Casp1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Casp1
Entrez Gene ID	25166
Full Name	caspase 1
Synonyms	Ice,Il1bc
General protein information	Preferred Names caspase 1 Names caspase-1 CASP-1 IL-1 beta-converting enzyme IL-1BC Interleukin 1beta converting enzyme interleukin 1, beta, convertase interleukin-1 beta-converting enzyme p45
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q11
Summary	apoptotic protease that may play a role in inflammation and apoptosis in male sex organs [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012762.2	NP_036894.2	caspase-1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	CASP4	NP_001003125.1
Mus musculus (house mouse)	Casp1	NP_033937.2
Gallus gallus (chicken)	CASP1	XP_003642432.2
Danio rerio (zebrafish)	caspbl	NP_001139064.1
Homo sapiens (human)	CASP1	NP_150634.1
Pan troglodytes (chimpanzee)	LOC101058924	XP_003952059.1
Danio rerio (zebrafish)	caspa	NP_571580.1
Danio rerio (zebrafish)	si:ch211-233g6.8	XP_003197824.1
	CASP1	XP_001094943.2
Bos taurus (cattle)	CASP1	XP_002692967.1
Rattus norvegicus (Norway rat)	Casp1	NP_036894.2
Danio rerio (zebrafish)	zgc:171731	NP_001103182.1
Xenopus tropicalis (tropical clawed frog)	LOC100491605	XP_002935240.2

Gene Ontology
Bibliography

Related articles in PubMed

The Correlation of Gene Expression of Inflammasome Indicators and Impaired Fertility in Rat Model of Spinal Cord Injury: A Time Course Study.
Nikmehr B, Bazrafkan M, Hassanzadeh G, Shahverdi A, Sadighi Gilani MA, Kiani S, Mokhtari T, Abolhassani F
Urology journal14(6)5057-5063(2017 Nov)

Emodin alleviates intestinal mucosal injury in rats with severe acute pancreatitis via the caspase-1 inhibition.
Ning JW, Zhang Y, Yu MS, Gu ML, Xu J, Usman A, Ji F
Hepatobiliary & pancreatic diseases international : HBPD INT16(4)431-436(2017 Aug)

NF-?B Blockade in Hypothalamic Paraventricular Nucleus Inhibits High-Salt-Induced Hypertension Through NLRP3 and Caspase-1.
Qi J, Yu XJ, Shi XL, Gao HL, Yi QY, Tan H, Fan XY, Zhang Y, Song XA, Cui W, Liu JJ, Kang YM
Cardiovascular toxicology16(4)345-54(2016 Oct)

Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism.
Lu A, Li Y, Schmidt FI, Yin Q, Chen S, Fu TM, Tong AB, Ploegh HL, Mao Y, Wu H
Nature structural & molecular biology23(5)416-25(2016 05)

Loss of caspase-1 and caspase-3 protein expression in human prostate cancer.
Winter RN, Kramer A, Borkowski A, Kyprianou N
Cancer research61(3)1227-32(2001 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

High-salt-induced NF-kappaB activation in the hypothalamic paraventricular nucleus caused hypertension via sympathoexcitation associated with the increases of NLRP3, IL-1beta and oxidative stress in the PVN; PVN inhibition of NF-kappaB activity attenuates NLRP3, IL-1beta and oxidative stress in the PVN and attenuates hypertension.
Title: NF-?B Blockade in Hypothalamic Paraventricular Nucleus Inhibits High-Salt-Induced Hypertension Through NLRP3 and Caspase-1.

LPS-induced delayed puberty can be prevented by administering NO and caspase-1 inhibitors to neonates.
Title: Endotoxin exposure and puberty in female rats: the role of nitric oxide and caspase-1 inhibition in neonates.

GATA4, a key regulator of cardiomyocyte survival, is a substrate for caspase-1.
Title: Caspase-1 cleavage of transcription factor GATA4 and regulation of cardiac cell fate.

The expression of caspase-1-activated cytokines IL-1beta and IL-18 plays a pivotal role in acute renal injury in rats with experimental severe acute pancreatitis. Caspase-1 inhibition improves renal function effectively.
Title: Caspase-1 inhibition alleviates acute renal injury in rats with severe acute pancreatitis.

The NOD-like receptor NLRP1a/Caspase-1 pathway is the best candidate to mediate the parasite-induced cell death.
Title: A highly conserved Toxo1 haplotype directs resistance to toxoplasmosis and its associated caspase-1 dependent killing of parasite and host macrophage.

The following Casp1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Casp1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00871	NM_012762.2 Latest version!	Rattus norvegicus caspase 1 (Casp1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Casp1 ( NM_012762.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036894.2 Rattus norvegicus caspase 1 (Casp1), mRNA.

Price & Availability↑

CloneID	ORa00871
Clone ID Related Accession (Same CDS sequence)	NM_012762.2
Accession Version	NM_012762.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1209bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	caspase-1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D85899.1. On Jun 9, 2003 this sequence version replaced NM_012762.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D85899.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMEA2689594 [ECO:0000348] ##Evidence-Data-END##

ATGGCCGACA AGGTCCTGAG GGCAAAGAGG AAGCAATTTA TCAACTCAGT GAGTGTAGGG 
ACAATAAATG GATTGCTGGA TGAACTTTTA GAGAAGAGAG TCCTGAACCA GGAAGAGATG 
GATACAATCA AACTTGCAAA TATCACTGTT ATGGAAAAGG CACGAGACCT GTGCGATCAT 
GTCACTAAAA AAGGACCCCG GGCAAGCCAG ATGTTTATCA CTTACATTTG TAATGAAGAC 
TGCTACCTGG CAGAAATTCT GGAGCTTCAG TCAGGTCCAT CAGCTGAAAC TGTTTTTGTT 
ACAGAAGATT CTAAGGGAGG ACATCCTTTC TCCTCAGAAA CAAAAGAAAA ACTGAACAAA 
GAAGGTGGCG CATTTCCTGG ACCGAGTGGT TCCCTCAAGT TTTGCCCTTT AGAAATAGCC 
CAGAAGTTAT GGAAAGAAAA TCATTCAGAG ATTTATCCAA TAATGAAAAC ACCCACTCGT 
ACACGTCTTG CCCTCATTAT CTGCAGCACA GACTTTCAAC ATCTTTCTCG GAGAGTCGGA 
GCTGATGTTG ACCTCAGAGA AATGAAGTTG CTGCTGCAGG ATCTGGGGTA TACTGTGAAA 
GTCAAAGAAA ATCTCACAGC TCTGGAGATG ACAAAAGAAT TGAAAGAATT TGCTGCCTGC 
CCAGAGCACA AGACTTCTGA CAGTACCTTC CTTGTATTCA TGTCTCATGG TCTCCAGGAG 
GGAATATGTG GGATCACATA CTCTAATGAA GTTGCAGATA TTTTAAAGGT TGACACAATC 
TTTCAAATGA TGAACACATT GAAGTGCCCA AGCTTGAAAG ACAAGCCCAA GGTTATCATT 
ATTCAGGCAT GCCGTGGAGA GAAACAAGGA GTGGTGTTGT TAAAAGATTC AGTAGGAAAC 
TCCGAAGAGG GATTCTTAAC AGATGCAATT TTTGAAGATG ATGGCATTAA GAAGGCCCAT 
ATAGAGAAAG ATTTTATTGC TTTCTGCTCT TCAACACCAG ATAATGTGTC CTGGAGACAT 
CCTGTCCGGG GATCCCTCTT CATTGAGTCA CTCATCAAAC ACATGAAAGA ATATGCCTGG 
TCTTGTGACT TGGAGGACAT TTTCAGAAAG GTTCGATTTT CTTTCGAACA ACCAGACTCT 
AGACTACAGA TGCCAACCAC TGAAAGGGTG ACCCTGACAA AACGTTTCTA CCTCTTCCCA 
GGACATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036894.2
CDS	1..1209
Translation	MADKVLRAKRKQFINSVSVGTINGLLDELLEKRVLNQEEMDTIKLANITVMEKARDLCDHVTKKGPRASQMFITYICNEDCYLAEILELQSGPSAETVFVTEDSKGGHPFSSETKEKLNKEGGAFPGPSGSLKFCPLEIAQKLWKENHSEIYPIMKTPTRTRLALIICSTDFQHLSRRVGADVDLREMKLLLQDLGYTVKVKENLTALEMTKELKEFAACPEHKTSDSTFLVFMSHGLQEGICGITYSNEVADILKVDTIFQMMNTLKCPSLKDKPKVIIIQACRGEKQGVVLLKDSVGNSEEGFLTDAIFEDDGIKKAHIEKDFIAFCSSTPDNVSWRHPVRGSLFIESLIKHMKEYAWSCDLEDIFRKVRFSFEQPDSRLQMPTTERVTLTKRFYLFPGH

Target ORF information:

RefSeq Version	NM_012762.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus caspase 1 (Casp1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012762.2

ORF Insert Sequence:

ATGGCCGACA AGGTCCTGAG GGCAAAGAGG AAGCAATTTA TCAACTCAGT GAGTGTAGGG 
ACAATAAATG GATTGCTGGA TGAACTTTTA GAGAAGAGAG TCCTGAACCA GGAAGAGATG 
GATACAATCA AACTTGCAAA TATCACTGTT ATGGAAAAGG CACGAGACCT GTGCGATCAT 
GTCACTAAAA AAGGACCCCG GGCAAGCCAG ATGTTTATCA CTTACATTTG TAATGAAGAC 
TGCTACCTGG CAGAAATTCT GGAGCTTCAG TCAGGTCCAT CAGCTGAAAC TGTTTTTGTT 
ACAGAAGATT CTAAGGGAGG ACATCCTTTC TCCTCAGAAA CAAAAGAAAA ACTGAACAAA 
GAAGGTGGCG CATTTCCTGG ACCGAGTGGT TCCCTCAAGT TTTGCCCTTT AGAAATAGCC 
CAGAAGTTAT GGAAAGAAAA TCATTCAGAG ATTTATCCAA TAATGAAAAC ACCCACTCGT 
ACACGTCTTG CCCTCATTAT CTGCAGCACA GACTTTCAAC ATCTTTCTCG GAGAGTCGGA 
GCTGATGTTG ACCTCAGAGA AATGAAGTTG CTGCTGCAGG ATCTGGGGTA TACTGTGAAA 
GTCAAAGAAA ATCTCACAGC TCTGGAGATG ACAAAAGAAT TGAAAGAATT TGCTGCCTGC 
CCAGAGCACA AGACTTCTGA CAGTACCTTC CTTGTATTCA TGTCTCATGG TCTCCAGGAG 
GGAATATGTG GGATCACATA CTCTAATGAA GTTGCAGATA TTTTAAAGGT TGACACAATC 
TTTCAAATGA TGAACACATT GAAGTGCCCA AGCTTGAAAG ACAAGCCCAA GGTTATCATT 
ATTCAGGCAT GCCGTGGAGA GAAACAAGGA GTGGTGTTGT TAAAAGATTC AGTAGGAAAC 
TCCGAAGAGG GATTCTTAAC AGATGCAATT TTTGAAGATG ATGGCATTAA GAAGGCCCAT 
ATAGAGAAAG ATTTTATTGC TTTCTGCTCT TCAACACCAG ATAATGTGTC CTGGAGACAT 
CCTGTCCGGG GATCCCTCTT CATTGAGTCA CTCATCAAAC ACATGAAAGA ATATGCCTGG 
TCTTGTGACT TGGAGGACAT TTTCAGAAAG GTTCGATTTT CTTTCGAACA ACCAGACTCT 
AGACTACAGA TGCCAACCAC TGAAAGGGTG ACCCTGACAA AACGTTTCTA CCTCTTCCCA 
GGACATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Correlation of Gene Expression of Inflammasome Indicators and Impaired Fertility in Rat Model of Spinal Cord Injury: A Time Course Study.
Urology journal14(6)5057-5063(2017 Nov)
Nikmehr B,Bazrafkan M,Hassanzadeh G,Shahverdi A,Sadighi Gilani MA,Kiani S,Mokhtari T,Abolhassani F

Emodin alleviates intestinal mucosal injury in rats with severe acute pancreatitis via the caspase-1 inhibition.
Hepatobiliary & pancreatic diseases international : HBPD INT16(4)431-436(2017 Aug)
Ning JW,Zhang Y,Yu MS,Gu ML,Xu J,Usman A,Ji F

NF-?B Blockade in Hypothalamic Paraventricular Nucleus Inhibits High-Salt-Induced Hypertension Through NLRP3 and Caspase-1.
Cardiovascular toxicology16(4)345-54(2016 Oct)
Qi J,Yu XJ,Shi XL,Gao HL,Yi QY,Tan H,Fan XY,Zhang Y,Song XA,Cui W,Liu JJ,Kang YM

Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism.
Nature structural & molecular biology23(5)416-25(2016 05)
Lu A,Li Y,Schmidt FI,Yin Q,Chen S,Fu TM,Tong AB,Ploegh HL,Mao Y,Wu H

Loss of caspase-1 and caspase-3 protein expression in human prostate cancer.
Cancer research61(3)1227-32(2001 Feb)
Winter RN,Kramer A,Borkowski A,Kyprianou N

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Casp1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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