selenos cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	selenos
Entrez Gene ID	735249
Full Name	selenoprotein S
Synonyms	sels,vimp,wu:fc16a03,zgc:136970
General protein information	Preferred Names selenoprotein S Names selenoprotein S VCP-interacting membrane protein VCP-interacting membrane selenoprotein
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)
Summary	This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control in higher eukaryotes. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs in vertebrates contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Aug 2017].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001045334.3	NP_001038799.2	selenoprotein S

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	VIMP	NP_001108228.1
	VIMP	NP_001108227.1
Canis lupus familiaris (dog)	VIMP	NP_001108229.1
Gallus gallus (chicken)	VIMP	NP_001019905.1
Xenopus tropicalis (tropical clawed frog)	vimp	NP_001011476.2
Mus musculus (house mouse)	Vimp	NP_077759.3
Bos taurus (cattle)	VIMP	NP_001039579.2
Homo sapiens (human)	VIMP	NP_060915.2
Rattus norvegicus (Norway rat)	Vimp	NP_775143.2
Danio rerio (zebrafish)	vimp	NP_001038799.2

Gene Ontology
Bibliography

Related articles in PubMed

Evolution of complexity in the zebrafish synapse proteome.
Bay?s ?, Collins MO, Reig-Viader R, Gou G, Goulding D, Izquierdo A, Choudhary JS, Emes RD, Grant SG
Nature communications814613(2017 Mar)

Selenoprotein Gene Nomenclature.
Gladyshev VN, Arn?r ES, Berry MJ, Brigelius-Floh? R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Floh? L, Green FR, Guig? R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, K?hrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonovi? M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y
The Journal of biological chemistry291(46)24036-24040(2016 Nov)

Targeted Gene Expression in Zebrafish Exposed to Chlorpyrifos-Oxon Confirms Phenotype-Specific Mechanisms Leading to Adverse Outcomes.
Garcia-Reyero N, Escalon L, Prats E, Faria M, Soares AM, Rald?a D
Bulletin of environmental contamination and toxicology96(6)707-13(2016 Jun)

RFX transcription factors are essential for hearing in mice.
Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M, Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD, Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W, Hertzano R
Nature communications68549(2015 Oct)

Composition and evolution of the vertebrate and mammalian selenoproteomes.
Mariotti M, Ridge PG, Zhang Y, Lobanov AV, Pringle TH, Guigo R, Hatfield DL, Gladyshev VN
PloS one7(3)e33066(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following selenos gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the selenos cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa39063	NM_001045334.3 Latest version!	Danio rerio selenoprotein S (selenos), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

selenos ( NM_001045334.3 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_001038799.2 Danio rerio selenoprotein S (selenos), mRNA.

Price & Availability↑

CloneID	ODa39063
Clone ID Related Accession (Same CDS sequence)	NM_001045334.3
Accession Version	NM_001045334.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 573bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-24
Organism	Danio rerio(zebrafish)
Product	selenoprotein S
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CU856378.10. On Jan 23, 2017 this sequence version replaced NM_001045334.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: EG574131.1, BC118685.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2168446, SAMEA2168447 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGGCGG AGGACGGAGC GCGTGTCCGG AATGAAGATG TTCCTCCGCA GAACCAGGAT 
CTAAGTTTCC TTCAACCGTC TGTCACTGCG TTCATGTCGG AGTATGGCTG GTATCTGCTG 
TTCGGATGTG TTGGAGTGTA TCTGCTCATC CAGCATCTCC GCAAGAGCAG ATCCTCCACA 
CAAACACGCA GCTCGTCTGG CTCAGCCGAG GCTCACGATG TGGGGTCAGT GGTGAGGCGT 
CAGGAGGCTC TGGAGGCGTC CCGCAGGAGA ATGCAGGAGG AGCAGGACGC CAGAGCAGCT 
GAGTTCAGGG AGAAACAGCG CATGCTGGAG GAGGAGAAGA GGAGGCAGAA GATCGAGATG 
TGGGACAGCA TGCAGGAAGG AAAGAGTTAC AAAGGGAGCG CTAAAGTTGC ACAACAGAAC 
ACAGAAGAGG CGGCTTCATC CAGCTCGCTG AGACCAAAGA CAGAGAAGAA ACCCCTGCGC 
AGCAGTGGCT ACAGTCCTCT GTCAGGAGAC GCTGGAGGCT CGTGCTCCTG GAGGCCCGGC 
CGCAGAGGCC CGTCTGCTGG AGGATGAGGA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001038799.2
CDS	150..722
Translation	MEAEDGARVRNEDVPPQNQDLSFLQPSVTAFMSEYGWYLLFGCVGVYLLIQHLRKSRSSTQTRSSSGSAEAHDVGSVVRRQEALEASRRRMQEEQDARAAEFREKQRMLEEEKRRQKIEMWDSMQEGKSYKGSAKVAQQNTEEAASSSSLRPKTEKKPLRSSGYSPLSGDAGGSCSWRPGRRGPSAGG*G

Target ORF information:

RefSeq Version	NM_001045334.3
Organism	Danio rerio(zebrafish)
Definition	Danio rerio selenoprotein S (selenos), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001045334.3

ORF Insert Sequence:

ATGGAGGCGG AGGACGGAGC GCGTGTCCGG AATGAAGATG TTCCTCCGCA GAACCAGGAT 
CTAAGTTTCC TTCAACCGTC TGTCACTGCG TTCATGTCGG AGTATGGCTG GTATCTGCTG 
TTCGGATGTG TTGGAGTGTA TCTGCTCATC CAGCATCTCC GCAAGAGCAG ATCCTCCACA 
CAAACACGCA GCTCGTCTGG CTCAGCCGAG GCTCACGATG TGGGGTCAGT GGTGAGGCGT 
CAGGAGGCTC TGGAGGCGTC CCGCAGGAGA ATGCAGGAGG AGCAGGACGC CAGAGCAGCT 
GAGTTCAGGG AGAAACAGCG CATGCTGGAG GAGGAGAAGA GGAGGCAGAA GATCGAGATG 
TGGGACAGCA TGCAGGAAGG AAAGAGTTAC AAAGGGAGCG CTAAAGTTGC ACAACAGAAC 
ACAGAAGAGG CGGCTTCATC CAGCTCGCTG AGACCAAAGA CAGAGAAGAA ACCCCTGCGC 
AGCAGTGGCT ACAGTCCTCT GTCAGGAGAC GCTGGAGGCT CGTGCTCCTG GAGGCCCGGC 
CGCAGAGGCC CGTCTGCTGG AGGATGAGGA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Evolution of complexity in the zebrafish synapse proteome.
Nature communications814613(2017 Mar)
Bay?s ?,Collins MO,Reig-Viader R,Gou G,Goulding D,Izquierdo A,Choudhary JS,Emes RD,Grant SG

Selenoprotein Gene Nomenclature.
The Journal of biological chemistry291(46)24036-24040(2016 Nov)
Gladyshev VN,Arn?r ES,Berry MJ,Brigelius-Floh? R,Bruford EA,Burk RF,Carlson BA,Castellano S,Chavatte L,Conrad M,Copeland PR,Diamond AM,Driscoll DM,Ferreiro A,Floh? L,Green FR,Guig? R,Handy DE,Hatfield DL,Hesketh J,Hoffmann PR,Holmgren A,Hondal RJ,Howard MT,Huang K,Kim HY,Kim IY,K?hrle J,Krol A,Kryukov GV,Lee BJ,Lee BC,Lei XG,Liu Q,Lescure A,Lobanov AV,Loscalzo J,Maiorino M,Mariotti M,Sandeep Prabhu K,Rayman MP,Rozovsky S,Salinas G,Schmidt EE,Schomburg L,Schweizer U,Simonovi? M,Sunde RA,Tsuji PA,Tweedie S,Ursini F,Whanger PD,Zhang Y

Targeted Gene Expression in Zebrafish Exposed to Chlorpyrifos-Oxon Confirms Phenotype-Specific Mechanisms Leading to Adverse Outcomes.
Bulletin of environmental contamination and toxicology96(6)707-13(2016 Jun)
Garcia-Reyero N,Escalon L,Prats E,Faria M,Soares AM,Rald?a D

RFX transcription factors are essential for hearing in mice.
Nature communications68549(2015 Oct)
Elkon R,Milon B,Morrison L,Shah M,Vijayakumar S,Racherla M,Leitch CC,Silipino L,Hadi S,Weiss-Gayet M,Barras E,Schmid CD,Ait-Lounis A,Barnes A,Song Y,Eisenman DJ,Eliyahu E,Frolenkov GI,Strome SE,Durand B,Zaghloul NA,Jones SM,Reith W,Hertzano R

Composition and evolution of the vertebrate and mammalian selenoproteomes.
PloS one7(3)e33066(2012)
Mariotti M,Ridge PG,Zhang Y,Lobanov AV,Pringle TH,Guigo R,Hatfield DL,Gladyshev VN

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selenos cDNA ORF clone, Danio rerio(zebrafish)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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