Xbp1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Xbp1
Entrez Gene ID	289754
Full Name	X-box binding protein 1
Synonyms	HTF
General protein information	Preferred Names X-box binding protein 1 Names X-box-binding protein 1 hepatocarcinogenesis-related transcription factor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 14 Map Location: 14q21
Summary	transcription factor; regulates MHC class II genes by binding to an X-box promoter element; agents that cause the unfolded protein response upregulate transcription [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001004210.2	NP_001004210.1	X-box-binding protein 1 isoform XBP1(U)
NM_001271731.1	NP_001258660.1	X-box-binding protein 1 isoform XBP1(S)

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Xbp1	NP_001258660.1
Mus musculus (house mouse)	Xbp1	NP_001258659.1
Bos taurus (cattle)	XBP1	NP_001258666.1
Homo sapiens (human)	XBP1	NP_001073007.1
Canis lupus familiaris (dog)	XBP1	XP_854633.3

Gene Ontology
Bibliography

Related articles in PubMed

BRD7 mediates hyperglycaemia-induced myocardial apoptosis via endoplasmic reticulum stress signalling pathway.
Wang XM, Wang YC, Liu XJ, Wang Q, Zhang CM, Zhang LP, Liu H, Zhang XY, Mao Y, Ge ZM
Journal of cellular and molecular medicine21(6)1094-1105(2017 Jun)

Critical role of X-box binding protein 1 in NADPH oxidase 4-triggered cardiac hypertrophy is mediated by receptor interacting protein kinase 1.
Chen L, Zhao M, Li J, Wang Y, Bao Q, Wu S, Deng X, Tang X, Wu W, Liu X
Cell cycle (Georgetown, Tex.)16(4)348-359(2017 Feb)

Deregulation of XBP1 expression contributes to myocardial vascular endothelial growth factor-A expression and angiogenesis during cardiac hypertrophy in?vivo.
Duan Q, Ni L, Wang P, Chen C, Yang L, Ma B, Gong W, Cai Z, Zou MH, Wang DW
Aging cell15(4)625-33(2016 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Xbp1s plays an important role in NOX4-triggered cardiomyocyte hypertrophy via activating its downstream effector RIPK1, which may prove significant for the development of future therapeutic strategies.
Title: Critical role of X-box binding protein 1 in NADPH oxidase 4-triggered cardiac hypertrophy is mediated by receptor interacting protein kinase 1.

XBP-1 and PARP protein are sensitive to variations in fluorine concentration, which indicates that oxidative stress from fluorine exposure can lead to apoptosis. XBP-1 and PARP may be the key proteins during the entire process.
Title: Effects of Sodium Fluoride on Lipid Peroxidation and PARP, XBP-1 Expression in PC12 Cell.

XBP1 regulates VEGF-mediated cardiac angiogenesis.
Title: Deregulation of XBP1 expression contributes to myocardial vascular endothelial growth factor-A expression and angiogenesis during cardiac hypertrophy in?vivo.

Enhanced splicing of XBP-1 was observed in BCL-2 overexpressing cells implicating BCL-2 in the complex regulation of IRE1alpha activity.
Title: BCL-2 modulates the unfolded protein response by enhancing splicing of X-box binding protein-1.

XBP1 lymphocyte expression is down-regulated under conditions of psychological stress in rats.
Title: Expression of XBP1 in lymphocytes of the small intestine in rats under chronic social stress and modulation of intestinal microflora composition.

The following Xbp1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Xbp1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12350	NM_001004210.2 Latest version!	Rattus norvegicus X-box binding protein 1 (Xbp1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
ORa12340	NM_001271731.1 Latest version!	Rattus norvegicus X-box binding protein 1 (Xbp1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Xbp1 ( NM_001004210.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001004210.1 Rattus norvegicus X-box binding protein 1 (Xbp1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ORa12350
Clone ID Related Accession (Same CDS sequence)	NM_001004210.2
Accession Version	NM_001004210.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 804bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Rattus norvegicus(Norway rat)
Product	X-box-binding protein 1 isoform XBP1(U)
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BU670819.1 and BC079450.1. On Nov 9, 2012 this sequence version replaced NM_001004210.1. Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform, XBP1(U). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC079450.1, CF111069.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGGTGG TGGCAGCGGC GCCGAGCGCG GCCTCGGCGG CCCCCAAAGT GCTACTCCTA 
TCTGGTCAGC CCGCCTCCGG CGGCCGAGCG CTGCCGCTCA TGGTTCCGGG CCCGCGAGCC 
GCAGGGTCGG AGGCGAGCGG GACACCGCAG GCTCGCAAGC GGCAGCGCCT CACGCACCTG 
AGCCCGGAGG AGAAAGCGCT GCGGAGGAAA CTGAAAAACA GAGTAGCAGC ACAGACTGCG 
CGAGATAGAA AGAAAGCCCG GATGAGCGAG CTGGAGCAGC AAGTGGTGGA TTTGGAAGAA 
GAGAACCAGA AACTCCAGCT AGAAAATCAG CTTTTACGAG AGAAAACTCA TGGGCTTGTG 
ATTGAGAACC AGGAGTTAAG GACACGCTTG GGGATGAATG CCCTGGTTAC TGAAGAGGTC 
TCAGAGGCAG AGTCCAAGGG GAATGGAGTA AGGCTGGTGG CCGGGTCTGC TGAGTCCGCA 
GCACTCAGAC TACGTGCGCC TCTGCAGCAG GTGCAGGCCC AGTTGTCACC TCCCCAGAAC 
ATCTTCCCAT GGATTCTGAC GCTGTTGCCT CTTCAGATTC TGAGTCTGAT ATCCTTTTGG 
GCATTCTGGA CAAGTTGGAC CCTGTCATGT TTTTCAAATG TCCTTCCCCA GAGTCTGCTA 
ATCTGGAGGA ACTCCCAGAG GTCTACCCAG AAGGACCTAG TTCCTTACCA GCCTCCCTTT 
CTCTGTCAGT GGGGACCTCA TCAGCCAAGC TGGAAGCCAT TAATGAACTC ATTCGTTTTG 
ACCATGTATA CACCAAGCCT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001004210.1
CDS	25..828
Translation	MVVVAAAPSAASAAPKVLLLSGQPASGGRALPLMVPGPRAAGSEASGTPQARKRQRLTHLSPEEKALRRKLKNRVAAQTARDRKKARMSELEQQVVDLEEENQKLQLENQLLREKTHGLVIENQELRTRLGMNALVTEEVSEAESKGNGVRLVAGSAESAALRLRAPLQQVQAQLSPPQNIFPWILTLLPLQILSLISFWAFWTSWTLSCFSNVLPQSLLIWRNSQRSTQKDLVPYQPPFLCQWGPHQPSWKPLMNSFVLTMYTPSL

Target ORF information:

RefSeq Version	NM_001004210.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus X-box binding protein 1 (Xbp1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001004210.2

ORF Insert Sequence:

ATGGTGGTGG TGGCAGCGGC GCCGAGCGCG GCCTCGGCGG CCCCCAAAGT GCTACTCCTA 
TCTGGTCAGC CCGCCTCCGG CGGCCGAGCG CTGCCGCTCA TGGTTCCGGG CCCGCGAGCC 
GCAGGGTCGG AGGCGAGCGG GACACCGCAG GCTCGCAAGC GGCAGCGCCT CACGCACCTG 
AGCCCGGAGG AGAAAGCGCT GCGGAGGAAA CTGAAAAACA GAGTAGCAGC ACAGACTGCG 
CGAGATAGAA AGAAAGCCCG GATGAGCGAG CTGGAGCAGC AAGTGGTGGA TTTGGAAGAA 
GAGAACCAGA AACTCCAGCT AGAAAATCAG CTTTTACGAG AGAAAACTCA TGGGCTTGTG 
ATTGAGAACC AGGAGTTAAG GACACGCTTG GGGATGAATG CCCTGGTTAC TGAAGAGGTC 
TCAGAGGCAG AGTCCAAGGG GAATGGAGTA AGGCTGGTGG CCGGGTCTGC TGAGTCCGCA 
GCACTCAGAC TACGTGCGCC TCTGCAGCAG GTGCAGGCCC AGTTGTCACC TCCCCAGAAC 
ATCTTCCCAT GGATTCTGAC GCTGTTGCCT CTTCAGATTC TGAGTCTGAT ATCCTTTTGG 
GCATTCTGGA CAAGTTGGAC CCTGTCATGT TTTTCAAATG TCCTTCCCCA GAGTCTGCTA 
ATCTGGAGGA ACTCCCAGAG GTCTACCCAG AAGGACCTAG TTCCTTACCA GCCTCCCTTT 
CTCTGTCAGT GGGGACCTCA TCAGCCAAGC TGGAAGCCAT TAATGAACTC ATTCGTTTTG 
ACCATGTATA CACCAAGCCT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Xbp1 ( NM_001271731.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001258660.1 Rattus norvegicus X-box binding protein 1 (Xbp1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	ORa12340
Clone ID Related Accession (Same CDS sequence)	NM_001271731.1
Accession Version	NM_001271731.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1116bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Rattus norvegicus(Norway rat)
Product	X-box-binding protein 1 isoform XBP1(S)
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BU670819.1, BC079450.1 and CB691171.1. Transcript Variant: This variant (2) lacks a 26 nt segment in the CDS compared to variant 1, that causes a frameshift. The resulting isoform, XBP1(S), has the same N-terminus, but a longer and distinct C-terminus compared to isoform XBP1(U). Isoform XBP1(S) functions as a transcription factor. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DN931840.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGGTGG TGGCAGCGGC GCCGAGCGCG GCCTCGGCGG CCCCCAAAGT GCTACTCCTA 
TCTGGTCAGC CCGCCTCCGG CGGCCGAGCG CTGCCGCTCA TGGTTCCGGG CCCGCGAGCC 
GCAGGGTCGG AGGCGAGCGG GACACCGCAG GCTCGCAAGC GGCAGCGCCT CACGCACCTG 
AGCCCGGAGG AGAAAGCGCT GCGGAGGAAA CTGAAAAACA GAGTAGCAGC ACAGACTGCG 
CGAGATAGAA AGAAAGCCCG GATGAGCGAG CTGGAGCAGC AAGTGGTGGA TTTGGAAGAA 
GAGAACCAGA AACTCCAGCT AGAAAATCAG CTTTTACGAG AGAAAACTCA TGGGCTTGTG 
ATTGAGAACC AGGAGTTAAG GACACGCTTG GGGATGAATG CCCTGGTTAC TGAAGAGGTC 
TCAGAGGCAG AGTCCAAGGG GAATGGAGTA AGGCTGGTGG CCGGGTCTGC TGAGTCCGCA 
GCAGGTGCAG GCCCAGTTGT CACCTCCCCA GAACATCTTC CCATGGATTC TGACGCTGTT 
GCCTCTTCAG ATTCTGAGTC TGATATCCTT TTGGGCATTC TGGACAAGTT GGACCCTGTC 
ATGTTTTTCA AATGTCCTTC CCCAGAGTCT GCTAATCTGG AGGAACTCCC AGAGGTCTAC 
CCAGAAGGAC CTAGTTCCTT ACCAGCCTCC CTTTCTCTGT CAGTGGGGAC CTCATCAGCC 
AAGCTGGAAG CCATTAATGA ACTCATTCGT TTTGACCATG TATACACCAA GCCTCTAGTC 
TTAGAGATCC CCTCTGAGAC AGAGAGCCAA ACTAATGTGG TAGTGAAAAT TGAGGAAGCA 
CCTCTAAGCT CTTCAGAAGA GGATCACCCT GAATTCATTG TCTCAGTGAA GAAAGAACCT 
TTGGATGATG ACTTCATTCC CGAGCTGGGC ATCTCAAACC TGCTTTCATC CAGCCATTGT 
CTGAGACCAC CTTCCTGCCT GCTGGATGCT CACAGTGACT GTGGATATGA GGGCTCCCCT 
TCTCCCTTCA GCGACATGTC TTCTCCACTT GGTACAGACC ACTCCTGGGA GGACACTTTT 
GCCAACGAAC TTTTCCCCCA GCTGATTAGT GTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001258660.1
CDS	25..1140
Translation	MVVVAAAPSAASAAPKVLLLSGQPASGGRALPLMVPGPRAAGSEASGTPQARKRQRLTHLSPEEKALRRKLKNRVAAQTARDRKKARMSELEQQVVDLEEENQKLQLENQLLREKTHGLVIENQELRTRLGMNALVTEEVSEAESKGNGVRLVAGSAESAAGAGPVVTSPEHLPMDSDAVASSDSESDILLGILDKLDPVMFFKCPSPESANLEELPEVYPEGPSSLPASLSLSVGTSSAKLEAINELIRFDHVYTKPLVLEIPSETESQTNVVVKIEEAPLSSSEEDHPEFIVSVKKEPLDDDFIPELGISNLLSSSHCLRPPSCLLDAHSDCGYEGSPSPFSDMSSPLGTDHSWEDTFANELFPQLISV

Target ORF information:

RefSeq Version	NM_001271731.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus X-box binding protein 1 (Xbp1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001271731.1

ORF Insert Sequence:

ATGGTGGTGG TGGCAGCGGC GCCGAGCGCG GCCTCGGCGG CCCCCAAAGT GCTACTCCTA 
TCTGGTCAGC CCGCCTCCGG CGGCCGAGCG CTGCCGCTCA TGGTTCCGGG CCCGCGAGCC 
GCAGGGTCGG AGGCGAGCGG GACACCGCAG GCTCGCAAGC GGCAGCGCCT CACGCACCTG 
AGCCCGGAGG AGAAAGCGCT GCGGAGGAAA CTGAAAAACA GAGTAGCAGC ACAGACTGCG 
CGAGATAGAA AGAAAGCCCG GATGAGCGAG CTGGAGCAGC AAGTGGTGGA TTTGGAAGAA 
GAGAACCAGA AACTCCAGCT AGAAAATCAG CTTTTACGAG AGAAAACTCA TGGGCTTGTG 
ATTGAGAACC AGGAGTTAAG GACACGCTTG GGGATGAATG CCCTGGTTAC TGAAGAGGTC 
TCAGAGGCAG AGTCCAAGGG GAATGGAGTA AGGCTGGTGG CCGGGTCTGC TGAGTCCGCA 
GCAGGTGCAG GCCCAGTTGT CACCTCCCCA GAACATCTTC CCATGGATTC TGACGCTGTT 
GCCTCTTCAG ATTCTGAGTC TGATATCCTT TTGGGCATTC TGGACAAGTT GGACCCTGTC 
ATGTTTTTCA AATGTCCTTC CCCAGAGTCT GCTAATCTGG AGGAACTCCC AGAGGTCTAC 
CCAGAAGGAC CTAGTTCCTT ACCAGCCTCC CTTTCTCTGT CAGTGGGGAC CTCATCAGCC 
AAGCTGGAAG CCATTAATGA ACTCATTCGT TTTGACCATG TATACACCAA GCCTCTAGTC 
TTAGAGATCC CCTCTGAGAC AGAGAGCCAA ACTAATGTGG TAGTGAAAAT TGAGGAAGCA 
CCTCTAAGCT CTTCAGAAGA GGATCACCCT GAATTCATTG TCTCAGTGAA GAAAGAACCT 
TTGGATGATG ACTTCATTCC CGAGCTGGGC ATCTCAAACC TGCTTTCATC CAGCCATTGT 
CTGAGACCAC CTTCCTGCCT GCTGGATGCT CACAGTGACT GTGGATATGA GGGCTCCCCT 
TCTCCCTTCA GCGACATGTC TTCTCCACTT GGTACAGACC ACTCCTGGGA GGACACTTTT 
GCCAACGAAC TTTTCCCCCA GCTGATTAGT GTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

BRD7 mediates hyperglycaemia-induced myocardial apoptosis via endoplasmic reticulum stress signalling pathway.
Journal of cellular and molecular medicine21(6)1094-1105(2017 Jun)
Wang XM,Wang YC,Liu XJ,Wang Q,Zhang CM,Zhang LP,Liu H,Zhang XY,Mao Y,Ge ZM

Critical role of X-box binding protein 1 in NADPH oxidase 4-triggered cardiac hypertrophy is mediated by receptor interacting protein kinase 1.
Cell cycle (Georgetown, Tex.)16(4)348-359(2017 Feb)
Chen L,Zhao M,Li J,Wang Y,Bao Q,Wu S,Deng X,Tang X,Wu W,Liu X

Deregulation of XBP1 expression contributes to myocardial vascular endothelial growth factor-A expression and angiogenesis during cardiac hypertrophy in?vivo.
Aging cell15(4)625-33(2016 Aug)
Duan Q,Ni L,Wang P,Chen C,Yang L,Ma B,Gong W,Cai Z,Zou MH,Wang DW

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Xbp1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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