCGCCAGCT GGGGCCCCGA GGACGACGGC 
AAGACCGTGG ATGGGCCAGC CCGGCTCGCC GAGGAGGCCT TCTTTCGGGG AGTTAGCCAG 
GGCCGCGGAG GGCTGGGCTC CATCTTTGTC TGGGCCTCAG GGAACGGGGG CCGGGAACAT 
GACAGCTGTA ACTGTGACGG CTACACCAAC AGCATCTACA CGCTGTCCAT CAGCAGTGCC 
ACACAATTCG GCAACGTGCC CTGGTACAGT GAGGCCTGCT CCTCCACACT GGCCACCACC 
TACAGCAGTG GCAACCAGAA TGAGAAGCAG ATTGTGACAA CTGACCTGAG GCAGAAGTGC 
ACTGAGTCTC ACACAGGCAC CTCAGCCTCC GCCCCTTTGG CAGCTGGTAT CATTGCTCTC 
ACCCTGGAGG CCAACAAGAA CCTCACCTGG CGGGACATGC AGCACCTGGT GGTGCAGACC 
TCAAAGCCAG CACATCTCAA CGCTAACGAT TGGGCCACCA ATGGCGTGGG CCGGAAAGTG 
AGCCATTCCT ATGGCTACGG GCTGTTGGAT GCAGGTGCCA TGGTGGCCCT GGCCCAGAAC 
TGGACAACAG TGGCCCCCCA GCGGAAGTGC ATCATTGAAA TCCTGGCAGA GCCCAAGGAC 
ATTGGCAAAC GGCTAGAGGT GCGCAAGACC GTGACAGCGT GCCTGGGTGA GCCCAACCAC 
ATCTCCAGAC TGGAACACGT TCAGGCACGG CTCACCCTGT CTTACAATCG CCGTGGTGAC 
CTGGCTATCC ACCTCATCAG CCCCATGGGC ACCCGTTCCA CCCTATTAGC TGCCAGACCA 
CATGACTACT CTGCTGATGG ATTTAATGAC TGGGCTTTCA TGACAACTCA TTCCTGGGAT 
GAGGACCCCT CTGGCGAGTG GGTCCTAGAG ATTGAAAATA CCAGCGAGGC CAACAACTAT 
GGGACGCTGA CCAAGTTCAC TCTCGTCCTA TATGGCACAG CCTCTGAGGG TCTCTCTGCA 
CCTCCAGAGA GCAGCGGCTG CAAGACCCTC ACATCCAGCC AGGCCTGCGT GGTGTGTGAG 
GAAGGTTTCT CACTGCACCA GAAAAGCTGT GTCCAGCGTT GCCCACCAGG CTTCACACCC 
CAAGTCCTTG ATACACACTA CAGCACTGAG AATGATGTGG AGATCATCCG TGCCAGTGTC 
TGCACCCCCT GCCACGCCTC ATGTGCCACT TGCCAGGGCC CAGCTCCCAC AGACTGCCTC 
AGCTGCCCCA GCCATGCCTC CCTGGACCCT GTGGAGCAAA CCTGCTCCCG GCAAAGCCAG 
AGCAGCCGAG AGTCCCGACC TCAGCAGCCA CCTCCCGCAC TGCGCCCAGA GGTGGAAGTG 
GAGCCCCGGT TGCGGGCTGG GCTGGCCTCT CACCTGCCGG AGGTCCTGGC CGGCCTCAGC 
TGCCTTATCA TCGCTCTCAT CTTTGGCATC GTCTTCCTCT TCCTGCATCG GTGTTCAGGC 
TTCAGCTTCC GGGGAGTGAA AGTGTACACC ATGGACCGTG GCCTCATCTC CTACAAGGGG 
CTGCCTCCTG AGGCCTGGCA GGAGGAGTGC CCATCTGACT CAGAAGAGGA TGAGGGCCGG 
GGCGAGAGGA CCGCCTTTAT CAAAGACCAG AGCGCCCTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008757777.1
CDS	329..2710
Translation	MELRPWLLWVVAAAGALVLLAAEARGQKIFTNTWAVHISGGPAVADSVARKHGFHNLGQIFGDYYHFWHRAVTKRSLSPHRPRHSRLQREPQVKWLEQQVAKQRAKRDVYQEPTDPKFPQQWYLSGVTQRDLNVKEAWAQGFTGRGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIEILAEPKDIGKRLEVRKTVTACLGEPNHISRLEHVQARLTLSYNRRGDLAIHLISPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTASEGLSAPPESSGCKTLTSSQACVVCEEGFSLHQKSCVQRCPPGFTPQVLDTHYSTENDVEIIRASVCTPCHASCATCQGPAPTDCLSCPSHASLDPVEQTCSRQSQSSRESRPQQPPPALRPEVEVEPRLRAGLASHLPEVLAGLSCLIIALIFGIVFLFLHRCSGFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEEDEGRGERTAFIKDQSAL

Target ORF information:

RefSeq Version	XM_008759555.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus furin (paired basic amino acid cleaving enzyme) (Furin), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008759555.2

ORF Insert Sequence:

ATGGAGCTGA GACCCTGGTT GCTATGGGTG GTAGCAGCAG CAGGAGCCTT GGTCCTGCTA 
GCAGCTGAAG CTCGCGGCCA GAAGATCTTC ACCAACACGT GGGCTGTGCA CATTTCTGGA 
GGCCCAGCTG TGGCTGATAG TGTGGCACGG AAGCATGGGT TCCACAACCT GGGCCAGATC 
TTCGGTGACT ATTACCACTT CTGGCACAGA GCAGTGACAA AGCGGTCCCT GTCGCCTCAC 
CGCCCGCGGC ACAGCCGGCT ACAGAGGGAG CCTCAAGTGA AGTGGCTGGA GCAGCAGGTA 
GCCAAGCAAA GGGCCAAGAG GGACGTGTAT CAGGAGCCCA CAGACCCCAA GTTCCCTCAG 
CAGTGGTACC TGTCTGGGGT CACTCAGCGA GACCTGAATG TGAAGGAAGC CTGGGCCCAG 
GGCTTCACAG GGCGTGGCAT TGTGGTCTCC ATCCTGGATG ACGGCATTGA AAAGAACCAT 
CCTGACTTGG CAGGCAATTA TGACCCGGGA GCCAGCTTTG ATGTCAATGA CCAGGACCCT 
GACCCACAGC CTCGGTACAC GCAGATGAAT GACAACAGGC ACGGCACTCG GTGTGCCGGG 
GAAGTGGCAG CGGTGGCCAA CAATGGTGTC TGTGGTGTAG GTGTAGCTTA CAATGCCCGG 
ATTGGAGGGG TGCGTATGTT GGATGGCGAG GTGACTGACG CGGTAGAGGC ACGTTCGCTG 
GGCCTGAATC CCAACCACAT CCACATCTAC AGCGCCAGCT GGGGCCCCGA GGACGACGGC 
AAGACCGTGG ATGGGCCAGC CCGGCTCGCC GAGGAGGCCT TCTTTCGGGG AGTTAGCCAG 
GGCCGCGGAG GGCTGGGCTC CATCTTTGTC TGGGCCTCAG GGAACGGGGG CCGGGAACAT 
GACAGCTGTA ACTGTGACGG CTACACCAAC AGCATCTACA CGCTGTCCAT CAGCAGTGCC 
ACACAATTCG GCAACGTGCC CTGGTACAGT GAGGCCTGCT CCTCCACACT GGCCACCACC 
TACAGCAGTG GCAACCAGAA TGAGAAGCAG ATTGTGACAA CTGACCTGAG GCAGAAGTGC 
ACTGAGTCTC ACACAGGCAC CTCAGCCTCC GCCCCTTTGG CAGCTGGTAT CATTGCTCTC 
ACCCTGGAGG CCAACAAGAA CCTCACCTGG CGGGACATGC AGCACCTGGT GGTGCAGACC 
TCAAAGCCAG CACATCTCAA CGCTAACGAT TGGGCCACCA ATGGCGTGGG CCGGAAAGTG 
AGCCATTCCT ATGGCTACGG GCTGTTGGAT GCAGGTGCCA TGGTGGCCCT GGCCCAGAAC 
TGGACAACAG TGGCCCCCCA GCGGAAGTGC ATCATTGAAA TCCTGGCAGA GCCCAAGGAC 
ATTGGCAAAC GGCTAGAGGT GCGCAAGACC GTGACAGCGT GCCTGGGTGA GCCCAACCAC 
ATCTCCAGAC TGGAACACGT TCAGGCACGG CTCACCCTGT CTTACAATCG CCGTGGTGAC 
CTGGCTATCC ACCTCATCAG CCCCATGGGC ACCCGTTCCA CCCTATTAGC TGCCAGACCA 
CATGACTACT CTGCTGATGG ATTTAATGAC TGGGCTTTCA TGACAACTCA TTCCTGGGAT 
GAGGACCCCT CTGGCGAGTG GGTCCTAGAG ATTGAAAATA CCAGCGAGGC CAACAACTAT 
GGGACGCTGA CCAAGTTCAC TCTCGTCCTA TATGGCACAG CCTCTGAGGG TCTCTCTGCA 
CCTCCAGAGA GCAGCGGCTG CAAGACCCTC ACATCCAGCC AGGCCTGCGT GGTGTGTGAG 
GAAGGTTTCT CACTGCACCA GAAAAGCTGT GTCCAGCGTT GCCCACCAGG CTTCACACCC 
CAAGTCCTTG ATACACACTA CAGCACTGAG AATGATGTGG AGATCATCCG TGCCAGTGTC 
TGCACCCCCT GCCACGCCTC ATGTGCCACT TGCCAGGGCC CAGCTCCCAC AGACTGCCTC 
AGCTGCCCCA GCCATGCCTC CCTGGACCCT GTGGAGCAAA CCTGCTCCCG GCAAAGCCAG 
AGCAGCCGAG AGTCCCGACC TCAGCAGCCA CCTCCCGCAC TGCGCCCAGA GGTGGAAGTG 
GAGCCCCGGT TGCGGGCTGG GCTGGCCTCT CACCTGCCGG AGGTCCTGGC CGGCCTCAGC 
TGCCTTATCA TCGCTCTCAT CTTTGGCATC GTCTTCCTCT TCCTGCATCG GTGTTCAGGC 
TTCAGCTTCC GGGGAGTGAA AGTGTACACC ATGGACCGTG GCCTCATCTC CTACAAGGGG 
CTGCCTCCTG AGGCCTGGCA GGAGGAGTGC CCATCTGACT CAGAAGAGGA TGAGGGCCGG 
GGCGAGAGGA CCGCCTTTAT CAAAGACCAG AGCGCCCTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes.
The Journal of biological chemistry288(37)26410-8(2013 Sep)
Essalmani R,Susan-Resiga D,Chamberland A,Asselin MC,Canuel M,Constam D,Creemers JW,Day R,Gauthier D,Prat A,Seidah NG

Proprotein convertases play an important role in regulating PKGI endoproteolytic cleavage and nuclear transport.
American journal of physiology. Lung cellular and molecular physiology305(2)L130-40(2013 Jul)
Kato S,Zhang R,Roberts JD Jr

Proprotein convertase furin regulates apoptosis and proliferation of granulosa cells in the rat ovary.
PloS one8(2)e50479(2013)
Yang X,Wang Q,Gao Z,Zhou Z,Peng S,Chang WL,Lin HY,Zhang W,Wang H

In vivo evidence that furin from hepatocytes inactivates PCSK9.
The Journal of biological chemistry286(6)4257-63(2011 Feb)
Essalmani R,Susan-Resiga D,Chamberland A,Abifadel M,Creemers JW,Boileau C,Seidah NG,Prat A

E-selectin ligand-1 regulates growth plate homeostasis in mice by inhibiting the intracellular processing and secretion of mature TGF-beta.
The Journal of clinical investigation120(7)2474-85(2010 Jul)
Yang T,Mendoza-Londono R,Lu H,Tao J,Li K,Keller B,Jiang MM,Shah R,Chen Y,Bertin TK,Engin F,Dabovic B,Rifkin DB,Hicks J,Jamrich M,Beaudet AL,Lee B

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Furin cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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