C3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	C3
Entrez Gene ID	24232
Full Name	complement C3
General protein information	Preferred Names complement C3 Names complement C3 complement component 3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q12
Summary	putative complement component C3; likely involved in innate immune response [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_016994.2	NP_058690.2	complement C3 precursor

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	c3c	XP_005168460.1
Danio rerio (zebrafish)	LOC100331492	XP_002660624.3
Danio rerio (zebrafish)	c3a	NP_571317.1
Xenopus tropicalis (tropical clawed frog)	c3	XP_004919147.1
Xenopus tropicalis (tropical clawed frog)	LOC100492293	XP_002940095.2
Xenopus tropicalis (tropical clawed frog)	LOC100497914	XP_002941061.2
Canis lupus familiaris (dog)	C3	XP_005633285.1
Bos taurus (cattle)	C3	NP_001035559.2
Mus musculus (house mouse)	C3	NP_033908.2
Rattus norvegicus (Norway rat)	C3	NP_058690.2
Xenopus tropicalis (tropical clawed frog)	LOC100492966	XP_002940099.2
Homo sapiens (human)	C3	NP_000055.2
Gallus gallus (chicken)	C3	NP_990736.1
Danio rerio (zebrafish)	LOC100331428	XP_002660623.3
Xenopus tropicalis (tropical clawed frog)	LOC100491968	XP_004919148.1
Pan troglodytes (chimpanzee)	C3	XP_512318.4
	C3	XP_001091921.2
Danio rerio (zebrafish)	zgc:103710	NP_001008582.3
Danio rerio (zebrafish)	c3b	NP_571318.1
Xenopus tropicalis (tropical clawed frog)	LOC100492134	XP_002940094.2
Xenopus tropicalis (tropical clawed frog)	LOC100497762	XP_004919229.1

Gene Ontology
Bibliography

Related articles in PubMed

Inhibition of complement C3 might rescue vascular hyporeactivity in a conscious hemorrhagic shock rat model.
Chen D, Song MQ, Liu YJ, Xue YK, Cheng P, Zheng H, Chen LB
Microvascular research10523-9(2016 May)

Endogenous C1-inhibitor production and expression in the heart after acute myocardial infarction.
Emmens RW, Baylan U, Juffermans LJ, Karia RV, Ylstra B, Wouters D, Zeerleder S, Simsek S, van Ham M, Niessen HW, Krijnen PA
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology25(1)33-9(2016 Jan-Feb)

Protective effects of Ephedra sinica extract on blood-brain barrier integrity and neurological function correlate with complement C3 reduction after subarachnoid hemorrhage in rats.
Zuo S, Li W, Li Q, Zhao H, Tang J, Chen Q, Liu X, Zhang JH, Chen Y, Feng H
Neuroscience letters609216-22(2015 Nov)

Nucleotide and deduced amino acid sequence of rat complement C3.
Misumi Y, Sohda M, Ikehara Y
Nucleic acids research18(8)2178(1990 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data suggest that locally produced C3 is an important prosurvival mechanism in pancreatic beta-cells under a proinflammatory assault.
Title: Protective Role of Complement C3 Against Cytokine-Mediated ?-Cell Apoptosis.

Inhibition of C3 might improve the reactivity of superior mesenteric arteries to norepinephrine during hemorrhagic shock possibly through the downregulation of NO, ET1, TNF-alpha and reactive oxygen radicals.
Title: Inhibition of complement C3 might rescue vascular hyporeactivity in a conscious hemorrhagic shock rat model.

Recruited microglia/monocytes contribute to activation of complement in the aging retina, through local expression of C3 mRNA.
Title: Synthesis and propagation of complement C3 by microglia/monocytes in the aging retina.

The C3 and C3a receptor system may primarily be involved in the pathogenesis of renal remodeling in hypertensive rats.
Title: Role of complement 3a in the growth of mesangial cells from stroke-prone spontaneously hypertensive rats.

The expression of the complement component C3f and the complement component 4A have potential for use in post-transplant diagnosis of rejection.
Title: Proteomic profiling of heterotopic heart-transplanted rats using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry: potential biomarkers and drug targets.

The following C3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the C3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02433	NM_016994.2 Latest version!	Rattus norvegicus complement C3 (C3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$811.30 $1159.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

C3 ( NM_016994.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058690.2 Rattus norvegicus complement C3 (C3), mRNA.

Price & Availability↑

CloneID	ORa02433
Clone ID Related Accession (Same CDS sequence)	NM_016994.2
Accession Version	NM_016994.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4992bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	complement C3 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from X52477.1, AABR07066499.1, CK366193.1, CO569380.1, CO800063.1, CO796620.1, CO565011.1 and BI281644.1. On Oct 11, 2007 this sequence version replaced NM_016994.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X52477.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGGACCCA CGTCAGGGTC CCAGCTACTA GTGCTACTGC TGCTGTTGGC CAGCTCCCTG 
CTAGCTCTGG GGAGCCCCAT GTACTCCATC ATTACTCCCA ATGTCCTGCG GCTGGAGAGT 
GAAGAGACTT TCATACTAGA GGCCCATGAT GCTCAGGGTG ATGTCCCAGT CACTGTCACT 
GTGCAAGACT TCCTAAAGAA GCAAGTGCTG ACCAGTGAGA AGACAGTGTT GACAGGAGCC 
ACTGGACATC TGAACAGGGT CTCCATCAAG ATTCCAGCCA GTAAGGAATT CAATGCAGAT 
AAGGGGCACA AGTACGTGAC AGTGGTGGCA AACTTCGGGG CAACAGTGGT GGAGAAAGCG 
GTGCTAGTAA GCTTTCAGAG TGGTTACCTC TTCATCCAGA CAGACAAGAC CATCTACACC 
CCAGGCTCCA CTGTTTTCTA TCGGATCTTC ACTGTGGACA ACAACCTATT GCCTGTGGGC 
AAGACAGTCG TCATCGTCAT TGAGACCCCG GACGGCGTTC CCATCAAGAG AGACATTCTA 
TCTTCCCACA ACCAATATGG CATCTTGCCT TTGTCTTGGA ACATTCCAGA ACTGGTCAAC 
ATGGGGCAGT GGAAGATCCG AGCCTTCTAT GAACATGCAC CAAAGCAGAC CTTCTCTGCA 
GAGTTTGAGG TGAAGGAATA CGTGCTGCCC AGTTTCGAAG TCCTGGTGGA GCCTACAGAG 
AAATTTTATT ACATCGATGA CCCAAAGGGC CTGGAAGTTT CCATCACAGC CAGATTCCTG 
TATGGGAAGA ACGTGGACGG GACAGCTTTC GTGATCTTTG GGGTCCAGGA TGAGGATAAG 
AAGATTTCTC TGGCCCAGTC CCTCACCCGC GTGCTGATCG AGGATGGTTC AGGGGAGGCA 
GTGCTCAGCC GAAAAGTGCT GATGGACGGG GTACGGCCCT CCAGCCCAGA AGCCCTAGTG 
GGGAAGTCCC TGTACGTCTC TGTCACTGTT ATCCTGCACT CAGGTAGCGA CATGGTAGAG 
GCAGAGCGCA GTGGGATCCC AATTGTCACT TCCCCGTACC AGATCCACTT CACCAAGACA 
CCCAAATTCT TCAAGCCAGC CATGCCTTTC GACCTCATGG TGTTTGTGAC CAACCCTGAT 
GGCTCTCCAG CCCGCAGAGT GCCAGTAGTC ACTCAGGGAT CCGACGCGCA GGCTCTCACC 
CAGGATGATG GTGTGGCCAA GCTGAGCGTC AACACACCCA ACAACCGCCA ACCCCTGACT 
ATCACGGTCC GCACCAAGAA GGAGGGTATC CCGGACGCGC GGCAGGCCAC CAGGACGATG 
CAGGCCCAGC CCTACAGCAC TATGCACAAT TCCAACAACT ACCTGCACTT GTCAGTGTCT 
CGGGTGGAGC TCAAGCCTGG GGACAACCTC AATGTCAACT TCCACCTGCG CACGGACGCT 
GGCCAAGAGG CCAAGATCCG ATACTACACC TATCTGGTTA TGAACAAGGG GAAGTTACTG 
AAGGCAGGCC GTCAGGTTCG GGAGCCTGGC CAGGACCTGG TGGTCTTGTC ACTGCCCATC 
ACTCCAGAAT TTATACCTTC CTTCCGCCTG GTGGCTTACT ACACCCTGAT TGGAGCTAAT 
GGCCAAAGGG AGGTGGTGGC CGACTCAGTG TGGGTGGATG TGAAGGACTC CTGTGTAGGC 
ACGCTGGTGG TGAAAGGTGA CCCAAGAGAT AACCGACAGC CCGCGCCTGG GCATCAAACG 
ACACTAAGGA TCGAGGGGAA CCAGGGGGCC CGAGTGGGGC TAGTGGCTGT GGACAAGGGG 
GTGTTTGTGC TGAACAAGAA GAACAAACTC ACACAGAGCA AGATCTGGGA TGTAGTAGAG 
AAGGCAGACA TTGGCTGCAC CCCAGGCAGT GGGAAGAACT ATGCGGGTGT CTTCATGGAT 
GCTGGCCTGA CCTTCAAGAC AAACCAAGGC CTGCAGACTG ATCAGAGAGA AGATCCTGAG 
TGCGCCAAGC CAGCTGCCCG CCGCCGTCGC TCAGTGCAGT TGATGGAAAG GAGGATGGAC 
AAAGCTGGTC AGTACACCGA CAAGGGTCTG CGGAAGTGTT GTGAGGATGG CATGCGTGAT 
ATCCCTATGA AGTACAGCTG CCAGCGCCGG GCTCGCCTCA TCACCCAGGG CGAGAGCTGC 
CTGAAGGCCT TCATGGACTG CTGCAACTAT ATCACCAAGC TTCGTGAGCA GCACAGAAGA 
GACCATGTGC TGGGCCTGGC CAGGAGTGAT GTGGATGAAG ACATAATCCC AGAAGAAGAT 
ATTATCTCTA GAAGCCACTT CCCAGAGAGC TGGTTGTGGA CCATAGAAGA GTTGAAAGAA 
CCAGAGAAAA ATGGAATCTC TACGAAGGTC ATGAACATCT TTCTCAAAGA TTCCATCACC 
ACCTGGGAGA TTCTGGCAGT GAGCTTGTCC GACAAGAAAG GGATCTGTGT GGCAGACCCC 
TATGAGATCA CAGTGATGCA GGACTTCTTC ATTGACCTGC GACTGCCCTA CTCTGTGGTG 
CGCAATGAAC AGGTGGAGAT CAGAGCTGTG CTCTTCAATT ACCGTGAACA GGAGAAACTT 
AAGGTAAGGG TGGAACTGTT GCATAACCCA GCCTTCTGCA GCATGGCCAC TGCCAAGAAG 
CGGTACTACC AGACCATCGA AATCCCTCCC AAGTCCTCTG TGGCTGTGCC TTATGTCATT 
GTCCCCTTGA AGATCGGCCT CCAGGAGGTG GAGGTCAAGG CCGCCGTCTT CAACCACTTC 
ATCAGTGATG GTGTCAAGAA GATACTGAAG GTCGTGCCAG AAGGAATGAG AGTCAACAAA 
ACTGTGGCTG TCCGTACACT GGATCCAGAA CACCTCGGTC AAGGGGGAGT GCAGAGGGAG 
GATGTACCTG CAGCAGACCT CAGTGACCAA GTGCCAGACA CAGATTCTGA GACCAGAATT 
CTCCTGCAAG GGACCCCGGT GGCTCAGATG GCCGAGGACG CTGTGGACGG GGAGCGGCTG 
AAACACCTGA TCGTGACCCC CTCTGGCTGT GGGGAGCAGA ACATGATTGG CATGACACCC 
ACGGTCATTG CAGTACACTA TCTGGATCAG ACCGAACAGT GGGAGAAATT CGGCCTAGAG 
AAGAGGCAAG AAGCTCTGGA GCTCATCAAG AAAGGGTACA CCCAGCAGCT GGCTTTCAAA 
CAGCCCAGCT CTGCCTATGC TGCCTTCAAC AACCGGCCTC CCAGCACCTG GCTGACAGCC 
TATGTGGTCA AGGTCTTCTC TCTGGCTGCC AACCTCATCG CCATCGACTC TCAGGTCCTG 
TGTGGGGCTG TCAAATGGCT GATTCTGGAG AAACAGAAGC CAGATGGTGT CTTTCAGGAG 
GACGGACCAG TGATTCACCA AGAAATGATT GGTGGCTTCC GGAACACCAA GGAGGCAGAT 
GTGTCGCTTA CAGCCTTTGT CCTCATCGCA CTGCAGGAAG CCAGAGATAT CTGTGAGGGG 
CAGGTCAACA GCCTTCCCGG GAGCATCAAC AAGGCAGGGG AGTATCTTGA AGCCAGTTAC 
CTGAACCTGC AGAGACCATA CACAGTAGCC ATTGCTGGGT ATGCCCTGGC CCTGATGAAC 
AAACTGGAGG AACCTTACCT CACCAAGTTT CTGAACACAG CCAAAGATCG GAACCGCTGG 
GAGGAGCCTG GCCAGCAGCT CTACAATGTG GAGGCCACCT CCTACGCCCT CCTGGCCCTG 
CTGCTGCTGA AAGACTTTGA CTCTGTGCCT CCTGTGGTGC GCTGGCTCAA CGAGCAAAGA 
TACTACGGAG GTGGCTATGG CTCCACGCAG GCTACCTTCA TGGTATTCCA AGCCTTGGCT 
CAATACCAAA CAGATGTCCC TGACCACAAG GACTTGAACA TGGATGTGTC CCTCCACCTC 
CCCAGCCGCA GCTCCCCAAC TGTGTTTCGC CTGCTATGGG AAAGTGGCAG TCTCCTGAGA 
TCAGAAGAGA CCAAGCAGAA TGAGGGCTTT TCTCTGACAG CCAAAGGAAA AGGCCAAGGC 
ACACTGTCGG TGGTGACAGT GTATCACGCC AAAGTCAAAG GCAAAGCCAC CTGCAAGAAG 
TTTGACCTCA GGGTCACCAT AAAACCAGCC CCTGAGACAG CCAAGAAGCC CCAGGATGCC 
AAGAGTTCTA TGATCCTTGA CATCTGCACC AGGTACTTGG GAGACGTGGA TGCTACTATG 
TCCATCCTGG ACATCTCCAT GATGACTGGC TTTATTCCAG ACACAAACGA CCTGGAACTG 
CTGAGCTCTG GAGTAGACAG ATACATTTCC AAGTATGAGA TGGACAAAGC CTTCTCCAAC 
AAGAACACCC TCATCATCTA CCTAGAAAAG ATCTCACACT CCGAAGAAGA CTGCCTGTCC 
TTCAAAGTCC ACCAGTTCTT TAACGTGGGA CTTATCCAGC CGGGGTCGGT CAAGGTCTAC 
TCCTACTACA ATCTAGAGGA GTCATGCACC CGGTTCTATC ATCCGGAGAA GGACGATGGA 
ATGCTGAGCA AGCTGTGCCA CAATGAAATG TGCCGCTGTG CAGAGGAGAA CTGCTTCATG 
CATCAGTCAC AGGATCAGGT CAGCCTGAAT GAACGACTAG ACAAGGCTTG TGAGCCTGGA 
GTGGACTACG TGTACAAGAC CAAGCTAACG ACGATAGAGC TGTCGGATGA TTTTGATGAG 
TACATCATGA CCATCGAGCA GGTCATCAAG TCAGGCTCAG ATGAGGTGCA GGCAGGTCAG 
GAACGAAGGT TCATCAGCCA CGTCAAGTGC AGAAACGCCC TAAAGCTGCA GAAAGGGAAG 
CAGTACCTCA TGTGGGGCCT CTCCTCCGAC CTCTGGGGAG AAAAGCCCAA TACCAGCTAC 
ATCATTGGGA AGGACACGTG GGTGGAGCAC TGGCCCGAGG CAGAGGAATG TCAGGATCAG 
AAGAACCAGA AACAGTGCGA AGACCTCGGG GCATTCACAG AAACAATGGT GGTTTTCGGC 
TGCCCCAACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058690.2
CDS	42..5033
Translation	MGPTSGSQLLVLLLLLASSLLALGSPMYSIITPNVLRLESEETFILEAHDAQGDVPVTVTVQDFLKKQVLTSEKTVLTGATGHLNRVSIKIPASKEFNADKGHKYVTVVANFGATVVEKAVLVSFQSGYLFIQTDKTIYTPGSTVFYRIFTVDNNLLPVGKTVVIVIETPDGVPIKRDILSSHNQYGILPLSWNIPELVNMGQWKIRAFYEHAPKQTFSAEFEVKEYVLPSFEVLVEPTEKFYYIDDPKGLEVSITARFLYGKNVDGTAFVIFGVQDEDKKISLAQSLTRVLIEDGSGEAVLSRKVLMDGVRPSSPEALVGKSLYVSVTVILHSGSDMVEAERSGIPIVTSPYQIHFTKTPKFFKPAMPFDLMVFVTNPDGSPARRVPVVTQGSDAQALTQDDGVAKLSVNTPNNRQPLTITVRTKKEGIPDARQATRTMQAQPYSTMHNSNNYLHLSVSRVELKPGDNLNVNFHLRTDAGQEAKIRYYTYLVMNKGKLLKAGRQVREPGQDLVVLSLPITPEFIPSFRLVAYYTLIGANGQREVVADSVWVDVKDSCVGTLVVKGDPRDNRQPAPGHQTTLRIEGNQGARVGLVAVDKGVFVLNKKNKLTQSKIWDVVEKADIGCTPGSGKNYAGVFMDAGLTFKTNQGLQTDQREDPECAKPAARRRRSVQLMERRMDKAGQYTDKGLRKCCEDGMRDIPMKYSCQRRARLITQGESCLKAFMDCCNYITKLREQHRRDHVLGLARSDVDEDIIPEEDIISRSHFPESWLWTIEELKEPEKNGISTKVMNIFLKDSITTWEILAVSLSDKKGICVADPYEITVMQDFFIDLRLPYSVVRNEQVEIRAVLFNYREQEKLKVRVELLHNPAFCSMATAKKRYYQTIEIPPKSSVAVPYVIVPLKIGLQEVEVKAAVFNHFISDGVKKILKVVPEGMRVNKTVAVRTLDPEHLGQGGVQREDVPAADLSDQVPDTDSETRILLQGTPVAQMAEDAVDGERLKHLIVTPSGCGEQNMIGMTPTVIAVHYLDQTEQWEKFGLEKRQEALELIKKGYTQQLAFKQPSSAYAAFNNRPPSTWLTAYVVKVFSLAANLIAIDSQVLCGAVKWLILEKQKPDGVFQEDGPVIHQEMIGGFRNTKEADVSLTAFVLIALQEARDICEGQVNSLPGSINKAGEYLEASYLNLQRPYTVAIAGYALALMNKLEEPYLTKFLNTAKDRNRWEEPGQQLYNVEATSYALLALLLLKDFDSVPPVVRWLNEQRYYGGGYGSTQATFMVFQALAQYQTDVPDHKDLNMDVSLHLPSRSSPTVFRLLWESGSLLRSEETKQNEGFSLTAKGKGQGTLSVVTVYHAKVKGKATCKKFDLRVTIKPAPETAKKPQDAKSSMILDICTRYLGDVDATMSILDISMMTGFIPDTNDLELLSSGVDRYISKYEMDKAFSNKNTLIIYLEKISHSEEDCLSFKVHQFFNVGLIQPGSVKVYSYYNLEESCTRFYHPEKDDGMLSKLCHNEMCRCAEENCFMHQSQDQVSLNERLDKACEPGVDYVYKTKLTTIELSDDFDEYIMTIEQVIKSGSDEVQAGQERRFISHVKCRNALKLQKGKQYLMWGLSSDLWGEKPNTSYIIGKDTWVEHWPEAEECQDQKNQKQCEDLGAFTETMVVFGCPN

Target ORF information:

RefSeq Version	NM_016994.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus complement C3 (C3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016994.2

ORF Insert Sequence:

ATGGGACCCA CGTCAGGGTC CCAGCTACTA GTGCTACTGC TGCTGTTGGC CAGCTCCCTG 
CTAGCTCTGG GGAGCCCCAT GTACTCCATC ATTACTCCCA ATGTCCTGCG GCTGGAGAGT 
GAAGAGACTT TCATACTAGA GGCCCATGAT GCTCAGGGTG ATGTCCCAGT CACTGTCACT 
GTGCAAGACT TCCTAAAGAA GCAAGTGCTG ACCAGTGAGA AGACAGTGTT GACAGGAGCC 
ACTGGACATC TGAACAGGGT CTCCATCAAG ATTCCAGCCA GTAAGGAATT CAATGCAGAT 
AAGGGGCACA AGTACGTGAC AGTGGTGGCA AACTTCGGGG CAACAGTGGT GGAGAAAGCG 
GTGCTAGTAA GCTTTCAGAG TGGTTACCTC TTCATCCAGA CAGACAAGAC CATCTACACC 
CCAGGCTCCA CTGTTTTCTA TCGGATCTTC ACTGTGGACA ACAACCTATT GCCTGTGGGC 
AAGACAGTCG TCATCGTCAT TGAGACCCCG GACGGCGTTC CCATCAAGAG AGACATTCTA 
TCTTCCCACA ACCAATATGG CATCTTGCCT TTGTCTTGGA ACATTCCAGA ACTGGTCAAC 
ATGGGGCAGT GGAAGATCCG AGCCTTCTAT GAACATGCAC CAAAGCAGAC CTTCTCTGCA 
GAGTTTGAGG TGAAGGAATA CGTGCTGCCC AGTTTCGAAG TCCTGGTGGA GCCTACAGAG 
AAATTTTATT ACATCGATGA CCCAAAGGGC CTGGAAGTTT CCATCACAGC CAGATTCCTG 
TATGGGAAGA ACGTGGACGG GACAGCTTTC GTGATCTTTG GGGTCCAGGA TGAGGATAAG 
AAGATTTCTC TGGCCCAGTC CCTCACCCGC GTGCTGATCG AGGATGGTTC AGGGGAGGCA 
GTGCTCAGCC GAAAAGTGCT GATGGACGGG GTACGGCCCT CCAGCCCAGA AGCCCTAGTG 
GGGAAGTCCC TGTACGTCTC TGTCACTGTT ATCCTGCACT CAGGTAGCGA CATGGTAGAG 
GCAGAGCGCA GTGGGATCCC AATTGTCACT TCCCCGTACC AGATCCACTT CACCAAGACA 
CCCAAATTCT TCAAGCCAGC CATGCCTTTC GACCTCATGG TGTTTGTGAC CAACCCTGAT 
GGCTCTCCAG CCCGCAGAGT GCCAGTAGTC ACTCAGGGAT CCGACGCGCA GGCTCTCACC 
CAGGATGATG GTGTGGCCAA GCTGAGCGTC AACACACCCA ACAACCGCCA ACCCCTGACT 
ATCACGGTCC GCACCAAGAA GGAGGGTATC CCGGACGCGC GGCAGGCCAC CAGGACGATG 
CAGGCCCAGC CCTACAGCAC TATGCACAAT TCCAACAACT ACCTGCACTT GTCAGTGTCT 
CGGGTGGAGC TCAAGCCTGG GGACAACCTC AATGTCAACT TCCACCTGCG CACGGACGCT 
GGCCAAGAGG CCAAGATCCG ATACTACACC TATCTGGTTA TGAACAAGGG GAAGTTACTG 
AAGGCAGGCC GTCAGGTTCG GGAGCCTGGC CAGGACCTGG TGGTCTTGTC ACTGCCCATC 
ACTCCAGAAT TTATACCTTC CTTCCGCCTG GTGGCTTACT ACACCCTGAT TGGAGCTAAT 
GGCCAAAGGG AGGTGGTGGC CGACTCAGTG TGGGTGGATG TGAAGGACTC CTGTGTAGGC 
ACGCTGGTGG TGAAAGGTGA CCCAAGAGAT AACCGACAGC CCGCGCCTGG GCATCAAACG 
ACACTAAGGA TCGAGGGGAA CCAGGGGGCC CGAGTGGGGC TAGTGGCTGT GGACAAGGGG 
GTGTTTGTGC TGAACAAGAA GAACAAACTC ACACAGAGCA AGATCTGGGA TGTAGTAGAG 
AAGGCAGACA TTGGCTGCAC CCCAGGCAGT GGGAAGAACT ATGCGGGTGT CTTCATGGAT 
GCTGGCCTGA CCTTCAAGAC AAACCAAGGC CTGCAGACTG ATCAGAGAGA AGATCCTGAG 
TGCGCCAAGC CAGCTGCCCG CCGCCGTCGC TCAGTGCAGT TGATGGAAAG GAGGATGGAC 
AAAGCTGGTC AGTACACCGA CAAGGGTCTG CGGAAGTGTT GTGAGGATGG CATGCGTGAT 
ATCCCTATGA AGTACAGCTG CCAGCGCCGG GCTCGCCTCA TCACCCAGGG CGAGAGCTGC 
CTGAAGGCCT TCATGGACTG CTGCAACTAT ATCACCAAGC TTCGTGAGCA GCACAGAAGA 
GACCATGTGC TGGGCCTGGC CAGGAGTGAT GTGGATGAAG ACATAATCCC AGAAGAAGAT 
ATTATCTCTA GAAGCCACTT CCCAGAGAGC TGGTTGTGGA CCATAGAAGA GTTGAAAGAA 
CCAGAGAAAA ATGGAATCTC TACGAAGGTC ATGAACATCT TTCTCAAAGA TTCCATCACC 
ACCTGGGAGA TTCTGGCAGT GAGCTTGTCC GACAAGAAAG GGATCTGTGT GGCAGACCCC 
TATGAGATCA CAGTGATGCA GGACTTCTTC ATTGACCTGC GACTGCCCTA CTCTGTGGTG 
CGCAATGAAC AGGTGGAGAT CAGAGCTGTG CTCTTCAATT ACCGTGAACA GGAGAAACTT 
AAGGTAAGGG TGGAACTGTT GCATAACCCA GCCTTCTGCA GCATGGCCAC TGCCAAGAAG 
CGGTACTACC AGACCATCGA AATCCCTCCC AAGTCCTCTG TGGCTGTGCC TTATGTCATT 
GTCCCCTTGA AGATCGGCCT CCAGGAGGTG GAGGTCAAGG CCGCCGTCTT CAACCACTTC 
ATCAGTGATG GTGTCAAGAA GATACTGAAG GTCGTGCCAG AAGGAATGAG AGTCAACAAA 
ACTGTGGCTG TCCGTACACT GGATCCAGAA CACCTCGGTC AAGGGGGAGT GCAGAGGGAG 
GATGTACCTG CAGCAGACCT CAGTGACCAA GTGCCAGACA CAGATTCTGA GACCAGAATT 
CTCCTGCAAG GGACCCCGGT GGCTCAGATG GCCGAGGACG CTGTGGACGG GGAGCGGCTG 
AAACACCTGA TCGTGACCCC CTCTGGCTGT GGGGAGCAGA ACATGATTGG CATGACACCC 
ACGGTCATTG CAGTACACTA TCTGGATCAG ACCGAACAGT GGGAGAAATT CGGCCTAGAG 
AAGAGGCAAG AAGCTCTGGA GCTCATCAAG AAAGGGTACA CCCAGCAGCT GGCTTTCAAA 
CAGCCCAGCT CTGCCTATGC TGCCTTCAAC AACCGGCCTC CCAGCACCTG GCTGACAGCC 
TATGTGGTCA AGGTCTTCTC TCTGGCTGCC AACCTCATCG CCATCGACTC TCAGGTCCTG 
TGTGGGGCTG TCAAATGGCT GATTCTGGAG AAACAGAAGC CAGATGGTGT CTTTCAGGAG 
GACGGACCAG TGATTCACCA AGAAATGATT GGTGGCTTCC GGAACACCAA GGAGGCAGAT 
GTGTCGCTTA CAGCCTTTGT CCTCATCGCA CTGCAGGAAG CCAGAGATAT CTGTGAGGGG 
CAGGTCAACA GCCTTCCCGG GAGCATCAAC AAGGCAGGGG AGTATCTTGA AGCCAGTTAC 
CTGAACCTGC AGAGACCATA CACAGTAGCC ATTGCTGGGT ATGCCCTGGC CCTGATGAAC 
AAACTGGAGG AACCTTACCT CACCAAGTTT CTGAACACAG CCAAAGATCG GAACCGCTGG 
GAGGAGCCTG GCCAGCAGCT CTACAATGTG GAGGCCACCT CCTACGCCCT CCTGGCCCTG 
CTGCTGCTGA AAGACTTTGA CTCTGTGCCT CCTGTGGTGC GCTGGCTCAA CGAGCAAAGA 
TACTACGGAG GTGGCTATGG CTCCACGCAG GCTACCTTCA TGGTATTCCA AGCCTTGGCT 
CAATACCAAA CAGATGTCCC TGACCACAAG GACTTGAACA TGGATGTGTC CCTCCACCTC 
CCCAGCCGCA GCTCCCCAAC TGTGTTTCGC CTGCTATGGG AAAGTGGCAG TCTCCTGAGA 
TCAGAAGAGA CCAAGCAGAA TGAGGGCTTT TCTCTGACAG CCAAAGGAAA AGGCCAAGGC 
ACACTGTCGG TGGTGACAGT GTATCACGCC AAAGTCAAAG GCAAAGCCAC CTGCAAGAAG 
TTTGACCTCA GGGTCACCAT AAAACCAGCC CCTGAGACAG CCAAGAAGCC CCAGGATGCC 
AAGAGTTCTA TGATCCTTGA CATCTGCACC AGGTACTTGG GAGACGTGGA TGCTACTATG 
TCCATCCTGG ACATCTCCAT GATGACTGGC TTTATTCCAG ACACAAACGA CCTGGAACTG 
CTGAGCTCTG GAGTAGACAG ATACATTTCC AAGTATGAGA TGGACAAAGC CTTCTCCAAC 
AAGAACACCC TCATCATCTA CCTAGAAAAG ATCTCACACT CCGAAGAAGA CTGCCTGTCC 
TTCAAAGTCC ACCAGTTCTT TAACGTGGGA CTTATCCAGC CGGGGTCGGT CAAGGTCTAC 
TCCTACTACA ATCTAGAGGA GTCATGCACC CGGTTCTATC ATCCGGAGAA GGACGATGGA 
ATGCTGAGCA AGCTGTGCCA CAATGAAATG TGCCGCTGTG CAGAGGAGAA CTGCTTCATG 
CATCAGTCAC AGGATCAGGT CAGCCTGAAT GAACGACTAG ACAAGGCTTG TGAGCCTGGA 
GTGGACTACG TGTACAAGAC CAAGCTAACG ACGATAGAGC TGTCGGATGA TTTTGATGAG 
TACATCATGA CCATCGAGCA GGTCATCAAG TCAGGCTCAG ATGAGGTGCA GGCAGGTCAG 
GAACGAAGGT TCATCAGCCA CGTCAAGTGC AGAAACGCCC TAAAGCTGCA GAAAGGGAAG 
CAGTACCTCA TGTGGGGCCT CTCCTCCGAC CTCTGGGGAG AAAAGCCCAA TACCAGCTAC 
ATCATTGGGA AGGACACGTG GGTGGAGCAC TGGCCCGAGG CAGAGGAATG TCAGGATCAG 
AAGAACCAGA AACAGTGCGA AGACCTCGGG GCATTCACAG AAACAATGGT GGTTTTCGGC 
TGCCCCAACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Inhibition of complement C3 might rescue vascular hyporeactivity in a conscious hemorrhagic shock rat model.
Microvascular research10523-9(2016 May)
Chen D,Song MQ,Liu YJ,Xue YK,Cheng P,Zheng H,Chen LB

Endogenous C1-inhibitor production and expression in the heart after acute myocardial infarction.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology25(1)33-9(2016 Jan-Feb)
Emmens RW,Baylan U,Juffermans LJ,Karia RV,Ylstra B,Wouters D,Zeerleder S,Simsek S,van Ham M,Niessen HW,Krijnen PA

Protective effects of Ephedra sinica extract on blood-brain barrier integrity and neurological function correlate with complement C3 reduction after subarachnoid hemorrhage in rats.
Neuroscience letters609216-22(2015 Nov)
Zuo S,Li W,Li Q,Zhao H,Tang J,Chen Q,Liu X,Zhang JH,Chen Y,Feng H

Nucleotide and deduced amino acid sequence of rat complement C3.
Nucleic acids research18(8)2178(1990 Apr)
Misumi Y,Sohda M,Ikehara Y

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C3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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