Tap2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tap2
Entrez Gene ID	24812
Full Name	transporter 2, ATP binding cassette subfamily B member
Synonyms	Abcb3,Cim
General protein information	Preferred Names transporter 2, ATP binding cassette subfamily B member Names antigen peptide transporter 2 APT2 ATP-binding cassette sub-family B member 3 Transporter 2 ABC (ATP binding cassette) transporter 2 ATP-binding cassette sub-family B transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 20 Map Location: 20p12
Summary	transports peptides into the ER lumen for binding with MHC class I molecules; plays a role in antigen processing and presentation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_032056.3	NP_114445.2	antigen peptide transporter 2 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Tap2	NP_035660.3
Xenopus tropicalis (tropical clawed frog)	tap2	XP_002942649.2
Pan troglodytes (chimpanzee)	TAP2	XP_003311251.2
Bos taurus (cattle)	TAP2	NP_776647.1
Danio rerio (zebrafish)	abcb3l1	NP_001006594.1
Canis lupus familiaris (dog)	TAP2	XP_532099.3
Bos taurus (cattle)	LOC618733	NP_001040087.1
Rattus norvegicus (Norway rat)	Tap2	NP_114445.2
Gallus gallus (chicken)	TAP2	NP_001092827.1
Homo sapiens (human)	TAP2	NP_000535.3
Danio rerio (zebrafish)	si:dkey-57h18.2	XP_682981.1

Gene Ontology
Bibliography

Related articles in PubMed

Natural polymorphisms in Tap2 influence negative selection and CD4?CD8 lineage commitment in the rat.
Tuncel J, Haag S, Yau AC, Norin U, Baud A, L?nnblom E, Maratou K, Ytterberg AJ, Ekman D, Thordardottir S, Johannesson M, Gillett A, , Stridh P, Jagodic M, Olsson T, Fern?ndez-Teruel A, Zubarev RA, Mott R, Aitman TJ, Flint J, Holmdahl R
PLoS genetics10(2)e1004151(2014 Feb)

Genetic association analysis of TAP1 and TAP2 polymorphisms with aspirin exacerbated respiratory disease and its FEV1 decline.
Kim JH, Park BL, Pasaje CF, Bae JS, Park JS, Park SW, Uh ST, Kim MK, Choi IS, Cho SH, Choi BW, Park CS, Shin HD
Journal of human genetics56(9)652-9(2011 Sep)

Defining the membrane proteome of NK cells.
Ghosh D, Lippert D, Krokhin O, Cortens JP, Wilkins JA
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)

TAP1 and TAP2 polymorphisms associated with ankylosing spondylitis in genetically homogenous Chinese Han population.
Feng M, Yin B, Shen T, Ma Q, Liu L, Zheng J, Zhao Y, Qian K, Liu D
Human immunology70(4)257-61(2009 Apr)

Down-regulation of HLA class I antigen-processing machinery components in esophageal squamous cell carcinomas: association with disease progression.
Liu Q, Hao C, Su P, Shi J
Scandinavian journal of gastroenterology44(8)960-9(2009)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Variants of Tap2 have previously been shown to influence the antigenicity of MHC class I molecules . Our results show that a restricted peptide repertoire on MHC class I molecules leads to reduced negative selection of CD8SP cells.
Title: Natural polymorphisms in Tap2 influence negative selection and CD4?CD8 lineage commitment in the rat.

The transmembrane core complex of transporter associated with antigen processing (TAP)1 and TAP2 is sufficient for UL49.5 protein of bovine herpesvirus type-1 to mediate its inhibitory activity.
Title: The varicellovirus UL49.5 protein blocks the transporter associated with antigen processing (TAP) by inhibiting essential conformational transitions in the 6+6 transmembrane TAP core complex.

TAP subunits alternate in the recruitment and loading of a single MHC class I
Title: Molecular architecture of the TAP-associated MHC class I peptide-loading complex.

the biogenesis of functional TAP depends on the assembly of preexisting TAP1 with newly synthesized TAP2, but not vice versa
Title: Biogenesis of functional antigenic peptide transporter TAP requires assembly of pre-existing TAP1 with newly synthesized TAP2.

the distinct nucleotide binding behaviour of TAP1 and TAP2 is controlled by the nonhomologous C-terminal tails of the two TAP chains
Title: The distinct nucleotide binding states of the transporter associated with antigen processing (TAP) are regulated by the nonhomologous C-terminal tails of TAP1 and TAP2.

The following Tap2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tap2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12137	NM_032056.3 Latest version!	Rattus norvegicus transporter 2, ATP binding cassette subfamily B member (Tap2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tap2 ( NM_032056.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_114445.2 Rattus norvegicus transporter 2, ATP binding cassette subfamily B member (Tap2), mRNA.

Price & Availability↑

CloneID	ORa12137
Clone ID Related Accession (Same CDS sequence)	NM_032056.3
Accession Version	NM_032056.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2112bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Rattus norvegicus(Norway rat)
Product	antigen peptide transporter 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from X63854.1 and BC091140.1. On or before Dec 15, 2013 this sequence version replaced XM_006256032.1, XM_003751929.1, NM_032056.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X75305.1, X75306.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCGCTGT CCTACCCGAG GCCCTGGGCC TCTCTGCTGC TGGTGGACCT GGCTTTACTT 
GGGTTGCTAC AAAGATCTCT GGGAACTCTG CTTCCCCCGG GGCTGCCAGG ATTATGGCTG 
GAGGGCACCC TGCGACTTGG AGTGCTGTGG GGACTGCTAA AAGTGGGAGG GCTGCTGAGA 
CTTGTGGGGA CCTTTCTGCC CTTGCTCTGC CTGACCACCC CCCTGTTTTT CTCGCTGAGA 
GCCCTGGTGG GAAGCACCAT GAGCACCTCA GTACTCAGAG TGGCTTCTGC CTCTTGGGGC 
TGGCTGCTTG CTGGCTATGT AGCCGCGGCG TTGAGCCTTG CCGTGTGGGC TGTGCTGAGC 
CCCGCTGGAG CACAGGAGAA GGAACCAGGC CAGGAGAACA ACAGAGCACT CATGATACGG 
TTGCTGAGGC TGTCCAAGCC GGATCTGCCT TTCCTCATTG TTGCCTTCAT CTTTCTTGCG 
ATGGCTGTGT GGGGGGAGAC GTTAATCCCT CATTATTCGG GTCGTGTGAT TGACATCCTG 
GGAGGTGATT TTGACCCAGA CGCCTTTGCG AGCGCCATCT TTTTCATGTG CTTATTCTCT 
GTTGGGAGCT CCCTCTCTGC AGGCTGCCGA GGAGGCTCCT TCCTCTTCAC CATGTCCAGG 
ATCAACCTTC GCATACGAGA GCAGCTTTTC TCATCTTTGT TGCGCCAAGA CCTTGCATTC 
TTCCAGGAGA CCAAGACAGG GGAGCTGAAC TCACGGCTGA GCTCGGACAC CTCCCTGATG 
AGCCGCTGGC TCCCTTTCAA TGCCAATATC CTGCTGCGGA GCCTGGTGAA GGTGGTGGGG 
CTGTACTACT TCATGCTCCA GGTCTCCCCG AGACTCACCT TCCTCTCCCT GCTGGACCTG 
CCCCTCACAA TAGCAGCCGA GAAGGTGTAC AACCCCCGCC ATCAGGCTGT GCTAAAGGAG 
ATCCAGGATG TAGTGGCGAA GGCAGGGCAG GTGGTGCGTG AGGCCGTAGG AGGGCTGCAG 
ACCGTGAGAA GCTTTGGCGC GGAGGAGCAG GAAGTCAGCC GCTACAAGGA GGCCCTGGAG 
CGATGTCGAC AGCTGTGGTG GCGCCGAGAC CTGGAAAAAG AATTGTATTT AGTCATACGG 
AGGGTAATGG CCTTGGGCAT GCAGGTGCTG ATTCTGAACT GCGGTGTGCA GCAGATCCTG 
GCTGGGGAGG TCACCCGGGG CGGCCTGCTC TCCTTCTTGC TGTATCAGGA GGAAGTGGGG 
CACCATGTCC GGAACCTGGT ATACATGTAT GGGGATATGC TGAGCAACGT GGGTGCCGCG 
GAAAAGGTTT TTTCCTACTT GGACCGAAGG CCAAATCTGC CGAAGCCTGG TACCCTGGCC 
CCTCCCAGGG TGGAGGGGCG CGTGGAATTT CAAGATGTCT CCTTCTCGTA CCCCAGTCGC 
CCCGAGAAGC CTGTGCTCCA GGGCCTGACG TTTACCCTGC ATCCTGGAAA GGTGACCGCG 
TTGGTGGGAC CCAATGGGTC AGGGAAGAGC ACCGTGGCCG CCCTGCTGCA GAACCTGTAC 
CAGCCAACCG GGGGCAAGGT GCTCCTGGAT GGCGAGCCCC TGGTCCAGTA CGATCACCAC 
TACCTGCACC GCCAGGTGGT TCTGGTGGGG CAGGAGCCTG TGCTGTTCTC CGGTTCTGTC 
AAGGACAATA TTGCCTATGG CCTGAGGAAC TGTGAGGATG CTCAAGTGAT GGCTGCTGCC 
CAGGCGGCCT GTGCAGACGA CTTCATAGGG GAAATGACGA ACGGAATAAA CACAGAAATC 
GGGGAGAGAG GGAGCCAGTT AGCTGTGGGA CAGAAGCAAC GTCTGGCCAT TGCCCGGGCC 
CTTGTGCGGA ACCCGCGGGT CCTCATCCTG GATGAGGCTA CCAGTGCCCT GGACGCCGAG 
TGCGAGCAGG CTCTTCAGAC CTGGAGATCG CAGGAGGACA GGACGATGCT GGTCATTGCT 
CACCGGCTGC ACACGGTTCA GAATGCTGAC CAAGTTCTGG TGCTCAAGCA GGGGCAGCTG 
GTGGAGCACG ACCAGCTCAG GGATGAGCAG GATGTCTACG CTCACTTGGT ACAGCAGCGG 
CTGGAAGCGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_114445.2
CDS	90..2201
Translation	MALSYPRPWASLLLVDLALLGLLQRSLGTLLPPGLPGLWLEGTLRLGVLWGLLKVGGLLRLVGTFLPLLCLTTPLFFSLRALVGSTMSTSVLRVASASWGWLLAGYVAAALSLAVWAVLSPAGAQEKEPGQENNRALMIRLLRLSKPDLPFLIVAFIFLAMAVWGETLIPHYSGRVIDILGGDFDPDAFASAIFFMCLFSVGSSLSAGCRGGSFLFTMSRINLRIREQLFSSLLRQDLAFFQETKTGELNSRLSSDTSLMSRWLPFNANILLRSLVKVVGLYYFMLQVSPRLTFLSLLDLPLTIAAEKVYNPRHQAVLKEIQDVVAKAGQVVREAVGGLQTVRSFGAEEQEVSRYKEALERCRQLWWRRDLEKELYLVIRRVMALGMQVLILNCGVQQILAGEVTRGGLLSFLLYQEEVGHHVRNLVYMYGDMLSNVGAAEKVFSYLDRRPNLPKPGTLAPPRVEGRVEFQDVSFSYPSRPEKPVLQGLTFTLHPGKVTALVGPNGSGKSTVAALLQNLYQPTGGKVLLDGEPLVQYDHHYLHRQVVLVGQEPVLFSGSVKDNIAYGLRNCEDAQVMAAAQAACADDFIGEMTNGINTEIGERGSQLAVGQKQRLAIARALVRNPRVLILDEATSALDAECEQALQTWRSQEDRTMLVIAHRLHTVQNADQVLVLKQGQLVEHDQLRDEQDVYAHLVQQRLEA

Target ORF information:

RefSeq Version	NM_032056.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus transporter 2, ATP binding cassette subfamily B member (Tap2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032056.3

ORF Insert Sequence:

ATGGCGCTGT CCTACCCGAG GCCCTGGGCC TCTCTGCTGC TGGTGGACCT GGCTTTACTT 
GGGTTGCTAC AAAGATCTCT GGGAACTCTG CTTCCCCCGG GGCTGCCAGG ATTATGGCTG 
GAGGGCACCC TGCGACTTGG AGTGCTGTGG GGACTGCTAA AAGTGGGAGG GCTGCTGAGA 
CTTGTGGGGA CCTTTCTGCC CTTGCTCTGC CTGACCACCC CCCTGTTTTT CTCGCTGAGA 
GCCCTGGTGG GAAGCACCAT GAGCACCTCA GTACTCAGAG TGGCTTCTGC CTCTTGGGGC 
TGGCTGCTTG CTGGCTATGT AGCCGCGGCG TTGAGCCTTG CCGTGTGGGC TGTGCTGAGC 
CCCGCTGGAG CACAGGAGAA GGAACCAGGC CAGGAGAACA ACAGAGCACT CATGATACGG 
TTGCTGAGGC TGTCCAAGCC GGATCTGCCT TTCCTCATTG TTGCCTTCAT CTTTCTTGCG 
ATGGCTGTGT GGGGGGAGAC GTTAATCCCT CATTATTCGG GTCGTGTGAT TGACATCCTG 
GGAGGTGATT TTGACCCAGA CGCCTTTGCG AGCGCCATCT TTTTCATGTG CTTATTCTCT 
GTTGGGAGCT CCCTCTCTGC AGGCTGCCGA GGAGGCTCCT TCCTCTTCAC CATGTCCAGG 
ATCAACCTTC GCATACGAGA GCAGCTTTTC TCATCTTTGT TGCGCCAAGA CCTTGCATTC 
TTCCAGGAGA CCAAGACAGG GGAGCTGAAC TCACGGCTGA GCTCGGACAC CTCCCTGATG 
AGCCGCTGGC TCCCTTTCAA TGCCAATATC CTGCTGCGGA GCCTGGTGAA GGTGGTGGGG 
CTGTACTACT TCATGCTCCA GGTCTCCCCG AGACTCACCT TCCTCTCCCT GCTGGACCTG 
CCCCTCACAA TAGCAGCCGA GAAGGTGTAC AACCCCCGCC ATCAGGCTGT GCTAAAGGAG 
ATCCAGGATG TAGTGGCGAA GGCAGGGCAG GTGGTGCGTG AGGCCGTAGG AGGGCTGCAG 
ACCGTGAGAA GCTTTGGCGC GGAGGAGCAG GAAGTCAGCC GCTACAAGGA GGCCCTGGAG 
CGATGTCGAC AGCTGTGGTG GCGCCGAGAC CTGGAAAAAG AATTGTATTT AGTCATACGG 
AGGGTAATGG CCTTGGGCAT GCAGGTGCTG ATTCTGAACT GCGGTGTGCA GCAGATCCTG 
GCTGGGGAGG TCACCCGGGG CGGCCTGCTC TCCTTCTTGC TGTATCAGGA GGAAGTGGGG 
CACCATGTCC GGAACCTGGT ATACATGTAT GGGGATATGC TGAGCAACGT GGGTGCCGCG 
GAAAAGGTTT TTTCCTACTT GGACCGAAGG CCAAATCTGC CGAAGCCTGG TACCCTGGCC 
CCTCCCAGGG TGGAGGGGCG CGTGGAATTT CAAGATGTCT CCTTCTCGTA CCCCAGTCGC 
CCCGAGAAGC CTGTGCTCCA GGGCCTGACG TTTACCCTGC ATCCTGGAAA GGTGACCGCG 
TTGGTGGGAC CCAATGGGTC AGGGAAGAGC ACCGTGGCCG CCCTGCTGCA GAACCTGTAC 
CAGCCAACCG GGGGCAAGGT GCTCCTGGAT GGCGAGCCCC TGGTCCAGTA CGATCACCAC 
TACCTGCACC GCCAGGTGGT TCTGGTGGGG CAGGAGCCTG TGCTGTTCTC CGGTTCTGTC 
AAGGACAATA TTGCCTATGG CCTGAGGAAC TGTGAGGATG CTCAAGTGAT GGCTGCTGCC 
CAGGCGGCCT GTGCAGACGA CTTCATAGGG GAAATGACGA ACGGAATAAA CACAGAAATC 
GGGGAGAGAG GGAGCCAGTT AGCTGTGGGA CAGAAGCAAC GTCTGGCCAT TGCCCGGGCC 
CTTGTGCGGA ACCCGCGGGT CCTCATCCTG GATGAGGCTA CCAGTGCCCT GGACGCCGAG 
TGCGAGCAGG CTCTTCAGAC CTGGAGATCG CAGGAGGACA GGACGATGCT GGTCATTGCT 
CACCGGCTGC ACACGGTTCA GAATGCTGAC CAAGTTCTGG TGCTCAAGCA GGGGCAGCTG 
GTGGAGCACG ACCAGCTCAG GGATGAGCAG GATGTCTACG CTCACTTGGT ACAGCAGCGG 
CTGGAAGCGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Natural polymorphisms in Tap2 influence negative selection and CD4?CD8 lineage commitment in the rat.
PLoS genetics10(2)e1004151(2014 Feb)
Tuncel J,Haag S,Yau AC,Norin U,Baud A,L?nnblom E,Maratou K,Ytterberg AJ,Ekman D,Thordardottir S,Johannesson M,Gillett A,,Stridh P,Jagodic M,Olsson T,Fern?ndez-Teruel A,Zubarev RA,Mott R,Aitman TJ,Flint J,Holmdahl R

Genetic association analysis of TAP1 and TAP2 polymorphisms with aspirin exacerbated respiratory disease and its FEV1 decline.
Journal of human genetics56(9)652-9(2011 Sep)
Kim JH,Park BL,Pasaje CF,Bae JS,Park JS,Park SW,Uh ST,Kim MK,Choi IS,Cho SH,Choi BW,Park CS,Shin HD

Defining the membrane proteome of NK cells.
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)
Ghosh D,Lippert D,Krokhin O,Cortens JP,Wilkins JA

TAP1 and TAP2 polymorphisms associated with ankylosing spondylitis in genetically homogenous Chinese Han population.
Human immunology70(4)257-61(2009 Apr)
Feng M,Yin B,Shen T,Ma Q,Liu L,Zheng J,Zhao Y,Qian K,Liu D

Down-regulation of HLA class I antigen-processing machinery components in esophageal squamous cell carcinomas: association with disease progression.
Scandinavian journal of gastroenterology44(8)960-9(2009)
Liu Q,Hao C,Su P,Shi J

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Tap2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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