XDH cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	XDH
Entrez Gene ID	280960
Full Name	xanthine dehydrogenase
Synonyms	XOR
General protein information	Preferred Names xanthine dehydrogenase Names xanthine dehydrogenase/oxidase xanthine oxidoreductase
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_173972.2	NP_776397.1	xanthine dehydrogenase/oxidase

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	XDH	XP_525729.2
Canis lupus familiaris (dog)	XDH	XP_540143.2
Bos taurus (cattle)	XDH	NP_776397.1
Gallus gallus (chicken)	XDH	NP_990458.1
Drosophila melanogaster (fruit fly)	ry	NP_524337.1
Arabidopsis thaliana (thale cress)	XDH1	NP_195215.2
Oryza sativa (rice)	Os03g0429800	NP_001050420.1
Homo sapiens (human)	XDH	NP_000370.2
Danio rerio (zebrafish)	xdh	XP_688983.3
Caenorhabditis elegans (roundworm)	F55B11.1	NP_502747.1
Arabidopsis thaliana (thale cress)	XDH2	NP_195216.2
Magnaporthe oryzae (rice blast fungus)	MGG_12738	XP_003716708.1
Neurospora crassa	NCU03350	XP_956459.2
Rattus norvegicus (Norway rat)	Xdh	NP_058850.1
Xenopus tropicalis (tropical clawed frog)	LOC100497499	XP_004914866.1
	XDH	XP_002808080.1
Mus musculus (house mouse)	Xdh	NP_035853.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007918	XP_317568.3

Gene Ontology
Bibliography

Related articles in PubMed

Measurement and characterization of superoxide generation from xanthine dehydrogenase: a redox-regulated pathway of radical generation in ischemic tissues.
Lee MC, Velayutham M, Komatsu T, Hille R, Zweier JL
Biochemistry53(41)6615-23(2014 Oct)

Modeling the effects of estradiol and progesterone on the acute phase proinflammatory axis: variability in tumor necrosis factor-?, nitric oxide, and xanthine oxidase responses to endotoxin challenge in steers.
Kahl S, Elsasser TH, Li CJ
Domestic animal endocrinology40(4)213-21(2011 May)

Crystal structures of urate bound form of xanthine oxidoreductase: substrate orientation and structure of the key reaction intermediate.
Okamoto K, Kawaguchi Y, Eger BT, Pai EF, Nishino T
Journal of the American Chemical Society132(48)17080-3(2010 Dec)

Substrate orientation and catalytic specificity in the action of xanthine oxidase: the sequential hydroxylation of hypoxanthine to uric acid.
Cao H, Pauff JM, Hille R
The Journal of biological chemistry285(36)28044-53(2010 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that XDH (xanthine dehydrogenase) can be an important redox-regulated source of superoxide generation in ischemic tissue; conversion XDH to XO (xanthine oxidase) is not required to activate radical formation and subsequent tissue injury.
Title: Measurement and characterization of superoxide generation from xanthine dehydrogenase: a redox-regulated pathway of radical generation in ischemic tissues.

Plasma tumor necrosis factor-alpha response to either of two lipopolysaccharide challenges was lower in progesterone-treated than in 17beta-estradiol-treated steers. Xanthine oxidase response to either challenge was greater for estradiol-treated steers.
Title: Modeling the effects of estradiol and progesterone on the acute phase proinflammatory axis: variability in tumor necrosis factor-?, nitric oxide, and xanthine oxidase responses to endotoxin challenge in steers.

crystal structures of the urate complexes of the demolybdo-form of the D428A mutant of rat xanthine oxidoreductase and of the reduced bovine milk enzyme [XOR]
Title: Crystal structures of urate bound form of xanthine oxidoreductase: substrate orientation and structure of the key reaction intermediate.

6,8-dihydroxypurine is effectively converted to uric acid by xanthine oxidase.
Title: Substrate orientation and catalytic specificity in the action of xanthine oxidase: the sequential hydroxylation of hypoxanthine to uric acid.

Hydrogen peroxide is the major oxidant product of xanthine oxidase
Title: Hydrogen peroxide is the major oxidant product of xanthine oxidase.

The following XDH gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the XDH cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa41783	NM_173972.2 Latest version!	Bos taurus xanthine dehydrogenase (XDH), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$713.30 $1019.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

XDH ( NM_173972.2 ) cDNA ORF clone, Bos taurus(cattle) -> NP_776397.1 Bos taurus xanthine dehydrogenase (XDH), mRNA.

Price & Availability↑

CloneID	OBa41783
Clone ID Related Accession (Same CDS sequence)	NM_173972.2
Accession Version	NM_173972.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3999bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Bos taurus(cattle)
Product	xanthine dehydrogenase/oxidase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X83508.1. On Jun 3, 2003 this sequence version replaced NM_173972.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X83508.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN03145412, SAMN03145413 [ECO:0000350] ##Evidence-Data-END##

ATGACAGCAG ATGAATTGGT TTTCTTTGTG AATGGCAAAA AGGTGGTGGA GAAAAATGCA 
GATCCAGAAA CAACCCTTTT GGCCTACCTG AGAAGAAAGT TGGGGCTGAG AGGAACCAAG 
CTGGGCTGTG GAGAAGGGGG CTGTGGGGCT TGTACAGTGA TGCTTTCCAA GTATGATCGT 
CTCCAAGACA AGATCATCCA CTTTTCTGCC AATGCCTGCC TGGCTCCCAT CTGCACCTTG 
CACCACGTGG CTGTGACGAC TGTGGAAGGA ATTGGAAGCA CCAAGACGAG GCTGCATCCT 
GTGCAGGAGA GAATCGCCAA AAGTCACGGC TCTCAGTGTG GGTTCTGCAC CCCCGGCATC 
GTCATGAGCA TGTACACACT GCTTCGGAAT CAGCCCGAGC CCACTGTTGA AGAAATCGAG 
GATGCTTTCC AAGGAAACTT ATGCCGCTGT ACAGGCTACA GACCCATCCT CCAGGGCTTC 
CGGACCTTTG CCAAGAATGG TGGATGCTGT GGAGGAAATG GGAACAACCC AAACTGCTGC 
ATGAACCAGA AGAAAGACCA CACCGTTACT CTCTCACCAT CTTTATTCAA CCCAGAGGAG 
TTCATGCCCC TGGATCCTAC CCAGGAACCC ATCTTCCCTC CAGAGTTGCT GAGGCTGAAA 
GACGTTCCAC CGAAGCAGCT GCGTTTTGAA GGGGAGCGTG TGACCTGGAT CCAAGCCTCC 
ACCTTGAAGG AGTTGCTGGA CCTCAAAGCT CAGCATCCCG AGGCCAAGCT GGTGGTGGGG 
AACACAGAGA TCGGCATTGA GATGAAGTTT AAGAATCAGC TATTTCCTAT GATCATCTGC 
CCAGCCTGGA TCCCTGAGCT GAATGCAGTG GAGCACGGAC CTGAGGGGAT CTCCTTTGGA 
GCTGCTTGTG CCCTGAGCTC TGTGGAAAAG ACCCTGCTCG AGGCCGTTGC CAAGCTTCCC 
ACCCAGAAAA CGGAGGTGTT CAGAGGAGTC CTGGAGCAGC TGCGCTGGTT CGCTGGGAAG 
CAGGTCAAGT CTGTGGCGTC CCTTGGAGGG AACATCATCA CAGCCAGCCC CATCTCTGAC 
CTCAACCCTG TGTTCATGGC CAGTGGGACC AAGCTGACCA TCGTGTCCAG AGGCACCAGA 
AGAACAGTTC CAATGGACCA CACCTTCTTC CCCAGCTACA GAAAGACCCT GCTGGGTCCA 
GAGGAGATAC TGCTCTCCAT TGAGATCCCC TACAGCAGGG AGGATGAGTT TTTCTCAGCA 
TTCAAGCAGG CAAGCCGGAG AGAAGATGAC ATAGCCAAGG TGACCTGCGG CATGAGAGTC 
CTGTTCCAGC CAGGAAGCAT GCAGGTAAAG GAGCTAGCCC TCTGCTATGG CGGAATGGCG 
GACAGAACCA TCTCAGCCCT CAAGACCACG CAGAAGCAGC TGTCAAAGTT CTGGAATGAG 
AAGCTGCTAC AGGACGTGTG TGCAGGCCTG GCGGAAGAAC TGTCCTTATC CCCAGACGCC 
CCTGGAGGCA TGATTGAATT CCGACGCACC CTCACCCTCA GCTTCTTCTT CAAGTTCTAC 
CTGACAGTAC TGAAGAAACT GGGCAAGGAC TCGAAAGATA AGTGTGGTAA ACTGGACCCC 
ACCTACACCA GCGCCACTTT ACTCTTTCAG AAACACCCTC CAGCCAACAT CCAGCTCTTC 
CAAGAGGTGC CCAATGGTCA GTCCAAGGAG GACACAGTGG GCCGGCCCCT GCCCCACCTG 
GCCGCGGCCA TGCAAGCCTC TGGGGAGGCC GTATACTGTG ACGACATCCC TCGCTACGAG 
AATGAGCTGT TCCTCCGGCT GGTCACCAGC ACCCGGGCCC ACGCCAAGAT CAAGTCCATT 
GATGTTTCAG AAGCTCAGAA AGTGCCAGGA TTTGTTTGCT TTCTCTCTGC TGATGATATT 
CCCGGGAGTA ATGAAACCGG ACTCTTTAAT GATGAGACAG TCTTTGCGAA GGATACGGTG 
ACTTGTGTTG GTCACATCAT TGGTGCTGTG GTCGCTGACA CCCCAGAACA TGCAGAGAGA 
GCTGCCCATG TAGTGAAAGT CACCTATGAG GATCTTCCTG CCATTATCAC AATTGAGGAT 
GCTATAAAAA ATAATTCCTT TTATGGATCT GAGCTGAAGA TTGAGAAAGG AGACCTCAAG 
AAGGGGTTTT CAGAAGCAGA TAATGTGGTT TCAGGTGAGC TGTACATTGG TGGCCAAGAC 
CACTTCTACC TGGAGACTCA CTGCACCATT GCTATCCCGA AAGGCGAGGA AGGGGAGATG 
GAGCTCTTTG TGTCCACACA GAATGCCATG AAAACCCAGT CCTTTGTTGC AAAAATGTTG 
GGGGTTCCAG TAAACCGGAT TTTGGTCCGA GTGAAGAGAA TGGGAGGAGG CTTTGGAGGG 
AAGGAGACCC GGAGCACCCT GGTGTCTGTG GCTGTGGCCC TGGCTGCATA CAAGACTGGA 
CACCCGGTGC GCTGCATGCT GGATCGTAAT GAGGATATGC TGATAACTGG CGGCAGACAC 
CCCTTCTTGG CCAGATACAA GGTTGGCTTC ATGAAGACAG GGACGATTGT GGCTCTAGAG 
GTGGATCACT ACAGCAATGC CGGGAACAGC CGGGACCTCT CTCACAGTAT AATGGAACGA 
GCTCTATTCC ACATGGACAA CTGCTATAAA ATCCCCAACA TCCGGGGCAC TGGGCGGCTG 
TGCAAGACCA ACCTGTCCTC CAACACGGCC TTCCGGGGCT TTGGGGGGCC CCAGGCTCTG 
TTCATTGCCG AGAACTGGAT GAGCGAAGTT GCAGTGACCT GTGGGCTGCC TGCAGAGGAA 
GTGCGGTGGA AGAACATGTA CAAAGAAGGG GACCTGACCC ACTTCAACCA GAGGCTTGAG 
GGGTTCAGCG TGCCCAGGTG CTGGGATGAG TGCCTGAAGA GCTCTCAGTA TTACGCTCGG 
AAGAGTGAGG TCGACAAGTT CAACAAGGAG AATTGTTGGA AAAAGAGAGG ATTGTGCATA 
ATTCCTACCA AATTTGGAAT AAGCTTCACA GTTCCTTTTC TAAATCAGGC AGGAGCCCTG 
ATCCACGTAT ACACAGATGG CTCCGTGCTG GTGAGCCACG GGGGCACAGA GATGGGCCAA 
GGCCTTCACA CCAAGATGGT GCAGGTGGCC AGCAAAGCTC TGAAGATCCC CATCTCTAAG 
ATCTATATCA GCGAGACGAG CACTAACACG GTGCCCAACT CCTCTCCCAC GGCCGCCTCC 
GTCAGTACCG ACATCTATGG ACAGGCCGTC TATGAAGCTT GCCAGACCAT CCTGAAAAGG 
TTGGAACCCT TCAAGAAAAA GAATCCTGAT GGCTCCTGGG AAGACTGGGT CATGGCTGCC 
TACCAGGATA GAGTGAGCTT ATCTACCACT GGGTTTTACA GGACACCCAA CCTTGGCTAC 
AGCTTTGAGA CCAACTCAGG GAATGCCTTC CACTATTTCA CCTACGGGGT GGCTTGCTCA 
GAAGTGGAAA TTGACTGTTT GACAGGGGAT CATAAGAACC TCCGTACAGA CATTGTCATG 
GATGTTGGCT CCAGTCTGAA CCCTGCCATC GATATTGGAC AGGTGGAAGG GGCGTTTGTC 
CAGGGCCTGG GCCTCTTCAC CCTGGAGGAG CTACACTATT CCCCTGAGGG GAGCCTGCAC 
ACCCGCGGCC CCAGCACCTA CAAGATCCCC GCGTTTGGCA GCATCCCCAC AGAGTTCAGG 
GTGTCCCTGC TTCGCGACTG CCCCAACAAG AAGGCCATCT ATGCCTCCAA GGCGGTCGGG 
GAGCCGCCCC TCTTCCTGGG CGCCTCCGTC TTCTTTGCCA TCAAGGATGC CATCCGCGCG 
GCTCGAGCTC AGCACACAAA TAATAACACG AAGGAGCTCT TCCGGCTAGA TAGCCCTGCC 
ACCCCGGAGA AGATCCGCAA TGCCTGCGTG GACAAGTTCA CCACTCTGTG TGTCACTGGT 
GCACCAGGAA ACTGTAAACC CTGGTCTCTG AGGGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_776397.1
CDS	97..4095
Translation	MTADELVFFVNGKKVVEKNADPETTLLAYLRRKLGLRGTKLGCGEGGCGACTVMLSKYDRLQDKIIHFSANACLAPICTLHHVAVTTVEGIGSTKTRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNQPEPTVEEIEDAFQGNLCRCTGYRPILQGFRTFAKNGGCCGGNGNNPNCCMNQKKDHTVTLSPSLFNPEEFMPLDPTQEPIFPPELLRLKDVPPKQLRFEGERVTWIQASTLKELLDLKAQHPEAKLVVGNTEIGIEMKFKNQLFPMIICPAWIPELNAVEHGPEGISFGAACALSSVEKTLLEAVAKLPTQKTEVFRGVLEQLRWFAGKQVKSVASLGGNIITASPISDLNPVFMASGTKLTIVSRGTRRTVPMDHTFFPSYRKTLLGPEEILLSIEIPYSREDEFFSAFKQASRREDDIAKVTCGMRVLFQPGSMQVKELALCYGGMADRTISALKTTQKQLSKFWNEKLLQDVCAGLAEELSLSPDAPGGMIEFRRTLTLSFFFKFYLTVLKKLGKDSKDKCGKLDPTYTSATLLFQKHPPANIQLFQEVPNGQSKEDTVGRPLPHLAAAMQASGEAVYCDDIPRYENELFLRLVTSTRAHAKIKSIDVSEAQKVPGFVCFLSADDIPGSNETGLFNDETVFAKDTVTCVGHIIGAVVADTPEHAERAAHVVKVTYEDLPAIITIEDAIKNNSFYGSELKIEKGDLKKGFSEADNVVSGELYIGGQDHFYLETHCTIAIPKGEEGEMELFVSTQNAMKTQSFVAKMLGVPVNRILVRVKRMGGGFGGKETRSTLVSVAVALAAYKTGHPVRCMLDRNEDMLITGGRHPFLARYKVGFMKTGTIVALEVDHYSNAGNSRDLSHSIMERALFHMDNCYKIPNIRGTGRLCKTNLSSNTAFRGFGGPQALFIAENWMSEVAVTCGLPAEEVRWKNMYKEGDLTHFNQRLEGFSVPRCWDECLKSSQYYARKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQAGALIHVYTDGSVLVSHGGTEMGQGLHTKMVQVASKALKIPISKIYISETSTNTVPNSSPTAASVSTDIYGQAVYEACQTILKRLEPFKKKNPDGSWEDWVMAAYQDRVSLSTTGFYRTPNLGYSFETNSGNAFHYFTYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAFVQGLGLFTLEELHYSPEGSLHTRGPSTYKIPAFGSIPTEFRVSLLRDCPNKKAIYASKAVGEPPLFLGASVFFAIKDAIRAARAQHTNNNTKELFRLDSPATPEKIRNACVDKFTTLCVTGAPGNCKPWSLRV

Target ORF information:

RefSeq Version	NM_173972.2
Organism	Bos taurus(cattle)
Definition	Bos taurus xanthine dehydrogenase (XDH), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_173972.2

ORF Insert Sequence:

ATGACAGCAG ATGAATTGGT TTTCTTTGTG AATGGCAAAA AGGTGGTGGA GAAAAATGCA 
GATCCAGAAA CAACCCTTTT GGCCTACCTG AGAAGAAAGT TGGGGCTGAG AGGAACCAAG 
CTGGGCTGTG GAGAAGGGGG CTGTGGGGCT TGTACAGTGA TGCTTTCCAA GTATGATCGT 
CTCCAAGACA AGATCATCCA CTTTTCTGCC AATGCCTGCC TGGCTCCCAT CTGCACCTTG 
CACCACGTGG CTGTGACGAC TGTGGAAGGA ATTGGAAGCA CCAAGACGAG GCTGCATCCT 
GTGCAGGAGA GAATCGCCAA AAGTCACGGC TCTCAGTGTG GGTTCTGCAC CCCCGGCATC 
GTCATGAGCA TGTACACACT GCTTCGGAAT CAGCCCGAGC CCACTGTTGA AGAAATCGAG 
GATGCTTTCC AAGGAAACTT ATGCCGCTGT ACAGGCTACA GACCCATCCT CCAGGGCTTC 
CGGACCTTTG CCAAGAATGG TGGATGCTGT GGAGGAAATG GGAACAACCC AAACTGCTGC 
ATGAACCAGA AGAAAGACCA CACCGTTACT CTCTCACCAT CTTTATTCAA CCCAGAGGAG 
TTCATGCCCC TGGATCCTAC CCAGGAACCC ATCTTCCCTC CAGAGTTGCT GAGGCTGAAA 
GACGTTCCAC CGAAGCAGCT GCGTTTTGAA GGGGAGCGTG TGACCTGGAT CCAAGCCTCC 
ACCTTGAAGG AGTTGCTGGA CCTCAAAGCT CAGCATCCCG AGGCCAAGCT GGTGGTGGGG 
AACACAGAGA TCGGCATTGA GATGAAGTTT AAGAATCAGC TATTTCCTAT GATCATCTGC 
CCAGCCTGGA TCCCTGAGCT GAATGCAGTG GAGCACGGAC CTGAGGGGAT CTCCTTTGGA 
GCTGCTTGTG CCCTGAGCTC TGTGGAAAAG ACCCTGCTCG AGGCCGTTGC CAAGCTTCCC 
ACCCAGAAAA CGGAGGTGTT CAGAGGAGTC CTGGAGCAGC TGCGCTGGTT CGCTGGGAAG 
CAGGTCAAGT CTGTGGCGTC CCTTGGAGGG AACATCATCA CAGCCAGCCC CATCTCTGAC 
CTCAACCCTG TGTTCATGGC CAGTGGGACC AAGCTGACCA TCGTGTCCAG AGGCACCAGA 
AGAACAGTTC CAATGGACCA CACCTTCTTC CCCAGCTACA GAAAGACCCT GCTGGGTCCA 
GAGGAGATAC TGCTCTCCAT TGAGATCCCC TACAGCAGGG AGGATGAGTT TTTCTCAGCA 
TTCAAGCAGG CAAGCCGGAG AGAAGATGAC ATAGCCAAGG TGACCTGCGG CATGAGAGTC 
CTGTTCCAGC CAGGAAGCAT GCAGGTAAAG GAGCTAGCCC TCTGCTATGG CGGAATGGCG 
GACAGAACCA TCTCAGCCCT CAAGACCACG CAGAAGCAGC TGTCAAAGTT CTGGAATGAG 
AAGCTGCTAC AGGACGTGTG TGCAGGCCTG GCGGAAGAAC TGTCCTTATC CCCAGACGCC 
CCTGGAGGCA TGATTGAATT CCGACGCACC CTCACCCTCA GCTTCTTCTT CAAGTTCTAC 
CTGACAGTAC TGAAGAAACT GGGCAAGGAC TCGAAAGATA AGTGTGGTAA ACTGGACCCC 
ACCTACACCA GCGCCACTTT ACTCTTTCAG AAACACCCTC CAGCCAACAT CCAGCTCTTC 
CAAGAGGTGC CCAATGGTCA GTCCAAGGAG GACACAGTGG GCCGGCCCCT GCCCCACCTG 
GCCGCGGCCA TGCAAGCCTC TGGGGAGGCC GTATACTGTG ACGACATCCC TCGCTACGAG 
AATGAGCTGT TCCTCCGGCT GGTCACCAGC ACCCGGGCCC ACGCCAAGAT CAAGTCCATT 
GATGTTTCAG AAGCTCAGAA AGTGCCAGGA TTTGTTTGCT TTCTCTCTGC TGATGATATT 
CCCGGGAGTA ATGAAACCGG ACTCTTTAAT GATGAGACAG TCTTTGCGAA GGATACGGTG 
ACTTGTGTTG GTCACATCAT TGGTGCTGTG GTCGCTGACA CCCCAGAACA TGCAGAGAGA 
GCTGCCCATG TAGTGAAAGT CACCTATGAG GATCTTCCTG CCATTATCAC AATTGAGGAT 
GCTATAAAAA ATAATTCCTT TTATGGATCT GAGCTGAAGA TTGAGAAAGG AGACCTCAAG 
AAGGGGTTTT CAGAAGCAGA TAATGTGGTT TCAGGTGAGC TGTACATTGG TGGCCAAGAC 
CACTTCTACC TGGAGACTCA CTGCACCATT GCTATCCCGA AAGGCGAGGA AGGGGAGATG 
GAGCTCTTTG TGTCCACACA GAATGCCATG AAAACCCAGT CCTTTGTTGC AAAAATGTTG 
GGGGTTCCAG TAAACCGGAT TTTGGTCCGA GTGAAGAGAA TGGGAGGAGG CTTTGGAGGG 
AAGGAGACCC GGAGCACCCT GGTGTCTGTG GCTGTGGCCC TGGCTGCATA CAAGACTGGA 
CACCCGGTGC GCTGCATGCT GGATCGTAAT GAGGATATGC TGATAACTGG CGGCAGACAC 
CCCTTCTTGG CCAGATACAA GGTTGGCTTC ATGAAGACAG GGACGATTGT GGCTCTAGAG 
GTGGATCACT ACAGCAATGC CGGGAACAGC CGGGACCTCT CTCACAGTAT AATGGAACGA 
GCTCTATTCC ACATGGACAA CTGCTATAAA ATCCCCAACA TCCGGGGCAC TGGGCGGCTG 
TGCAAGACCA ACCTGTCCTC CAACACGGCC TTCCGGGGCT TTGGGGGGCC CCAGGCTCTG 
TTCATTGCCG AGAACTGGAT GAGCGAAGTT GCAGTGACCT GTGGGCTGCC TGCAGAGGAA 
GTGCGGTGGA AGAACATGTA CAAAGAAGGG GACCTGACCC ACTTCAACCA GAGGCTTGAG 
GGGTTCAGCG TGCCCAGGTG CTGGGATGAG TGCCTGAAGA GCTCTCAGTA TTACGCTCGG 
AAGAGTGAGG TCGACAAGTT CAACAAGGAG AATTGTTGGA AAAAGAGAGG ATTGTGCATA 
ATTCCTACCA AATTTGGAAT AAGCTTCACA GTTCCTTTTC TAAATCAGGC AGGAGCCCTG 
ATCCACGTAT ACACAGATGG CTCCGTGCTG GTGAGCCACG GGGGCACAGA GATGGGCCAA 
GGCCTTCACA CCAAGATGGT GCAGGTGGCC AGCAAAGCTC TGAAGATCCC CATCTCTAAG 
ATCTATATCA GCGAGACGAG CACTAACACG GTGCCCAACT CCTCTCCCAC GGCCGCCTCC 
GTCAGTACCG ACATCTATGG ACAGGCCGTC TATGAAGCTT GCCAGACCAT CCTGAAAAGG 
TTGGAACCCT TCAAGAAAAA GAATCCTGAT GGCTCCTGGG AAGACTGGGT CATGGCTGCC 
TACCAGGATA GAGTGAGCTT ATCTACCACT GGGTTTTACA GGACACCCAA CCTTGGCTAC 
AGCTTTGAGA CCAACTCAGG GAATGCCTTC CACTATTTCA CCTACGGGGT GGCTTGCTCA 
GAAGTGGAAA TTGACTGTTT GACAGGGGAT CATAAGAACC TCCGTACAGA CATTGTCATG 
GATGTTGGCT CCAGTCTGAA CCCTGCCATC GATATTGGAC AGGTGGAAGG GGCGTTTGTC 
CAGGGCCTGG GCCTCTTCAC CCTGGAGGAG CTACACTATT CCCCTGAGGG GAGCCTGCAC 
ACCCGCGGCC CCAGCACCTA CAAGATCCCC GCGTTTGGCA GCATCCCCAC AGAGTTCAGG 
GTGTCCCTGC TTCGCGACTG CCCCAACAAG AAGGCCATCT ATGCCTCCAA GGCGGTCGGG 
GAGCCGCCCC TCTTCCTGGG CGCCTCCGTC TTCTTTGCCA TCAAGGATGC CATCCGCGCG 
GCTCGAGCTC AGCACACAAA TAATAACACG AAGGAGCTCT TCCGGCTAGA TAGCCCTGCC 
ACCCCGGAGA AGATCCGCAA TGCCTGCGTG GACAAGTTCA CCACTCTGTG TGTCACTGGT 
GCACCAGGAA ACTGTAAACC CTGGTCTCTG AGGGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Measurement and characterization of superoxide generation from xanthine dehydrogenase: a redox-regulated pathway of radical generation in ischemic tissues.
Biochemistry53(41)6615-23(2014 Oct)
Lee MC,Velayutham M,Komatsu T,Hille R,Zweier JL

Modeling the effects of estradiol and progesterone on the acute phase proinflammatory axis: variability in tumor necrosis factor-?, nitric oxide, and xanthine oxidase responses to endotoxin challenge in steers.
Domestic animal endocrinology40(4)213-21(2011 May)
Kahl S,Elsasser TH,Li CJ

Crystal structures of urate bound form of xanthine oxidoreductase: substrate orientation and structure of the key reaction intermediate.
Journal of the American Chemical Society132(48)17080-3(2010 Dec)
Okamoto K,Kawaguchi Y,Eger BT,Pai EF,Nishino T

Substrate orientation and catalytic specificity in the action of xanthine oxidase: the sequential hydroxylation of hypoxanthine to uric acid.
The Journal of biological chemistry285(36)28044-53(2010 Sep)
Cao H,Pauff JM,Hille R

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XDH cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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