Ppid cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ppid
Entrez Gene ID	361967
Full Name	peptidylprolyl isomerase D
Synonyms	Cyp-40,CypD
General protein information	Preferred Names peptidylprolyl isomerase D Names peptidyl-prolyl cis-trans isomerase D 40 kDa peptidyl-prolyl cis-trans isomerase Cyclophilin D PPIase D cyclophilin-40 rotamase D
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q33

mRNA and Protein(s)

mRNA	Protein	Name
NM_001004279.1	NP_001004279.1	peptidyl-prolyl cis-trans isomerase D

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Ppid	NP_080628.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003265	XP_307775.3
Oryza sativa (rice)	Os02g0761100	NP_001048194.1
Homo sapiens (human)	PPID	NP_005029.1
Rattus norvegicus (Norway rat)	Ppid	NP_001004279.1
Danio rerio (zebrafish)	ppid	NP_001002065.1
Eremothecium gossypii	AGOS_ADR087C	NP_984183.1
Oryza sativa (rice)	Os06g0216800	NP_001057148.1
Xenopus tropicalis (tropical clawed frog)	ppid	NP_988984.1
Schizosaccharomyces pombe (fission yeast)	wis2	NP_594787.1
Magnaporthe oryzae (rice blast fungus)	MGG_08104	XP_003715059.1
Neurospora crassa	NCU03853	XP_955863.1
Arabidopsis thaliana (thale cress)	SQN	NP_565381.1
Pan troglodytes (chimpanzee)	PPID	XP_001145793.1
	LOC696657	XP_001083759.1
	PPID	XP_001097233.1
Canis lupus familiaris (dog)	PPID	XP_532704.1
Kluyveromyces lactis	KLLA0F05093g	XP_455311.1
Bos taurus (cattle)	PPID	NP_776578.1
Rattus norvegicus (Norway rat)	Ppidl1	XP_003750805.1
Gallus gallus (chicken)	PPID	XP_426283.3
Drosophila melanogaster (fruit fly)	CG8336	NP_001261636.1
Saccharomyces cerevisiae (baker's yeast)	CPR6	NP_013317.1

Gene Ontology
Bibliography

Related articles in PubMed

The beneficial effects of AMP kinase activation against oxidative stress are associated with prevention of PPAR?-cyclophilin D interaction in cardiomyocytes.
Barreto-Torres G, Hernandez JS, Jang S, Rodr?guez-Mu?oz AR, Torres-Ramos CA, Basnakian AG, Javadov S
American journal of physiology. Heart and circulatory physiology308(7)H749-58(2015 Apr)

Cyclophilin 40 alters UVA-induced apoptosis and mitochondrial ROS generation in keratinocytes.
Jandova J, Janda J, Sligh JE
Experimental cell research319(5)750-60(2013 Mar)

Glucocorticoid sensitizers Bag1 and Ppid are regulated by adolescent stress in a sex-dependent manner.
Bourke CH, Raees MQ, Malviya S, Bradburn CA, Binder EB, Neigh GN
Psychoneuroendocrinology38(1)84-93(2013 Jan)

Inhibition of cyclophilins alters lipid trafficking and blocks hepatitis C virus secretion.
Anderson LJ, Lin K, Compton T, Wiedmann B
Virology journal8329(2011 Jun)

N-methyl-4-isoleucine cyclosporine attenuates CCl -induced liver fibrosis in rats by interacting with cyclophilin B and D.
Wang H, Zhang Y, Wang T, You H, Jia J
Journal of gastroenterology and hepatology26(3)558-67(2011 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

cyclophilin D may modify mitochondrial features by inducing the translocation of molecules to the mitochondria through the mechanism associated with cellular energy metabolism
Title: Long-term inhibition of cyclophilin D results in intracellular translocation of calcein AM from mitochondria to lysosomes.

Data show that the redox state of cyclophilin D was stimulated by thioredoxin 1 and 2 and peroxiredoxin 3 in heart mitochondria.
Title: Mitochondrial Thioredoxin System as a Modulator of Cyclophilin D Redox State.

In cardiomyocytes the protective effects of metformin-induced AMPK activation against oxidative stress converge on mitochondria and are mediated, at least in part, through the dissociation of PPARalpha-CypD interactions.
Title: The beneficial effects of AMP kinase activation against oxidative stress are associated with prevention of PPAR?-cyclophilin D interaction in cardiomyocytes.

Ppid expression was predicted by plasma estradiol & 34% lower in control adolescent females than males. After chronic adolescent stress, females had elevated hippocampal Ppid expression that was not seen in males.
Title: Glucocorticoid sensitizers Bag1 and Ppid are regulated by adolescent stress in a sex-dependent manner.

NIM811 attenuates liver fibrosis in a CCl(4)-induced rat liver fibrosis model, which may be related to binding with cyclophilin B and D.
Title: N-methyl-4-isoleucine cyclosporine attenuates CCl -induced liver fibrosis in rats by interacting with cyclophilin B and D.

The following Ppid gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ppid cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10338	NM_001004279.1 Latest version!	Rattus norvegicus peptidylprolyl isomerase D (Ppid), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ppid ( NM_001004279.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001004279.1 Rattus norvegicus peptidylprolyl isomerase D (Ppid), mRNA.

Price & Availability↑

CloneID	ORa10338
Clone ID Related Accession (Same CDS sequence)	NM_001004279.1
Accession Version	NM_001004279.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1113bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	peptidyl-prolyl cis-trans isomerase D
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC076386.1. On Sep 10, 2004 this sequence version replaced XM_342265.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC076386.1, FQ214826.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGTCCCACC CATCCCCAGC AGGCAAGCCC TCCAATTCCA AGAACCCGCG AGTCTTCTTT 
GACGTGGACA TCGGCGGGGA GCGAGTTGGA CGAATTGTTT TAGAATTGTT TGCAGATATT 
GTTCCTAAAA CTGCAGAAAA TTTTCGTGCA TTGTGTACAG GAGAAAAGGG CACTGGACCG 
ACAACTGGGA AACCTCTGCA TTTTAAAGGA TGCCCTTTCC ACCGAATTAT TAAGAAATTT 
ATGATTCAGG GTGGAGACTT CTCAAATCAG AATGGGACAG GTGGAGAAAG TATTTATGGT 
GAAAAATTTG AAGATGAGAA TTTTCATTAT AAGCATGATC GGGAGGGTTT GCTGAGCATG 
GCAAATGCAG GCCCCAATAC AAATGGTTCT CAGTTCTTTA TCACAACAGT TCCAACTCCT 
CATTTGGATG GGAAACATGT GGTATTTGGT CAAGTAATAA AAGGACTAGG TGTGGCAAGG 
ATGCTTGAAA ATGTAGAAGT GAATGGTGAA AAACCTGCCA AACTCTGTGT TATTGCAGAA 
TGTGGAGAAT TGAAGGAAGG GGATGAATGG GGAATATTCC CCAAAGATGG CTCTGGGGAT 
AGTCATCCAG ATTTCCCTGA GGATGCAGAC ATAGACTTAA AGGATGTAGA TAAAATTTTA 
TTAATATCTG AAGACTTAAA AAACATTGGA AATACTTTTT TCAAGTCTCA AAACTGGGAG 
ATGGCTATTA AAAAATATGC AAAGGTTTTA AGGTACTTGG ATAGTTCAAA GGCTGTTATT 
GAGAAAGCAG ATGTATCCAG ACTGCAACCC ATAGCCTTAA GTTGTGTGCT GAATATTGGT 
GCTTGTAAAT TGAAGATGTC AAATTGGCAG GGGGCAATTG ACAGTTGCTT GGAGGCTCTT 
GAAATGGACC CTTCAAACAC TAAAGCACTA TACCGAAAAG CACAAGGATG GCAAGGATTG 
AAAGAATATG ATCAAGCATT GGCTGATCTT AAGAAGGCGC AGGAGATAGC CCCAGGAGAT 
AAAGCTATCC AGGCAGAATT GCTTAAAGTC AAACAAATGA TAAAGGCACA GAAAGATAAA 
GAGAAGGCAG TGTATGCAAA AATGTTTGCT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001004279.1
CDS	61..1173
Translation	MSHPSPAGKPSNSKNPRVFFDVDIGGERVGRIVLELFADIVPKTAENFRALCTGEKGTGPTTGKPLHFKGCPFHRIIKKFMIQGGDFSNQNGTGGESIYGEKFEDENFHYKHDREGLLSMANAGPNTNGSQFFITTVPTPHLDGKHVVFGQVIKGLGVARMLENVEVNGEKPAKLCVIAECGELKEGDEWGIFPKDGSGDSHPDFPEDADIDLKDVDKILLISEDLKNIGNTFFKSQNWEMAIKKYAKVLRYLDSSKAVIEKADVSRLQPIALSCVLNIGACKLKMSNWQGAIDSCLEALEMDPSNTKALYRKAQGWQGLKEYDQALADLKKAQEIAPGDKAIQAELLKVKQMIKAQKDKEKAVYAKMFA

Target ORF information:

RefSeq Version	NM_001004279.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus peptidylprolyl isomerase D (Ppid), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001004279.1

ORF Insert Sequence:

ATGTCCCACC CATCCCCAGC AGGCAAGCCC TCCAATTCCA AGAACCCGCG AGTCTTCTTT 
GACGTGGACA TCGGCGGGGA GCGAGTTGGA CGAATTGTTT TAGAATTGTT TGCAGATATT 
GTTCCTAAAA CTGCAGAAAA TTTTCGTGCA TTGTGTACAG GAGAAAAGGG CACTGGACCG 
ACAACTGGGA AACCTCTGCA TTTTAAAGGA TGCCCTTTCC ACCGAATTAT TAAGAAATTT 
ATGATTCAGG GTGGAGACTT CTCAAATCAG AATGGGACAG GTGGAGAAAG TATTTATGGT 
GAAAAATTTG AAGATGAGAA TTTTCATTAT AAGCATGATC GGGAGGGTTT GCTGAGCATG 
GCAAATGCAG GCCCCAATAC AAATGGTTCT CAGTTCTTTA TCACAACAGT TCCAACTCCT 
CATTTGGATG GGAAACATGT GGTATTTGGT CAAGTAATAA AAGGACTAGG TGTGGCAAGG 
ATGCTTGAAA ATGTAGAAGT GAATGGTGAA AAACCTGCCA AACTCTGTGT TATTGCAGAA 
TGTGGAGAAT TGAAGGAAGG GGATGAATGG GGAATATTCC CCAAAGATGG CTCTGGGGAT 
AGTCATCCAG ATTTCCCTGA GGATGCAGAC ATAGACTTAA AGGATGTAGA TAAAATTTTA 
TTAATATCTG AAGACTTAAA AAACATTGGA AATACTTTTT TCAAGTCTCA AAACTGGGAG 
ATGGCTATTA AAAAATATGC AAAGGTTTTA AGGTACTTGG ATAGTTCAAA GGCTGTTATT 
GAGAAAGCAG ATGTATCCAG ACTGCAACCC ATAGCCTTAA GTTGTGTGCT GAATATTGGT 
GCTTGTAAAT TGAAGATGTC AAATTGGCAG GGGGCAATTG ACAGTTGCTT GGAGGCTCTT 
GAAATGGACC CTTCAAACAC TAAAGCACTA TACCGAAAAG CACAAGGATG GCAAGGATTG 
AAAGAATATG ATCAAGCATT GGCTGATCTT AAGAAGGCGC AGGAGATAGC CCCAGGAGAT 
AAAGCTATCC AGGCAGAATT GCTTAAAGTC AAACAAATGA TAAAGGCACA GAAAGATAAA 
GAGAAGGCAG TGTATGCAAA AATGTTTGCT TAA