gRNAs
The following Acly gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Acly cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | ORa12061 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001111095.1 | |
| Accession Version | NM_001111095.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 3276bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-26 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | ATP-citrate synthase isoform 2 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB800173.1, J05210.1, BC100618.1, DY473160.1 and CR471829.1. Transcript Variant: This variant (2) lacks an alternate exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC100618.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## | |
1 | ATGTCAGCCA AGGCAATTTC AGAGCAGACC GGCAAAGAAC TCCTTTACAA GTACATCTGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001104565.1 |
| CDS | 122..3397 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001111095.1 |
1 | ATGTCAGCCA AGGCAATTTC AGAGCAGACC GGCAAAGAAC TCCTTTACAA GTACATCTGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | ORa12088 | |
| Clone ID Related Accession (Same CDS sequence) | NM_016987.2 | |
| Accession Version | NM_016987.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 3306bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-26 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | ATP-citrate synthase isoform 1 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB800173.1, J05210.1, BC100618.1, DY473160.1 and CR471829.1. On Dec 11, 2007 this sequence version replaced NM_016987.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: J05210.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## | |
1 | ATGTCAGCCA AGGCAATTTC AGAGCAGACC GGCAAAGAAC TCCTTTACAA GTACATCTGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_058683.2 |
| CDS | 122..3427 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_016987.2 |
1 | ATGTCAGCCA AGGCAATTTC AGAGCAGACC GGCAAAGAAC TCCTTTACAA GTACATCTGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Enhanced lipid accumulation in the yeast Yarrowia lipolytica by over-expression of ATP:citrate lyase from Mus musculus. |
Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth. |
High level of ATP citrate lyase expression in human and rat pancreatic islets. |
Differences between human and rodent pancreatic islets: low pyruvate carboxylase, atp citrate lyase, and pyruvate carboxylation and high glucose-stimulated acetoacetate in human pancreatic islets. |
Lower succinyl-CoA:3-ketoacid-CoA transferase (SCOT) and ATP citrate lyase in pancreatic islets of a rat model of type 2 diabetes: knockdown of SCOT inhibits insulin release in rat insulinoma cells. |
