furinb cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	furinb
Entrez Gene ID	566591
Full Name	furin (paired basic amino acid cleaving enzyme) b
General protein information	Preferred Names furin (paired basic amino acid cleaving enzyme) b Names furin
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001045109.2	NP_001038574.2	furin precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	FURIN	XP_510596.2
Rattus norvegicus (Norway rat)	Furin	NP_062204.1
Caenorhabditis elegans (roundworm)	kpc-1	NP_492974.2
Mus musculus (house mouse)	Furin	NP_001074923.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001330	XP_321814.4
Homo sapiens (human)	FURIN	NP_002560.1
Canis lupus familiaris (dog)	FURIN	XP_850069.2
Bos taurus (cattle)	FURIN	NP_776561.1
Danio rerio (zebrafish)	furinb	NP_001038574.2
Xenopus tropicalis (tropical clawed frog)	furin	XP_004912697.1
	FURIN	XP_001094068.1
Gallus gallus (chicken)	FURIN	NP_990046.1
Danio rerio (zebrafish)	furina	NP_001038571.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I, Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y, Bobe J
BMC genomics17368(2016 05)

RFX transcription factors are essential for hearing in mice.
Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M, Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD, Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W, Hertzano R
Nature communications68549(2015 Oct)

The proprotein convertase subtilisin/kexin furinA regulates zebrafish host response against Mycobacterium marinum.
Ojanen MJ, Turpeinen H, Cordova ZM, Hammar?n MM, Harjula SK, Parikka M, R?met M, Pesu M
Infection and immunity83(4)1431-42(2015 Apr)

Proprotein convertase subtilisin/kexin type 7 (PCSK7) is essential for the zebrafish development and bioavailability of transforming growth factor ?1a (TGF?1a).
Turpeinen H, Oksanen A, Kivinen V, Kukkurainen S, Uusim?ki A, R?met M, Parikka M, Hyt?nen VP, Nykter M, Pesu M
The Journal of biological chemistry288(51)36610-23(2013 Dec)

Hepatocyte growth factor signaling in intrapancreatic ductal cells drives pancreatic morphogenesis.
Anderson RM, Delous M, Bosch JA, Ye L, Robertson MA, Hesselson D, Stainier DY
PLoS genetics9(7)e1003650(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

furin genes may function partially redundantly to activate Endothelin1 signaling in craniofacial patterning
Title: Zebrafish furin mutants reveal intricacies in regulating Endothelin1 signaling in craniofacial patterning.

The following furinb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the furinb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa00994	NM_001045109.2 Latest version!	Danio rerio furin (paired basic amino acid cleaving enzyme) b (furinb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$426.30 $609.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

furinb ( NM_001045109.2 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_001038574.2 Danio rerio furin (paired basic amino acid cleaving enzyme) b (furinb), mRNA.

Price & Availability↑

CloneID	ODa00994
Clone ID Related Accession (Same CDS sequence)	NM_001045109.2
Accession Version	NM_001045109.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2472bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-11-23
Organism	Danio rerio(zebrafish)
Product	furin precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL935203.12 and CR407564.8. On or before Mar 14, 2010 this sequence version replaced NM_001172171.1, NM_001045109.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: DQ499477.1, GDQH01002392.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2168446, SAMEA2168447 [ECO:0000350] ##Evidence-Data-END##

ATGGAGGGCC GCTTGATCCT GCTGTTATTT CTGGGGGCGT ACCTGGTCCT CCTGGCTGCT 
GAGGTGCACT TGATTACAGG CCAAGGCATC TACATCAACA CGTGGGCCGT CCATATTGAA 
GGGGGGGTCG AGGAGGCTGA AAGGATTGCA CAAAAGCATG GTTTCGTCAG TCACGGGCAG 
GTTTTCGGGG ATTTCTATCA TTTCCAGCAC AGAGGTGTGG TGAGGAGATC TTTGTCCAGC 
CATAGAGGGG TTCATGTCCG ACTGCACACC GAGCCACAGG TGCTTTGGGC AGAGCAGCAG 
ATTGCCAAGC GGAGACGCAA GAGAGACATT CACATGGAAC CCACAGATCC CAAATTCCCC 
CAGCAGTGGT ACCTGTACAA TCCCAGCCAT GGAGACCTGA ATGTGAAGGA GGCTTGGGCT 
CAAGGGTTCA CTGGGCGAGG AGTGGTCGTG ACCATTCTAG ATGACGGCAT TGAGAAGGAC 
CACCCTGATC TGGCCAAAAA CTATGATCCT GACGCCAGTT ATGATGTGAA TGACAGAGAT 
CCAGACCCTC AGCCCAGATA CACACAGCTG AATGACAACA GACATGGCAC ACGTTGTGCC 
GGCGAGGTGG CAGCAGCAGC GAACAATGGC GTCTGCGGAG TGGGTGTGGC TTACAATGCC 
AAAATTGGAG GTGTGCGCAT GTTGGATGGA GAGGTAACAG ATGTTGTGGA GGCTCAGTCT 
CTAAGCTTGA ACTCCCAGCA CATCCACATT TACAGCGCCA GCTGGGGCCC AGAGGATGAT 
GGGAAGACAG TGGACGGCCC TGCCAAACTG GCCAAAGAAG CTTTCCTGCA GGGAGTCACA 
GAGGGTCGAT CTGGGCTTGG ATCCATCTTC GTTTGGGCAT CGGGTAATGG AGGGCGAGAG 
CGGGACAGCT GCAACTGTGA TGGATACACC AACAGCATCT ACACGCTCTC CATCAGCAGC 
ACCACACAGT ACGGCAGCGT GCCATGGTAC AGCGAGGCCT GTTCCTCCAC TCTCGCCACC 
ACCTACAGCA GCGGAAACCT CAACGAGAAA CAGATCGTAA CAACAGACCT GAGGAAGAAG 
TGCACAGATT CGCACACGGG CACGTCGGCA TCGGCTCCCC TGGCCGCCGG AATCATCGCT 
CTCGCTCTGG AGGCCAACAT GAACCTGACC TGGAGAGACA TGCAGCATCT CGTGGTGAGA 
ACCTCACGTC CCGCCCACCT AATAACAAAC GACTGGAGGA CCAATGGTGT GGGCCGATTA 
GTGAGCCATT CTTACGGCTA CGGTCTGCTG GATGCTACTG CAATGGTCGC TTTGGCCCAG 
AACTGGACCA GCATGGGGCC GCAGCACAAA TGTGTCATTA ATATGCTGAC TGAGCCCAGG 
GACATAAAGA ATCACCTGAC ATTCAGCAGA AGTGTGGAGG CCTGTTCGGG TCAGCCGGAT 
TTTGTGAGCT CTTTGGAGCA CGTGCAGGCC AGACTCACGC TCTCCTATAA CCACAGAGGA 
AACCTGGCTG TTCACCTCAT CAGCCCGCTG GGGACTCGTT CCACATTGCT GGCTCCACGG 
CCACAGGATA ACTCAGCCGA AGGATTCAAC GACTGGGCGT TCATGACCAC TCATTCCTGG 
GATGAGGACC CTCGTGGAGA ATGGACCCTG GAGATTGAGA ACGTGGCTGG ACTTAATGAC 
TACGGCGTTC TTTCTCAGTT CACTCTCATC TTATACGGCA CTGGCTCTAG TGCCACAGAT 
CCGTCCGTTT CTGACTACAC CAGACCTTCA AACAACAGCT GCAAGACCTT CGACACACAG 
CAGATCTGCA TTGAATGCAG CACGGGTTTC TCTCTTTTCC TGCAAGGCTG TGTGAAGTCC 
TGTCCTCCGG GCTTCATCTC TGGGCCGCAG GTGCTCAACT TGTCGTTGGA CAACTGGGTG 
GAGCACTCGA CTGTACAGGC GTGCCTGCCC TGCCACCCGG CCTGCCTGAC GTGCTCCGGC 
TCCGGAGAGA ACGAGTGTCT GTCCTGCCCC CCACACAGTC ACTTAGTGGC CACTTCTTGC 
TTGCACCAGA ACCAGGTGCA GAGAAAATCC CCCAGCATTC CCGTGATCCA GCACGAGGCG 
GATTCCAGCT CGGAGGAATC ATTGCGTGAT CCCGGGCTTT CCTCCAGATT GCCGGCGCTG 
GTGGCGGTGC TCAGCTGTGC CTTCATCCTG GCCACTTTTG CAGCCGTTTT TGTGCTGCTT 
CAGCTGCACT CCGGTGCAGC CAGCGCCCCC TTCTGTCGGA GGACCAAACT GCCAGTGATC 
GACACAGGCC GAGGGGGGAT TCGAGTGGGT TTTGGGTTTG GACTCAACCG GGGGAAAGTG 
TCGTATCGGG GGATTCCCAC TGTGTGGGGG GATGAGGATG CGGCGGGAGG GATGAACTCT 
GAGTCGGACA GCGAAGAGCT GGAATTTCAC AGCGAAAAAA CTGCTTTTAT ACGAACTCAG 
AGTGTTCTTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001038574.2
CDS	549..3020
Translation	MEGRLILLLFLGAYLVLLAAEVHLITGQGIYINTWAVHIEGGVEEAERIAQKHGFVSHGQVFGDFYHFQHRGVVRRSLSSHRGVHVRLHTEPQVLWAEQQIAKRRRKRDIHMEPTDPKFPQQWYLYNPSHGDLNVKEAWAQGFTGRGVVVTILDDGIEKDHPDLAKNYDPDASYDVNDRDPDPQPRYTQLNDNRHGTRCAGEVAAAANNGVCGVGVAYNAKIGGVRMLDGEVTDVVEAQSLSLNSQHIHIYSASWGPEDDGKTVDGPAKLAKEAFLQGVTEGRSGLGSIFVWASGNGGRERDSCNCDGYTNSIYTLSISSTTQYGSVPWYSEACSSTLATTYSSGNLNEKQIVTTDLRKKCTDSHTGTSASAPLAAGIIALALEANMNLTWRDMQHLVVRTSRPAHLITNDWRTNGVGRLVSHSYGYGLLDATAMVALAQNWTSMGPQHKCVINMLTEPRDIKNHLTFSRSVEACSGQPDFVSSLEHVQARLTLSYNHRGNLAVHLISPLGTRSTLLAPRPQDNSAEGFNDWAFMTTHSWDEDPRGEWTLEIENVAGLNDYGVLSQFTLILYGTGSSATDPSVSDYTRPSNNSCKTFDTQQICIECSTGFSLFLQGCVKSCPPGFISGPQVLNLSLDNWVEHSTVQACLPCHPACLTCSGSGENECLSCPPHSHLVATSCLHQNQVQRKSPSIPVIQHEADSSSEESLRDPGLSSRLPALVAVLSCAFILATFAAVFVLLQLHSGAASAPFCRRTKLPVIDTGRGGIRVGFGFGLNRGKVSYRGIPTVWGDEDAAGGMNSESDSEELEFHSEKTAFIRTQSVL

Target ORF information:

RefSeq Version	NM_001045109.2
Organism	Danio rerio(zebrafish)
Definition	Danio rerio furin (paired basic amino acid cleaving enzyme) b (furinb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001045109.2

ORF Insert Sequence:

ATGGAGGGCC GCTTGATCCT GCTGTTATTT CTGGGGGCGT ACCTGGTCCT CCTGGCTGCT 
GAGGTGCACT TGATTACAGG CCAAGGCATC TACATCAACA CGTGGGCCGT CCATATTGAA 
GGGGGGGTCG AGGAGGCTGA AAGGATTGCA CAAAAGCATG GTTTCGTCAG TCACGGGCAG 
GTTTTCGGGG ATTTCTATCA TTTCCAGCAC AGAGGTGTGG TGAGGAGATC TTTGTCCAGC 
CATAGAGGGG TTCATGTCCG ACTGCACACC GAGCCACAGG TGCTTTGGGC AGAGCAGCAG 
ATTGCCAAGC GGAGACGCAA GAGAGACATT CACATGGAAC CCACAGATCC CAAATTCCCC 
CAGCAGTGGT ACCTGTACAA TCCCAGCCAT GGAGACCTGA ATGTGAAGGA GGCTTGGGCT 
CAAGGGTTCA CTGGGCGAGG AGTGGTCGTG ACCATTCTAG ATGACGGCAT TGAGAAGGAC 
CACCCTGATC TGGCCAAAAA CTATGATCCT GACGCCAGTT ATGATGTGAA TGACAGAGAT 
CCAGACCCTC AGCCCAGATA CACACAGCTG AATGACAACA GACATGGCAC ACGTTGTGCC 
GGCGAGGTGG CAGCAGCAGC GAACAATGGC GTCTGCGGAG TGGGTGTGGC TTACAATGCC 
AAAATTGGAG GTGTGCGCAT GTTGGATGGA GAGGTAACAG ATGTTGTGGA GGCTCAGTCT 
CTAAGCTTGA ACTCCCAGCA CATCCACATT TACAGCGCCA GCTGGGGCCC AGAGGATGAT 
GGGAAGACAG TGGACGGCCC TGCCAAACTG GCCAAAGAAG CTTTCCTGCA GGGAGTCACA 
GAGGGTCGAT CTGGGCTTGG ATCCATCTTC GTTTGGGCAT CGGGTAATGG AGGGCGAGAG 
CGGGACAGCT GCAACTGTGA TGGATACACC AACAGCATCT ACACGCTCTC CATCAGCAGC 
ACCACACAGT ACGGCAGCGT GCCATGGTAC AGCGAGGCCT GTTCCTCCAC TCTCGCCACC 
ACCTACAGCA GCGGAAACCT CAACGAGAAA CAGATCGTAA CAACAGACCT GAGGAAGAAG 
TGCACAGATT CGCACACGGG CACGTCGGCA TCGGCTCCCC TGGCCGCCGG AATCATCGCT 
CTCGCTCTGG AGGCCAACAT GAACCTGACC TGGAGAGACA TGCAGCATCT CGTGGTGAGA 
ACCTCACGTC CCGCCCACCT AATAACAAAC GACTGGAGGA CCAATGGTGT GGGCCGATTA 
GTGAGCCATT CTTACGGCTA CGGTCTGCTG GATGCTACTG CAATGGTCGC TTTGGCCCAG 
AACTGGACCA GCATGGGGCC GCAGCACAAA TGTGTCATTA ATATGCTGAC TGAGCCCAGG 
GACATAAAGA ATCACCTGAC ATTCAGCAGA AGTGTGGAGG CCTGTTCGGG TCAGCCGGAT 
TTTGTGAGCT CTTTGGAGCA CGTGCAGGCC AGACTCACGC TCTCCTATAA CCACAGAGGA 
AACCTGGCTG TTCACCTCAT CAGCCCGCTG GGGACTCGTT CCACATTGCT GGCTCCACGG 
CCACAGGATA ACTCAGCCGA AGGATTCAAC GACTGGGCGT TCATGACCAC TCATTCCTGG 
GATGAGGACC CTCGTGGAGA ATGGACCCTG GAGATTGAGA ACGTGGCTGG ACTTAATGAC 
TACGGCGTTC TTTCTCAGTT CACTCTCATC TTATACGGCA CTGGCTCTAG TGCCACAGAT 
CCGTCCGTTT CTGACTACAC CAGACCTTCA AACAACAGCT GCAAGACCTT CGACACACAG 
CAGATCTGCA TTGAATGCAG CACGGGTTTC TCTCTTTTCC TGCAAGGCTG TGTGAAGTCC 
TGTCCTCCGG GCTTCATCTC TGGGCCGCAG GTGCTCAACT TGTCGTTGGA CAACTGGGTG 
GAGCACTCGA CTGTACAGGC GTGCCTGCCC TGCCACCCGG CCTGCCTGAC GTGCTCCGGC 
TCCGGAGAGA ACGAGTGTCT GTCCTGCCCC CCACACAGTC ACTTAGTGGC CACTTCTTGC 
TTGCACCAGA ACCAGGTGCA GAGAAAATCC CCCAGCATTC CCGTGATCCA GCACGAGGCG 
GATTCCAGCT CGGAGGAATC ATTGCGTGAT CCCGGGCTTT CCTCCAGATT GCCGGCGCTG 
GTGGCGGTGC TCAGCTGTGC CTTCATCCTG GCCACTTTTG CAGCCGTTTT TGTGCTGCTT 
CAGCTGCACT CCGGTGCAGC CAGCGCCCCC TTCTGTCGGA GGACCAAACT GCCAGTGATC 
GACACAGGCC GAGGGGGGAT TCGAGTGGGT TTTGGGTTTG GACTCAACCG GGGGAAAGTG 
TCGTATCGGG GGATTCCCAC TGTGTGGGGG GATGAGGATG CGGCGGGAGG GATGAACTCT 
GAGTCGGACA GCGAAGAGCT GGAATTTCAC AGCGAAAAAA CTGCTTTTAT ACGAACTCAG 
AGTGTTCTTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
BMC genomics17368(2016 05)
Pasquier J,Cabau C,Nguyen T,Jouanno E,Severac D,Braasch I,Journot L,Pontarotti P,Klopp C,Postlethwait JH,Guiguen Y,Bobe J

RFX transcription factors are essential for hearing in mice.
Nature communications68549(2015 Oct)
Elkon R,Milon B,Morrison L,Shah M,Vijayakumar S,Racherla M,Leitch CC,Silipino L,Hadi S,Weiss-Gayet M,Barras E,Schmid CD,Ait-Lounis A,Barnes A,Song Y,Eisenman DJ,Eliyahu E,Frolenkov GI,Strome SE,Durand B,Zaghloul NA,Jones SM,Reith W,Hertzano R

The proprotein convertase subtilisin/kexin furinA regulates zebrafish host response against Mycobacterium marinum.
Infection and immunity83(4)1431-42(2015 Apr)
Ojanen MJ,Turpeinen H,Cordova ZM,Hammar?n MM,Harjula SK,Parikka M,R?met M,Pesu M

Proprotein convertase subtilisin/kexin type 7 (PCSK7) is essential for the zebrafish development and bioavailability of transforming growth factor ?1a (TGF?1a).
The Journal of biological chemistry288(51)36610-23(2013 Dec)
Turpeinen H,Oksanen A,Kivinen V,Kukkurainen S,Uusim?ki A,R?met M,Parikka M,Hyt?nen VP,Nykter M,Pesu M

Hepatocyte growth factor signaling in intrapancreatic ductal cells drives pancreatic morphogenesis.
PLoS genetics9(7)e1003650(2013)
Anderson RM,Delous M,Bosch JA,Ye L,Robertson MA,Hesselson D,Stainier DY

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furinb cDNA ORF clone, Danio rerio(zebrafish)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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