Ak1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ak1
Entrez Gene ID	24183
Full Name	adenylate kinase 1
Synonyms	Ak 1
General protein information	Preferred Names adenylate kinase 1 Names adenylate kinase isoenzyme 1 ATP-AMP transphosphorylase 1 ATP:AMP phosphotransferase adenylate monophosphate kinase myokinase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3p11
Summary	catalyzes the conversion of ATP and AMP to ADP in adenine nucleotide metabolism [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_024349.3	NP_077325.2	adenylate kinase isoenzyme 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	AK1	NP_001124519.1
Bos taurus (cattle)	AK1	NP_001013600.1
Arabidopsis thaliana (thale cress)	AT4G25280	NP_194258.2
Homo sapiens (human)	AK1	NP_000467.1
	AK1	XP_002800218.1
Gallus gallus (chicken)	AK1	NP_990440.1
Mus musculus (house mouse)	Ak1	NP_067490.1
Rattus norvegicus (Norway rat)	Ak1	NP_077325.2
Xenopus tropicalis (tropical clawed frog)	ak1	NP_001006817.1
Pan troglodytes (chimpanzee)	AK1	XP_003951582.1
Danio rerio (zebrafish)	ak1	NP_001003993.1
Drosophila melanogaster (fruit fly)	Adk1	NP_729792.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009317	XP_309986.3
Caenorhabditis elegans (roundworm)	F38B2.4	NP_001257141.1

Gene Ontology
Bibliography

Related articles in PubMed

Effects of ?-alanine administration on selected parameters of oxidative stress and phosphoryltransfer network in cerebral cortex and cerebellum of rats.
Gemelli T, de Andrade RB, Rojas DB, Bonorino NF, Mazzola PN, Tortorelli LS, Funchal C, Filho CS, Wannmacher CM
Molecular and cellular biochemistry380(1-2)161-70(2013 Aug)

The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase.
Amiri M, Conserva F, Panayiotou C, Karlsson A, Solaroli N
The international journal of biochemistry & cell biology45(5)925-31(2013 May)

Resveratrol protects left ventricle by increasing adenylate kinase and isocitrate dehydrogenase activities in rats with myocardial infarction.
Lin JF, Wu S, Huang SS, Lu BY, Lin SM, Tsai SK
The Chinese journal of physiology54(6)406-12(2011 Dec)

Metformin activates AMP kinase through inhibition of AMP deaminase.
Ouyang J, Parakhia RA, Ochs RS
The Journal of biological chemistry286(1)1-11(2011 Jan)

5-ALA mediated photodynamic therapy induces autophagic cell death via AMP-activated protein kinase.
Ji HT, Chien LT, Lin YH, Chien HF, Chen CT
Molecular cancer991(2010 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate that the beta-alanine administration was able to inhibit the enzyme pyruvate kinase, cytosolic creatine kinase, and adenylate kinase activities in cerebral cortex, and increase in cerebellum.
Title: Effects of ?-alanine administration on selected parameters of oxidative stress and phosphoryltransfer network in cerebral cortex and cerebellum of rats.

it is the activation of AMPK that plays a crucial role in mediating autophagic cell death induced by 5-aminolevulinic acid (ALA)-mediated photodynamic therapy
Title: 5-ALA mediated photodynamic therapy induces autophagic cell death via AMP-activated protein kinase.

Adenylate kinase activity was found diminished in the brain cortex of rats loaded with cystine dimethylester and co-administration of cysteamine prevented the diminution of the enzyme activity.
Title: Cysteamine prevents inhibition of adenylate kinase caused by cystine in rat brain cortex.

adenylate kinase (AK) was increased in senescent muscle fibres.
Title: Opposite pathobiochemical fate of pyruvate kinase and adenylate kinase in aged rat skeletal muscle as revealed by proteomic DIGE analysis.

The following Ak1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ak1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa06903	NM_024349.3 Latest version!	Rattus norvegicus adenylate kinase 1 (Ak1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ak1 ( NM_024349.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_077325.2 Rattus norvegicus adenylate kinase 1 (Ak1), mRNA.

Price & Availability↑

CloneID	ORa06903
Clone ID Related Accession (Same CDS sequence)	NM_024349.3
Accession Version	NM_024349.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 585bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Rattus norvegicus(Norway rat)
Product	adenylate kinase isoenzyme 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC089797.1 and AABR07051450.1. On Mar 19, 2013 this sequence version replaced NM_024349.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAAGACA AGCTGAAGAA GGCCAAGATC ATCTTCGTGG TGGGCGGGCC TGGCTCAGGA 
AAAGGTACCC AGTGTGAGAA GATTGTGCAG AAATATGGCT ACACCCACCT CTCTACTGGG 
GACCTGCTTC GGGCAGAAGT CAGCTCTGGA TCGTCGAGGG GCAAGATGCT GTCATCTATC 
ATGGAGAAGG GAGAGCTGGT GCCACTGGAG ACGGTGCTGG ACATGCTTCG GGATGCTATG 
TTAGCCAAAG TGGACTCTTC CAACGGCTTC TTGATTGACG GCTACCCGAG GGAGGTGAAA 
CAGGGAGAAG AGTTTGAACG GAAGATCGCA CAGCCCACAC TGCTACTGTA TGTGGACGCA 
GGCCCCGAGA CCATGACCCA ACGACTCCTA AAGCGAGGGG AGACCAGTGG CCGTGTGGAC 
GATAACGAGG AGACCATCAA GAAGAGGCTG GAGACGTATT ACAAAGCCAC AGAACCTGTC 
ATCTCCTTCT ATGACAAACG CGGCATTGTG CGCAAGGTCA ATGCTGAAGG CTCAGTGGAC 
ACTGTCTTCT CCCAGGTCTG CACCTATCTT GACTCCCTGA AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_077325.2
CDS	39..623
Translation	MEDKLKKAKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAMLAKVDSSNGFLIDGYPREVKQGEEFERKIAQPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVISFYDKRGIVRKVNAEGSVDTVFSQVCTYLDSLK

Target ORF information:

RefSeq Version	NM_024349.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus adenylate kinase 1 (Ak1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024349.3

ORF Insert Sequence:

ATGGAAGACA AGCTGAAGAA GGCCAAGATC ATCTTCGTGG TGGGCGGGCC TGGCTCAGGA 
AAAGGTACCC AGTGTGAGAA GATTGTGCAG AAATATGGCT ACACCCACCT CTCTACTGGG 
GACCTGCTTC GGGCAGAAGT CAGCTCTGGA TCGTCGAGGG GCAAGATGCT GTCATCTATC 
ATGGAGAAGG GAGAGCTGGT GCCACTGGAG ACGGTGCTGG ACATGCTTCG GGATGCTATG 
TTAGCCAAAG TGGACTCTTC CAACGGCTTC TTGATTGACG GCTACCCGAG GGAGGTGAAA 
CAGGGAGAAG AGTTTGAACG GAAGATCGCA CAGCCCACAC TGCTACTGTA TGTGGACGCA 
GGCCCCGAGA CCATGACCCA ACGACTCCTA AAGCGAGGGG AGACCAGTGG CCGTGTGGAC 
GATAACGAGG AGACCATCAA GAAGAGGCTG GAGACGTATT ACAAAGCCAC AGAACCTGTC 
ATCTCCTTCT ATGACAAACG CGGCATTGTG CGCAAGGTCA ATGCTGAAGG CTCAGTGGAC 
ACTGTCTTCT CCCAGGTCTG CACCTATCTT GACTCCCTGA AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Effects of ?-alanine administration on selected parameters of oxidative stress and phosphoryltransfer network in cerebral cortex and cerebellum of rats.
Molecular and cellular biochemistry380(1-2)161-70(2013 Aug)
Gemelli T,de Andrade RB,Rojas DB,Bonorino NF,Mazzola PN,Tortorelli LS,Funchal C,Filho CS,Wannmacher CM

The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase.
The international journal of biochemistry & cell biology45(5)925-31(2013 May)
Amiri M,Conserva F,Panayiotou C,Karlsson A,Solaroli N

Resveratrol protects left ventricle by increasing adenylate kinase and isocitrate dehydrogenase activities in rats with myocardial infarction.
The Chinese journal of physiology54(6)406-12(2011 Dec)
Lin JF,Wu S,Huang SS,Lu BY,Lin SM,Tsai SK

Metformin activates AMP kinase through inhibition of AMP deaminase.
The Journal of biological chemistry286(1)1-11(2011 Jan)
Ouyang J,Parakhia RA,Ochs RS

5-ALA mediated photodynamic therapy induces autophagic cell death via AMP-activated protein kinase.
Molecular cancer991(2010 Apr)
Ji HT,Chien LT,Lin YH,Chien HF,Chen CT

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Ak1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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