Selenos cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Selenos
Entrez Gene ID	286900
Full Name	selenoprotein S
Synonyms	Sels,Vimp,sg2
General protein information	Preferred Names selenoprotein S Names selenoprotein S Tanis VCP-interacting membrane protein VCP-interacting membrane selenoprotein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q22
Summary	This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion (PMID:23614019). [provided by RefSeq, Jul 2017].

mRNA and Protein(s)

mRNA	Protein	Name
NM_173120.2	NP_775143.2	selenoprotein S

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	VIMP	NP_001108228.1
	VIMP	NP_001108227.1
Canis lupus familiaris (dog)	VIMP	NP_001108229.1
Gallus gallus (chicken)	VIMP	NP_001019905.1
Xenopus tropicalis (tropical clawed frog)	vimp	NP_001011476.2
Mus musculus (house mouse)	Vimp	NP_077759.3
Bos taurus (cattle)	VIMP	NP_001039579.2
Homo sapiens (human)	VIMP	NP_060915.2
Rattus norvegicus (Norway rat)	Vimp	NP_775143.2
Danio rerio (zebrafish)	vimp	NP_001038799.2

Gene Ontology
Bibliography

Related articles in PubMed

Selenoprotein Gene Nomenclature.
Gladyshev VN, Arn?r ES, Berry MJ, Brigelius-Floh? R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Floh? L, Green FR, Guig? R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, K?hrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonovi? M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y
The Journal of biological chemistry291(46)24036-24040(2016 Nov)

Selenoprotein S Is Highly Expressed in the Blood Vessels and Prevents Vascular Smooth Muscle Cells From Apoptosis.
Ye Y, Fu F, Li X, Yang J, Liu H
Journal of cellular biochemistry117(1)106-17(2016 Jan)

USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation.
Liu Y, Soetandyo N, Lee JG, Liu L, Xu Y, Clemons WM Jr, Ye Y
eLife3e01369(2014)

Selenoprotein S expression in the rat brain following focal cerebral ischemia.
Liu LX, Zhou XY, Li CS, Liu LQ, Huang SY, Zhou SN
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology34(9)1671-8(2013 Sep)

Alternative transcripts and 3'UTR elements govern the incorporation of selenocysteine into selenoprotein S.
Bubenik JL, Miniard AC, Driscoll DM
PloS one8(4)e62102(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Selenoprotein S Is Highly Expressed in the Blood Vessels and Prevents Vascular Smooth Muscle Cells From Apoptosis
Title: Selenoprotein S Is Highly Expressed in the Blood Vessels and Prevents Vascular Smooth Muscle Cells From Apoptosis.

we propose that the upregulation of Sels represents a reaction of astrocytes against inflammatory stimuli
Title: Selenoprotein S expression in the rat brain following focal cerebral ischemia.

High expression of Tanis mRNA in the liver is associated with the development of insulin resistance probably via the function of SAA1.
Title: Upregulation of Tanis mRNA expression in the liver is associated with insulin resistance in rats.

The following Selenos gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Selenos cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12526	NM_173120.2 Latest version!	Rattus norvegicus selenoprotein S (Selenos), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Selenos ( NM_173120.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_775143.2 Rattus norvegicus selenoprotein S (Selenos), mRNA.

Price & Availability↑

CloneID	ORa12526
Clone ID Related Accession (Same CDS sequence)	NM_173120.2
Accession Version	NM_173120.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 573bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Rattus norvegicus(Norway rat)
Product	selenoprotein S
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC059111.1 and AF367467.1. On Aug 2, 2006 this sequence version replaced NM_173120.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF367467.1, FQ218853.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGATCGCG GGGAGGAACC TCTGTCCGCG AGGCCGGCGC TGGAGACCGA GAGCCTGCGA 
TTCCTGCACG TCACAGTGGG CTCCCTGCTG GCCAGCTATG GCTGGTACAT CCTCTTCAGC 
TGCGTCCTTC TCTACATTGT CATCCAGAAG CTCTCCCTGC GACTGAGGGC TTTAAGGCAG 
AGGCAGCTGG ACCAAGCTGA GGCTGTTCTG GAGCCTGATG TTGTTGTTAA GCGACAAGAG 
GCTTTAGCAG CTGCTCGTTT GAGAATGCAG GAAGATCTGA ATGCCCAAGT TGAAAAACAT 
AAGGAAAAAC TAAGACAGCT TGAAGAAGAG AAAAGGAGAC AGAAGATTGA AATGTGGGAC 
AGCATGCAAG AAGGCAGAAG TTACAAAAGA AACTCAGGAA GGCCTCAGGA AGAAGATGGT 
CCTGGACCTT CTACTTCATC GGTCATCCCC AAAGGAAAAT CTGACAAAAA GCCTTTACGG 
GGAGGTGGTT ATAACCCTCT GACAGGTGAA GGGGGTGGAA CCTGCTCCTG GAGACCTGGA 
CGCAGGGGCC CATCATCTGG TGGATGAAGC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_775143.2
CDS	29..601
Translation	MDRGEEPLSARPALETESLRFLHVTVGSLLASYGWYILFSCVLLYIVIQKLSLRLRALRQRQLDQAEAVLEPDVVVKRQEALAAARLRMQEDLNAQVEKHKEKLRQLEEEKRRQKIEMWDSMQEGRSYKRNSGRPQEEDGPGPSTSSVIPKGKSDKKPLRGGGYNPLTGEGGGTCSWRPGRRGPSSGG*S

Target ORF information:

RefSeq Version	NM_173120.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus selenoprotein S (Selenos), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_173120.2

ORF Insert Sequence:

ATGGATCGCG GGGAGGAACC TCTGTCCGCG AGGCCGGCGC TGGAGACCGA GAGCCTGCGA 
TTCCTGCACG TCACAGTGGG CTCCCTGCTG GCCAGCTATG GCTGGTACAT CCTCTTCAGC 
TGCGTCCTTC TCTACATTGT CATCCAGAAG CTCTCCCTGC GACTGAGGGC TTTAAGGCAG 
AGGCAGCTGG ACCAAGCTGA GGCTGTTCTG GAGCCTGATG TTGTTGTTAA GCGACAAGAG 
GCTTTAGCAG CTGCTCGTTT GAGAATGCAG GAAGATCTGA ATGCCCAAGT TGAAAAACAT 
AAGGAAAAAC TAAGACAGCT TGAAGAAGAG AAAAGGAGAC AGAAGATTGA AATGTGGGAC 
AGCATGCAAG AAGGCAGAAG TTACAAAAGA AACTCAGGAA GGCCTCAGGA AGAAGATGGT 
CCTGGACCTT CTACTTCATC GGTCATCCCC AAAGGAAAAT CTGACAAAAA GCCTTTACGG 
GGAGGTGGTT ATAACCCTCT GACAGGTGAA GGGGGTGGAA CCTGCTCCTG GAGACCTGGA 
CGCAGGGGCC CATCATCTGG TGGATGAAGC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Selenoprotein Gene Nomenclature.
The Journal of biological chemistry291(46)24036-24040(2016 Nov)
Gladyshev VN,Arn?r ES,Berry MJ,Brigelius-Floh? R,Bruford EA,Burk RF,Carlson BA,Castellano S,Chavatte L,Conrad M,Copeland PR,Diamond AM,Driscoll DM,Ferreiro A,Floh? L,Green FR,Guig? R,Handy DE,Hatfield DL,Hesketh J,Hoffmann PR,Holmgren A,Hondal RJ,Howard MT,Huang K,Kim HY,Kim IY,K?hrle J,Krol A,Kryukov GV,Lee BJ,Lee BC,Lei XG,Liu Q,Lescure A,Lobanov AV,Loscalzo J,Maiorino M,Mariotti M,Sandeep Prabhu K,Rayman MP,Rozovsky S,Salinas G,Schmidt EE,Schomburg L,Schweizer U,Simonovi? M,Sunde RA,Tsuji PA,Tweedie S,Ursini F,Whanger PD,Zhang Y

Selenoprotein S Is Highly Expressed in the Blood Vessels and Prevents Vascular Smooth Muscle Cells From Apoptosis.
Journal of cellular biochemistry117(1)106-17(2016 Jan)
Ye Y,Fu F,Li X,Yang J,Liu H

USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation.
eLife3e01369(2014)
Liu Y,Soetandyo N,Lee JG,Liu L,Xu Y,Clemons WM Jr,Ye Y

Selenoprotein S expression in the rat brain following focal cerebral ischemia.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology34(9)1671-8(2013 Sep)
Liu LX,Zhou XY,Li CS,Liu LQ,Huang SY,Zhou SN

Alternative transcripts and 3'UTR elements govern the incorporation of selenocysteine into selenoprotein S.
PloS one8(4)e62102(2013)
Bubenik JL,Miniard AC,Driscoll DM

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Selenos cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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