Svip cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Svip
Entrez Gene ID	499157
Full Name	small VCP interacting protein
Synonyms	RGD1565432
General protein information	Preferred Names small VCP interacting protein Names small VCP/p97-interacting protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q22

mRNA and Protein(s)

mRNA	Protein	Name
NM_001271084.1	NP_001258013.1	small VCP/p97-interacting protein

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Svip	NP_001153817.1
	SVIP	XP_001091376.1
Bos taurus (cattle)	SVIP	XP_002699120.1
Homo sapiens (human)	SVIP	NP_683691.1
Canis lupus familiaris (dog)	SVIP	NP_001182538.1
Rattus norvegicus (Norway rat)	Svip	NP_001258013.1
Pan troglodytes (chimpanzee)	SVIP	XP_001173949.1

Gene Ontology
Bibliography

Related articles in PubMed

Silencing of Small Valosin-containing Protein-interacting Protein (SVIP) Reduces Very Low Density Lipoprotein (VLDL) Secretion from Rat Hepatocytes by Disrupting Its Endoplasmic Reticulum (ER)-to-Golgi Trafficking.
Tiwari S, Siddiqi S, Zhelyabovska O, Siddiqi SA
The Journal of biological chemistry291(24)12514-26(2016 Jun)

Identification of ERAD components essential for dislocation of the null Hong Kong variant of ?-1-antitrypsin (NHK).
Zhong Y, Shen H, Wang Y, Yang Y, Yang P, Fang S
Biochemical and biophysical research communications458(2)424-8(2015 Mar)

Structure and expression of a novel compact myelin protein - small VCP-interacting protein (SVIP).
Wu J, Peng D, Voehler M, Sanders CR, Li J
Biochemical and biophysical research communications440(1)173-8(2013 Oct)

SVIP induces localization of p97/VCP to the plasma and lysosomal membranes and regulates autophagy.
Wang Y, Ballar P, Zhong Y, Zhang X, Liu C, Zhang YJ, Monteiro MJ, Li J, Fang S
PloS one6(8)e24478(2011)

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W
Immunology and cell biology88(8)851-6(2010 Nov-Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data sugggest that small valosin-containing protein-interacting protein (SVIP) acts as a regulator of VLDL transport vesicle (VTV) formation by interacting with its cargo and coat proteins.
Title: Silencing of Small Valosin-containing Protein-interacting Protein (SVIP) Reduces Very Low Density Lipoprotein (VLDL) Secretion from Rat Hepatocytes by Disrupting Its Endoplasmic Reticulum (ER)-to-Golgi Trafficking.

SVIP and valosin containing protein were seen to be co-localized in neuronal cell bodies.
Title: Structure and expression of a novel compact myelin protein - small VCP-interacting protein (SVIP).

The following Svip gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Svip cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10208	NM_001271084.1 Latest version!	Rattus norvegicus small VCP interacting protein (Svip), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Svip ( NM_001271084.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001258013.1 Rattus norvegicus small VCP interacting protein (Svip), mRNA.

Price & Availability↑

CloneID	ORa10208
Clone ID Related Accession (Same CDS sequence)	NM_001271084.1
Accession Version	NM_001271084.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 231bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-23
Organism	Rattus norvegicus(Norway rat)
Product	small VCP/p97-interacting protein
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AABR07003356.1. On or before Sep 1, 2012 this sequence version replaced XM_001080929.2, XM_574455.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: CB607646.1, CB577167.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906347, SAMN01906350 [ECO:0000348] ##Evidence-Data-END##

ATGGGGCTGT GCTTCCCGTG TCCCGCGGAG TCCGCACCGC CATCCCCGAG CCCGGAAGAG 
AAAAGAGCAA AGCTGGCAGA GGCAGCAGAA AGAAGGCAAA AGGAGGCGGC ATCTCGGGGA 
ATTTTGGATA TCCAGTCGGT GGAGGCAAAG AAAAAGAAGA AAGAACAATT AGAAAAGCAG 
ATGGAAACAT CAGGGCCACC AGCAGGGGGA CTTAGATGGA CAGTGTCATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001258013.1
CDS	122..352
Translation	MGLCFPCPAESAPPSPSPEEKRAKLAEAAERRQKEAASRGILDIQSVEAKKKKKEQLEKQMETSGPPAGGLRWTVS

Target ORF information:

RefSeq Version	NM_001271084.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus small VCP interacting protein (Svip), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001271084.1

ORF Insert Sequence:

ATGGGGCTGT GCTTCCCGTG TCCCGCGGAG TCCGCACCGC CATCCCCGAG CCCGGAAGAG 
AAAAGAGCAA AGCTGGCAGA GGCAGCAGAA AGAAGGCAAA AGGAGGCGGC ATCTCGGGGA 
ATTTTGGATA TCCAGTCGGT GGAGGCAAAG AAAAAGAAGA AAGAACAATT AGAAAAGCAG 
ATGGAAACAT CAGGGCCACC AGCAGGGGGA CTTAGATGGA CAGTGTCATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Silencing of Small Valosin-containing Protein-interacting Protein (SVIP) Reduces Very Low Density Lipoprotein (VLDL) Secretion from Rat Hepatocytes by Disrupting Its Endoplasmic Reticulum (ER)-to-Golgi Trafficking.
The Journal of biological chemistry291(24)12514-26(2016 Jun)
Tiwari S,Siddiqi S,Zhelyabovska O,Siddiqi SA

Identification of ERAD components essential for dislocation of the null Hong Kong variant of ?-1-antitrypsin (NHK).
Biochemical and biophysical research communications458(2)424-8(2015 Mar)
Zhong Y,Shen H,Wang Y,Yang Y,Yang P,Fang S

Structure and expression of a novel compact myelin protein - small VCP-interacting protein (SVIP).
Biochemical and biophysical research communications440(1)173-8(2013 Oct)
Wu J,Peng D,Voehler M,Sanders CR,Li J

SVIP induces localization of p97/VCP to the plasma and lysosomal membranes and regulates autophagy.
PloS one6(8)e24478(2011)
Wang Y,Ballar P,Zhong Y,Zhang X,Liu C,Zhang YJ,Monteiro MJ,Li J,Fang S

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Immunology and cell biology88(8)851-6(2010 Nov-Dec)
Buschow SI,van Balkom BW,Aalberts M,Heck AJ,Wauben M,Stoorvogel W

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Svip cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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