Txnrd2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Txnrd2
Entrez Gene ID	50551
Full Name	thioredoxin reductase 2
Synonyms	Tr3,Trxr2,Trxrd2
General protein information	Preferred Names thioredoxin reductase 2 Names thioredoxin reductase 2, mitochondrial thioredoxin reductase TR3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 11 Map Location: 11q23
Summary	The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes a mitochondrial form important for scavenging reactive oxygen species in mitochondria. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jun 2017].

mRNA and Protein(s)

mRNA	Protein	Name
NM_022584.2	NP_072106.1	thioredoxin reductase 2, mitochondrial precursor
NM_022584.3	NP_072106.1	thioredoxin reductase 2, mitochondrial precursor

Pathways from BioSystems

Homologies

	TXNRD2	NP_001152971.1
Drosophila melanogaster (fruit fly)	Trxr-2	NP_524216.1
Drosophila melanogaster (fruit fly)	Trxr-1	NP_727252.1
Anopheles gambiae (African malaria mosquito)	TRXR	XP_003437030.1
Caenorhabditis elegans (roundworm)	trxr-2	NP_498971.1
Homo sapiens (human)	TXNRD2	NP_006431.2
Mus musculus (house mouse)	Txnrd2	NP_038739.2
Rattus norvegicus (Norway rat)	Txnrd2	NP_072106.1
Pan troglodytes (chimpanzee)	TXNRD2	XP_001166615.2
Xenopus tropicalis (tropical clawed frog)	txnrd2	NP_001120487.1
Canis lupus familiaris (dog)	TXNRD2	XP_005636641.1
Bos taurus (cattle)	TXNRD2	NP_777051.1
Gallus gallus (chicken)	TXNRD2	NP_001116163.1

Gene Ontology
Bibliography

Related articles in PubMed

Different doxorubicin formulations affect plasma 4-hydroxy-2-nonenal and gene expression of aldehyde dehydrogenase 3A1 and thioredoxin reductase 2 in rat.
Hlav??ov? M, Gumulec J, Stra?ina T, Fojt? M, Raudensk? M, Masa??k M, Nov?kov? M, Paulov? H
Physiological research64 Suppl 5S653-60(2015)

Thioredoxin/thioredoxin reductase system involvement in cerebellar granule cell apoptosis.
Bobba A, Casalino E, Petragallo VA, Atlante A
Apoptosis : an international journal on programmed cell death19(10)1497-508(2014 Oct)

Thioredoxin Reductase 2 (TXNRD2) mutation associated with familial glucocorticoid deficiency (FGD).
Prasad R, Chan LF, Hughes CR, Kaski JP, Kowalczyk JC, Savage MO, Peters CJ, Nathwani N, Clark AJ, Storr HL, Metherell LA
The Journal of clinical endocrinology and metabolism99(8)E1556-63(2014 Aug)

Novel role for thioredoxin reductase-2 in mitochondrial redox adaptations to obesogenic diet and exercise in heart and skeletal muscle.
Fisher-Wellman KH, Mattox TA, Thayne K, Katunga LA, La Favor JD, Neufer PD, Hickner RC, Wingard CJ, Anderson EJ
The Journal of physiology591(14)3471-86(2013 Jul)

Thioredoxin reductase deficiency potentiates oxidative stress, mitochondrial dysfunction and cell death in dopaminergic cells.
Lopert P, Day BJ, Patel M
PloS one7(11)e50683(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Different doxorubicin formulations decreased liver expression of TXNRD2.
Title: Different doxorubicin formulations affect plasma 4-hydroxy-2-nonenal and gene expression of aldehyde dehydrogenase 3A1 and thioredoxin reductase 2 in rat.

Active TrxR1 and TrxR2 are required for cerebellar granule cell survival.
Title: Thioredoxin/thioredoxin reductase system involvement in cerebellar granule cell apoptosis.

Upregulation of thioredoxin reductase-2 plays a critical role in preserving the mitochondrial redox status in the heart and skeletal muscle with exercise.
Title: Novel role for thioredoxin reductase-2 in mitochondrial redox adaptations to obesogenic diet and exercise in heart and skeletal muscle.

the role of Trx/Prx system in dopaminergic cell death
Title: Thioredoxin reductase deficiency potentiates oxidative stress, mitochondrial dysfunction and cell death in dopaminergic cells.

TRX1 and TRX2 overexpression protected retinal ganglion cells(RCGs) from death after optic nerve axotomy, in oxidative stress, and in an animal model of glaucoma.
Title: Overexpression of thioredoxins 1 and 2 increases retinal ganglion cell survival after pharmacologically induced oxidative stress, optic nerve transection, and in experimental glaucoma.

The following Txnrd2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Txnrd2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa12518	NM_022584.3 Latest version!	Rattus norvegicus thioredoxin reductase 2 (Txnrd2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00
View Old Accession Versions >>
ORa12518	NM_022584.2	Rattus norvegicus thioredoxin reductase 2 (Txnrd2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Txnrd2 ( NM_022584.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_072106.1 Rattus norvegicus thioredoxin reductase 2 (Txnrd2), mRNA.

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CloneID	ORa12518
Clone ID Related Accession (Same CDS sequence)	NM_022584.2 , NM_022584.3
Accession Version	NM_022584.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1581bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-04-15
Organism	Rattus norvegicus(Norway rat)
Product	thioredoxin reductase 2, mitochondrial precursor
Comment	REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC085734.1. On Apr 18, 2007 this sequence version replaced NM_022584.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC085734.1, AF072865.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology NMD candidate :: translation inferred from conservation protein contains selenocysteine :: PMID: 9988709 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGA TTGTGGCGGC GCTGCGCGGA TCCAGCGGGC GCTTCCGGCC GCAGACACGG 
GTTTTAACAC GCGGGACGCG GGGCGCGGCG GGCGCGGCGA GCGCAGCGGG AGGGCAGCAG 
AACTTTGATC TCTTGGTGAT CGGTGGGGGA TCCGGTGGCC TAGCTTGTGC CAAGGAAGCG 
GCTCAGCTGG GAAGGAAGGT GGCTGTGGCT GACTATGTGG AACCCTCTCC CCGAGGCACC 
AAATGGGGCC TTGGTGGCAC CTGTGTCAAC GTGGGCTGCA TACCCAAGAA GCTGATGCAT 
CAGGCCGCAC TGCTGGGGGG CATGATCAGA GATGCTCAGC ACTACGGCTG GGAGGTGGCC 
CAGCCTGTCC AGCACAACTG GAAGGCAATG GCCGAAGCCG TGCAAAACCA TGTGAAGTCC 
TTGAACTGGG GTCATCGTGT CCAACTGCAG GACAGGAAAG TCAAGTACTT TAACATCAAA 
GCCAGCTTTG TCAACGAGCA CACAGTTCAC GGTGTCGACA AAGCCGGGAA GGTGACTCAG 
CTTTCAGCCA AGCACATAGT CATCGCTACA GGAGGACGGC CGAAGTACCC CACACAGGTC 
AAAGGAGCCC TGGAACACGG AATCACAAGT GATGACATCT TCTGGCTGAA GGAGTCCCCT 
GGGAAAACGT TGGTGGTTGG AGCCAGTTAT GTGGCCCTGG AGTGTGCCGG CTTCCTCACT 
GGTATTGGCC TGGATACCAC GGTCATGATG CGCAGCGTGC CCCTCCGAGG CTTTGACCAG 
CAAATGGCGT CTTTGGTCAC AGAGCACATG GAGTCTCATG GCACCCGGTT CCTGAAAGGC 
TGTGTCCCCT CCCTCATCAG AAAACTCCCG ACTAACCAAC TGCAGGTCAC TTGGGAGGAT 
CTCGCTTCTG GCAAGGAGGA CGTGGGCACC TTTGACACTG TCCTGTGGGC CATAGGGCGA 
GTTCCAGAGA CCAGAAATTT GAATCTGGAG AAGGCTGGCG TTAATACCAA CCCTAAGAAT 
CAGAAGATCA TTGTGGATGC CCAGGAGGCC ACCTCTGTCC CCCACATCTA TGCCATTGGA 
GATGTTGCTG AGGGGCGGCC TGAGCTGACA CCCACAGCTA TCAAGGCAGG AAAGCTTCTG 
GCTCAGCGGC TCTTTGGGAA ATCCTCAACC TTAATGAATT ACAGCAACGT CCCCACAACT 
GTCTTTACAC CACTGGAGTA TGGCTGTGTG GGACTGTCTG AGGAGGAGGC TGTGGCTCTC 
CACGGCCAGG AGCATATAGA GGTTTACCAT GCATATTACA AGCCCCTAGA GTTCACAGTG 
GCAGATCGGG ATGCATCACA GTGCTACATA AAGATGGTAT GCATGAGGGA GCCCCCACAA 
CTGGTACTGG GCCTGCACTT CCTTGGCCCC AACGCTGGAG AAGTCACACA AGGATTTGCT 
CTTGGGATCC AGTGTGGGGC TTCATACGCA CAGGTGATGC AGACAGTAGG GATCCACCCC 
ACCTGCTCTG AGGAGGTGGT TAAGCTGCAC ATCTCCAAGC GCTCTGGCCT GGATCCTACT 
GTGACTGGCT GCTGAGGTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_072106.1
CDS	7..1587
Translation	MAAIVAALRGSSGRFRPQTRVLTRGTRGAAGAASAAGGQQNFDLLVIGGGSGGLACAKEAAQLGRKVAVADYVEPSPRGTKWGLGGTCVNVGCIPKKLMHQAALLGGMIRDAQHYGWEVAQPVQHNWKAMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIKASFVNEHTVHGVDKAGKVTQLSAKHIVIATGGRPKYPTQVKGALEHGITSDDIFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTVMMRSVPLRGFDQQMASLVTEHMESHGTRFLKGCVPSLIRKLPTNQLQVTWEDLASGKEDVGTFDTVLWAIGRVPETRNLNLEKAGVNTNPKNQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSSTLMNYSNVPTTVFTPLEYGCVGLSEEEAVALHGQEHIEVYHAYYKPLEFTVADRDASQCYIKMVCMREPPQLVLGLHFLGPNAGEVTQGFALGIQCGASYAQVMQTVGIHPTCSEEVVKLHISKRSGLDPTVTGC*G

Target ORF information:

RefSeq Version	NM_022584.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus thioredoxin reductase 2 (Txnrd2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022584.2

ORF Insert Sequence:

ATGGCGGCGA TTGTGGCGGC GCTGCGCGGA TCCAGCGGGC GCTTCCGGCC GCAGACACGG 
GTTTTAACAC GCGGGACGCG GGGCGCGGCG GGCGCGGCGA GCGCAGCGGG AGGGCAGCAG 
AACTTTGATC TCTTGGTGAT CGGTGGGGGA TCCGGTGGCC TAGCTTGTGC CAAGGAAGCG 
GCTCAGCTGG GAAGGAAGGT GGCTGTGGCT GACTATGTGG AACCCTCTCC CCGAGGCACC 
AAATGGGGCC TTGGTGGCAC CTGTGTCAAC GTGGGCTGCA TACCCAAGAA GCTGATGCAT 
CAGGCCGCAC TGCTGGGGGG CATGATCAGA GATGCTCAGC ACTACGGCTG GGAGGTGGCC 
CAGCCTGTCC AGCACAACTG GAAGGCAATG GCCGAAGCCG TGCAAAACCA TGTGAAGTCC 
TTGAACTGGG GTCATCGTGT CCAACTGCAG GACAGGAAAG TCAAGTACTT TAACATCAAA 
GCCAGCTTTG TCAACGAGCA CACAGTTCAC GGTGTCGACA AAGCCGGGAA GGTGACTCAG 
CTTTCAGCCA AGCACATAGT CATCGCTACA GGAGGACGGC CGAAGTACCC CACACAGGTC 
AAAGGAGCCC TGGAACACGG AATCACAAGT GATGACATCT TCTGGCTGAA GGAGTCCCCT 
GGGAAAACGT TGGTGGTTGG AGCCAGTTAT GTGGCCCTGG AGTGTGCCGG CTTCCTCACT 
GGTATTGGCC TGGATACCAC GGTCATGATG CGCAGCGTGC CCCTCCGAGG CTTTGACCAG 
CAAATGGCGT CTTTGGTCAC AGAGCACATG GAGTCTCATG GCACCCGGTT CCTGAAAGGC 
TGTGTCCCCT CCCTCATCAG AAAACTCCCG ACTAACCAAC TGCAGGTCAC TTGGGAGGAT 
CTCGCTTCTG GCAAGGAGGA CGTGGGCACC TTTGACACTG TCCTGTGGGC CATAGGGCGA 
GTTCCAGAGA CCAGAAATTT GAATCTGGAG AAGGCTGGCG TTAATACCAA CCCTAAGAAT 
CAGAAGATCA TTGTGGATGC CCAGGAGGCC ACCTCTGTCC CCCACATCTA TGCCATTGGA 
GATGTTGCTG AGGGGCGGCC TGAGCTGACA CCCACAGCTA TCAAGGCAGG AAAGCTTCTG 
GCTCAGCGGC TCTTTGGGAA ATCCTCAACC TTAATGAATT ACAGCAACGT CCCCACAACT 
GTCTTTACAC CACTGGAGTA TGGCTGTGTG GGACTGTCTG AGGAGGAGGC TGTGGCTCTC 
CACGGCCAGG AGCATATAGA GGTTTACCAT GCATATTACA AGCCCCTAGA GTTCACAGTG 
GCAGATCGGG ATGCATCACA GTGCTACATA AAGATGGTAT GCATGAGGGA GCCCCCACAA 
CTGGTACTGG GCCTGCACTT CCTTGGCCCC AACGCTGGAG AAGTCACACA AGGATTTGCT 
CTTGGGATCC AGTGTGGGGC TTCATACGCA CAGGTGATGC AGACAGTAGG GATCCACCCC 
ACCTGCTCTG AGGAGGTGGT TAAGCTGCAC ATCTCCAAGC GCTCTGGCCT GGATCCTACT 
GTGACTGGCT GCTGAGGTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Txnrd2 ( NM_022584.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_072106.1 Rattus norvegicus thioredoxin reductase 2 (Txnrd2), mRNA.

Price & Availability↑

CloneID	ORa12518
Clone ID Related Accession (Same CDS sequence)	NM_022584.2 , NM_022584.3
Accession Version	NM_022584.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1581bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Rattus norvegicus(Norway rat)
Product	thioredoxin reductase 2, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC121199.4 and BC085734.1. On Jun 29, 2017 this sequence version replaced NM_022584.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF072865.1, BC085734.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 9988709 NMD candidate :: PMID: 9988709 protein contains selenocysteine :: PMID: 9988709 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGA TTGTGGCGGC GCTGCGCGGA TCCAGCGGGC GCTTCCGGCC GCAGACACGG 
GTTTTAACAC GCGGGACGCG GGGCGCGGCG GGCGCGGCGA GCGCAGCGGG AGGGCAGCAG 
AACTTTGATC TCTTGGTGAT CGGTGGGGGA TCCGGTGGCC TAGCTTGTGC CAAGGAAGCG 
GCTCAGCTGG GAAGGAAGGT GGCTGTGGCT GACTATGTGG AACCCTCTCC CCGAGGCACC 
AAATGGGGCC TTGGTGGCAC CTGTGTCAAC GTGGGCTGCA TACCCAAGAA GCTGATGCAT 
CAGGCCGCAC TGCTGGGGGG CATGATCAGA GATGCTCAGC ACTACGGCTG GGAGGTGGCC 
CAGCCTGTCC AGCACAACTG GAAGGCAATG GCCGAAGCCG TGCAAAACCA TGTGAAGTCC 
TTGAACTGGG GTCATCGTGT CCAACTGCAG GACAGGAAAG TCAAGTACTT TAACATCAAA 
GCCAGCTTTG TCAACGAGCA CACAGTTCAC GGTGTCGACA AAGCCGGGAA GGTGACTCAG 
CTTTCAGCCA AGCACATAGT CATCGCTACA GGAGGACGGC CGAAGTACCC CACACAGGTC 
AAAGGAGCCC TGGAACACGG AATCACAAGT GATGACATCT TCTGGCTGAA GGAGTCCCCT 
GGGAAAACGT TGGTGGTTGG AGCCAGTTAT GTGGCCCTGG AGTGTGCCGG CTTCCTCACT 
GGTATTGGCC TGGATACCAC GGTCATGATG CGCAGCGTGC CCCTCCGAGG CTTTGACCAG 
CAAATGGCGT CTTTGGTCAC AGAGCACATG GAGTCTCATG GCACCCGGTT CCTGAAAGGC 
TGTGTCCCCT CCCTCATCAG AAAACTCCCG ACTAACCAAC TGCAGGTCAC TTGGGAGGAT 
CTCGCTTCTG GCAAGGAGGA CGTGGGCACC TTTGACACTG TCCTGTGGGC CATAGGGCGA 
GTTCCAGAGA CCAGAAATTT GAATCTGGAG AAGGCTGGCG TTAATACCAA CCCTAAGAAT 
CAGAAGATCA TTGTGGATGC CCAGGAGGCC ACCTCTGTCC CCCACATCTA TGCCATTGGA 
GATGTTGCTG AGGGGCGGCC TGAGCTGACA CCCACAGCTA TCAAGGCAGG AAAGCTTCTG 
GCTCAGCGGC TCTTTGGGAA ATCCTCAACC TTAATGAATT ACAGCAACGT CCCCACAACT 
GTCTTTACAC CACTGGAGTA TGGCTGTGTG GGACTGTCTG AGGAGGAGGC TGTGGCTCTC 
CACGGCCAGG AGCATATAGA GGTTTACCAT GCATATTACA AGCCCCTAGA GTTCACAGTG 
GCAGATCGGG ATGCATCACA GTGCTACATA AAGATGGTAT GCATGAGGGA GCCCCCACAA 
CTGGTACTGG GCCTGCACTT CCTTGGCCCC AACGCTGGAG AAGTCACACA AGGATTTGCT 
CTTGGGATCC AGTGTGGGGC TTCATACGCA CAGGTGATGC AGACAGTAGG GATCCACCCC 
ACCTGCTCTG AGGAGGTGGT TAAGCTGCAC ATCTCCAAGC GCTCTGGCCT GGATCCTACT 
GTGACTGGCT GCTGAGGTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_072106.1
CDS	29..1609
Translation	MAAIVAALRGSSGRFRPQTRVLTRGTRGAAGAASAAGGQQNFDLLVIGGGSGGLACAKEAAQLGRKVAVADYVEPSPRGTKWGLGGTCVNVGCIPKKLMHQAALLGGMIRDAQHYGWEVAQPVQHNWKAMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIKASFVNEHTVHGVDKAGKVTQLSAKHIVIATGGRPKYPTQVKGALEHGITSDDIFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTVMMRSVPLRGFDQQMASLVTEHMESHGTRFLKGCVPSLIRKLPTNQLQVTWEDLASGKEDVGTFDTVLWAIGRVPETRNLNLEKAGVNTNPKNQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSSTLMNYSNVPTTVFTPLEYGCVGLSEEEAVALHGQEHIEVYHAYYKPLEFTVADRDASQCYIKMVCMREPPQLVLGLHFLGPNAGEVTQGFALGIQCGASYAQVMQTVGIHPTCSEEVVKLHISKRSGLDPTVTGC*G

Target ORF information:

RefSeq Version	NM_022584.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus thioredoxin reductase 2 (Txnrd2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022584.3

ORF Insert Sequence:

ATGGCGGCGA TTGTGGCGGC GCTGCGCGGA TCCAGCGGGC GCTTCCGGCC GCAGACACGG 
GTTTTAACAC GCGGGACGCG GGGCGCGGCG GGCGCGGCGA GCGCAGCGGG AGGGCAGCAG 
AACTTTGATC TCTTGGTGAT CGGTGGGGGA TCCGGTGGCC TAGCTTGTGC CAAGGAAGCG 
GCTCAGCTGG GAAGGAAGGT GGCTGTGGCT GACTATGTGG AACCCTCTCC CCGAGGCACC 
AAATGGGGCC TTGGTGGCAC CTGTGTCAAC GTGGGCTGCA TACCCAAGAA GCTGATGCAT 
CAGGCCGCAC TGCTGGGGGG CATGATCAGA GATGCTCAGC ACTACGGCTG GGAGGTGGCC 
CAGCCTGTCC AGCACAACTG GAAGGCAATG GCCGAAGCCG TGCAAAACCA TGTGAAGTCC 
TTGAACTGGG GTCATCGTGT CCAACTGCAG GACAGGAAAG TCAAGTACTT TAACATCAAA 
GCCAGCTTTG TCAACGAGCA CACAGTTCAC GGTGTCGACA AAGCCGGGAA GGTGACTCAG 
CTTTCAGCCA AGCACATAGT CATCGCTACA GGAGGACGGC CGAAGTACCC CACACAGGTC 
AAAGGAGCCC TGGAACACGG AATCACAAGT GATGACATCT TCTGGCTGAA GGAGTCCCCT 
GGGAAAACGT TGGTGGTTGG AGCCAGTTAT GTGGCCCTGG AGTGTGCCGG CTTCCTCACT 
GGTATTGGCC TGGATACCAC GGTCATGATG CGCAGCGTGC CCCTCCGAGG CTTTGACCAG 
CAAATGGCGT CTTTGGTCAC AGAGCACATG GAGTCTCATG GCACCCGGTT CCTGAAAGGC 
TGTGTCCCCT CCCTCATCAG AAAACTCCCG ACTAACCAAC TGCAGGTCAC TTGGGAGGAT 
CTCGCTTCTG GCAAGGAGGA CGTGGGCACC TTTGACACTG TCCTGTGGGC CATAGGGCGA 
GTTCCAGAGA CCAGAAATTT GAATCTGGAG AAGGCTGGCG TTAATACCAA CCCTAAGAAT 
CAGAAGATCA TTGTGGATGC CCAGGAGGCC ACCTCTGTCC CCCACATCTA TGCCATTGGA 
GATGTTGCTG AGGGGCGGCC TGAGCTGACA CCCACAGCTA TCAAGGCAGG AAAGCTTCTG 
GCTCAGCGGC TCTTTGGGAA ATCCTCAACC TTAATGAATT ACAGCAACGT CCCCACAACT 
GTCTTTACAC CACTGGAGTA TGGCTGTGTG GGACTGTCTG AGGAGGAGGC TGTGGCTCTC 
CACGGCCAGG AGCATATAGA GGTTTACCAT GCATATTACA AGCCCCTAGA GTTCACAGTG 
GCAGATCGGG ATGCATCACA GTGCTACATA AAGATGGTAT GCATGAGGGA GCCCCCACAA 
CTGGTACTGG GCCTGCACTT CCTTGGCCCC AACGCTGGAG AAGTCACACA AGGATTTGCT 
CTTGGGATCC AGTGTGGGGC TTCATACGCA CAGGTGATGC AGACAGTAGG GATCCACCCC 
ACCTGCTCTG AGGAGGTGGT TAAGCTGCAC ATCTCCAAGC GCTCTGGCCT GGATCCTACT 
GTGACTGGCT GCTGAGGTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Different doxorubicin formulations affect plasma 4-hydroxy-2-nonenal and gene expression of aldehyde dehydrogenase 3A1 and thioredoxin reductase 2 in rat.
Physiological research64 Suppl 5S653-60(2015)
Hlav??ov? M,Gumulec J,Stra?ina T,Fojt? M,Raudensk? M,Masa??k M,Nov?kov? M,Paulov? H

Thioredoxin/thioredoxin reductase system involvement in cerebellar granule cell apoptosis.
Apoptosis : an international journal on programmed cell death19(10)1497-508(2014 Oct)
Bobba A,Casalino E,Petragallo VA,Atlante A

Thioredoxin Reductase 2 (TXNRD2) mutation associated with familial glucocorticoid deficiency (FGD).
The Journal of clinical endocrinology and metabolism99(8)E1556-63(2014 Aug)
Prasad R,Chan LF,Hughes CR,Kaski JP,Kowalczyk JC,Savage MO,Peters CJ,Nathwani N,Clark AJ,Storr HL,Metherell LA

Novel role for thioredoxin reductase-2 in mitochondrial redox adaptations to obesogenic diet and exercise in heart and skeletal muscle.
The Journal of physiology591(14)3471-86(2013 Jul)
Fisher-Wellman KH,Mattox TA,Thayne K,Katunga LA,La Favor JD,Neufer PD,Hickner RC,Wingard CJ,Anderson EJ

Thioredoxin reductase deficiency potentiates oxidative stress, mitochondrial dysfunction and cell death in dopaminergic cells.
PloS one7(11)e50683(2012)
Lopert P,Day BJ,Patel M

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Txnrd2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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