Gene Symbol | XBP1 |
Entrez Gene ID | 541236 |
Full Name | X-box binding protein 1 |
Synonyms | XBPP1 |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
ORF » Species Summary » Bos taurus » XBP1 cDNA ORF clone
Gene Symbol | XBP1 |
Entrez Gene ID | 541236 |
Full Name | X-box binding protein 1 |
Synonyms | XBPP1 |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
mRNA | Protein | Name |
---|---|---|
NM_001271737.1 | NP_001258666.1 | X-box-binding protein 1 isoform XBP1(S) |
NM_001034727.3 | NP_001029899.1 | X-box-binding protein 1 isoform XBP1(U) |
Targeting the IRE1?/XBP1 and ATF6 arms of the unfolded protein response enhances VEGF blockade to prevent retinal and choroidal neovascularization.
Liu L, Qi X, Chen Z, Shaw L, Cai J, Smith LH, Grant MB, Boulton ME
The American journal of pathology182(4)1412-24(2013 Apr)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Exposure of endothelial cells to VEGF, high glucose, or hydrogen peroxide up-regulated the XBP1/IRE1 alpha and ATF6 arms of the unfolded protein response compared with untreated cells.
Title: Targeting the IRE1?/XBP1 and ATF6 arms of the unfolded protein response enhances VEGF blockade to prevent retinal and choroidal neovascularization.
The following XBP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the XBP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OBa00495 | |
Clone ID Related Accession (Same CDS sequence) | NM_001271737.1 | |
Accession Version | NM_001271737.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1131bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-13 | |
Organism | Bos taurus(cattle) | |
Product | X-box-binding protein 1 isoform XBP1(S) | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH145309.1 and DAAA02045588.1. Transcript Variant: This variant (2) lacks a 26 nt segment in the CDS compared to variant 1, that causes a frameshift. The resulting isoform, XBP1(S), has the same N-terminus, but a longer and distinct C-terminus compared to isoform XBP1(U). Isoform XBP1(S) functions as a transcription factor. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN03145413, SAMN03145442 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGTGGTGG TTGCACCCGC GCAGAGCCCG GCCGCCGGGG CCCCTAAAGT ACTGCTTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001258666.1 |
CDS | 44..1174 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001271737.1 |
1 | ATGGTGGTGG TTGCACCCGC GCAGAGCCCG GCCGCCGGGG CCCCTAAAGT ACTGCTTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OBa01527 | |
Clone ID Related Accession (Same CDS sequence) | NM_001034727.3 | |
Accession Version | NM_001034727.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 786bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-13 | |
Organism | Bos taurus(cattle) | |
Product | X-box-binding protein 1 isoform XBP1(U) | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH145309.1, EH156163.1 and DAAA02045588.1. On Nov 10, 2012 this sequence version replaced NM_001034727.2. Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform, XBP1(U). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC102639.1, DV785532.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145413, SAMN03145442 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGTGGTGG TTGCACCCGC GCAGAGCCCG GCCGCCGGGG CCCCTAAAGT ACTGCTTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001029899.1 |
CDS | 44..829 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001034727.3 |
1 | ATGGTGGTGG TTGCACCCGC GCAGAGCCCG GCCGCCGGGG CCCCTAAAGT ACTGCTTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Targeting the IRE1?/XBP1 and ATF6 arms of the unfolded protein response enhances VEGF blockade to prevent retinal and choroidal neovascularization. |