SELENOS cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	SELENOS
Entrez Gene ID	415522
Full Name	selenoprotein S
Synonyms	SELS,VIMP
General protein information	Preferred Names selenoprotein S Names selenoprotein S VCP interacting membrane selenoprotein VCP-interacting membrane protein
Gene Type	protein-coding
Organism	Gallus gallus(chicken)
Summary	This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional stem-loop structures in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion (PMID:23614019). [provided by RefSeq, Jul 2017].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001024734.3	NP_001019905.1	selenoprotein S

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	VIMP	NP_001108228.1
	VIMP	NP_001108227.1
Canis lupus familiaris (dog)	VIMP	NP_001108229.1
Gallus gallus (chicken)	VIMP	NP_001019905.1
Xenopus tropicalis (tropical clawed frog)	vimp	NP_001011476.2
Mus musculus (house mouse)	Vimp	NP_077759.3
Bos taurus (cattle)	VIMP	NP_001039579.2
Homo sapiens (human)	VIMP	NP_060915.2
Rattus norvegicus (Norway rat)	Vimp	NP_775143.2
Danio rerio (zebrafish)	vimp	NP_001038799.2

Gene Ontology
Bibliography

Related articles in PubMed

Selenoprotein Gene Nomenclature.
Gladyshev VN, Arn?r ES, Berry MJ, Brigelius-Floh? R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Floh? L, Green FR, Guig? R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, K?hrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonovi? M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y
The Journal of biological chemistry291(46)24036-24040(2016 Nov)

Alternative transcripts and 3'UTR elements govern the incorporation of selenocysteine into selenoprotein S.
Bubenik JL, Miniard AC, Driscoll DM
PloS one8(4)e62102(2013)

Composition and evolution of the vertebrate and mammalian selenoproteomes.
Mariotti M, Ridge PG, Zhang Y, Lobanov AV, Pringle TH, Guigo R, Hatfield DL, Gladyshev VN
PloS one7(3)e33066(2012)

Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis.
Caldwell RB, Kierzek AM, Arakawa H, Bezzubov Y, Zaim J, Fiedler P, Kutter S, Blagodatski A, Kostovska D, Koter M, Plachy J, Carninci P, Hayashizaki Y, Buerstedde JM
Genome biology6(1)R6(2005)

A comprehensive collection of chicken cDNAs.
Boardman PE, Sanz-Ezquerro J, Overton IM, Burt DW, Bosch E, Fong WT, Tickle C, Brown WR, Wilson SA, Hubbard SJ
Current biology : CB12(22)1965-9(2002 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following SELENOS gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SELENOS cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa26492	NM_001024734.3 Latest version!	Gallus gallus selenoprotein S (SELENOS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$104.30 $149.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SELENOS ( NM_001024734.3 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_001019905.1 Gallus gallus selenoprotein S (SELENOS), mRNA.

Price & Availability↑

CloneID	OGa26492
Clone ID Related Accession (Same CDS sequence)	NM_001024734.3
Accession Version	NM_001024734.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 585bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-01
Organism	Gallus gallus(chicken)
Product	selenoprotein S
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL588177.1, BX934085.2, BX931291.2 and AJ731176.1. On Jan 23, 2017 this sequence version replaced NM_001024734.2. ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGCTCG GGGACCGCGG CGGGGCCGGG CCCGGCCCCG GGAAACCGGC CCTGGAACGA 
GAGGGCCTCG AGCTGCTGCA GCACACGGTG GGCGCCCTGC TGTCGAGCTA TGGCTGGTAC 
ATCCTCCTGG CCTGCGTCGC CATCTATCTC ATCGTCCAGA AGATATCCCC ATACTTGAGG 
ATGAGGCCCA GCAGCCAGCA AGGAGCAACT GGCGCAGCTG TCGAGCCCGA CATGGTGGTA 
AGAAGACAAG AAGCTTTGTT GGCGTCTCGC CTGAGGATGC AAGAGGAGTT GAATGCACAA 
GCAGAAAGAT ACAAAGAAAA ACAAAGACAG CTTGAAGAAC AGAAGCGAAG GCAGAAGATA 
GAAATGTGGG AAAGCATGCA AGAAGGAAAA AGTTATAAAG GAAACCTGAA ACTGAGTCAG 
CAAGAAGCAG AATCTGGTGC CTCCACCTCA TCAGCAGTCC CGAAATCTAA ACCAAACAAG 
AAGCCCTTGC GAGGAGGTGG CTATAACCCC CTGTCTGGAG AAGGAGGTGG AACTTGTTCC 
TGGAGACCGG GCCGCAGGGG TCCCTCTGCG GGTGGATGAG GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001019905.1
CDS	36..620
Translation	MELGDRGGAGPGPGKPALEREGLELLQHTVGALLSSYGWYILLACVAIYLIVQKISPYLRMRPSSQQGATGAAVEPDMVVRRQEALLASRLRMQEELNAQAERYKEKQRQLEEQKRRQKIEMWESMQEGKSYKGNLKLSQQEAESGASTSSAVPKSKPNKKPLRGGGYNPLSGEGGGTCSWRPGRRGPSAGG*G

Target ORF information:

RefSeq Version	NM_001024734.3
Organism	Gallus gallus(chicken)
Definition	Gallus gallus selenoprotein S (SELENOS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001024734.3

ORF Insert Sequence:

ATGGAGCTCG GGGACCGCGG CGGGGCCGGG CCCGGCCCCG GGAAACCGGC CCTGGAACGA 
GAGGGCCTCG AGCTGCTGCA GCACACGGTG GGCGCCCTGC TGTCGAGCTA TGGCTGGTAC 
ATCCTCCTGG CCTGCGTCGC CATCTATCTC ATCGTCCAGA AGATATCCCC ATACTTGAGG 
ATGAGGCCCA GCAGCCAGCA AGGAGCAACT GGCGCAGCTG TCGAGCCCGA CATGGTGGTA 
AGAAGACAAG AAGCTTTGTT GGCGTCTCGC CTGAGGATGC AAGAGGAGTT GAATGCACAA 
GCAGAAAGAT ACAAAGAAAA ACAAAGACAG CTTGAAGAAC AGAAGCGAAG GCAGAAGATA 
GAAATGTGGG AAAGCATGCA AGAAGGAAAA AGTTATAAAG GAAACCTGAA ACTGAGTCAG 
CAAGAAGCAG AATCTGGTGC CTCCACCTCA TCAGCAGTCC CGAAATCTAA ACCAAACAAG 
AAGCCCTTGC GAGGAGGTGG CTATAACCCC CTGTCTGGAG AAGGAGGTGG AACTTGTTCC 
TGGAGACCGG GCCGCAGGGG TCCCTCTGCG GGTGGATGAG GCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Selenoprotein Gene Nomenclature.
The Journal of biological chemistry291(46)24036-24040(2016 Nov)
Gladyshev VN,Arn?r ES,Berry MJ,Brigelius-Floh? R,Bruford EA,Burk RF,Carlson BA,Castellano S,Chavatte L,Conrad M,Copeland PR,Diamond AM,Driscoll DM,Ferreiro A,Floh? L,Green FR,Guig? R,Handy DE,Hatfield DL,Hesketh J,Hoffmann PR,Holmgren A,Hondal RJ,Howard MT,Huang K,Kim HY,Kim IY,K?hrle J,Krol A,Kryukov GV,Lee BJ,Lee BC,Lei XG,Liu Q,Lescure A,Lobanov AV,Loscalzo J,Maiorino M,Mariotti M,Sandeep Prabhu K,Rayman MP,Rozovsky S,Salinas G,Schmidt EE,Schomburg L,Schweizer U,Simonovi? M,Sunde RA,Tsuji PA,Tweedie S,Ursini F,Whanger PD,Zhang Y

Alternative transcripts and 3'UTR elements govern the incorporation of selenocysteine into selenoprotein S.
PloS one8(4)e62102(2013)
Bubenik JL,Miniard AC,Driscoll DM

Composition and evolution of the vertebrate and mammalian selenoproteomes.
PloS one7(3)e33066(2012)
Mariotti M,Ridge PG,Zhang Y,Lobanov AV,Pringle TH,Guigo R,Hatfield DL,Gladyshev VN

Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis.
Genome biology6(1)R6(2005)
Caldwell RB,Kierzek AM,Arakawa H,Bezzubov Y,Zaim J,Fiedler P,Kutter S,Blagodatski A,Kostovska D,Koter M,Plachy J,Carninci P,Hayashizaki Y,Buerstedde JM

A comprehensive collection of chicken cDNAs.
Current biology : CB12(22)1965-9(2002 Nov)
Boardman PE,Sanz-Ezquerro J,Overton IM,Burt DW,Bosch E,Fong WT,Tickle C,Brown WR,Wilson SA,Hubbard SJ

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SELENOS cDNA ORF clone, Gallus gallus(chicken)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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