Tap2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tap2
Entrez Gene ID	21355
Full Name	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Synonyms	ABC18,AI462429,APT2,Abcb3,Ham-2,Ham2,MTP2,PSF2,RING11,Tap-2,Y1,jas
General protein information	Preferred Names transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) Names antigen peptide transporter 2 ATP dependent transport protein family member ATP-binding cassette sub-family B member 3 ATP-binding cassette, sub-family B (MDR/TAP), member 3 histocompatibility antigen modifier 2 transporter 2 ATP-binding cassette sub-family B transporter 2, ABC (ATP binding cassette)
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17 B1\|17 17.98 cM
Summary	The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with Tap1 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in the human gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
NM_011530.3	NP_035660.3	antigen peptide transporter 2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Tap2	NP_035660.3
Xenopus tropicalis (tropical clawed frog)	tap2	XP_002942649.2
Pan troglodytes (chimpanzee)	TAP2	XP_003311251.2
Bos taurus (cattle)	TAP2	NP_776647.1
Danio rerio (zebrafish)	abcb3l1	NP_001006594.1
Canis lupus familiaris (dog)	TAP2	XP_532099.3
Bos taurus (cattle)	LOC618733	NP_001040087.1
Rattus norvegicus (Norway rat)	Tap2	NP_114445.2
Gallus gallus (chicken)	TAP2	NP_001092827.1
Homo sapiens (human)	TAP2	NP_000535.3
Danio rerio (zebrafish)	si:dkey-57h18.2	XP_682981.1

Gene Ontology
Bibliography

Related articles in PubMed

A novel spontaneous mutation in the TAP2 gene unravels its role in macrophage survival.
Lapenna A, Omar I, Berger M
Immunology150(4)432-443(2017 04)

The QTL within the H2 Complex Involved in the Control of Tuberculosis Infection in Mice Is the Classical Class II H2-Ab1 Gene.
Logunova N, Korotetskaya M, Polshakov V, Apt A
PLoS genetics11(11)e1005672(2015 Nov)

Hydrophobicity as a driver of MHC class I antigen processing.
Huang L, Kuhls MC, Eisenlohr LC
The EMBO journal30(8)1634-44(2011 Apr)

Mouse strains with point mutations in TAP1 and TAP2.
Theodoratos A, Whittle B, Enders A, Tscharke DC, Roots CM, Goodnow CC, Fahrer AM
Immunology and cell biology88(1)72-8(2010 Jan)

The role of tapasin in MHC class I protein trafficking in embryos and T cells.
Lampton PW, Goldstein CY, Warner CM
Journal of reproductive immunology78(1)28-39(2008 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this study show that a new mouse strain with a single point mutation (Tap2 knock-out strain) shows impaired survival of macrophage survival following peritoneal iflammation
Title: A novel spontaneous mutation in the TAP2 gene unravels its role in macrophage survival.

The Rose strain has an A to T substitution in exon 10 of TAP1, resulting in an asparagine to valine substitution at position 643; defective TAP expression mice have very low major histocompatibility complex-I cell-surface expression, and few CD8 T cells.
Title: Mouse strains with point mutations in TAP1 and TAP2.

A major role for tapasin as a stabilizer of the TAP peptide transporter and consequences for MHC class I expression
Title: A major role for tapasin as a stabilizer of the TAP peptide transporter and consequences for MHC class I expression.

The following Tap2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tap2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu23748	NM_011530.3 Latest version!	Mus musculus transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) (Tap2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tap2 ( NM_011530.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035660.3 Mus musculus transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) (Tap2), mRNA.

Price & Availability↑

CloneID	OMu23748
Clone ID Related Accession (Same CDS sequence)	NM_011530.3
Accession Version	NM_011530.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2109bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Mus musculus(house mouse)
Product	antigen peptide transporter 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CJ046345.1, M90459.1 and BE691532.1. On Jun 13, 2009 this sequence version replaced NM_011530.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC051257.1, AK159200.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGCTGT CCTACCTGAG GCCCTGGGTC TCTCTGCTGC TGGCGGACAT GGCTTTACTT 
GGGTTGCTAC AAGGATCTCT GGGAAATCTG CTTCCCCAGG GGCTGCCAGG ACTCTGGATA 
GAGGGCACCC TGCGACTTGG AGTGCTGTGG GGACTGCTAA AAGTGGGAGA GCTGCTGGGA 
CTTGTGGGGA CCCTTCTGCC CTTGCTCTGC CTTGCCACTC CCCTGTTTTT CTCGCTAAGA 
GCTCTGGTGG GAGGCACCGC GAGCACCTCA GTAGTCCGAG TGGCTTCTGC CTCTTGGGGC 
TGGCTGCTGG CTGGCTATGG GGCTGTTGCG CTGAGCTGGG CCGTGTGGGC TGTGCTGAGC 
CCGGCTGGAG TCCAGGAGAA GGAACCAGGC CAGGAGAACA GAACACTGAT GAAGCGGTTG 
CTGAAGCTGT CCAGGCCGGA CCTGCCTTTC CTCATAGCTG CCTTCTTCTT CCTTGTGGTG 
GCTGTGTGGG GGGAGACATT AATCCCTCGC TATTCGGGTC GTGTAATTGA CATCCTGGGA 
GGTGATTTCG ACCCCGACGC CTTTGCAAGC GCCATCTTTT TCATGTGCCT GTTCTCTGTT 
GGGAGCTCCT TCTCTGCAGG CTGTAGAGGA GGCTCCTTCC TCTTCACCAT GTCCAGGATC 
AACCTGCGGA TACGAGAGCA GCTTTTCTCA TCTTTGTTGC GCCAAGACCT TGGATTCTTC 
CAGGAGACCA AGACAGGGGA GCTGAACTCG AGGCTGAGCT CTGACACCTC TCTGATGAGC 
CGCTGGCTCC CTTTCAATGC CAATATCCTG CTGCGGAGCC TGGTGAAGGT GGTGGGGCTC 
TACTTCTTCA TGCTCCAGGT ATCGCCCCGA CTCACCTTCC TCTCCCTGCT GGACCTGCCC 
CTCACGATAG CAGCTGAGAA GGTGTACAAC CCCCGCCATC AGGCGGTGCT AAAGGAGATC 
CAGGATGCAG TGGCCAAGGC GGGGCAGGTG GTGCGCGAGG CGGTAGGAGG GCTGCAGACT 
GTGCGAAGCT TTGGGGCCGA GGAGCAGGAA GTCAGCCACT ACAAGGAGGC CCTGGAGCGA 
TGTAGACAGC TGTGGTGGCG CCGAGACCTG GAAAAAGACG TGTATCTAGT CATACGGAGG 
GTGATGGCCT TGGGCATGCA GGTGCTGATT CTGAACTGCG GCGTGCAGCA GATTCTGGCT 
GGAGAGGTCA CCCGGGGTGG CCTGCTCTCC TTCCTGCTGT ACCAGGAGGA AGTGGGACAA 
TATGTCCGGA ACCTGGTTTA CATGTACGGG GATATGCTGA GCAACGTGGG CGCTGCTGAA 
AAGGTGTTTT CCTACCTGGA CCGAAAGCCG AATCTGCCCC AGCCTGGGAT CCTGGCCCCT 
CCCTGGCTGG AGGGGCGCGT GGAATTCCAA GACGTCTCCT TTTCGTATCC CAGGCGCCCC 
GAGAAGCCTG TGCTCCAGGG TCTGACGTTC ACCCTGCATC CTGGAACGGT GACAGCGTTG 
GTGGGACCCA ATGGATCAGG GAAGAGCACC GTGGCCGCCC TGCTGCAGAA CCTGTACCAG 
CCCACTGGGG GCCAGCTGCT GCTGGATGGC GAGCCCCTGA CCGAGTATGA TCACCACTAC 
CTGCACCGCC AGGTGGTTCT GGTGGGGCAG GAGCCTGTGC TGTTCTCGGG TTCTGTCAAG 
GACAATATTG CCTATGGCCT GAGGGACTGT GAGGACGCTC AAGTGATGGC AGCTGCCCAG 
GCGGCCTGTG CAGACGACTT CATAGGGGAA ATGACTAATG GAATAAACAC AGAAATCGGG 
GAAAAAGGGG GCCAGTTAGC TGTGGGACAG AAGCAACGTC TGGCCATTGC CCGGGCCCTT 
GTGCGGAACC CACGGGTCCT CATCCTGGAT GAGGCTACCA GCGCCCTGGA CGCCCAGTGT 
GAACAGGCCC TACAGAACTG GAGATCGCAG GGGGACAGGA CGATGCTGGT GATTGCCCAC 
AGGCTGCACA CGGTTCAGAA TGCTGACCAA GTTCTGGTGC TCAAGCAGGG ACGTCTGGTG 
GAGCATGACC AGCTCAGGGA CGGCCAGGAT GTCTACGCCC ACCTGGTACA GCAGCGGCTG 
GAGGCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035660.3
CDS	154..2262
Translation	MALSYLRPWVSLLLADMALLGLLQGSLGNLLPQGLPGLWIEGTLRLGVLWGLLKVGELLGLVGTLLPLLCLATPLFFSLRALVGGTASTSVVRVASASWGWLLAGYGAVALSWAVWAVLSPAGVQEKEPGQENRTLMKRLLKLSRPDLPFLIAAFFFLVVAVWGETLIPRYSGRVIDILGGDFDPDAFASAIFFMCLFSVGSSFSAGCRGGSFLFTMSRINLRIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTSLMSRWLPFNANILLRSLVKVVGLYFFMLQVSPRLTFLSLLDLPLTIAAEKVYNPRHQAVLKEIQDAVAKAGQVVREAVGGLQTVRSFGAEEQEVSHYKEALERCRQLWWRRDLEKDVYLVIRRVMALGMQVLILNCGVQQILAGEVTRGGLLSFLLYQEEVGQYVRNLVYMYGDMLSNVGAAEKVFSYLDRKPNLPQPGILAPPWLEGRVEFQDVSFSYPRRPEKPVLQGLTFTLHPGTVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGEPLTEYDHHYLHRQVVLVGQEPVLFSGSVKDNIAYGLRDCEDAQVMAAAQAACADDFIGEMTNGINTEIGEKGGQLAVGQKQRLAIARALVRNPRVLILDEATSALDAQCEQALQNWRSQGDRTMLVIAHRLHTVQNADQVLVLKQGRLVEHDQLRDGQDVYAHLVQQRLEA

Target ORF information:

RefSeq Version	NM_011530.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) (Tap2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011530.3

ORF Insert Sequence:

ATGGCGCTGT CCTACCTGAG GCCCTGGGTC TCTCTGCTGC TGGCGGACAT GGCTTTACTT 
GGGTTGCTAC AAGGATCTCT GGGAAATCTG CTTCCCCAGG GGCTGCCAGG ACTCTGGATA 
GAGGGCACCC TGCGACTTGG AGTGCTGTGG GGACTGCTAA AAGTGGGAGA GCTGCTGGGA 
CTTGTGGGGA CCCTTCTGCC CTTGCTCTGC CTTGCCACTC CCCTGTTTTT CTCGCTAAGA 
GCTCTGGTGG GAGGCACCGC GAGCACCTCA GTAGTCCGAG TGGCTTCTGC CTCTTGGGGC 
TGGCTGCTGG CTGGCTATGG GGCTGTTGCG CTGAGCTGGG CCGTGTGGGC TGTGCTGAGC 
CCGGCTGGAG TCCAGGAGAA GGAACCAGGC CAGGAGAACA GAACACTGAT GAAGCGGTTG 
CTGAAGCTGT CCAGGCCGGA CCTGCCTTTC CTCATAGCTG CCTTCTTCTT CCTTGTGGTG 
GCTGTGTGGG GGGAGACATT AATCCCTCGC TATTCGGGTC GTGTAATTGA CATCCTGGGA 
GGTGATTTCG ACCCCGACGC CTTTGCAAGC GCCATCTTTT TCATGTGCCT GTTCTCTGTT 
GGGAGCTCCT TCTCTGCAGG CTGTAGAGGA GGCTCCTTCC TCTTCACCAT GTCCAGGATC 
AACCTGCGGA TACGAGAGCA GCTTTTCTCA TCTTTGTTGC GCCAAGACCT TGGATTCTTC 
CAGGAGACCA AGACAGGGGA GCTGAACTCG AGGCTGAGCT CTGACACCTC TCTGATGAGC 
CGCTGGCTCC CTTTCAATGC CAATATCCTG CTGCGGAGCC TGGTGAAGGT GGTGGGGCTC 
TACTTCTTCA TGCTCCAGGT ATCGCCCCGA CTCACCTTCC TCTCCCTGCT GGACCTGCCC 
CTCACGATAG CAGCTGAGAA GGTGTACAAC CCCCGCCATC AGGCGGTGCT AAAGGAGATC 
CAGGATGCAG TGGCCAAGGC GGGGCAGGTG GTGCGCGAGG CGGTAGGAGG GCTGCAGACT 
GTGCGAAGCT TTGGGGCCGA GGAGCAGGAA GTCAGCCACT ACAAGGAGGC CCTGGAGCGA 
TGTAGACAGC TGTGGTGGCG CCGAGACCTG GAAAAAGACG TGTATCTAGT CATACGGAGG 
GTGATGGCCT TGGGCATGCA GGTGCTGATT CTGAACTGCG GCGTGCAGCA GATTCTGGCT 
GGAGAGGTCA CCCGGGGTGG CCTGCTCTCC TTCCTGCTGT ACCAGGAGGA AGTGGGACAA 
TATGTCCGGA ACCTGGTTTA CATGTACGGG GATATGCTGA GCAACGTGGG CGCTGCTGAA 
AAGGTGTTTT CCTACCTGGA CCGAAAGCCG AATCTGCCCC AGCCTGGGAT CCTGGCCCCT 
CCCTGGCTGG AGGGGCGCGT GGAATTCCAA GACGTCTCCT TTTCGTATCC CAGGCGCCCC 
GAGAAGCCTG TGCTCCAGGG TCTGACGTTC ACCCTGCATC CTGGAACGGT GACAGCGTTG 
GTGGGACCCA ATGGATCAGG GAAGAGCACC GTGGCCGCCC TGCTGCAGAA CCTGTACCAG 
CCCACTGGGG GCCAGCTGCT GCTGGATGGC GAGCCCCTGA CCGAGTATGA TCACCACTAC 
CTGCACCGCC AGGTGGTTCT GGTGGGGCAG GAGCCTGTGC TGTTCTCGGG TTCTGTCAAG 
GACAATATTG CCTATGGCCT GAGGGACTGT GAGGACGCTC AAGTGATGGC AGCTGCCCAG 
GCGGCCTGTG CAGACGACTT CATAGGGGAA ATGACTAATG GAATAAACAC AGAAATCGGG 
GAAAAAGGGG GCCAGTTAGC TGTGGGACAG AAGCAACGTC TGGCCATTGC CCGGGCCCTT 
GTGCGGAACC CACGGGTCCT CATCCTGGAT GAGGCTACCA GCGCCCTGGA CGCCCAGTGT 
GAACAGGCCC TACAGAACTG GAGATCGCAG GGGGACAGGA CGATGCTGGT GATTGCCCAC 
AGGCTGCACA CGGTTCAGAA TGCTGACCAA GTTCTGGTGC TCAAGCAGGG ACGTCTGGTG 
GAGCATGACC AGCTCAGGGA CGGCCAGGAT GTCTACGCCC ACCTGGTACA GCAGCGGCTG 
GAGGCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A novel spontaneous mutation in the TAP2 gene unravels its role in macrophage survival.
Immunology150(4)432-443(2017 04)
Lapenna A,Omar I,Berger M

The QTL within the H2 Complex Involved in the Control of Tuberculosis Infection in Mice Is the Classical Class II H2-Ab1 Gene.
PLoS genetics11(11)e1005672(2015 Nov)
Logunova N,Korotetskaya M,Polshakov V,Apt A

Hydrophobicity as a driver of MHC class I antigen processing.
The EMBO journal30(8)1634-44(2011 Apr)
Huang L,Kuhls MC,Eisenlohr LC

Mouse strains with point mutations in TAP1 and TAP2.
Immunology and cell biology88(1)72-8(2010 Jan)
Theodoratos A,Whittle B,Enders A,Tscharke DC,Roots CM,Goodnow CC,Fahrer AM

The role of tapasin in MHC class I protein trafficking in embryos and T cells.
Journal of reproductive immunology78(1)28-39(2008 Jun)
Lampton PW,Goldstein CY,Warner CM

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Tap2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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