Corin cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Corin
Entrez Gene ID	289596
Full Name	corin, serine peptidase
General protein information	Preferred Names corin, serine peptidase Names atrial natriuretic peptide-converting enzyme pro-ANP-converting enzyme
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 14 Map Location: 14p11

mRNA and Protein(s)

mRNA	Protein	Name
XM_008770139.2	XP_008768361.1	atrial natriuretic peptide-converting enzyme isoform X1
NM_182473.1	NP_872279.1	atrial natriuretic peptide-converting enzyme

Pathways from BioSystems

Homologies

Bos taurus (cattle)	CORIN	XP_005207990.1
Xenopus tropicalis (tropical clawed frog)	corin	XP_002933508.2
	CORIN	XP_001102245.1
Homo sapiens (human)	CORIN	NP_006578.2
Mus musculus (house mouse)	Corin	NP_058565.2
Rattus norvegicus (Norway rat)	Corin	NP_872279.1
Gallus gallus (chicken)	CORIN	XP_003641257.2
Canis lupus familiaris (dog)	CORIN	XP_005628222.1
Danio rerio (zebrafish)	si:ch1073-76a20.1	XP_005174214.1
Pan troglodytes (chimpanzee)	CORIN	XP_001153181.1

Gene Ontology
Bibliography

Related articles in PubMed

Short-Term High-Salt Diet Increases Corin Level to Regulate the Salt-Water Balance in Humans and Rodents.
Zhang J, Yin Y, Chen L, Chu C, Wang Y, Lv Y, He M, Martin M, Huang PH, Mu JJ, Shyy JY, Yuan ZY
American journal of hypertension31(2)253-260(2018 Jan)

The Involvement of Corin in the Progression of Diabetic Erectile Dysfunction in a Rat Model by Down-Regulating ANP /NO/cGMP Signal Pathway.
Wang J, Mi Y, Yuan F, Wu S, You X, Dai F, Huang Y, Cao J, Zhu J, Xue B, Zhu L
Journal of cellular biochemistry118(8)2325-2332(2017 Aug)

Corin is down-regulated and exerts cardioprotective action via activating pro-atrial natriuretic peptide pathway in diabetic cardiomyopathy.
Pang A, Hu Y, Zhou P, Long G, Tian X, Men L, Shen Y, Liu Y, Cui Y
Cardiovascular diabetology14134(2015 Oct)

Impaired sodium excretion and salt-sensitive hypertension in corin-deficient mice.
Wang W, Shen J, Cui Y, Jiang J, Chen S, Peng J, Wu Q
Kidney international82(1)26-33(2012 Jul)

Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy.
Cui Y, Wang W, Dong N, Lou J, Srinivasan DK, Cheng W, Huang X, Liu M, Fang C, Peng J, Chen S, Wu S, Liu Z, Dong L, Zhou Y, Wu Q
Nature484(7393)246-50(2012 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Corin contributes to the progression of diabetic ED and the underlying mechanism is associated with the down-regulation of ANP /NO/cGMP signal pathway.
Title: The Involvement of Corin in the Progression of Diabetic Erectile Dysfunction in a Rat Model by Down-Regulating ANP /NO/cGMP Signal Pathway.

Corin mRNA and protein are downregulated in diabetic cardiomyopathy (DCM). Corin plays an important role in cardioprotection by activating pro-atrial natriuretic peptide pathway in DCM.
Title: Corin is down-regulated and exerts cardioprotective action via activating pro-atrial natriuretic peptide pathway in diabetic cardiomyopathy.

corin might be involved in the salt retention seen in glomerular diseases.
Title: Decreased renal corin expression contributes to sodium retention in proteinuric kidney diseases.

N-linked oligosaccharides play an important role in corin activation
Title: Role of glycosylation in corin zymogen activation.

corin gene is upregulated in hypertrophic cardiomyocytes and failing myocardium and may contribute to elevation of ANP in the setting of cardiac hypertrophy and heart failure.
Title: Upregulation of corin gene expression in hypertrophic cardiomyocytes and failing myocardium.

The following Corin gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Corin cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42725	NM_182473.1 Latest version!	Rattus norvegicus corin, serine peptidase (Corin), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$818.30 $1169.00
ORa44804	XM_008770139.2 Latest version!	Rattus norvegicus corin, serine peptidase (Corin), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$559.30 $799.00

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Corin ( NM_182473.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_872279.1 Rattus norvegicus corin, serine peptidase (Corin), mRNA.

Price & Availability↑

CloneID	ORa42725
Clone ID Related Accession (Same CDS sequence)	NM_182473.1
Accession Version	NM_182473.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3336bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Rattus norvegicus(Norway rat)
Product	atrial natriuretic peptide-converting enzyme
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY251285.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY251285.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689596, SAMEA2689600 [ECO:0000348] ##Evidence-Data-END##

ATGGGCAGGG TTTCTTTCAA CGTTCGGGTC AGCTCTGTGA GGAGAGCCCG CTGCTCTTGT 
CCTGGGCGAT GCTACCTGTC CTGCAGAGTC CCTCCAACCA CCGCCCTCCA TGCACTGAAC 
GGGTTTGGCC GCGCGGGGGT TCTGGGGGAG ACTGCAGGTG GAACCGTCGG ACTCGGCCCC 
TCGGGGACCC GTGGCTTCCT CTCCGGGTCC AAGTTCCAGG CTTCGGGCAG CTTGAAGGAT 
TGCTTTGGAG CCCCGCCTGC TCCAGACGTC TTGAGAGCAG ACAGCAGCGT GGGCGAGGGC 
TGTCCTCAGA AGCTGGTGAC AGCAAATTTG CTACGCTTCC TCCTGCTTGT GCTCATCCCC 
TGCATCTGCG CCCTTATCGT GCTGCTGGCC ATCCTGCTGT CCTTCGTGGG AACATTAAAG 
AAGGTTTATT TCAAATCAAA TGACAGTGAA CCTTTGGTCA CTGATGGTGA AGTTCGAGTG 
CCTGGTGTTA TCCATGTAAA TAGATATGAG AACACAGGGG CGCCCTCTAT GTCCCCCAGC 
CAATCCATTC CTGCCTGGAC ACCTAGAGCT CCTTCTCTAG AGGACCAGAG TCACGGAAAT 
ACAAGCACCT GCGTGAACAT CACTCACAGA CAGTGTCAAA TTCTGCCCTA CCACAGCACG 
CTGGCACCCC TCTTGCCAAT TGTCAAAAAT ATGGACACGG AGAAGTTCCT CAAGTTCTTC 
ACGTACCTCC ATCGCCTCGG TTGCTATCAA CACATCCTGC TCTTTGGCTG TAGCCTCGCC 
TTCCCCAAGT GCATTGTTGA TGGCGATGAC AGGCACGGCC TCCTACCCTG TAGATCTTTC 
TGTGAGGCTG CAAAAGAAGG ATGTGAATCA GTCCTGGGAA TGGTGAACTC CTCCTGGCCA 
GATTCCCTCA GATGCTCTCA GTTTAGATAC CACACTGAGA ATAACAGCGA CGCCAGCACG 
ATCTGCTTCT CACTGCAGCA GGAGCATGGA AAGCAATCGC TCTGTGGAGG AGGTGAGAGC 
TTCCTGTGTA CCAGCGGGCT CTGCATCTCC AAGAAGCTGC AGTGTAATGG CTACAATGAC 
TGTGATGACT GGAGCGACGA GGCTCACTGC AACTGCAGCG AGGATCTGTT TCACTGTGGA 
ACAGGCAAGT GCCTCCACCA CAGCCTTGTG TGCGATGGGT ATGATGACTG TGGGGACCTG 
AGCGACGAGC AAAACTGTGA TTGCAATCTC ACAAAAGAGC ATCGCTGTGG AGACGGGCGC 
TGCATCGCGG CTGAGTGGGT GTGTGATGGG GACCATGACT GTGTGGACAA GTCTGACGAG 
GTCAACTGCT CTTGTCCCAG CCAGGGCCTT GTGGAATGCA GAAGTGGACA GTGCATCCCT 
AGCACCTTCC AGTGTGATGG GGACGAAGAC TGTAAGGACG GGAGTGACGA GGAGAACTGC 
AGTGACCGTC CGACACCGTG TCCTGGAGGA GATCGGGGTT GCCTTGACAG TTCCTGTGTC 
GAATCCTGTG CTGGTAGCTC TCTGTGTGAC TCAGACAGCA GCCTGAGTAA CTGCAGTCAC 
TGTGAGCCCA TCACTTTGGA ACTCTGCATG AATTTGCCCT ACAACCTTAC ACATTATCCA 
AATTACCTTG GCCACAGAAC TCAAAAGGAA GCGTCCATCA GCTGGGAGTC AGCTCTCTTC 
CCTGCCCTTG TACAAACCAA CTGTTACAAA TACCTCATGT TTTTCGCTTG CACCATTTTG 
GTTCCAAAGT GTGATGTGAA TACAGGCCAG CGCGTCCCGC CTTGCAGACT CCTGTGTGAG 
CACTCCAAAG AGCGCTGTGA GTCTGTTCTG GGGATCGTAG GCCTCCAGTG GCCTGAAGAC 
ACAGACTGCA GTCAATTTCC AGAGCAAAGT TCAGACAATC AAACTTGCCT CCTGCCCAAT 
GAAGACGTGG AAGAATGCTC TCCGAGTCAC TTCAAGTGCC GCTCGGGACG ATGCGTTCTG 
GGTTCCAGAA GATGCGACGG CCAGGCTGAC TGTGATGACG ACAGTGACGA AGAGAACTGT 
GGTTGTAAAG AGAGAGATCT TTGGGAATGT CCACTCAATA AGCAATGTCT GAAGCATACA 
TTAATCTGTG ATGGGTTTCC AGACTGTTCA GATAGTATGG ATGAAAAAAA CTGCTCATTT 
TGCCAGGACG ATGAGCTGGA ATGTGCCAAC CATGAGTGTG TGCCACGCGA CCTGTGGTGC 
GATGGATGGA CAGATTGCTC AGACAGTTCA GATGAATGGG GCTGTGTGAC CCTCTCTAAA 
AATGGGAACT CCTCCTCATT CCTGACTGTT CACAGATCTG CAAGAGATCA CCACGTGTGT 
GCTGATGGCT GGCAGGAGAC GTTGAGTCAG CTGGCCTGCA GGCAGATGGG TTTAGGAGAA 
CCATCTGTGA CTGAACTGGT CCAAGGGCAG GAAGGCCAGC AGTGGCTGAG GTTGCACTCC 
AGCTGGGAGA ATCTCAATGG GAGCACCCTG CAGGAGCTGC TGGTGCACAG GCGGTCCTGC 
CCAAGCGGAA GTGAGATTTC CCTTCTGTGT ACCAAGCAAG ACTGTGGTCG CCGCCCTGCT 
GCCCGAATGA ACAAGAGGAT CCTTGGGGGT CGGACTAGTC GTCCTGGGAG GTGGCCGTGG 
CAGTGTTCTC TGCAGAGTGA ACCCAGTGGA CATATCTGTG GCTGTGTCCT CATTGCCAAG 
AAGTGGGTCC TGACAGTTGC CCATTGCTTT GAAGGGAGAG AGGATGCTGA TGTCTGGAAA 
GTGGTATTTG GCATAAACAA CCTGGACCAT CCGTCAGGCT TCATGCAGAC CCGCTTTGTG 
AAGACCATTC TGCTACATCC CCGTTACAGT CGAGCAGTGG TAGACTATGA CATCAGTGTG 
GTGGAGCTGA GTGATGATAT CAATGAGACA AGCTACGTCA GACCTGTCTG CCTACCCAGC 
CCCAGGGAGT TCCTAGAACC AGATACATAC TGCTACATCA CAGGCTGGGG CCACATGGGC 
AATAAAATGC CCTTTAAGCT GCAGGAGGGG GAAGTCCGCA TTATTCCTCT GGAGCAGTGC 
CAGTCCTATT TTGACATGAA GACCATCACC AATCGGATGA TATGTGCTGG CTATGAGTCC 
GGCACTGTGG ACTCATGTAT GGGAGACAGT GGTGGTCCTC TGGTTTGTGA ACGACCCGGA 
GGACAGTGGA CATTATTTGG TTTAACTTCA TGGGGCTCCG TCTGCTTTTC CAAAGTCCTA 
GGACCTGGAG TGTACAGCAA TGTGTCTTAC TTTGTTGACT GGATCGAAAG ACAAATATAT 
ATCCAGACCT TTCTCCAAAA GAAATCCCAA GGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_872279.1
CDS	26..3361
Translation	MGRVSFNVRVSSVRRARCSCPGRCYLSCRVPPTTALHALNGFGRAGVLGETAGGTVGLGPSGTRGFLSGSKFQASGSLKDCFGAPPAPDVLRADSSVGEGCPQKLVTANLLRFLLLVLIPCICALIVLLAILLSFVGTLKKVYFKSNDSEPLVTDGEVRVPGVIHVNRYENTGAPSMSPSQSIPAWTPRAPSLEDQSHGNTSTCVNITHRQCQILPYHSTLAPLLPIVKNMDTEKFLKFFTYLHRLGCYQHILLFGCSLAFPKCIVDGDDRHGLLPCRSFCEAAKEGCESVLGMVNSSWPDSLRCSQFRYHTENNSDASTICFSLQQEHGKQSLCGGGESFLCTSGLCISKKLQCNGYNDCDDWSDEAHCNCSEDLFHCGTGKCLHHSLVCDGYDDCGDLSDEQNCDCNLTKEHRCGDGRCIAAEWVCDGDHDCVDKSDEVNCSCPSQGLVECRSGQCIPSTFQCDGDEDCKDGSDEENCSDRPTPCPGGDRGCLDSSCVESCAGSSLCDSDSSLSNCSHCEPITLELCMNLPYNLTHYPNYLGHRTQKEASISWESALFPALVQTNCYKYLMFFACTILVPKCDVNTGQRVPPCRLLCEHSKERCESVLGIVGLQWPEDTDCSQFPEQSSDNQTCLLPNEDVEECSPSHFKCRSGRCVLGSRRCDGQADCDDDSDEENCGCKERDLWECPLNKQCLKHTLICDGFPDCSDSMDEKNCSFCQDDELECANHECVPRDLWCDGWTDCSDSSDEWGCVTLSKNGNSSSFLTVHRSARDHHVCADGWQETLSQLACRQMGLGEPSVTELVQGQEGQQWLRLHSSWENLNGSTLQELLVHRRSCPSGSEISLLCTKQDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCFEGREDADVWKVVFGINNLDHPSGFMQTRFVKTILLHPRYSRAVVDYDISVVELSDDINETSYVRPVCLPSPREFLEPDTYCYITGWGHMGNKMPFKLQEGEVRIIPLEQCQSYFDMKTITNRMICAGYESGTVDSCMGDSGGPLVCERPGGQWTLFGLTSWGSVCFSKVLGPGVYSNVSYFVDWIERQIYIQTFLQKKSQG

Target ORF information:

RefSeq Version	NM_182473.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus corin, serine peptidase (Corin), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_182473.1

ORF Insert Sequence:

ATGGGCAGGG TTTCTTTCAA CGTTCGGGTC AGCTCTGTGA GGAGAGCCCG CTGCTCTTGT 
CCTGGGCGAT GCTACCTGTC CTGCAGAGTC CCTCCAACCA CCGCCCTCCA TGCACTGAAC 
GGGTTTGGCC GCGCGGGGGT TCTGGGGGAG ACTGCAGGTG GAACCGTCGG ACTCGGCCCC 
TCGGGGACCC GTGGCTTCCT CTCCGGGTCC AAGTTCCAGG CTTCGGGCAG CTTGAAGGAT 
TGCTTTGGAG CCCCGCCTGC TCCAGACGTC TTGAGAGCAG ACAGCAGCGT GGGCGAGGGC 
TGTCCTCAGA AGCTGGTGAC AGCAAATTTG CTACGCTTCC TCCTGCTTGT GCTCATCCCC 
TGCATCTGCG CCCTTATCGT GCTGCTGGCC ATCCTGCTGT CCTTCGTGGG AACATTAAAG 
AAGGTTTATT TCAAATCAAA TGACAGTGAA CCTTTGGTCA CTGATGGTGA AGTTCGAGTG 
CCTGGTGTTA TCCATGTAAA TAGATATGAG AACACAGGGG CGCCCTCTAT GTCCCCCAGC 
CAATCCATTC CTGCCTGGAC ACCTAGAGCT CCTTCTCTAG AGGACCAGAG TCACGGAAAT 
ACAAGCACCT GCGTGAACAT CACTCACAGA CAGTGTCAAA TTCTGCCCTA CCACAGCACG 
CTGGCACCCC TCTTGCCAAT TGTCAAAAAT ATGGACACGG AGAAGTTCCT CAAGTTCTTC 
ACGTACCTCC ATCGCCTCGG TTGCTATCAA CACATCCTGC TCTTTGGCTG TAGCCTCGCC 
TTCCCCAAGT GCATTGTTGA TGGCGATGAC AGGCACGGCC TCCTACCCTG TAGATCTTTC 
TGTGAGGCTG CAAAAGAAGG ATGTGAATCA GTCCTGGGAA TGGTGAACTC CTCCTGGCCA 
GATTCCCTCA GATGCTCTCA GTTTAGATAC CACACTGAGA ATAACAGCGA CGCCAGCACG 
ATCTGCTTCT CACTGCAGCA GGAGCATGGA AAGCAATCGC TCTGTGGAGG AGGTGAGAGC 
TTCCTGTGTA CCAGCGGGCT CTGCATCTCC AAGAAGCTGC AGTGTAATGG CTACAATGAC 
TGTGATGACT GGAGCGACGA GGCTCACTGC AACTGCAGCG AGGATCTGTT TCACTGTGGA 
ACAGGCAAGT GCCTCCACCA CAGCCTTGTG TGCGATGGGT ATGATGACTG TGGGGACCTG 
AGCGACGAGC AAAACTGTGA TTGCAATCTC ACAAAAGAGC ATCGCTGTGG AGACGGGCGC 
TGCATCGCGG CTGAGTGGGT GTGTGATGGG GACCATGACT GTGTGGACAA GTCTGACGAG 
GTCAACTGCT CTTGTCCCAG CCAGGGCCTT GTGGAATGCA GAAGTGGACA GTGCATCCCT 
AGCACCTTCC AGTGTGATGG GGACGAAGAC TGTAAGGACG GGAGTGACGA GGAGAACTGC 
AGTGACCGTC CGACACCGTG TCCTGGAGGA GATCGGGGTT GCCTTGACAG TTCCTGTGTC 
GAATCCTGTG CTGGTAGCTC TCTGTGTGAC TCAGACAGCA GCCTGAGTAA CTGCAGTCAC 
TGTGAGCCCA TCACTTTGGA ACTCTGCATG AATTTGCCCT ACAACCTTAC ACATTATCCA 
AATTACCTTG GCCACAGAAC TCAAAAGGAA GCGTCCATCA GCTGGGAGTC AGCTCTCTTC 
CCTGCCCTTG TACAAACCAA CTGTTACAAA TACCTCATGT TTTTCGCTTG CACCATTTTG 
GTTCCAAAGT GTGATGTGAA TACAGGCCAG CGCGTCCCGC CTTGCAGACT CCTGTGTGAG 
CACTCCAAAG AGCGCTGTGA GTCTGTTCTG GGGATCGTAG GCCTCCAGTG GCCTGAAGAC 
ACAGACTGCA GTCAATTTCC AGAGCAAAGT TCAGACAATC AAACTTGCCT CCTGCCCAAT 
GAAGACGTGG AAGAATGCTC TCCGAGTCAC TTCAAGTGCC GCTCGGGACG ATGCGTTCTG 
GGTTCCAGAA GATGCGACGG CCAGGCTGAC TGTGATGACG ACAGTGACGA AGAGAACTGT 
GGTTGTAAAG AGAGAGATCT TTGGGAATGT CCACTCAATA AGCAATGTCT GAAGCATACA 
TTAATCTGTG ATGGGTTTCC AGACTGTTCA GATAGTATGG ATGAAAAAAA CTGCTCATTT 
TGCCAGGACG ATGAGCTGGA ATGTGCCAAC CATGAGTGTG TGCCACGCGA CCTGTGGTGC 
GATGGATGGA CAGATTGCTC AGACAGTTCA GATGAATGGG GCTGTGTGAC CCTCTCTAAA 
AATGGGAACT CCTCCTCATT CCTGACTGTT CACAGATCTG CAAGAGATCA CCACGTGTGT 
GCTGATGGCT GGCAGGAGAC GTTGAGTCAG CTGGCCTGCA GGCAGATGGG TTTAGGAGAA 
CCATCTGTGA CTGAACTGGT CCAAGGGCAG GAAGGCCAGC AGTGGCTGAG GTTGCACTCC 
AGCTGGGAGA ATCTCAATGG GAGCACCCTG CAGGAGCTGC TGGTGCACAG GCGGTCCTGC 
CCAAGCGGAA GTGAGATTTC CCTTCTGTGT ACCAAGCAAG ACTGTGGTCG CCGCCCTGCT 
GCCCGAATGA ACAAGAGGAT CCTTGGGGGT CGGACTAGTC GTCCTGGGAG GTGGCCGTGG 
CAGTGTTCTC TGCAGAGTGA ACCCAGTGGA CATATCTGTG GCTGTGTCCT CATTGCCAAG 
AAGTGGGTCC TGACAGTTGC CCATTGCTTT GAAGGGAGAG AGGATGCTGA TGTCTGGAAA 
GTGGTATTTG GCATAAACAA CCTGGACCAT CCGTCAGGCT TCATGCAGAC CCGCTTTGTG 
AAGACCATTC TGCTACATCC CCGTTACAGT CGAGCAGTGG TAGACTATGA CATCAGTGTG 
GTGGAGCTGA GTGATGATAT CAATGAGACA AGCTACGTCA GACCTGTCTG CCTACCCAGC 
CCCAGGGAGT TCCTAGAACC AGATACATAC TGCTACATCA CAGGCTGGGG CCACATGGGC 
AATAAAATGC CCTTTAAGCT GCAGGAGGGG GAAGTCCGCA TTATTCCTCT GGAGCAGTGC 
CAGTCCTATT TTGACATGAA GACCATCACC AATCGGATGA TATGTGCTGG CTATGAGTCC 
GGCACTGTGG ACTCATGTAT GGGAGACAGT GGTGGTCCTC TGGTTTGTGA ACGACCCGGA 
GGACAGTGGA CATTATTTGG TTTAACTTCA TGGGGCTCCG TCTGCTTTTC CAAAGTCCTA 
GGACCTGGAG TGTACAGCAA TGTGTCTTAC TTTGTTGACT GGATCGAAAG ACAAATATAT 
ATCCAGACCT TTCTCCAAAA GAAATCCCAA GGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Corin ( XM_008770139.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008768361.1 Rattus norvegicus corin, serine peptidase (Corin), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa44804
Clone ID Related Accession (Same CDS sequence)	XM_008770139.2
Accession Version	XM_008770139.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3138bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	atrial natriuretic peptide-converting enzyme isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005113.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008770139.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTCACGA AACGGCCCCC CGCCCTTGCT CCGGAGGAGC ACAGTCGCCG AGCCGACGCC 
CCAAAGAGGG TCTTGAGAGC AGACAGCAGC GTGGGCGAGG GCTGTCCTCA GAAGCTGGTG 
ACAGCAAATT TGCTACGCTT CCTCCTGCTT GTGCTCATCC CCTGCATCTG CGCCCTTATC 
GTGCTGCTGG CCATCCTGCT GTCCTTCGTG GGAACATTAA AGAAGGTTTA TTTCAAATCA 
AATGACAGTG AACCTTTGGT CACTGATGGT GAAGTTCGAG TGCCTGGTGT TATCCATGTA 
AATAGATATG AGAACACAGG GGCGCCCTCT ATGCCCCCCA GCCAATCCAT TCCTGCCTGG 
ACACCTAGAG CTCCTTCTCT AGAGGACCAG AGTCACGGAA ATACAAGCAC CTGCGTGAAC 
ATCACTCACA GACAGTGTCA AATTCTGCCC TACCACAGCA CGCTGGCACC CCTCTTGCCA 
ATTGTCAAAA ATATGGACAC GGAGAAGTTC CTCAAGTTCT TCACGTACCT CCATCGCCTC 
GGTTGCTATC AACACATCCT GCTCTTTGGC TGTAGCCTCG CCTTCCCCAA GTGCATTGTT 
GATGGCGATG ACAGGCATGG CCTCCTACCC TGTAGATCTT TCTGTGAGGC TGCAAAAGAA 
GGATGTGAAT CAGTCCTGGG AATGGTGAAC TCCTCCTGGC CAGATTCCCT CAGATGCTCT 
CAGTTTAGAT ACCACACTGA GAATAACAGC GACGCCAGCA GGATCTGCTT CTCACTGCAG 
CAGGAGCATG GAAAGCAATC GCTCTGTGGA GGAGGTGAGA GCTTCCTGTG TACCAGCGGG 
CTCTGCATCT CCAAGAAGCT GCAGTGTAAC GGCTACAATG ACTGTGATGA CTGGAGCGAC 
GAGGCTCACT GCAACTGCAG CGAGGATCTG TTTCACTGTG GAACAGGCAA GTGCCTCCAC 
CACAGCCTTG TGTGCGATGG GTATGATGAC TGTGGGGACC TGAGCGACGA GCAAAACTGT 
GATTGCAATC TCACAAAAGA GCATCGCTGT GGAGACGGGC GCTGCATCGC GGCTGAGTGG 
GTGTGTGATG GGGACCATGA CTGTGTGGAC AAGTCTGACG AGGTCAACTG CTCTTGTCCC 
AGCCAGGGCC TTGTGGAATG CAGAAGTGGA CAGTGCATCC CTAGCACCTT CCAGTGTGAT 
GGGGACGAAG ACTGTAAGGA CGGGAGTGAC GAGGAGAACT GCAGTGACCG TCCGACACCG 
TGTCCTGGAG GAGATCGGGG TTGCCTTGAC AGTTCCTGTG TCGAATCCTG TGCTGGTAGC 
TCTCTGTGTG ACTCAGACAG CAGCCTGAGT AACTGCAGTC ACTGTGAGCC CATCACTTTG 
GAACTCTGCA TGAATTTGCC CTACAACCTT ACACATTATC CAAATTACCT TGGCCACAGA 
ACTCAAAAGG AAGCGTCCAT CAGCTGGGAG TCAGCTCTCT TCCCTGCCCT TGTACAAACC 
AACTGTTACA AATACCTCAT GTTTTTCGCT TGCACCATTT TGGTTCCAAA GTGTGATGTG 
AATACAGGCC AGCGCGTCCC GCCTTGCAGA CTCCTGTGTG AGCACTCCAA AGAGCGCTGT 
GAGTCTGTTC TGGGGATCGT AGGCCTCCAG TGGCCTGAAG ACACAGATTG CAGTCAATTT 
CCAGAGCAAA GTTCAGACAA TCAAACTTGC CTCCTGCCCA ATGAAGACGT GGAAGAATGC 
TCTCCGAGTC ACTTCAAGTG CCGCTCGGGA CGATGCGTTC TGGGTTCCAG AAGATGCGAC 
GGCCAGGCTG ACTGTGATGA CGACAGTGAC GAAGAGAACT GTGGTTGTAA AGAGAGAGAT 
CTTTGGGAAT GTCCACTCAA TAAGCAATGT CTGAAGCATA CATTAATCTG TGATGGGTTT 
CCAGACTGTT CAGATAGTAT GGATGAAAAA AACTGCTCAT TTTGCCAGGA CGATGAGCTG 
GAATGTGCCA ACCATGAGTG TGTGCCACGC GACCTGTGGT GCGATGGATG GACAGATTGC 
TCAGACAGTT CAGATGAATG GGGCTGTGTG ACCCTCTCTA AAAATGGGAA CTCCTCCTCA 
TTCCTGACTG TTCACAGATC TGCAAGAGAT CACCACGTGT GTGCTGATGG CTGGCAGGAG 
ACGTTGAGTC AGCTGGCCTG CAGGCAGATG GGTTTAGGAG AACCATCTGT GACTGAACTG 
GTCCAAGGGC AGGAAGGCCA GCAGTGGCTG AGGTTGCACT CCAGCTGGGA GAATCTCAAT 
GGGAGCACCC TGCAGGAGCT GCTGGTGCAC AGGCGGTCCT GCCCAAGCGG AAGTGAGATT 
TCCCTTCTGT GTACCAAGCA AGACTGTGGT CGCCGCCCTG CTGCCCGAAT GAACAAGAGG 
ATCCTTGGGG GTCGGACTAG TCGTCCTGGG AGGTGGCCGT GGCAGTGTTC TCTGCAGAGT 
GAACCCAGTG GACATATCTG TGGCTGTGTC CTCATTGCCA AGAAGTGGGT CCTGACAGTT 
GCCCATTGCT TTGAAGGGAG AGAGGATGCT GATGTCTGGA AAGTGGTATT TGGCATAAAC 
AACCTGGACC ATCCGTCAGG CTTCATGCAG ACCCGCTTTG TGAAGACCAT TCTGCTACAT 
CCCCGTTACA GTCGAGCGGT GGTAGACTAT GACATCAGCG TGGTGGAGCT GAGTGATGAT 
ATCAATGAGA CAAGCTACGT CAGACCTGTC TGCCTACCCA GCCCCAGGGA GTTCCTAGAA 
CCAGATACAT ACTGCTACAT CACAGGCTGG GGCCACATGG GCAATAAAAT GCCCTTTAAG 
CTGCAGGAGG GGGAAGTCCG CATTATTCCT CTGGAGCAGT GCCAGTCCTA TTTTGACATG 
AAGACCATCA CCAATCGGAT GATATGTGCT GGCTATGAGT CCGGCACTGT GGACTCATGT 
ATGGGAGACA GTGGTGGTCC TCTGGTTTGT GAACGACCCG GAGGACAGTG GACATTATTT 
GGTTTAACTT CATGGGGCTC CGTCTGCTTT TCCAAAGTCC TAGGACCTGG AGTGTACAGC 
AATGTGTCTT ACTTTGTTGA CTGGATCGAA AGACAAATAT ATATCCAGAC CTTTCTCCAA 
AAGAAATCCC AAGGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008768361.1
CDS	280..3417
Translation	MFTKRPPALAPEEHSRRADAPKRVLRADSSVGEGCPQKLVTANLLRFLLLVLIPCICALIVLLAILLSFVGTLKKVYFKSNDSEPLVTDGEVRVPGVIHVNRYENTGAPSMPPSQSIPAWTPRAPSLEDQSHGNTSTCVNITHRQCQILPYHSTLAPLLPIVKNMDTEKFLKFFTYLHRLGCYQHILLFGCSLAFPKCIVDGDDRHGLLPCRSFCEAAKEGCESVLGMVNSSWPDSLRCSQFRYHTENNSDASRICFSLQQEHGKQSLCGGGESFLCTSGLCISKKLQCNGYNDCDDWSDEAHCNCSEDLFHCGTGKCLHHSLVCDGYDDCGDLSDEQNCDCNLTKEHRCGDGRCIAAEWVCDGDHDCVDKSDEVNCSCPSQGLVECRSGQCIPSTFQCDGDEDCKDGSDEENCSDRPTPCPGGDRGCLDSSCVESCAGSSLCDSDSSLSNCSHCEPITLELCMNLPYNLTHYPNYLGHRTQKEASISWESALFPALVQTNCYKYLMFFACTILVPKCDVNTGQRVPPCRLLCEHSKERCESVLGIVGLQWPEDTDCSQFPEQSSDNQTCLLPNEDVEECSPSHFKCRSGRCVLGSRRCDGQADCDDDSDEENCGCKERDLWECPLNKQCLKHTLICDGFPDCSDSMDEKNCSFCQDDELECANHECVPRDLWCDGWTDCSDSSDEWGCVTLSKNGNSSSFLTVHRSARDHHVCADGWQETLSQLACRQMGLGEPSVTELVQGQEGQQWLRLHSSWENLNGSTLQELLVHRRSCPSGSEISLLCTKQDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCFEGREDADVWKVVFGINNLDHPSGFMQTRFVKTILLHPRYSRAVVDYDISVVELSDDINETSYVRPVCLPSPREFLEPDTYCYITGWGHMGNKMPFKLQEGEVRIIPLEQCQSYFDMKTITNRMICAGYESGTVDSCMGDSGGPLVCERPGGQWTLFGLTSWGSVCFSKVLGPGVYSNVSYFVDWIERQIYIQTFLQKKSQG

Target ORF information:

RefSeq Version	XM_008770139.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus corin, serine peptidase (Corin), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008770139.2

ORF Insert Sequence:

ATGTTCACGA AACGGCCCCC CGCCCTTGCT CCGGAGGAGC ACAGTCGCCG AGCCGACGCC 
CCAAAGAGGG TCTTGAGAGC AGACAGCAGC GTGGGCGAGG GCTGTCCTCA GAAGCTGGTG 
ACAGCAAATT TGCTACGCTT CCTCCTGCTT GTGCTCATCC CCTGCATCTG CGCCCTTATC 
GTGCTGCTGG CCATCCTGCT GTCCTTCGTG GGAACATTAA AGAAGGTTTA TTTCAAATCA 
AATGACAGTG AACCTTTGGT CACTGATGGT GAAGTTCGAG TGCCTGGTGT TATCCATGTA 
AATAGATATG AGAACACAGG GGCGCCCTCT ATGCCCCCCA GCCAATCCAT TCCTGCCTGG 
ACACCTAGAG CTCCTTCTCT AGAGGACCAG AGTCACGGAA ATACAAGCAC CTGCGTGAAC 
ATCACTCACA GACAGTGTCA AATTCTGCCC TACCACAGCA CGCTGGCACC CCTCTTGCCA 
ATTGTCAAAA ATATGGACAC GGAGAAGTTC CTCAAGTTCT TCACGTACCT CCATCGCCTC 
GGTTGCTATC AACACATCCT GCTCTTTGGC TGTAGCCTCG CCTTCCCCAA GTGCATTGTT 
GATGGCGATG ACAGGCATGG CCTCCTACCC TGTAGATCTT TCTGTGAGGC TGCAAAAGAA 
GGATGTGAAT CAGTCCTGGG AATGGTGAAC TCCTCCTGGC CAGATTCCCT CAGATGCTCT 
CAGTTTAGAT ACCACACTGA GAATAACAGC GACGCCAGCA GGATCTGCTT CTCACTGCAG 
CAGGAGCATG GAAAGCAATC GCTCTGTGGA GGAGGTGAGA GCTTCCTGTG TACCAGCGGG 
CTCTGCATCT CCAAGAAGCT GCAGTGTAAC GGCTACAATG ACTGTGATGA CTGGAGCGAC 
GAGGCTCACT GCAACTGCAG CGAGGATCTG TTTCACTGTG GAACAGGCAA GTGCCTCCAC 
CACAGCCTTG TGTGCGATGG GTATGATGAC TGTGGGGACC TGAGCGACGA GCAAAACTGT 
GATTGCAATC TCACAAAAGA GCATCGCTGT GGAGACGGGC GCTGCATCGC GGCTGAGTGG 
GTGTGTGATG GGGACCATGA CTGTGTGGAC AAGTCTGACG AGGTCAACTG CTCTTGTCCC 
AGCCAGGGCC TTGTGGAATG CAGAAGTGGA CAGTGCATCC CTAGCACCTT CCAGTGTGAT 
GGGGACGAAG ACTGTAAGGA CGGGAGTGAC GAGGAGAACT GCAGTGACCG TCCGACACCG 
TGTCCTGGAG GAGATCGGGG TTGCCTTGAC AGTTCCTGTG TCGAATCCTG TGCTGGTAGC 
TCTCTGTGTG ACTCAGACAG CAGCCTGAGT AACTGCAGTC ACTGTGAGCC CATCACTTTG 
GAACTCTGCA TGAATTTGCC CTACAACCTT ACACATTATC CAAATTACCT TGGCCACAGA 
ACTCAAAAGG AAGCGTCCAT CAGCTGGGAG TCAGCTCTCT TCCCTGCCCT TGTACAAACC 
AACTGTTACA AATACCTCAT GTTTTTCGCT TGCACCATTT TGGTTCCAAA GTGTGATGTG 
AATACAGGCC AGCGCGTCCC GCCTTGCAGA CTCCTGTGTG AGCACTCCAA AGAGCGCTGT 
GAGTCTGTTC TGGGGATCGT AGGCCTCCAG TGGCCTGAAG ACACAGATTG CAGTCAATTT 
CCAGAGCAAA GTTCAGACAA TCAAACTTGC CTCCTGCCCA ATGAAGACGT GGAAGAATGC 
TCTCCGAGTC ACTTCAAGTG CCGCTCGGGA CGATGCGTTC TGGGTTCCAG AAGATGCGAC 
GGCCAGGCTG ACTGTGATGA CGACAGTGAC GAAGAGAACT GTGGTTGTAA AGAGAGAGAT 
CTTTGGGAAT GTCCACTCAA TAAGCAATGT CTGAAGCATA CATTAATCTG TGATGGGTTT 
CCAGACTGTT CAGATAGTAT GGATGAAAAA AACTGCTCAT TTTGCCAGGA CGATGAGCTG 
GAATGTGCCA ACCATGAGTG TGTGCCACGC GACCTGTGGT GCGATGGATG GACAGATTGC 
TCAGACAGTT CAGATGAATG GGGCTGTGTG ACCCTCTCTA AAAATGGGAA CTCCTCCTCA 
TTCCTGACTG TTCACAGATC TGCAAGAGAT CACCACGTGT GTGCTGATGG CTGGCAGGAG 
ACGTTGAGTC AGCTGGCCTG CAGGCAGATG GGTTTAGGAG AACCATCTGT GACTGAACTG 
GTCCAAGGGC AGGAAGGCCA GCAGTGGCTG AGGTTGCACT CCAGCTGGGA GAATCTCAAT 
GGGAGCACCC TGCAGGAGCT GCTGGTGCAC AGGCGGTCCT GCCCAAGCGG AAGTGAGATT 
TCCCTTCTGT GTACCAAGCA AGACTGTGGT CGCCGCCCTG CTGCCCGAAT GAACAAGAGG 
ATCCTTGGGG GTCGGACTAG TCGTCCTGGG AGGTGGCCGT GGCAGTGTTC TCTGCAGAGT 
GAACCCAGTG GACATATCTG TGGCTGTGTC CTCATTGCCA AGAAGTGGGT CCTGACAGTT 
GCCCATTGCT TTGAAGGGAG AGAGGATGCT GATGTCTGGA AAGTGGTATT TGGCATAAAC 
AACCTGGACC ATCCGTCAGG CTTCATGCAG ACCCGCTTTG TGAAGACCAT TCTGCTACAT 
CCCCGTTACA GTCGAGCGGT GGTAGACTAT GACATCAGCG TGGTGGAGCT GAGTGATGAT 
ATCAATGAGA CAAGCTACGT CAGACCTGTC TGCCTACCCA GCCCCAGGGA GTTCCTAGAA 
CCAGATACAT ACTGCTACAT CACAGGCTGG GGCCACATGG GCAATAAAAT GCCCTTTAAG 
CTGCAGGAGG GGGAAGTCCG CATTATTCCT CTGGAGCAGT GCCAGTCCTA TTTTGACATG 
AAGACCATCA CCAATCGGAT GATATGTGCT GGCTATGAGT CCGGCACTGT GGACTCATGT 
ATGGGAGACA GTGGTGGTCC TCTGGTTTGT GAACGACCCG GAGGACAGTG GACATTATTT 
GGTTTAACTT CATGGGGCTC CGTCTGCTTT TCCAAAGTCC TAGGACCTGG AGTGTACAGC 
AATGTGTCTT ACTTTGTTGA CTGGATCGAA AGACAAATAT ATATCCAGAC CTTTCTCCAA 
AAGAAATCCC AAGGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Short-Term High-Salt Diet Increases Corin Level to Regulate the Salt-Water Balance in Humans and Rodents.
American journal of hypertension31(2)253-260(2018 Jan)
Zhang J,Yin Y,Chen L,Chu C,Wang Y,Lv Y,He M,Martin M,Huang PH,Mu JJ,Shyy JY,Yuan ZY

The Involvement of Corin in the Progression of Diabetic Erectile Dysfunction in a Rat Model by Down-Regulating ANP /NO/cGMP Signal Pathway.
Journal of cellular biochemistry118(8)2325-2332(2017 Aug)
Wang J,Mi Y,Yuan F,Wu S,You X,Dai F,Huang Y,Cao J,Zhu J,Xue B,Zhu L

Corin is down-regulated and exerts cardioprotective action via activating pro-atrial natriuretic peptide pathway in diabetic cardiomyopathy.
Cardiovascular diabetology14134(2015 Oct)
Pang A,Hu Y,Zhou P,Long G,Tian X,Men L,Shen Y,Liu Y,Cui Y

Impaired sodium excretion and salt-sensitive hypertension in corin-deficient mice.
Kidney international82(1)26-33(2012 Jul)
Wang W,Shen J,Cui Y,Jiang J,Chen S,Peng J,Wu Q

Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy.
Nature484(7393)246-50(2012 Mar)
Cui Y,Wang W,Dong N,Lou J,Srinivasan DK,Cheng W,Huang X,Liu M,Fang C,Peng J,Chen S,Wu S,Liu Z,Dong L,Zhou Y,Wu Q

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Corin cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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