Xdh cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Xdh
Entrez Gene ID	497811
Full Name	xanthine dehydrogenase
Synonyms	XOR
General protein information	Preferred Names xanthine dehydrogenase Names xanthine dehydrogenase/oxidase xanthine oxidase xanthine oxidoreductase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q13-q14
Summary	This gene encodes a member of the xanthine dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein is involved in purine degradation and functions as both a dehydrogenase and an oxidase. [provided by RefSeq, Jan 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017154.1	NP_058850.1	xanthine dehydrogenase/oxidase

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	XDH	XP_525729.2
Canis lupus familiaris (dog)	XDH	XP_540143.2
Bos taurus (cattle)	XDH	NP_776397.1
Gallus gallus (chicken)	XDH	NP_990458.1
Drosophila melanogaster (fruit fly)	ry	NP_524337.1
Arabidopsis thaliana (thale cress)	XDH1	NP_195215.2
Oryza sativa (rice)	Os03g0429800	NP_001050420.1
Homo sapiens (human)	XDH	NP_000370.2
Danio rerio (zebrafish)	xdh	XP_688983.3
Caenorhabditis elegans (roundworm)	F55B11.1	NP_502747.1
Arabidopsis thaliana (thale cress)	XDH2	NP_195216.2
Magnaporthe oryzae (rice blast fungus)	MGG_12738	XP_003716708.1
Neurospora crassa	NCU03350	XP_956459.2
Rattus norvegicus (Norway rat)	Xdh	NP_058850.1
Xenopus tropicalis (tropical clawed frog)	LOC100497499	XP_004914866.1
	XDH	XP_002808080.1
Mus musculus (house mouse)	Xdh	NP_035853.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007918	XP_317568.3

Gene Ontology
Bibliography

Related articles in PubMed

IFN-? regulates xanthine oxidase-mediated iNOS-independent oxidative stress in maneb- and paraquat-treated rat polymorphonuclear leukocytes.
Singh D, Kumar V, Singh C
Molecular and cellular biochemistry427(1-2)133-143(2017 Mar)

Abdominal paracentesis drainage protects rats against severe acute pancreatitis-associated lung injury by reducing the mobilization of intestinal XDH/XOD.
Zhou J, Huang Z, Lin N, Liu W, Yang G, Wu D, Xiao H, Sun H, Tang L
Free radical biology & medicine99374-384(2016 10)

Hepatocyte growth factor inhibits hypoxia/reoxygenation-induced activation of xanthine oxidase in endothelial cells through the JAK2 signaling pathway.
Zhang YQ, Hu SY, Chen YD, Guo MZ, Wang S
International journal of molecular medicine38(4)1055-62(2016 Oct)

Febuxostat, a novel xanthine oxidoreductase inhibitor, improves hypertension and endothelial dysfunction in spontaneously hypertensive rats.
Shirakura T, Nomura J, Matsui C, Kobayashi T, Tamura M, Masuzaki H
Naunyn-Schmiedeberg's archives of pharmacology389(8)831-8(2016 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results thus demonstrate that XO mediates oxidative stress in MB+PQ-treated rat PMNs via iNOS-independent but cytokine (predominantly IFN-gamma)-dependent mechanism.
Title: IFN-? regulates xanthine oxidase-mediated iNOS-independent oxidative stress in maneb- and paraquat-treated rat polymorphonuclear leukocytes.

Abdominal paracentesis drainage protects rats against severe acute pancreatitis-associated lung injury by reducing the mobilization of intestinal xanthine dehydrogenase.
Title: Abdominal paracentesis drainage protects rats against severe acute pancreatitis-associated lung injury by reducing the mobilization of intestinal XDH/XOD.

Hepatocyte growth factor prevents XO activation following hypoxia/reoxygenation primarily by inhibiting the JAK2 signaling pathway and in turn, inhibiting the increase in cytosolic Calcium.
Title: Hepatocyte growth factor inhibits hypoxia/reoxygenation-induced activation of xanthine oxidase in endothelial cells through the JAK2 signaling pathway.

Results suggest that exaggerated XO activity and resultant increase in oxidative stress contributes to hypertension and xanthine oxidase inhibition could treat treating hypertension and related endothelial dysfunction.
Title: Febuxostat, a novel xanthine oxidoreductase inhibitor, improves hypertension and endothelial dysfunction in spontaneously hypertensive rats.

Our results show that XOR is important to the cardiovascular responses to nitrite in 2K1C hypertension, and XOR inhibitors commonly used by patients may cancel this effect. This finding suggests that nitrite treatment may not be effective in patients being treated with XOR inhibitors
Title: Tempol improves xanthine oxidoreductase-mediated vascular responses to nitrite in experimental renovascular hypertension.

The following Xdh gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Xdh cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13015	NM_017154.1 Latest version!	Rattus norvegicus xanthine dehydrogenase (Xdh), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$643.30 $919.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Xdh ( NM_017154.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058850.1 Rattus norvegicus xanthine dehydrogenase (Xdh), mRNA.

Price & Availability↑

CloneID	ORa13015
Clone ID Related Accession (Same CDS sequence)	NM_017154.1
Accession Version	NM_017154.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3996bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Rattus norvegicus(Norway rat)
Product	xanthine dehydrogenase/oxidase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from J05579.1. On Jan 12, 2005 this sequence version replaced XM_346760.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: J05579.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## multifunctional gene product(s) :: PMID: 15878860 ##RefSeq-Attributes-END##

ATGACTGCGG ATGAGTTGGT CTTCTTTGTG AATGGCAAAA AGGTGGTGGA GAAAAATGCG 
GACCCTGAAA CAACACTTCT GGTCTACCTG AGAAGAAAGT TGGGGCTATG TGGGACCAAG 
CTTGGCTGTG GAGAAGGTGG CTGTGGGGCA TGCACCGTGA TGATCTCCAA GTATGACCGT 
CTTCAGAACA AGATTGTTCA TTTTTCTGTC AATGCCTGCT TGGCTCCCAT CTGCTCCTTG 
CACCATGTTG CTGTGACCAC CGTGGAAGGC ATAGGAAACA CCCAGAAGCT GCATCCTGTA 
CAGGAGAGAA TTGCCAGAAG CCATGGTTCC CAGTGTGGGT TCTGCACTCC TGGCATTGTC 
ATGAGTATGT ACACACTGCT CCGGAACCAG CCTGAGCCTA CTGTTGAGGA GATCGAGAAT 
GCCTTCCAAG GAAACCTCTG TCGCTGTACA GGCTACAGAC CCATCCTCCA GGGATTCCGG 
ACCTTTGCCA AGGATGGTGG GTGCTGTGGA GGGAGTGGAA ACAACCCAAA CTGCTGTATG 
AACCAGACGA AAGACCAAAC GGTTTCTCTC TCACCTTCTT TATTCAACCC AGAGGATTTC 
AAACCTTTAG ATCCCACGCA AGAGCCCATC TTCCCCCCAG AGTTGCTGAG GCTGAAAGAC 
ACTCCCCAGA AGAAGCTGCG TTTTGAAGGG GAACGTGTGA CCTGGATCCA GGCTTCAACT 
ATGGAGGAGC TGCTTGACCT GAAAGCTCAG CACCCTGATG CCAAGCTGGT GGTGGGAAAC 
ACAGAGATAG GCATTGAAAT GAAATTTAAG AATATGCTAT TTCCTCTGAT CGTCTGCCCA 
GCCTGGATCC CTGAACTGAA TTCAGTGGTG CATGGGCCTG AGGGAATCTC CTTCGGAGCT 
TCTTGCCCCC TTAGCTTGGT GGAAAGTGTC CTGGCGGAGG AGATTGCTAA ACTTCCAGAG 
CAAAAGACAG AGGTGTTCAG AGGCGTGATG GAGCAGCTGC GCTGGTTTGC CGGCAAGCAG 
GTCAAGTCCG TGGCGTCCAT CGGAGGGAAC ATCATCACTG CCAGCCCCAT CTCTGACCTC 
AACCCTGTGT TCATGGCCAG TGGAGCCAAG CTGACTCTGG TGTCTAGAGG TACCAGGAGA 
ACTGTTCGGA TGGATCATAC CTTCTTCCCT GGCTACAGAA AGACTCTGCT CAGACCAGAG 
GAGATATTGC TGTCCATCGA GATCCCCTAT AGCAAGGAGG GAGAGTTTTT CTCAGCCTTC 
AAGCAGGCCT CCAGGAGGGA AGATGACATT GCCAAGGTGA CTAGTGGCAT GAGAGTCCTG 
TTCAAACCGG GGACCATTGA AGTGCAGGAA CTGTCCCTTT GCTTCGGAGG GATGGCCGAC 
AGAACTATCT CAGCCCTCAA GACCACTCCG AAGCAGCTAT CGAAGTCCTG GAATGAGGAG 
CTGCTGCAGA GCGTGTGTGC CGGCTTGGCA GAGGAGCTGC AGCTGGCCCC CGATGCCCCT 
GGTGGTATGG TGGAATTCCG GCGCACCCTC ACCCTCAGCT TCTTCTTCAA GTTCTACCTG 
ACAGTGCTCC AGAAGCTGGG CAGAGCGGAC CTTGAGGATA TGTGTGGTAA ACTGGACCCC 
ACCTTTGCCA GTGCCACCCT GCTCTTTCAG AAGGACCCTC CAGCTAATGT CCAGCTTTTC 
CAAGAGGTGC CAAAGGATCA GTCTGAGGAG GACATGGTGG GCCGGCCCCT GCCTCACCTG 
GCGGCAAACA TGCAGGCATC GGGAGAGGCC GTGTACTGTG ATGACATTCC CCGCTATGAG 
AATGAGCTCT CTCTCAGGCT GGTCACCAGC ACCCGGGCGC ATGCTAAAAT CACGTCCATC 
GACACTTCAG AAGCCAAGAA GGTGCCAGGG TTTGTTTGCT TCCTCACCGC AGAGGATGTC 
CCTAATAGTA ATGCAACCGG CCTTTTCAAT GATGAAACTG TCTTTGCGAA GGATGAGGTT 
ACTTGTGTTG GGCACATCAT TGGTGCTGTG GTCGCTGACA CCCCAGAACA CGCACAGAGA 
GCTGCGAGAG GGGTGAAAAT CACCTATGAA GATCTTCCAG CCATTATCAC AATCCAGGAT 
GCTATAAACA ACAACTCCTT TTATGGCTCT GAGATAAAAA TTGAGAAAGG AGATCTCAAG 
AAAGGCTTTT CAGAAGCTGA CAATGTTGTC TCAGGAGAGT TGTATATCGG TGGCCAGGAG 
CACTTCTACC TGGAGACCAA CTGCACCATT GCCGTGCCAA AAGGCGAGGC AGGCGAGATG 
GAGCTGTTCG TGAGCACACA GAACACCATG AAAACCCAGA GCTTTGTTGC AAAAATGTTG 
GGCGTTCCGG ACAACAGAAT CGTAGTCCGA GTGAAGAGGA TGGGTGGAGG CTTTGGAGGG 
AAGGAGACCC GGAGCACTGT GGTGTCCACA GCACTGGCCT TGGCTGCACA CAAGACTGGC 
CGGCCCGTAC GTTGCATGTT GGACCGAGAT GAGGACATGC TGATAACTGG TGGCAGACAT 
CCCTTCCTGG CTAAATACAA GGTTGGCTTC ATGAAGACTG GGACTGTAGT GGCTCTCGAG 
GTGGCTCACT TCAGCAATGG TGGTAACACT GAGGATCTCT CTCGGAGTAT AATGGAACGA 
GCTTTGTTCC ACATGGATAA CGCCTATAAG ATCCCCAACA TTCGAGGCAC TGGGAGGATT 
TGCAAGACTA ATCTGCCCTC CAACACAGCC TTCAGAGGTT TTGGGGGTCC TCAGGGGATG 
CTAATCGCAG AATACTGGAT GAGCGAGGTC GCCATAACCT GTGGGCTGCC TGCAGAGGAG 
GTACGGAGGA AAAACATGTA CAAAGAAGGG GACCTGACTC ACTTCAACCA GAAGCTGGAG 
GGGTTCACCT TGCCCAGGTG CTGGGATGAA TGCATCGCCA GCTCTCAGTA TCTTGCTCGC 
AAGAGGGAAG TGGAGAAATT CAACAGGGAG AATTGTTGGA AAAAGAGAGG GCTGTGTATA 
ATCCCAACTA AGTTTGGAAT AAGCTTTACA CTTCCTTTTC TGAACCAGGG AGGCGCTCTG 
GTTCACGTGT ACACTGATGG TTCGGTGCTG TTGACCCATG GAGGGACTGA GATGGGCCAA 
GGCCTTCACA CCAAGATGGT TCAGGTGGCC AGCAGAGCTC TGAAAATCCC CACCTCCAAG 
ATTCATATAA GTGAGACAAG CACTAACACC GTCCCCAACA CTTCTCCCAC AGCTGCCTCT 
GCCAGTGCTG ACCTCAATGG ACAGGGTGTT TATGAAGCAT GCCAGACCAT ACTGAAAAGG 
CTGGAACCTT TCAAGAAGAA GAAACCCACC GGCCCCTGGG AGGCATGGGT GATGGACGCC 
TATACGAGCG CAGTGAGTTT GTCCGCAACT GGATTTTATA AGACACCCAA CCTTGGCTAC 
AGCTTTGAGA CAAACTCCGG AAATCCCTTC CACTATTTCA GTTATGGGGT GGCTTGCTCT 
GAAGTAGAAA TTGACTGCTT AACAGGGGAT CATAAGAATC TCCGTACGGA TATCGTCATG 
GATGTTGGTT CCAGCTTGAA TCCTGCCATT GATATTGGAC AAGTAGAGGG GGCATTTGTC 
CAGGGCCTTG GTCTCTTCAC TATGGAGGAG CTGCACTACT CCCCTGAGGG GAGCCTGCAT 
ACTCGTGGCC CCAGTACCTA CAAAATCCCT GCATTTGGTA GCATCCCCAT TGAGTTCAGA 
GTATCCCTAC TCCGGGACTG CCCCAACAAG AGGGCCATCT ATGCATCCAA GGCTGTTGGG 
GAGCCACCTC TTTTCCTGGC TTCCTCTATC TTCTTTGCCA TCAAAGATGC CATTCGTGCA 
GCTCGAGCTC AGCACGGAGA TAACGCAAAA CAACTTTTCC AGCTAGACAG CCCTGCCACT 
CCGGAGAAGA TCCGAAACGC CTGTGTGGAC CAGTTCACCA CCCTGTGTGT CACTGGAGTA 
CCAGAAAACT GTAAATCCTG GTCTGTGAGG ATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058850.1
CDS	27..4022
Translation	MTADELVFFVNGKKVVEKNADPETTLLVYLRRKLGLCGTKLGCGEGGCGACTVMISKYDRLQNKIVHFSVNACLAPICSLHHVAVTTVEGIGNTQKLHPVQERIARSHGSQCGFCTPGIVMSMYTLLRNQPEPTVEEIENAFQGNLCRCTGYRPILQGFRTFAKDGGCCGGSGNNPNCCMNQTKDQTVSLSPSLFNPEDFKPLDPTQEPIFPPELLRLKDTPQKKLRFEGERVTWIQASTMEELLDLKAQHPDAKLVVGNTEIGIEMKFKNMLFPLIVCPAWIPELNSVVHGPEGISFGASCPLSLVESVLAEEIAKLPEQKTEVFRGVMEQLRWFAGKQVKSVASIGGNIITASPISDLNPVFMASGAKLTLVSRGTRRTVRMDHTFFPGYRKTLLRPEEILLSIEIPYSKEGEFFSAFKQASRREDDIAKVTSGMRVLFKPGTIEVQELSLCFGGMADRTISALKTTPKQLSKSWNEELLQSVCAGLAEELQLAPDAPGGMVEFRRTLTLSFFFKFYLTVLQKLGRADLEDMCGKLDPTFASATLLFQKDPPANVQLFQEVPKDQSEEDMVGRPLPHLAANMQASGEAVYCDDIPRYENELSLRLVTSTRAHAKITSIDTSEAKKVPGFVCFLTAEDVPNSNATGLFNDETVFAKDEVTCVGHIIGAVVADTPEHAQRAARGVKITYEDLPAIITIQDAINNNSFYGSEIKIEKGDLKKGFSEADNVVSGELYIGGQEHFYLETNCTIAVPKGEAGEMELFVSTQNTMKTQSFVAKMLGVPDNRIVVRVKRMGGGFGGKETRSTVVSTALALAAHKTGRPVRCMLDRDEDMLITGGRHPFLAKYKVGFMKTGTVVALEVAHFSNGGNTEDLSRSIMERALFHMDNAYKIPNIRGTGRICKTNLPSNTAFRGFGGPQGMLIAEYWMSEVAITCGLPAEEVRRKNMYKEGDLTHFNQKLEGFTLPRCWDECIASSQYLARKREVEKFNRENCWKKRGLCIIPTKFGISFTLPFLNQGGALVHVYTDGSVLLTHGGTEMGQGLHTKMVQVASRALKIPTSKIHISETSTNTVPNTSPTAASASADLNGQGVYEACQTILKRLEPFKKKKPTGPWEAWVMDAYTSAVSLSATGFYKTPNLGYSFETNSGNPFHYFSYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAFVQGLGLFTMEELHYSPEGSLHTRGPSTYKIPAFGSIPIEFRVSLLRDCPNKRAIYASKAVGEPPLFLASSIFFAIKDAIRAARAQHGDNAKQLFQLDSPATPEKIRNACVDQFTTLCVTGVPENCKSWSVRI

Target ORF information:

RefSeq Version	NM_017154.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus xanthine dehydrogenase (Xdh), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017154.1

ORF Insert Sequence:

ATGACTGCGG ATGAGTTGGT CTTCTTTGTG AATGGCAAAA AGGTGGTGGA GAAAAATGCG 
GACCCTGAAA CAACACTTCT GGTCTACCTG AGAAGAAAGT TGGGGCTATG TGGGACCAAG 
CTTGGCTGTG GAGAAGGTGG CTGTGGGGCA TGCACCGTGA TGATCTCCAA GTATGACCGT 
CTTCAGAACA AGATTGTTCA TTTTTCTGTC AATGCCTGCT TGGCTCCCAT CTGCTCCTTG 
CACCATGTTG CTGTGACCAC CGTGGAAGGC ATAGGAAACA CCCAGAAGCT GCATCCTGTA 
CAGGAGAGAA TTGCCAGAAG CCATGGTTCC CAGTGTGGGT TCTGCACTCC TGGCATTGTC 
ATGAGTATGT ACACACTGCT CCGGAACCAG CCTGAGCCTA CTGTTGAGGA GATCGAGAAT 
GCCTTCCAAG GAAACCTCTG TCGCTGTACA GGCTACAGAC CCATCCTCCA GGGATTCCGG 
ACCTTTGCCA AGGATGGTGG GTGCTGTGGA GGGAGTGGAA ACAACCCAAA CTGCTGTATG 
AACCAGACGA AAGACCAAAC GGTTTCTCTC TCACCTTCTT TATTCAACCC AGAGGATTTC 
AAACCTTTAG ATCCCACGCA AGAGCCCATC TTCCCCCCAG AGTTGCTGAG GCTGAAAGAC 
ACTCCCCAGA AGAAGCTGCG TTTTGAAGGG GAACGTGTGA CCTGGATCCA GGCTTCAACT 
ATGGAGGAGC TGCTTGACCT GAAAGCTCAG CACCCTGATG CCAAGCTGGT GGTGGGAAAC 
ACAGAGATAG GCATTGAAAT GAAATTTAAG AATATGCTAT TTCCTCTGAT CGTCTGCCCA 
GCCTGGATCC CTGAACTGAA TTCAGTGGTG CATGGGCCTG AGGGAATCTC CTTCGGAGCT 
TCTTGCCCCC TTAGCTTGGT GGAAAGTGTC CTGGCGGAGG AGATTGCTAA ACTTCCAGAG 
CAAAAGACAG AGGTGTTCAG AGGCGTGATG GAGCAGCTGC GCTGGTTTGC CGGCAAGCAG 
GTCAAGTCCG TGGCGTCCAT CGGAGGGAAC ATCATCACTG CCAGCCCCAT CTCTGACCTC 
AACCCTGTGT TCATGGCCAG TGGAGCCAAG CTGACTCTGG TGTCTAGAGG TACCAGGAGA 
ACTGTTCGGA TGGATCATAC CTTCTTCCCT GGCTACAGAA AGACTCTGCT CAGACCAGAG 
GAGATATTGC TGTCCATCGA GATCCCCTAT AGCAAGGAGG GAGAGTTTTT CTCAGCCTTC 
AAGCAGGCCT CCAGGAGGGA AGATGACATT GCCAAGGTGA CTAGTGGCAT GAGAGTCCTG 
TTCAAACCGG GGACCATTGA AGTGCAGGAA CTGTCCCTTT GCTTCGGAGG GATGGCCGAC 
AGAACTATCT CAGCCCTCAA GACCACTCCG AAGCAGCTAT CGAAGTCCTG GAATGAGGAG 
CTGCTGCAGA GCGTGTGTGC CGGCTTGGCA GAGGAGCTGC AGCTGGCCCC CGATGCCCCT 
GGTGGTATGG TGGAATTCCG GCGCACCCTC ACCCTCAGCT TCTTCTTCAA GTTCTACCTG 
ACAGTGCTCC AGAAGCTGGG CAGAGCGGAC CTTGAGGATA TGTGTGGTAA ACTGGACCCC 
ACCTTTGCCA GTGCCACCCT GCTCTTTCAG AAGGACCCTC CAGCTAATGT CCAGCTTTTC 
CAAGAGGTGC CAAAGGATCA GTCTGAGGAG GACATGGTGG GCCGGCCCCT GCCTCACCTG 
GCGGCAAACA TGCAGGCATC GGGAGAGGCC GTGTACTGTG ATGACATTCC CCGCTATGAG 
AATGAGCTCT CTCTCAGGCT GGTCACCAGC ACCCGGGCGC ATGCTAAAAT CACGTCCATC 
GACACTTCAG AAGCCAAGAA GGTGCCAGGG TTTGTTTGCT TCCTCACCGC AGAGGATGTC 
CCTAATAGTA ATGCAACCGG CCTTTTCAAT GATGAAACTG TCTTTGCGAA GGATGAGGTT 
ACTTGTGTTG GGCACATCAT TGGTGCTGTG GTCGCTGACA CCCCAGAACA CGCACAGAGA 
GCTGCGAGAG GGGTGAAAAT CACCTATGAA GATCTTCCAG CCATTATCAC AATCCAGGAT 
GCTATAAACA ACAACTCCTT TTATGGCTCT GAGATAAAAA TTGAGAAAGG AGATCTCAAG 
AAAGGCTTTT CAGAAGCTGA CAATGTTGTC TCAGGAGAGT TGTATATCGG TGGCCAGGAG 
CACTTCTACC TGGAGACCAA CTGCACCATT GCCGTGCCAA AAGGCGAGGC AGGCGAGATG 
GAGCTGTTCG TGAGCACACA GAACACCATG AAAACCCAGA GCTTTGTTGC AAAAATGTTG 
GGCGTTCCGG ACAACAGAAT CGTAGTCCGA GTGAAGAGGA TGGGTGGAGG CTTTGGAGGG 
AAGGAGACCC GGAGCACTGT GGTGTCCACA GCACTGGCCT TGGCTGCACA CAAGACTGGC 
CGGCCCGTAC GTTGCATGTT GGACCGAGAT GAGGACATGC TGATAACTGG TGGCAGACAT 
CCCTTCCTGG CTAAATACAA GGTTGGCTTC ATGAAGACTG GGACTGTAGT GGCTCTCGAG 
GTGGCTCACT TCAGCAATGG TGGTAACACT GAGGATCTCT CTCGGAGTAT AATGGAACGA 
GCTTTGTTCC ACATGGATAA CGCCTATAAG ATCCCCAACA TTCGAGGCAC TGGGAGGATT 
TGCAAGACTA ATCTGCCCTC CAACACAGCC TTCAGAGGTT TTGGGGGTCC TCAGGGGATG 
CTAATCGCAG AATACTGGAT GAGCGAGGTC GCCATAACCT GTGGGCTGCC TGCAGAGGAG 
GTACGGAGGA AAAACATGTA CAAAGAAGGG GACCTGACTC ACTTCAACCA GAAGCTGGAG 
GGGTTCACCT TGCCCAGGTG CTGGGATGAA TGCATCGCCA GCTCTCAGTA TCTTGCTCGC 
AAGAGGGAAG TGGAGAAATT CAACAGGGAG AATTGTTGGA AAAAGAGAGG GCTGTGTATA 
ATCCCAACTA AGTTTGGAAT AAGCTTTACA CTTCCTTTTC TGAACCAGGG AGGCGCTCTG 
GTTCACGTGT ACACTGATGG TTCGGTGCTG TTGACCCATG GAGGGACTGA GATGGGCCAA 
GGCCTTCACA CCAAGATGGT TCAGGTGGCC AGCAGAGCTC TGAAAATCCC CACCTCCAAG 
ATTCATATAA GTGAGACAAG CACTAACACC GTCCCCAACA CTTCTCCCAC AGCTGCCTCT 
GCCAGTGCTG ACCTCAATGG ACAGGGTGTT TATGAAGCAT GCCAGACCAT ACTGAAAAGG 
CTGGAACCTT TCAAGAAGAA GAAACCCACC GGCCCCTGGG AGGCATGGGT GATGGACGCC 
TATACGAGCG CAGTGAGTTT GTCCGCAACT GGATTTTATA AGACACCCAA CCTTGGCTAC 
AGCTTTGAGA CAAACTCCGG AAATCCCTTC CACTATTTCA GTTATGGGGT GGCTTGCTCT 
GAAGTAGAAA TTGACTGCTT AACAGGGGAT CATAAGAATC TCCGTACGGA TATCGTCATG 
GATGTTGGTT CCAGCTTGAA TCCTGCCATT GATATTGGAC AAGTAGAGGG GGCATTTGTC 
CAGGGCCTTG GTCTCTTCAC TATGGAGGAG CTGCACTACT CCCCTGAGGG GAGCCTGCAT 
ACTCGTGGCC CCAGTACCTA CAAAATCCCT GCATTTGGTA GCATCCCCAT TGAGTTCAGA 
GTATCCCTAC TCCGGGACTG CCCCAACAAG AGGGCCATCT ATGCATCCAA GGCTGTTGGG 
GAGCCACCTC TTTTCCTGGC TTCCTCTATC TTCTTTGCCA TCAAAGATGC CATTCGTGCA 
GCTCGAGCTC AGCACGGAGA TAACGCAAAA CAACTTTTCC AGCTAGACAG CCCTGCCACT 
CCGGAGAAGA TCCGAAACGC CTGTGTGGAC CAGTTCACCA CCCTGTGTGT CACTGGAGTA 
CCAGAAAACT GTAAATCCTG GTCTGTGAGG ATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

IFN-? regulates xanthine oxidase-mediated iNOS-independent oxidative stress in maneb- and paraquat-treated rat polymorphonuclear leukocytes.
Molecular and cellular biochemistry427(1-2)133-143(2017 Mar)
Singh D,Kumar V,Singh C

Abdominal paracentesis drainage protects rats against severe acute pancreatitis-associated lung injury by reducing the mobilization of intestinal XDH/XOD.
Free radical biology & medicine99374-384(2016 10)
Zhou J,Huang Z,Lin N,Liu W,Yang G,Wu D,Xiao H,Sun H,Tang L

Hepatocyte growth factor inhibits hypoxia/reoxygenation-induced activation of xanthine oxidase in endothelial cells through the JAK2 signaling pathway.
International journal of molecular medicine38(4)1055-62(2016 Oct)
Zhang YQ,Hu SY,Chen YD,Guo MZ,Wang S

Febuxostat, a novel xanthine oxidoreductase inhibitor, improves hypertension and endothelial dysfunction in spontaneously hypertensive rats.
Naunyn-Schmiedeberg's archives of pharmacology389(8)831-8(2016 Aug)
Shirakura T,Nomura J,Matsui C,Kobayashi T,Tamura M,Masuzaki H

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Xdh cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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