TAP2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TAP2
Entrez Gene ID	6891
Full Name	transporter 2, ATP binding cassette subfamily B member
Synonyms	ABC18,ABCB3,APT2,D6S217E,PSF-2,PSF2,RING11
General protein information	Preferred Names transporter 2, ATP binding cassette subfamily B member Names antigen peptide transporter 2 ABC transporter, MHC 2 ATP-binding cassette, sub-family B (MDR/TAP), member 3 peptide supply factor 2 peptide transporter PSF2 peptide transporter involved in antigen processing 2 really interesting new gene 11 protein transporter 2, ABC (ATP binding cassette) transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p21.32
Summary	The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. [provided by RefSeq, Feb 2014].
Disorder MIM:	170261
Disorder Html:	Bare lymphocyte syndrome, type I, due to TAP2 deficiency, 604571 (3); Wegener-like granulomatosis (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000544.3	NP_000535.3	antigen peptide transporter 2 isoform 1
NM_001290043.2	NP_001276972.1	antigen peptide transporter 2 isoform 3
NM_001290043.1	NP_001276972.1	antigen peptide transporter 2 isoform 3
NM_018833.2	NP_061313.2	antigen peptide transporter 2 isoform 2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Tap2	NP_035660.3
Xenopus tropicalis (tropical clawed frog)	tap2	XP_002942649.2
Pan troglodytes (chimpanzee)	TAP2	XP_003311251.2
Bos taurus (cattle)	TAP2	NP_776647.1
Danio rerio (zebrafish)	abcb3l1	NP_001006594.1
Canis lupus familiaris (dog)	TAP2	XP_532099.3
Bos taurus (cattle)	LOC618733	NP_001040087.1
Rattus norvegicus (Norway rat)	Tap2	NP_114445.2
Gallus gallus (chicken)	TAP2	NP_001092827.1
Homo sapiens (human)	TAP2	NP_000535.3
Danio rerio (zebrafish)	si:dkey-57h18.2	XP_682981.1

Gene Ontology
Bibliography

Related articles in PubMed

The association of LMP7 and TAP2 gene polymorphisms with treatment response to interferon/ribavirin in patients with genotype 1 chronic hepatitis C.
Zang F, Yao Y, Liu M, Fan H, Yue M, Chen M, Wang J, Yu R, Huang P
International journal of molecular medicine40(6)1983-1990(2017 Dec)

A functional SNP in the 3'-UTR of TAP2 gene interacts with microRNA hsa-miR-1270 to suppress the gene expression.
Knox B, Wang Y, Rogers LJ, Xuan J, Yu D, Guan H, Chen J, Shi T, Ning B, Kadlubar SA
Environmental and molecular mutagenesis(2017 Dec)

Downregulation of TAP1 and TAP2 in early stage breast cancer.
Henle AM, Nassar A, Puglisi-Knutson D, Youssef B, Knutson KL
PloS one12(11)e0187323(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Both TAP1 and TAP2 overexpression in breast cancer might be an indicator of an aggressive breast tumor
Title: Downregulation of TAP1 and TAP2 in early stage breast cancer.

We replicated the association between the rs2071473 genotype and TAP2 expression by using GTEx data and demonstrated that TAP2 is expressed by decidual stromal cells at the maternal-fetal interface.
Title: An Ancient Fecundability-Associated Polymorphism Switches a Repressor into an Enhancer of Endometrial TAP2 Expression.

These results suggest that TAP2 polymorphisms influence TB susceptibility in a Japanese population.
Title: Association of polymorphisms of the transporter associated with antigen processing (TAP2) gene with pulmonary tuberculosis in an elderly Japanese population.

Two eSNPs were associated with fecundability at a FDR of 5%; both were in the HLA region and were eQTLs for the TAP2 gene (P = 1.3x10-4) and the HLA-F gene (P = 4.0x10-4), respectively.
Title: Expression Quantitative Trait Locus Mapping Studies in Mid-secretory Phase Endometrial Cells Identifies HLA-F and TAP2 as Fecundability-Associated Genes.

there was no significant difference with respect to the genotypic frequencies of the SNPs in PSMB8, TAP1, and TAP2 loci in Parkinson's disease patients
Title: Association Analysis of Proteasome Subunits and Transporter Associated with Antigen Processing on Chinese Patients with Parkinson's Disease.

The following TAP2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TAP2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19274	NM_000544.3 Latest version!	Homo sapiens transporter 2, ATP binding cassette subfamily B member (TAP2), transcript variant 1, B allele, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$354.50-$496.30 $709.00
OHu19417	NM_018833.2 Latest version!	Homo sapiens transporter 2, ATP binding cassette subfamily B member (TAP2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$274.50-$384.30 $549.00
OHu22215	NM_001290043.2 Latest version!	Homo sapiens transporter 2, ATP binding cassette subfamily B member (TAP2), transcript variant 1, A allele, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
View Old Accession Versions >>
OHu22215	NM_001290043.1	Homo sapiens transporter 2, ATP binding cassette subfamily B member (TAP2), transcript variant 1, A allele, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TAP2 ( NM_000544.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000535.3 Homo sapiens transporter 2, ATP binding cassette subfamily B member (TAP2), transcript variant 1, B allele, mRNA.

Price & Availability↑

CloneID	OHu19274
Clone ID Related Accession (Same CDS sequence)	NM_000544.3
Accession Version	NM_000544.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2112bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	antigen peptide transporter 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG423357.1, BC002751.2, Z22935.1 and AL669918.5. This sequence is a reference standard in the RefSeqGene project. On Aug 24, 2005 this sequence version replaced NM_000544.2. Transcript Variant: This variant (1, B allele) represents the longer transcript and encodes the longest isoform (1). An allele (variant 1, A allele) exists in which a single nt change creates an internal stop codon, leading to a protein that is 17 aa shorter at the C-terminus. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.81912.1, AB208953.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGGCTCC CTGACCTGAG ACCCTGGACC TCCCTGCTGC TGGTGGACGC GGCTTTACTG 
TGGCTGCTTC AGGGCCCTCT GGGGACTTTG CTTCCTCAAG GGCTGCCAGG ACTATGGCTG 
GAGGGGACCC TGCGGCTGGG AGGGCTGTGG GGGCTGCTAA AGCTAAGAGG GCTGCTGGGA 
TTTGTGGGGA CACTGCTGCT CCCGCTCTGT CTGGCCACCC CCCTGACTGT CTCCCTGAGA 
GCCCTGGTCG CGGGGGCCTC ACGTGCTCCC CCAGCCAGAG TCGCTTCAGC CCCTTGGAGC 
TGGCTGCTGG TGGGGTACGG GGCTGCGGGG CTCAGCTGGT CACTGTGGGC TGTTCTGAGC 
CCTCCTGGAG CCCAGGAGAA GGAGCAGGAC CAGGTGAACA ACAAAGTCTT GATGTGGAGG 
CTGCTGAAGC TCTCCAGGCC GGACCTGCCT CTCCTCGTTG CCGCCTTCTT CTTCCTTGTC 
CTTGCTGTTT TGGGTGAGAC ATTAATCCCT CACTATTCTG GTCGTGTGAT TGACATCCTG 
GGAGGTGATT TTGACCCCCA TGCCTTTGCC AGTGCCATCT TCTTCATGTG CCTCTTCTCC 
TTTGGCAGCT CACTGTCTGC AGGCTGCCGA GGAGGCTGCT TCACCTACAC CATGTCTCGA 
ATCAACTTGC GGATCCGGGA GCAGCTTTTC TCCTCCCTGC TGCGCCAGGA CCTCGGTTTC 
TTCCAGGAGA CTAAGACAGG GGAGCTGAAC TCACGGCTGA GCTCGGATAC CACCCTGATG 
AGTAACTGGC TTCCTTTAAA TGCCAATGTG CTCTTGCGAA GCCTGGTGAA AGTGGTGGGG 
CTGTATGGCT TCATGCTCAG CATATCGCCT CGACTCACCC TCCTTTCTCT GCTGCACATG 
CCCTTCACAA TAGCAGCGGA GAAGGTGTAC AACACCCGCC ATCAGGAAGT GCTTCGGGAG 
ATCCAGGATG CAGTGGCCAG GGCGGGGCAG GTGGTGCGGG AAGCCGTTGG AGGGCTGCAG 
ACCGTTCGCA GTTTTGGGGC CGAGGAGCAT GAAGTCTGTC GCTATAAAGA GGCCCTTGAA 
CAATGTCGGC AGCTGTATTG GCGGAGAGAC CTGGAACGCG CCTTGTACCT GCTCGTAAGG 
AGGGTGCTGC ACTTGGGGGT GCAGATGCTG ATGCTGAGCT GTGGGCTGCA GCAGATGCAG 
GATGGGGAGC TCACCCAGGG CAGCCTGCTT TCCTTTATGA TCTACCAGGA GAGCGTGGGG 
AGCTATGTGC AGACCCTGGT ATACATATAT GGGGATATGC TCAGCAACGT GGGAGCTGCA 
GAGAAGGTTT TCTCCTACAT GGACCGACAG CCAAATCTGC CTTCACCTGG CACGCTTGCC 
CCCACCACTC TGCAGGGGGT TGTGAAATTC CAAGACGTCT CCTTTGCATA TCCCAATCGC 
CCTGACAGGC CTGTGCTCAA GGGGCTGACG TTTACCCTAC GTCCTGGTGA GGTGACGGCG 
CTGGTGGGAC CCAATGGGTC TGGGAAGAGC ACAGTGGCTG CCCTGCTGCA GAATCTGTAC 
CAGCCCACAG GGGGACAGGT GCTGCTGGAT GAAAAGCCCA TCTCACAGTA TGAACACTGC 
TACCTGCACA GCCAGGTGGT TTCAGTTGGG CAGGAGCCTG TGCTGTTCTC CGGTTCTGTG 
AGGAACAACA TTGCTTATGG GCTGCAGAGC TGCGAAGATG ATAAGGTGAT GGCGGCTGCC 
CAGGCTGCCC ACGCAGATGA CTTCATCCAG GAAATGGAGC ATGGAATATA CACAGATGTA 
GGGGAGAAGG GAAGCCAGCT GGCTGCGGGA CAGAAACAAC GTCTGGCCAT TGCCCGGGCC 
CTTGTACGAG ACCCGCGGGT CCTCATCCTG GATGAGGCTA CTAGTGCCCT AGATGTGCAG 
TGCGAGCAGG CCCTGCAGGA CTGGAATTCC CGTGGGGATC GCACAGTGCT GGTGATTGCT 
CACAGGCTGC AGGCAGTTCA GCGCGCCCAC CAGATCCTGG TGCTCCAGGA GGGCAAGCTG 
CAGAAGCTTG CCCAGCTCCA GGAGGGACAG GACCTCTATT CCCGCCTGGT TCAGCAGCGG 
CTGATGGACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000535.3
CDS	123..2234
Translation	MRLPDLRPWTSLLLVDAALLWLLQGPLGTLLPQGLPGLWLEGTLRLGGLWGLLKLRGLLGFVGTLLLPLCLATPLTVSLRALVAGASRAPPARVASAPWSWLLVGYGAAGLSWSLWAVLSPPGAQEKEQDQVNNKVLMWRLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYSGRVIDILGGDFDPHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDWNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQKLAQLQEGQDLYSRLVQQRLMD

Target ORF information:

RefSeq Version	NM_000544.3
Organism	Homo sapiens(human)
Definition	Homo sapiens transporter 2, ATP binding cassette subfamily B member (TAP2), transcript variant 1, B allele, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000544.3

ORF Insert Sequence:

ATGCGGCTCC CTGACCTGAG ACCCTGGACC TCCCTGCTGC TGGTGGACGC GGCTTTACTG 
TGGCTGCTTC AGGGCCCTCT GGGGACTTTG CTTCCTCAAG GGCTGCCAGG ACTATGGCTG 
GAGGGGACCC TGCGGCTGGG AGGGCTGTGG GGGCTGCTAA AGCTAAGAGG GCTGCTGGGA 
TTTGTGGGGA CACTGCTGCT CCCGCTCTGT CTGGCCACCC CCCTGACTGT CTCCCTGAGA 
GCCCTGGTCG CGGGGGCCTC ACGTGCTCCC CCAGCCAGAG TCGCTTCAGC CCCTTGGAGC 
TGGCTGCTGG TGGGGTACGG GGCTGCGGGG CTCAGCTGGT CACTGTGGGC TGTTCTGAGC 
CCTCCTGGAG CCCAGGAGAA GGAGCAGGAC CAGGTGAACA ACAAAGTCTT GATGTGGAGG 
CTGCTGAAGC TCTCCAGGCC GGACCTGCCT CTCCTCGTTG CCGCCTTCTT CTTCCTTGTC 
CTTGCTGTTT TGGGTGAGAC ATTAATCCCT CACTATTCTG GTCGTGTGAT TGACATCCTG 
GGAGGTGATT TTGACCCCCA TGCCTTTGCC AGTGCCATCT TCTTCATGTG CCTCTTCTCC 
TTTGGCAGCT CACTGTCTGC AGGCTGCCGA GGAGGCTGCT TCACCTACAC CATGTCTCGA 
ATCAACTTGC GGATCCGGGA GCAGCTTTTC TCCTCCCTGC TGCGCCAGGA CCTCGGTTTC 
TTCCAGGAGA CTAAGACAGG GGAGCTGAAC TCACGGCTGA GCTCGGATAC CACCCTGATG 
AGTAACTGGC TTCCTTTAAA TGCCAATGTG CTCTTGCGAA GCCTGGTGAA AGTGGTGGGG 
CTGTATGGCT TCATGCTCAG CATATCGCCT CGACTCACCC TCCTTTCTCT GCTGCACATG 
CCCTTCACAA TAGCAGCGGA GAAGGTGTAC AACACCCGCC ATCAGGAAGT GCTTCGGGAG 
ATCCAGGATG CAGTGGCCAG GGCGGGGCAG GTGGTGCGGG AAGCCGTTGG AGGGCTGCAG 
ACCGTTCGCA GTTTTGGGGC CGAGGAGCAT GAAGTCTGTC GCTATAAAGA GGCCCTTGAA 
CAATGTCGGC AGCTGTATTG GCGGAGAGAC CTGGAACGCG CCTTGTACCT GCTCGTAAGG 
AGGGTGCTGC ACTTGGGGGT GCAGATGCTG ATGCTGAGCT GTGGGCTGCA GCAGATGCAG 
GATGGGGAGC TCACCCAGGG CAGCCTGCTT TCCTTTATGA TCTACCAGGA GAGCGTGGGG 
AGCTATGTGC AGACCCTGGT ATACATATAT GGGGATATGC TCAGCAACGT GGGAGCTGCA 
GAGAAGGTTT TCTCCTACAT GGACCGACAG CCAAATCTGC CTTCACCTGG CACGCTTGCC 
CCCACCACTC TGCAGGGGGT TGTGAAATTC CAAGACGTCT CCTTTGCATA TCCCAATCGC 
CCTGACAGGC CTGTGCTCAA GGGGCTGACG TTTACCCTAC GTCCTGGTGA GGTGACGGCG 
CTGGTGGGAC CCAATGGGTC TGGGAAGAGC ACAGTGGCTG CCCTGCTGCA GAATCTGTAC 
CAGCCCACAG GGGGACAGGT GCTGCTGGAT GAAAAGCCCA TCTCACAGTA TGAACACTGC 
TACCTGCACA GCCAGGTGGT TTCAGTTGGG CAGGAGCCTG TGCTGTTCTC CGGTTCTGTG 
AGGAACAACA TTGCTTATGG GCTGCAGAGC TGCGAAGATG ATAAGGTGAT GGCGGCTGCC 
CAGGCTGCCC ACGCAGATGA CTTCATCCAG GAAATGGAGC ATGGAATATA CACAGATGTA 
GGGGAGAAGG GAAGCCAGCT GGCTGCGGGA CAGAAACAAC GTCTGGCCAT TGCCCGGGCC 
CTTGTACGAG ACCCGCGGGT CCTCATCCTG GATGAGGCTA CTAGTGCCCT AGATGTGCAG 
TGCGAGCAGG CCCTGCAGGA CTGGAATTCC CGTGGGGATC GCACAGTGCT GGTGATTGCT 
CACAGGCTGC AGGCAGTTCA GCGCGCCCAC CAGATCCTGG TGCTCCAGGA GGGCAAGCTG 
CAGAAGCTTG CCCAGCTCCA GGAGGGACAG GACCTCTATT CCCGCCTGGT TCAGCAGCGG 
CTGATGGACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TAP2 ( NM_018833.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_061313.2 Homo sapiens transporter 2, ATP binding cassette subfamily B member (TAP2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu19417
Clone ID Related Accession (Same CDS sequence)	NM_018833.2
Accession Version	NM_018833.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1962bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	antigen peptide transporter 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG423357.1, BC002751.2 and AF105151.1. This sequence is a reference standard in the RefSeqGene project. On Aug 24, 2005 this sequence version replaced NM_018833.1. Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF105151.1, AF078671.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGGCTCC CTGACCTGAG ACCCTGGACC TCCCTGCTGC TGGTGGACGC GGCTTTACTG 
TGGCTGCTTC AGGGCCCTCT GGGGACTTTG CTTCCTCAAG GGCTGCCAGG ACTATGGCTG 
GAGGGGACCC TGCGGCTGGG AGGGCTGTGG GGGCTGCTAA AGCTAAGAGG GCTGCTGGGA 
TTTGTGGGGA CACTGCTGCT CCCGCTCTGT CTGGCCACCC CCCTGACTGT CTCCCTGAGA 
GCCCTGGTCG CGGGGGCCTC ACGTGCTCCC CCAGCCAGAG TCGCTTCAGC CCCTTGGAGC 
TGGCTGCTGG TGGGGTACGG GGCTGCGGGG CTCAGCTGGT CACTGTGGGC TGTTCTGAGC 
CCTCCTGGAG CCCAGGAGAA GGAGCAGGAC CAGGTGAACA ACAAAGTCTT GATGTGGAGG 
CTGCTGAAGC TCTCCAGGCC GGACCTGCCT CTCCTCGTTG CCGCCTTCTT CTTCCTTGTC 
CTTGCTGTTT TGGGTGAGAC ATTAATCCCT CACTATTCTG GTCGTGTGAT TGACATCCTG 
GGAGGTGATT TTGACCCCCA TGCCTTTGCC AGTGCCATCT TCTTCATGTG CCTCTTCTCC 
TTTGGCAGCT CACTGTCTGC AGGCTGCCGA GGAGGCTGCT TCACCTACAC CATGTCTCGA 
ATCAACTTGC GGATCCGGGA GCAGCTTTTC TCCTCCCTGC TGCGCCAGGA CCTCGGTTTC 
TTCCAGGAGA CTAAGACAGG GGAGCTGAAC TCACGGCTGA GCTCGGATAC CACCCTGATG 
AGTAACTGGC TTCCTTTAAA TGCCAATGTG CTCTTGCGAA GCCTGGTGAA AGTGGTGGGG 
CTGTATGGCT TCATGCTCAG CATATCGCCT CGACTCACCC TCCTTTCTCT GCTGCACATG 
CCCTTCACAA TAGCAGCGGA GAAGGTGTAC AACACCCGCC ATCAGGAAGT GCTTCGGGAG 
ATCCAGGATG CAGTGGCCAG GGCGGGGCAG GTGGTGCGGG AAGCCGTTGG AGGGCTGCAG 
ACCGTTCGCA GTTTTGGGGC CGAGGAGCAT GAAGTCTGTC GCTATAAAGA GGCCCTTGAA 
CAATGTCGGC AGCTGTATTG GCGGAGAGAC CTGGAACGCG CCTTGTACCT GCTCGTAAGG 
AGGGTGCTGC ACTTGGGGGT GCAGATGCTG ATGCTGAGCT GTGGGCTGCA GCAGATGCAG 
GATGGGGAGC TCACCCAGGG CAGCCTGCTT TCCTTTATGA TCTACCAGGA GAGCGTGGGG 
AGCTATGTGC AGACCCTGGT ATACATATAT GGGGATATGC TCAGCAACGT GGGAGCTGCA 
GAGAAGGTTT TCTCCTACAT GGACCGACAG CCAAATCTGC CTTCACCTGG CACGCTTGCC 
CCCACCACTC TGCAGGGGGT TGTGAAATTC CAAGACGTCT CCTTTGCATA TCCCAATCGC 
CCTGACAGGC CTGTGCTCAA GGGGCTGACG TTTACCCTAC GTCCTGGTGA GGTGACGGCG 
CTGGTGGGAC CCAATGGGTC TGGGAAGAGC ACAGTGGCTG CCCTGCTGCA GAATCTGTAC 
CAGCCCACAG GGGGACAGGT GCTGCTGGAT GAAAAGCCCA TCTCACAGTA TGAACACTGC 
TACCTGCACA GCCAGGTGGT TTCAGTTGGG CAGGAGCCTG TGCTGTTCTC CGGTTCTGTG 
AGGAACAACA TTGCTTATGG GCTGCAGAGC TGCGAAGATG ATAAGGTGAT GGCGGCTGCC 
CAGGCTGCCC ACGCAGATGA CTTCATCCAG GAAATGGAGC ATGGAATATA CACAGATGTA 
GGGGAGAAGG GAAGCCAGCT GGCTGCGGGA CAGAAACAAC GTCTGGCCAT TGCCCGGGCC 
CTTGTACGAG ACCCGCGGGT CCTCATCCTG GATGAGGCTA CTAGTGCCCT AGATGTGCAG 
TGCGAGCAGG CCAAAACCCT TTGGAAGTTC ATGATATTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061313.2
CDS	123..2084
Translation	MRLPDLRPWTSLLLVDAALLWLLQGPLGTLLPQGLPGLWLEGTLRLGGLWGLLKLRGLLGFVGTLLLPLCLATPLTVSLRALVAGASRAPPARVASAPWSWLLVGYGAAGLSWSLWAVLSPPGAQEKEQDQVNNKVLMWRLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYSGRVIDILGGDFDPHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQAKTLWKFMIF

Target ORF information:

RefSeq Version	NM_018833.2
Organism	Homo sapiens(human)
Definition	Homo sapiens transporter 2, ATP binding cassette subfamily B member (TAP2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018833.2

ORF Insert Sequence:

ATGCGGCTCC CTGACCTGAG ACCCTGGACC TCCCTGCTGC TGGTGGACGC GGCTTTACTG 
TGGCTGCTTC AGGGCCCTCT GGGGACTTTG CTTCCTCAAG GGCTGCCAGG ACTATGGCTG 
GAGGGGACCC TGCGGCTGGG AGGGCTGTGG GGGCTGCTAA AGCTAAGAGG GCTGCTGGGA 
TTTGTGGGGA CACTGCTGCT CCCGCTCTGT CTGGCCACCC CCCTGACTGT CTCCCTGAGA 
GCCCTGGTCG CGGGGGCCTC ACGTGCTCCC CCAGCCAGAG TCGCTTCAGC CCCTTGGAGC 
TGGCTGCTGG TGGGGTACGG GGCTGCGGGG CTCAGCTGGT CACTGTGGGC TGTTCTGAGC 
CCTCCTGGAG CCCAGGAGAA GGAGCAGGAC CAGGTGAACA ACAAAGTCTT GATGTGGAGG 
CTGCTGAAGC TCTCCAGGCC GGACCTGCCT CTCCTCGTTG CCGCCTTCTT CTTCCTTGTC 
CTTGCTGTTT TGGGTGAGAC ATTAATCCCT CACTATTCTG GTCGTGTGAT TGACATCCTG 
GGAGGTGATT TTGACCCCCA TGCCTTTGCC AGTGCCATCT TCTTCATGTG CCTCTTCTCC 
TTTGGCAGCT CACTGTCTGC AGGCTGCCGA GGAGGCTGCT TCACCTACAC CATGTCTCGA 
ATCAACTTGC GGATCCGGGA GCAGCTTTTC TCCTCCCTGC TGCGCCAGGA CCTCGGTTTC 
TTCCAGGAGA CTAAGACAGG GGAGCTGAAC TCACGGCTGA GCTCGGATAC CACCCTGATG 
AGTAACTGGC TTCCTTTAAA TGCCAATGTG CTCTTGCGAA GCCTGGTGAA AGTGGTGGGG 
CTGTATGGCT TCATGCTCAG CATATCGCCT CGACTCACCC TCCTTTCTCT GCTGCACATG 
CCCTTCACAA TAGCAGCGGA GAAGGTGTAC AACACCCGCC ATCAGGAAGT GCTTCGGGAG 
ATCCAGGATG CAGTGGCCAG GGCGGGGCAG GTGGTGCGGG AAGCCGTTGG AGGGCTGCAG 
ACCGTTCGCA GTTTTGGGGC CGAGGAGCAT GAAGTCTGTC GCTATAAAGA GGCCCTTGAA 
CAATGTCGGC AGCTGTATTG GCGGAGAGAC CTGGAACGCG CCTTGTACCT GCTCGTAAGG 
AGGGTGCTGC ACTTGGGGGT GCAGATGCTG ATGCTGAGCT GTGGGCTGCA GCAGATGCAG 
GATGGGGAGC TCACCCAGGG CAGCCTGCTT TCCTTTATGA TCTACCAGGA GAGCGTGGGG 
AGCTATGTGC AGACCCTGGT ATACATATAT GGGGATATGC TCAGCAACGT GGGAGCTGCA 
GAGAAGGTTT TCTCCTACAT GGACCGACAG CCAAATCTGC CTTCACCTGG CACGCTTGCC 
CCCACCACTC TGCAGGGGGT TGTGAAATTC CAAGACGTCT CCTTTGCATA TCCCAATCGC 
CCTGACAGGC CTGTGCTCAA GGGGCTGACG TTTACCCTAC GTCCTGGTGA GGTGACGGCG 
CTGGTGGGAC CCAATGGGTC TGGGAAGAGC ACAGTGGCTG CCCTGCTGCA GAATCTGTAC 
CAGCCCACAG GGGGACAGGT GCTGCTGGAT GAAAAGCCCA TCTCACAGTA TGAACACTGC 
TACCTGCACA GCCAGGTGGT TTCAGTTGGG CAGGAGCCTG TGCTGTTCTC CGGTTCTGTG 
AGGAACAACA TTGCTTATGG GCTGCAGAGC TGCGAAGATG ATAAGGTGAT GGCGGCTGCC 
CAGGCTGCCC ACGCAGATGA CTTCATCCAG GAAATGGAGC ATGGAATATA CACAGATGTA 
GGGGAGAAGG GAAGCCAGCT GGCTGCGGGA CAGAAACAAC GTCTGGCCAT TGCCCGGGCC 
CTTGTACGAG ACCCGCGGGT CCTCATCCTG GATGAGGCTA CTAGTGCCCT AGATGTGCAG 
TGCGAGCAGG CCAAAACCCT TTGGAAGTTC ATGATATTTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TAP2 ( NM_001290043.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001276972.1 Homo sapiens transporter 2, ATP binding cassette subfamily B member (TAP2), transcript variant 1, A allele, mRNA.

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CloneID	OHu22215
Clone ID Related Accession (Same CDS sequence)	NM_001290043.2 , NM_001290043.1
Accession Version	NM_001290043.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2061bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	antigen peptide transporter 2 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC345324.1, AK292963.1 and AL669918.5. On Nov 30, 2019 this sequence version replaced NM_001290043.1. Transcript Variant: This variant (1, A allele) differs at 3 nt positions compared to variant 1, B allele. The resulting isoform (3) is shorter at the C-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M84748.1, Z22936.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCGGCTCC CTGACCTGAG ACCCTGGACC TCCCTGCTGC TGGTGGACGC GGCTTTACTG 
TGGCTGCTTC AGGGCCCTCT GGGGACTTTG CTTCCTCAAG GGCTGCCAGG ACTATGGCTG 
GAGGGGACCC TGCGGCTGGG AGGGCTGTGG GGGCTGCTAA AGCTAAGAGG GCTGCTGGGA 
TTTGTGGGGA CACTGCTGCT CCCGCTCTGT CTGGCCACCC CCCTGACTGT CTCCCTGAGA 
GCCCTGGTCG CGGGGGCCTC ACGTGCTCCC CCAGCCAGAG TCGCTTCAGC CCCTTGGAGC 
TGGCTGCTGG TGGGGTACGG GGCTGCGGGG CTCAGCTGGT CACTGTGGGC TGTTCTGAGC 
CCTCCTGGAG CCCAGGAGAA GGAGCAGGAC CAGGTGAACA ACAAAGTCTT GATGTGGAGG 
CTGCTGAAGC TCTCCAGGCC GGACCTGCCT CTCCTCGTTG CCGCCTTCTT CTTCCTTGTC 
CTTGCTGTTT TGGGTGAGAC ATTAATCCCT CACTATTCTG GTCGTGTGAT TGACATCCTG 
GGAGGTGATT TTGACCCCCA TGCCTTTGCC AGTGCCATCT TCTTCATGTG CCTCTTCTCC 
TTTGGCAGCT CACTGTCTGC AGGCTGCCGA GGAGGCTGCT TCACCTACAC CATGTCTCGA 
ATCAACTTGC GGATCCGGGA GCAGCTTTTC TCCTCCCTGC TGCGCCAGGA CCTCGGTTTC 
TTCCAGGAGA CTAAGACAGG GGAGCTGAAC TCACGGCTGA GCTCGGATAC CACCCTGATG 
AGTAACTGGC TTCCTTTAAA TGCCAATGTG CTCTTGCGAA GCCTGGTGAA AGTGGTGGGG 
CTGTATGGCT TCATGCTCAG CATATCGCCT CGACTCACCC TCCTTTCTCT GCTGCACATG 
CCCTTCACAA TAGCAGCGGA GAAGGTGTAC AACACCCGCC ATCAGGAAGT GCTTCGGGAG 
ATCCAGGATG CAGTGGCCAG GGCGGGGCAG GTGGTGCGGG AAGCCGTTGG AGGGCTGCAG 
ACCGTTCGCA GTTTTGGGGC CGAGGAGCAT GAAGTCTGTC GCTATAAAGA GGCCCTTGAA 
CAATGTCGGC AGCTGTATTG GCGGAGAGAC CTGGAACGCG CCTTGTACCT GCTCGTAAGG 
AGGGTGCTGC ACTTGGGGGT GCAGATGCTG ATGCTGAGCT GTGGGCTGCA GCAGATGCAG 
GATGGGGAGC TCACCCAGGG CAGCCTGCTT TCCTTTATGA TCTACCAGGA GAGCGTGGGG 
AGCTATGTGC AGACCCTGGT ATACATATAT GGGGATATGC TCAGCAACGT GGGAGCTGCA 
GAGAAGGTTT TCTCCTACAT GGACCGACAG CCAAATCTGC CTTCACCTGG CACGCTTGCC 
CCCACCACTC TGCAGGGGGT TGTGAAATTC CAAGACGTCT CCTTTGCATA TCCCAATCGC 
CCTGACAGGC CTGTGCTCAA GGGGCTGACG TTTACCCTAC GTCCTGGTGA GGTGACGGCG 
CTGGTGGGAC CCAATGGGTC TGGGAAGAGC ACAGTGGCTG CCCTGCTGCA GAATCTGTAC 
CAGCCCACAG GGGGACAGGT GCTGCTGGAT GAAAAGCCCA TCTCACAGTA TGAACACTGC 
TACCTGCACA GCCAGGTGGT TTCAGTTGGG CAGGAGCCTG TGCTGTTCTC CGGTTCTGTG 
AGGAACAACA TTGCTTATGG GCTGCAGAGC TGCGAAGATG ATAAGGTGAT GGCGGCTGCC 
CAGGCTGCCC ACGCAGATGA CTTCATCCAG GAAATGGAGC ATGGAATATA CACAGATGTA 
GGGGAGAAGG GAAGCCAGCT GGCTGCGGGA CAGAAACAAC GTCTGGCCAT TGCCCGGGCC 
CTTGTACGAG ACCCGCGGGT CCTCATCCTG GATGAGGCTA CTAGTGCCCT AGATGTGCAG 
TGCGAGCAGG CCCTGCAGGA CTGGAATTCC CGTGGGGATC GCACAGTGCT GGTGATTGCT 
CACAGGCTGC AGACAGTTCA GCGCGCCCAC CAGATCCTGG TGCTCCAGGA GGGCAAGCTG 
CAGAAGCTTG CCCAGCTCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001276972.1
CDS	92..2152
Translation	MRLPDLRPWTSLLLVDAALLWLLQGPLGTLLPQGLPGLWLEGTLRLGGLWGLLKLRGLLGFVGTLLLPLCLATPLTVSLRALVAGASRAPPARVASAPWSWLLVGYGAAGLSWSLWAVLSPPGAQEKEQDQVNNKVLMWRLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYSGRVIDILGGDFDPHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDWNSRGDRTVLVIAHRLQTVQRAHQILVLQEGKLQKLAQL

Target ORF information:

RefSeq Version	NM_001290043.2
Organism	Homo sapiens(human)
Definition	Homo sapiens transporter 2, ATP binding cassette subfamily B member (TAP2), transcript variant 1, A allele, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001290043.2

ORF Insert Sequence:

ATGCGGCTCC CTGACCTGAG ACCCTGGACC TCCCTGCTGC TGGTGGACGC GGCTTTACTG 
TGGCTGCTTC AGGGCCCTCT GGGGACTTTG CTTCCTCAAG GGCTGCCAGG ACTATGGCTG 
GAGGGGACCC TGCGGCTGGG AGGGCTGTGG GGGCTGCTAA AGCTAAGAGG GCTGCTGGGA 
TTTGTGGGGA CACTGCTGCT CCCGCTCTGT CTGGCCACCC CCCTGACTGT CTCCCTGAGA 
GCCCTGGTCG CGGGGGCCTC ACGTGCTCCC CCAGCCAGAG TCGCTTCAGC CCCTTGGAGC 
TGGCTGCTGG TGGGGTACGG GGCTGCGGGG CTCAGCTGGT CACTGTGGGC TGTTCTGAGC 
CCTCCTGGAG CCCAGGAGAA GGAGCAGGAC CAGGTGAACA ACAAAGTCTT GATGTGGAGG 
CTGCTGAAGC TCTCCAGGCC GGACCTGCCT CTCCTCGTTG CCGCCTTCTT CTTCCTTGTC 
CTTGCTGTTT TGGGTGAGAC ATTAATCCCT CACTATTCTG GTCGTGTGAT TGACATCCTG 
GGAGGTGATT TTGACCCCCA TGCCTTTGCC AGTGCCATCT TCTTCATGTG CCTCTTCTCC 
TTTGGCAGCT CACTGTCTGC AGGCTGCCGA GGAGGCTGCT TCACCTACAC CATGTCTCGA 
ATCAACTTGC GGATCCGGGA GCAGCTTTTC TCCTCCCTGC TGCGCCAGGA CCTCGGTTTC 
TTCCAGGAGA CTAAGACAGG GGAGCTGAAC TCACGGCTGA GCTCGGATAC CACCCTGATG 
AGTAACTGGC TTCCTTTAAA TGCCAATGTG CTCTTGCGAA GCCTGGTGAA AGTGGTGGGG 
CTGTATGGCT TCATGCTCAG CATATCGCCT CGACTCACCC TCCTTTCTCT GCTGCACATG 
CCCTTCACAA TAGCAGCGGA GAAGGTGTAC AACACCCGCC ATCAGGAAGT GCTTCGGGAG 
ATCCAGGATG CAGTGGCCAG GGCGGGGCAG GTGGTGCGGG AAGCCGTTGG AGGGCTGCAG 
ACCGTTCGCA GTTTTGGGGC CGAGGAGCAT GAAGTCTGTC GCTATAAAGA GGCCCTTGAA 
CAATGTCGGC AGCTGTATTG GCGGAGAGAC CTGGAACGCG CCTTGTACCT GCTCGTAAGG 
AGGGTGCTGC ACTTGGGGGT GCAGATGCTG ATGCTGAGCT GTGGGCTGCA GCAGATGCAG 
GATGGGGAGC TCACCCAGGG CAGCCTGCTT TCCTTTATGA TCTACCAGGA GAGCGTGGGG 
AGCTATGTGC AGACCCTGGT ATACATATAT GGGGATATGC TCAGCAACGT GGGAGCTGCA 
GAGAAGGTTT TCTCCTACAT GGACCGACAG CCAAATCTGC CTTCACCTGG CACGCTTGCC 
CCCACCACTC TGCAGGGGGT TGTGAAATTC CAAGACGTCT CCTTTGCATA TCCCAATCGC 
CCTGACAGGC CTGTGCTCAA GGGGCTGACG TTTACCCTAC GTCCTGGTGA GGTGACGGCG 
CTGGTGGGAC CCAATGGGTC TGGGAAGAGC ACAGTGGCTG CCCTGCTGCA GAATCTGTAC 
CAGCCCACAG GGGGACAGGT GCTGCTGGAT GAAAAGCCCA TCTCACAGTA TGAACACTGC 
TACCTGCACA GCCAGGTGGT TTCAGTTGGG CAGGAGCCTG TGCTGTTCTC CGGTTCTGTG 
AGGAACAACA TTGCTTATGG GCTGCAGAGC TGCGAAGATG ATAAGGTGAT GGCGGCTGCC 
CAGGCTGCCC ACGCAGATGA CTTCATCCAG GAAATGGAGC ATGGAATATA CACAGATGTA 
GGGGAGAAGG GAAGCCAGCT GGCTGCGGGA CAGAAACAAC GTCTGGCCAT TGCCCGGGCC 
CTTGTACGAG ACCCGCGGGT CCTCATCCTG GATGAGGCTA CTAGTGCCCT AGATGTGCAG 
TGCGAGCAGG CCCTGCAGGA CTGGAATTCC CGTGGGGATC GCACAGTGCT GGTGATTGCT 
CACAGGCTGC AGACAGTTCA GCGCGCCCAC CAGATCCTGG TGCTCCAGGA GGGCAAGCTG 
CAGAAGCTTG CCCAGCTCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TAP2 ( NM_001290043.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001276972.1 Homo sapiens transporter 2, ATP binding cassette subfamily B member (TAP2), transcript variant 1, A allele, mRNA.

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CloneID	OHu22215
Clone ID Related Accession (Same CDS sequence)	NM_001290043.2 , NM_001290043.1
Accession Version	NM_001290043.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2061bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-03
Organism	Homo sapiens(human)
Product	antigen peptide transporter 2 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC345324.1, AK292963.1 and AL669918.5. Transcript Variant: This variant (1, A allele) differs at 3 nt positions compared to variant 1, B allele. The resulting isoform (3) is shorter at the C-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.81912.1, AB208953.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCGGCTCC CTGACCTGAG ACCCTGGACC TCCCTGCTGC TGGTGGACGC GGCTTTACTG 
TGGCTGCTTC AGGGCCCTCT GGGGACTTTG CTTCCTCAAG GGCTGCCAGG ACTATGGCTG 
GAGGGGACCC TGCGGCTGGG AGGGCTGTGG GGGCTGCTAA AGCTAAGAGG GCTGCTGGGA 
TTTGTGGGGA CACTGCTGCT CCCGCTCTGT CTGGCCACCC CCCTGACTGT CTCCCTGAGA 
GCCCTGGTCG CGGGGGCCTC ACGTGCTCCC CCAGCCAGAG TCGCTTCAGC CCCTTGGAGC 
TGGCTGCTGG TGGGGTACGG GGCTGCGGGG CTCAGCTGGT CACTGTGGGC TGTTCTGAGC 
CCTCCTGGAG CCCAGGAGAA GGAGCAGGAC CAGGTGAACA ACAAAGTCTT GATGTGGAGG 
CTGCTGAAGC TCTCCAGGCC GGACCTGCCT CTCCTCGTTG CCGCCTTCTT CTTCCTTGTC 
CTTGCTGTTT TGGGTGAGAC ATTAATCCCT CACTATTCTG GTCGTGTGAT TGACATCCTG 
GGAGGTGATT TTGACCCCCA TGCCTTTGCC AGTGCCATCT TCTTCATGTG CCTCTTCTCC 
TTTGGCAGCT CACTGTCTGC AGGCTGCCGA GGAGGCTGCT TCACCTACAC CATGTCTCGA 
ATCAACTTGC GGATCCGGGA GCAGCTTTTC TCCTCCCTGC TGCGCCAGGA CCTCGGTTTC 
TTCCAGGAGA CTAAGACAGG GGAGCTGAAC TCACGGCTGA GCTCGGATAC CACCCTGATG 
AGTAACTGGC TTCCTTTAAA TGCCAATGTG CTCTTGCGAA GCCTGGTGAA AGTGGTGGGG 
CTGTATGGCT TCATGCTCAG CATATCGCCT CGACTCACCC TCCTTTCTCT GCTGCACATG 
CCCTTCACAA TAGCAGCGGA GAAGGTGTAC AACACCCGCC ATCAGGAAGT GCTTCGGGAG 
ATCCAGGATG CAGTGGCCAG GGCGGGGCAG GTGGTGCGGG AAGCCGTTGG AGGGCTGCAG 
ACCGTTCGCA GTTTTGGGGC CGAGGAGCAT GAAGTCTGTC GCTATAAAGA GGCCCTTGAA 
CAATGTCGGC AGCTGTATTG GCGGAGAGAC CTGGAACGCG CCTTGTACCT GCTCGTAAGG 
AGGGTGCTGC ACTTGGGGGT GCAGATGCTG ATGCTGAGCT GTGGGCTGCA GCAGATGCAG 
GATGGGGAGC TCACCCAGGG CAGCCTGCTT TCCTTTATGA TCTACCAGGA GAGCGTGGGG 
AGCTATGTGC AGACCCTGGT ATACATATAT GGGGATATGC TCAGCAACGT GGGAGCTGCA 
GAGAAGGTTT TCTCCTACAT GGACCGACAG CCAAATCTGC CTTCACCTGG CACGCTTGCC 
CCCACCACTC TGCAGGGGGT TGTGAAATTC CAAGACGTCT CCTTTGCATA TCCCAATCGC 
CCTGACAGGC CTGTGCTCAA GGGGCTGACG TTTACCCTAC GTCCTGGTGA GGTGACGGCG 
CTGGTGGGAC CCAATGGGTC TGGGAAGAGC ACAGTGGCTG CCCTGCTGCA GAATCTGTAC 
CAGCCCACAG GGGGACAGGT GCTGCTGGAT GAAAAGCCCA TCTCACAGTA TGAACACTGC 
TACCTGCACA GCCAGGTGGT TTCAGTTGGG CAGGAGCCTG TGCTGTTCTC CGGTTCTGTG 
AGGAACAACA TTGCTTATGG GCTGCAGAGC TGCGAAGATG ATAAGGTGAT GGCGGCTGCC 
CAGGCTGCCC ACGCAGATGA CTTCATCCAG GAAATGGAGC ATGGAATATA CACAGATGTA 
GGGGAGAAGG GAAGCCAGCT GGCTGCGGGA CAGAAACAAC GTCTGGCCAT TGCCCGGGCC 
CTTGTACGAG ACCCGCGGGT CCTCATCCTG GATGAGGCTA CTAGTGCCCT AGATGTGCAG 
TGCGAGCAGG CCCTGCAGGA CTGGAATTCC CGTGGGGATC GCACAGTGCT GGTGATTGCT 
CACAGGCTGC AGACAGTTCA GCGCGCCCAC CAGATCCTGG TGCTCCAGGA GGGCAAGCTG 
CAGAAGCTTG CCCAGCTCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001276972.1
CDS	176..2236
Translation	MRLPDLRPWTSLLLVDAALLWLLQGPLGTLLPQGLPGLWLEGTLRLGGLWGLLKLRGLLGFVGTLLLPLCLATPLTVSLRALVAGASRAPPARVASAPWSWLLVGYGAAGLSWSLWAVLSPPGAQEKEQDQVNNKVLMWRLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYSGRVIDILGGDFDPHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDWNSRGDRTVLVIAHRLQTVQRAHQILVLQEGKLQKLAQL

Target ORF information:

RefSeq Version	NM_001290043.1
Organism	Homo sapiens(human)
Definition	Homo sapiens transporter 2, ATP binding cassette subfamily B member (TAP2), transcript variant 1, A allele, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001290043.1

ORF Insert Sequence:

ATGCGGCTCC CTGACCTGAG ACCCTGGACC TCCCTGCTGC TGGTGGACGC GGCTTTACTG 
TGGCTGCTTC AGGGCCCTCT GGGGACTTTG CTTCCTCAAG GGCTGCCAGG ACTATGGCTG 
GAGGGGACCC TGCGGCTGGG AGGGCTGTGG GGGCTGCTAA AGCTAAGAGG GCTGCTGGGA 
TTTGTGGGGA CACTGCTGCT CCCGCTCTGT CTGGCCACCC CCCTGACTGT CTCCCTGAGA 
GCCCTGGTCG CGGGGGCCTC ACGTGCTCCC CCAGCCAGAG TCGCTTCAGC CCCTTGGAGC 
TGGCTGCTGG TGGGGTACGG GGCTGCGGGG CTCAGCTGGT CACTGTGGGC TGTTCTGAGC 
CCTCCTGGAG CCCAGGAGAA GGAGCAGGAC CAGGTGAACA ACAAAGTCTT GATGTGGAGG 
CTGCTGAAGC TCTCCAGGCC GGACCTGCCT CTCCTCGTTG CCGCCTTCTT CTTCCTTGTC 
CTTGCTGTTT TGGGTGAGAC ATTAATCCCT CACTATTCTG GTCGTGTGAT TGACATCCTG 
GGAGGTGATT TTGACCCCCA TGCCTTTGCC AGTGCCATCT TCTTCATGTG CCTCTTCTCC 
TTTGGCAGCT CACTGTCTGC AGGCTGCCGA GGAGGCTGCT TCACCTACAC CATGTCTCGA 
ATCAACTTGC GGATCCGGGA GCAGCTTTTC TCCTCCCTGC TGCGCCAGGA CCTCGGTTTC 
TTCCAGGAGA CTAAGACAGG GGAGCTGAAC TCACGGCTGA GCTCGGATAC CACCCTGATG 
AGTAACTGGC TTCCTTTAAA TGCCAATGTG CTCTTGCGAA GCCTGGTGAA AGTGGTGGGG 
CTGTATGGCT TCATGCTCAG CATATCGCCT CGACTCACCC TCCTTTCTCT GCTGCACATG 
CCCTTCACAA TAGCAGCGGA GAAGGTGTAC AACACCCGCC ATCAGGAAGT GCTTCGGGAG 
ATCCAGGATG CAGTGGCCAG GGCGGGGCAG GTGGTGCGGG AAGCCGTTGG AGGGCTGCAG 
ACCGTTCGCA GTTTTGGGGC CGAGGAGCAT GAAGTCTGTC GCTATAAAGA GGCCCTTGAA 
CAATGTCGGC AGCTGTATTG GCGGAGAGAC CTGGAACGCG CCTTGTACCT GCTCGTAAGG 
AGGGTGCTGC ACTTGGGGGT GCAGATGCTG ATGCTGAGCT GTGGGCTGCA GCAGATGCAG 
GATGGGGAGC TCACCCAGGG CAGCCTGCTT TCCTTTATGA TCTACCAGGA GAGCGTGGGG 
AGCTATGTGC AGACCCTGGT ATACATATAT GGGGATATGC TCAGCAACGT GGGAGCTGCA 
GAGAAGGTTT TCTCCTACAT GGACCGACAG CCAAATCTGC CTTCACCTGG CACGCTTGCC 
CCCACCACTC TGCAGGGGGT TGTGAAATTC CAAGACGTCT CCTTTGCATA TCCCAATCGC 
CCTGACAGGC CTGTGCTCAA GGGGCTGACG TTTACCCTAC GTCCTGGTGA GGTGACGGCG 
CTGGTGGGAC CCAATGGGTC TGGGAAGAGC ACAGTGGCTG CCCTGCTGCA GAATCTGTAC 
CAGCCCACAG GGGGACAGGT GCTGCTGGAT GAAAAGCCCA TCTCACAGTA TGAACACTGC 
TACCTGCACA GCCAGGTGGT TTCAGTTGGG CAGGAGCCTG TGCTGTTCTC CGGTTCTGTG 
AGGAACAACA TTGCTTATGG GCTGCAGAGC TGCGAAGATG ATAAGGTGAT GGCGGCTGCC 
CAGGCTGCCC ACGCAGATGA CTTCATCCAG GAAATGGAGC ATGGAATATA CACAGATGTA 
GGGGAGAAGG GAAGCCAGCT GGCTGCGGGA CAGAAACAAC GTCTGGCCAT TGCCCGGGCC 
CTTGTACGAG ACCCGCGGGT CCTCATCCTG GATGAGGCTA CTAGTGCCCT AGATGTGCAG 
TGCGAGCAGG CCCTGCAGGA CTGGAATTCC CGTGGGGATC GCACAGTGCT GGTGATTGCT 
CACAGGCTGC AGACAGTTCA GCGCGCCCAC CAGATCCTGG TGCTCCAGGA GGGCAAGCTG 
CAGAAGCTTG CCCAGCTCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The association of LMP7 and TAP2 gene polymorphisms with treatment response to interferon/ribavirin in patients with genotype 1 chronic hepatitis C.
International journal of molecular medicine40(6)1983-1990(2017 Dec)
Zang F,Yao Y,Liu M,Fan H,Yue M,Chen M,Wang J,Yu R,Huang P

A functional SNP in the 3'-UTR of TAP2 gene interacts with microRNA hsa-miR-1270 to suppress the gene expression.
Environmental and molecular mutagenesis(2017 Dec)
Knox B,Wang Y,Rogers LJ,Xuan J,Yu D,Guan H,Chen J,Shi T,Ning B,Kadlubar SA

Downregulation of TAP1 and TAP2 in early stage breast cancer.
PloS one12(11)e0187323(2017)
Henle AM,Nassar A,Puglisi-Knutson D,Youssef B,Knutson KL

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TAP2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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