SELENOS cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	SELENOS
Entrez Gene ID	512276
Full Name	selenoprotein S
Synonyms	SELS,VIMP
Gene Type	protein-coding
Organism	Bos taurus(cattle)
Summary	This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion (PMID:23614019). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2017].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001348226.1	NP_001335155.1	selenoprotein S isoform 2
NM_001348225.1	NP_001335154.1	selenoprotein S isoform 2
NM_001046114.3	NP_001039579.2	selenoprotein S isoform 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	VIMP	NP_001108228.1
	VIMP	NP_001108227.1
Canis lupus familiaris (dog)	VIMP	NP_001108229.1
Gallus gallus (chicken)	VIMP	NP_001019905.1
Xenopus tropicalis (tropical clawed frog)	vimp	NP_001011476.2
Mus musculus (house mouse)	Vimp	NP_077759.3
Bos taurus (cattle)	VIMP	NP_001039579.2
Homo sapiens (human)	VIMP	NP_060915.2
Rattus norvegicus (Norway rat)	Vimp	NP_775143.2
Danio rerio (zebrafish)	vimp	NP_001038799.2

Gene Ontology
Bibliography

Related articles in PubMed

Selenoprotein Gene Nomenclature.
Gladyshev VN, Arn?r ES, Berry MJ, Brigelius-Floh? R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Floh? L, Green FR, Guig? R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, K?hrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonovi? M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y
The Journal of biological chemistry291(46)24036-24040(2016 Nov)

Alternative transcripts and 3'UTR elements govern the incorporation of selenocysteine into selenoprotein S.
Bubenik JL, Miniard AC, Driscoll DM
PloS one8(4)e62102(2013)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

Characterization of mammalian selenoproteomes.
Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guig? R, Gladyshev VN
Science (New York, N.Y.)300(5624)1439-43(2003 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following SELENOS gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SELENOS cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OBa43209	NM_001046114.3 Latest version!	Bos taurus selenoprotein S (SELENOS), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00
OBa134041	NM_001348225.1 Latest version!	Bos taurus selenoprotein S (SELENOS), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$104.30 $149.00
OBa134041	NM_001348226.1 Latest version!	Bos taurus selenoprotein S (SELENOS), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$104.30 $149.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SELENOS ( NM_001046114.3 ) cDNA ORF clone, Bos taurus(cattle) -> NP_001039579.2 Bos taurus selenoprotein S (SELENOS), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OBa43209
Clone ID Related Accession (Same CDS sequence)	NM_001046114.3
Accession Version	NM_001046114.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 573bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Bos taurus(cattle)
Product	selenoprotein S isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DV822816.1, BC112740.1 and EE934364.1. On Jan 19, 2017 this sequence version replaced NM_001046114.2. Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: BC112740.1, DV790825.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145412, SAMN03145413 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGCGGG ACGGGGATCA GCTGTCCGCG CGGCCCACCC TCGAGACCGA GGGGCTGCGT 
TTCCTTCACG TCACGGTGGG CTCCCTGCTG GCCACTTACG GCTGGTACAT CGTCTTCAGC 
TGCATCCTTC TCTACGTGGT GTTTCAGAAG CTTTCCACCC GGTTGAGGGC CTTGAGGCAG 
AGGCACTTAG ATCAAGCTGC CGCTGCTCTG GAACCTGATA TTGTTGTTAA ACGACAGGAG 
GCTTTAGCAG CTGCTCGTTT GAAAATGCAA GAAGAATTAA ATGCACAAGT TGAAAAGCAT 
AAAGAGAAAT TAAGACAGCT TGAAGAAGAA AAAAGGAGAC AGAAGATCGA AATGTGGGAT 
AGCATGCAAG AAGGAAAAAG TTATAAAGGA AATACAAGAA AGCCTCAGGA AGAAGACAGT 
CCTGGGCCTT CTACTTCATC AGTCATCCCA AAACGAAAAT CTGACAGAAA GCCTTTGCGA 
GGAGGAGGTT ACAATCCTTT GTCTGGTGAA GGTGGTGGAA CCTGTTCCTG GAGACCTGGA 
CGCAGAGGAC CCTCATCTGG TGGATGAGGC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001039579.2
CDS	88..660
Translation	MERDGDQLSARPTLETEGLRFLHVTVGSLLATYGWYIVFSCILLYVVFQKLSTRLRALRQRHLDQAAAALEPDIVVKRQEALAAARLKMQEELNAQVEKHKEKLRQLEEEKRRQKIEMWDSMQEGKSYKGNTRKPQEEDSPGPSTSSVIPKRKSDRKPLRGGGYNPLSGEGGGTCSWRPGRRGPSSGG*G

Target ORF information:

RefSeq Version	NM_001046114.3
Organism	Bos taurus(cattle)
Definition	Bos taurus selenoprotein S (SELENOS), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001046114.3

ORF Insert Sequence:

ATGGAGCGGG ACGGGGATCA GCTGTCCGCG CGGCCCACCC TCGAGACCGA GGGGCTGCGT 
TTCCTTCACG TCACGGTGGG CTCCCTGCTG GCCACTTACG GCTGGTACAT CGTCTTCAGC 
TGCATCCTTC TCTACGTGGT GTTTCAGAAG CTTTCCACCC GGTTGAGGGC CTTGAGGCAG 
AGGCACTTAG ATCAAGCTGC CGCTGCTCTG GAACCTGATA TTGTTGTTAA ACGACAGGAG 
GCTTTAGCAG CTGCTCGTTT GAAAATGCAA GAAGAATTAA ATGCACAAGT TGAAAAGCAT 
AAAGAGAAAT TAAGACAGCT TGAAGAAGAA AAAAGGAGAC AGAAGATCGA AATGTGGGAT 
AGCATGCAAG AAGGAAAAAG TTATAAAGGA AATACAAGAA AGCCTCAGGA AGAAGACAGT 
CCTGGGCCTT CTACTTCATC AGTCATCCCA AAACGAAAAT CTGACAGAAA GCCTTTGCGA 
GGAGGAGGTT ACAATCCTTT GTCTGGTGAA GGTGGTGGAA CCTGTTCCTG GAGACCTGGA 
CGCAGAGGAC CCTCATCTGG TGGATGAGGC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SELENOS ( NM_001348226.1 ) cDNA ORF clone, Bos taurus(cattle) -> NP_001335155.1 Bos taurus selenoprotein S (SELENOS), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OBa134041
Clone ID Related Accession (Same CDS sequence)	NM_001348226.1 , NM_001348225.1
Accession Version	NM_001348226.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 309bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Bos taurus(cattle)
Product	selenoprotein S isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DT848352.1, NKLS02000021.1, BC112740.1 and EE934364.1. Transcript Variant: This variant (3) is alternatively spliced at the 5' end, which results in translation initiation from an in-frame downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform. ##Evidence-Data-START## Transcript exon combination :: SRR5571257.34843.1, SRR5571257.28746.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145415, SAMN03145425 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCAAGAAG AATTAAATGC ACAAGTTGAA AAGCATAAAG AGAAATTAAG ACAGCTTGAA 
GAAGAAAAAA GGAGACAGAA GATCGAAATG TGGGATAGCA TGCAAGAAGG AAAAAGTTAT 
AAAGGAAATA CAAGAAAGCC TCAGGAAGAA GACAGTCCTG GGCCTTCTAC TTCATCAGTC 
ATCCCAAAAC GAAAATCTGA CAGAAAGCCT TTGCGAGGAG GAGGTTACAA TCCTTTGTCT 
GGTGAAGGTG GTGGAACCTG TTCCTGGAGA CCTGGACGCA GAGGACCCTC ATCTGGTGGA 
TGAGGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001335155.1
CDS	516..824
Translation	MQEELNAQVEKHKEKLRQLEEEKRRQKIEMWDSMQEGKSYKGNTRKPQEEDSPGPSTSSVIPKRKSDRKPLRGGGYNPLSGEGGGTCSWRPGRRGPSSGG*G

Target ORF information:

RefSeq Version	NM_001348226.1
Organism	Bos taurus(cattle)
Definition	Bos taurus selenoprotein S (SELENOS), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001348226.1

ORF Insert Sequence:

ATGCAAGAAG AATTAAATGC ACAAGTTGAA AAGCATAAAG AGAAATTAAG ACAGCTTGAA 
GAAGAAAAAA GGAGACAGAA GATCGAAATG TGGGATAGCA TGCAAGAAGG AAAAAGTTAT 
AAAGGAAATA CAAGAAAGCC TCAGGAAGAA GACAGTCCTG GGCCTTCTAC TTCATCAGTC 
ATCCCAAAAC GAAAATCTGA CAGAAAGCCT TTGCGAGGAG GAGGTTACAA TCCTTTGTCT 
GGTGAAGGTG GTGGAACCTG TTCCTGGAGA CCTGGACGCA GAGGACCCTC ATCTGGTGGA 
TGAGGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SELENOS ( NM_001348225.1 ) cDNA ORF clone, Bos taurus(cattle) -> NP_001335154.1 Bos taurus selenoprotein S (SELENOS), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OBa134041
Clone ID Related Accession (Same CDS sequence)	NM_001348226.1 , NM_001348225.1
Accession Version	NM_001348225.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 309bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-22
Organism	Bos taurus(cattle)
Product	selenoprotein S isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from EE243695.1, DN534347.1 and EV727840.1. Transcript Variant: This variant (2) is alternatively spliced at the 5' end, which results in translation initiation from an in-frame downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform. ##Evidence-Data-START## Transcript exon combination :: DN534347.1, CK967401.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145412, SAMN03145413 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCAAGAAG AATTAAATGC ACAAGTTGAA AAGCATAAAG AGAAATTAAG ACAGCTTGAA 
GAAGAAAAAA GGAGACAGAA GATCGAAATG TGGGATAGCA TGCAAGAAGG AAAAAGTTAT 
AAAGGAAATA CAAGAAAGCC TCAGGAAGAA GACAGTCCTG GGCCTTCTAC TTCATCAGTC 
ATCCCAAAAC GAAAATCTGA CAGAAAGCCT TTGCGAGGAG GAGGTTACAA TCCTTTGTCT 
GGTGAAGGTG GTGGAACCTG TTCCTGGAGA CCTGGACGCA GAGGACCCTC ATCTGGTGGA 
TGAGGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001335154.1
CDS	553..861
Translation	MQEELNAQVEKHKEKLRQLEEEKRRQKIEMWDSMQEGKSYKGNTRKPQEEDSPGPSTSSVIPKRKSDRKPLRGGGYNPLSGEGGGTCSWRPGRRGPSSGG*G

Target ORF information:

RefSeq Version	NM_001348225.1
Organism	Bos taurus(cattle)
Definition	Bos taurus selenoprotein S (SELENOS), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001348225.1

ORF Insert Sequence:

ATGCAAGAAG AATTAAATGC ACAAGTTGAA AAGCATAAAG AGAAATTAAG ACAGCTTGAA 
GAAGAAAAAA GGAGACAGAA GATCGAAATG TGGGATAGCA TGCAAGAAGG AAAAAGTTAT 
AAAGGAAATA CAAGAAAGCC TCAGGAAGAA GACAGTCCTG GGCCTTCTAC TTCATCAGTC 
ATCCCAAAAC GAAAATCTGA CAGAAAGCCT TTGCGAGGAG GAGGTTACAA TCCTTTGTCT 
GGTGAAGGTG GTGGAACCTG TTCCTGGAGA CCTGGACGCA GAGGACCCTC ATCTGGTGGA 
TGAGGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Selenoprotein Gene Nomenclature.
The Journal of biological chemistry291(46)24036-24040(2016 Nov)
Gladyshev VN,Arn?r ES,Berry MJ,Brigelius-Floh? R,Bruford EA,Burk RF,Carlson BA,Castellano S,Chavatte L,Conrad M,Copeland PR,Diamond AM,Driscoll DM,Ferreiro A,Floh? L,Green FR,Guig? R,Handy DE,Hatfield DL,Hesketh J,Hoffmann PR,Holmgren A,Hondal RJ,Howard MT,Huang K,Kim HY,Kim IY,K?hrle J,Krol A,Kryukov GV,Lee BJ,Lee BC,Lei XG,Liu Q,Lescure A,Lobanov AV,Loscalzo J,Maiorino M,Mariotti M,Sandeep Prabhu K,Rayman MP,Rozovsky S,Salinas G,Schmidt EE,Schomburg L,Schweizer U,Simonovi? M,Sunde RA,Tsuji PA,Tweedie S,Ursini F,Whanger PD,Zhang Y

Alternative transcripts and 3'UTR elements govern the incorporation of selenocysteine into selenoprotein S.
PloS one8(4)e62102(2013)
Bubenik JL,Miniard AC,Driscoll DM

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

Characterization of mammalian selenoproteomes.
Science (New York, N.Y.)300(5624)1439-43(2003 May)
Kryukov GV,Castellano S,Novoselov SV,Lobanov AV,Zehtab O,Guig? R,Gladyshev VN

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SELENOS cDNA ORF clone, Bos taurus(cattle)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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