Dusp5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dusp5
Entrez Gene ID	171109
Full Name	dual specificity phosphatase 5
Synonyms	Cpg21
General protein information	Preferred Names dual specificity phosphatase 5 Names dual specificity protein phosphatase 5 MAP-kinase phosphatase (cpg21) MAP-kinase phosphatase CPG21 candidate plasticity-related gene 21
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q55
Summary	inactivates MAP kinase; may be involved in long term potentiation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_133578.1	NP_598262.1	dual specificity protein phosphatase 5

Pathways from BioSystems

Homologies

Bos taurus (cattle)	DUSP5	XP_003587938.2
Danio rerio (zebrafish)	dusp5	NP_997730.1
Xenopus tropicalis (tropical clawed frog)	dusp5	NP_001015856.1
Canis lupus familiaris (dog)	DUSP5	XP_544014.2
	DUSP5	XP_001086701.2
Mus musculus (house mouse)	Dusp5	NP_001078859.1
Homo sapiens (human)	DUSP5	NP_004410.3
Rattus norvegicus (Norway rat)	Dusp5	NP_598262.1
Gallus gallus (chicken)	DUSP5	XP_421754.2

Gene Ontology
Bibliography

Related articles in PubMed

miR-32-5p-mediated Dusp5 downregulation contributes to neuropathic pain.
Yan T, Zhang F, Sun C, Sun J, Wang Y, Xu X, Shi J, Shi G
Biochemical and biophysical research communications495(1)506-511(2018 01)

MeCP2 regulation of cardiac fibroblast proliferation and fibrosis by down-regulation of DUSP5.
Tao H, Yang JJ, Hu W, Shi KH, Deng ZY, Li J
International journal of biological macromolecules8268-75(2016 Jan)

The family-wide structure and function of human dual-specificity protein phosphatases.
Jeong DG, Wei CH, Ku B, Jeon TJ, Chien PN, Kim JK, Park SY, Hwang HS, Ryu SY, Park H, Kim DS, Kim SJ, Ryu SE
Acta crystallographica. Section D, Biological crystallography70(Pt 2)421-35(2014 Feb)

Zinc-finger nuclease knockout of dual-specificity protein phosphatase-5 enhances the myogenic response and autoregulation of cerebral blood flow in FHH.1BN rats.
Fan F, Geurts AM, Pabbidi MR, Smith SV, Harder DR, Jacob H, Roman RJ
PloS one9(11)e112878(2014)

Signal-dependent repression of DUSP5 by class I HDACs controls nuclear ERK activity and cardiomyocyte hypertrophy.
Ferguson BS, Harrison BC, Jeong MY, Reid BG, Wempe MF, Wagner FF, Holson EB, McKinsey TA
Proceedings of the National Academy of Sciences of the United States of America110(24)9806-11(2013 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

miR-32-5p promotes neuroinflammation and neuropathic pain development through regulation of Dusp5.
Title: miR-32-5p-mediated Dusp5 downregulation contributes to neuropathic pain.

MeCP2 acts as a key regulator of pathological cardiac fibrosis, promotes cardiac fibroblasts proliferation and fibrosis by down-regulation of DUSP5.
Title: MeCP2 regulation of cardiac fibroblast proliferation and fibrosis by down-regulation of DUSP5.

Dusp5 modulates myogenic reactivity and autoregulation in the cerebral circulation.
Title: Zinc-finger nuclease knockout of dual-specificity protein phosphatase-5 enhances the myogenic response and autoregulation of cerebral blood flow in FHH.1BN rats.

Data indicate that class I HDACs function as signal-dependent repressors of cardiac hypertrophy via inhibition of the gene encoding dual-specificity phosphatase 5 (DUSP5) DUSP5, a nuclear phosphatase that negatively regulates signaling by ERK1/2.
Title: Signal-dependent repression of DUSP5 by class I HDACs controls nuclear ERK activity and cardiomyocyte hypertrophy.

DUSP-5, native in cerebral arterial muscle cells, appears to regulate signaling of pressure-dependent myogenic cerebral arterial constriction, which is crucial for the maintenance of constant cerebral blood flow to the brain.
Title: Role of dual-specificity protein phosphatase-5 in modulating the myogenic response in rat cerebral arteries.

The following Dusp5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dusp5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00996	NM_133578.1 Latest version!	Rattus norvegicus dual specificity phosphatase 5 (Dusp5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dusp5 ( NM_133578.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_598262.1 Rattus norvegicus dual specificity phosphatase 5 (Dusp5), mRNA.

Price & Availability↑

CloneID	ORa00996
Clone ID Related Accession (Same CDS sequence)	NM_133578.1
Accession Version	NM_133578.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1155bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-11-09
Organism	Rattus norvegicus(Norway rat)
Product	dual specificity protein phosphatase 5
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF013144.1. On Dec 17, 2003 this sequence version replaced XM_346588.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF013144.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAAGGTCA CGTCGCTCGA CGGGCGCCGG CTGCGCAAGA TGCTCCGCAA GGAGGCGGAG 
GCGCGCTGCG TGGTGCTCGA TTGCCGGCCC TACCTGGCCT TCGCCGCGTC GAGCGTGCGC 
GGCTCGCTCA ACGTCAACCT CAACTCCGTG GTGCTGCGGC GGGCCCGGGG CGGCGCGGTG 
TCTGCGCGCT ACGTGCTGGC CGACGAGGCA GCCCGCGCTC GGCTGCTGCA GGAGGGCGGC 
GGCGGCGTGG CGGCGGTGGT CGTGCTGGAC CAGGGCAGCC GCCACTGGCA GAAGCTGCGG 
GAGGAGAGTG CCGCGCGCGT CGTCCTCACC TCGCTGCTGG CCTGTCTGTC CGCCGGACCG 
CGGGTCTACT TCCTTAAAGG TGGGTACGAG ACCTTCTACT CACAGTATCC TGAGTGCTGT 
GTGGATGCGA AGCCCATTTC ACAAGAGAAG CTCGAAGGTG AAAGAGGCCT CCTCAGCCAG 
TGCGGAAAGC CCATTCTCAG CGTCGCCTAC AGACCAGCTT ATGACCAGGG TGGCCCAGTT 
GAAATCCTTC CCTTCCTCTA CCTTGGAAGT GCCTACCATG CATCCAAGTG CGAGTTCCTC 
GCCAACCTGC ACATCACAGC CCTGCTGAAT GTTTCCCGCC GGACCTCTGA GGCCTGCACA 
ACCCACCTAC ACTACAAGTG GATCCCTGTG GAGGACAGCC ACACCGCCGA CATTAGCTCC 
CACTTTCAAG AAGCAATAGA TTTTATTGAC TGTGTCAGGG AAGAGGGAGG CAAGGTCCTG 
GTTCACTGTG AAGCCGGGGT CTCCCGGTCG CCCACCATCT GCATGGCTTA CCTCATGAAG 
ACCAAGCAGT TCCGCCTGAA GGAGGCCTTC GAGTATATCA AGCAGAGGAG GAGCGTGGTC 
TCTCCCAACT TTGGCTTCAT GGGACAGCTC CTGCAGTATG AGTCTGAGAT CCTGCCCTCC 
ACACCCACCC CCCAACCTCC CTCCTGCCAA GGGGAGGCAG CCAGCTCCAC CTTTATAGGC 
CACTTACAGA CACTGAGCCC TGATATGCAG GGTGCCTACT GCACATTCCC TACCTCAGTG 
CTGGCACCGG TGCCCACCCA CGCCACCGTC GCAGAGCTCC ACAGGAGCCC CGTGGCCACA 
GCCACATCCT GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598262.1
CDS	175..1329
Translation	MKVTSLDGRRLRKMLRKEAEARCVVLDCRPYLAFAASSVRGSLNVNLNSVVLRRARGGAVSARYVLADEAARARLLQEGGGGVAAVVVLDQGSRHWQKLREESAARVVLTSLLACLSAGPRVYFLKGGYETFYSQYPECCVDAKPISQEKLEGERGLLSQCGKPILSVAYRPAYDQGGPVEILPFLYLGSAYHASKCEFLANLHITALLNVSRRTSEACTTHLHYKWIPVEDSHTADISSHFQEAIDFIDCVREEGGKVLVHCEAGVSRSPTICMAYLMKTKQFRLKEAFEYIKQRRSVVSPNFGFMGQLLQYESEILPSTPTPQPPSCQGEAASSTFIGHLQTLSPDMQGAYCTFPTSVLAPVPTHATVAELHRSPVATATSC

Target ORF information:

RefSeq Version	NM_133578.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus dual specificity phosphatase 5 (Dusp5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133578.1

ORF Insert Sequence:

ATGAAGGTCA CGTCGCTCGA CGGGCGCCGG CTGCGCAAGA TGCTCCGCAA GGAGGCGGAG 
GCGCGCTGCG TGGTGCTCGA TTGCCGGCCC TACCTGGCCT TCGCCGCGTC GAGCGTGCGC 
GGCTCGCTCA ACGTCAACCT CAACTCCGTG GTGCTGCGGC GGGCCCGGGG CGGCGCGGTG 
TCTGCGCGCT ACGTGCTGGC CGACGAGGCA GCCCGCGCTC GGCTGCTGCA GGAGGGCGGC 
GGCGGCGTGG CGGCGGTGGT CGTGCTGGAC CAGGGCAGCC GCCACTGGCA GAAGCTGCGG 
GAGGAGAGTG CCGCGCGCGT CGTCCTCACC TCGCTGCTGG CCTGTCTGTC CGCCGGACCG 
CGGGTCTACT TCCTTAAAGG TGGGTACGAG ACCTTCTACT CACAGTATCC TGAGTGCTGT 
GTGGATGCGA AGCCCATTTC ACAAGAGAAG CTCGAAGGTG AAAGAGGCCT CCTCAGCCAG 
TGCGGAAAGC CCATTCTCAG CGTCGCCTAC AGACCAGCTT ATGACCAGGG TGGCCCAGTT 
GAAATCCTTC CCTTCCTCTA CCTTGGAAGT GCCTACCATG CATCCAAGTG CGAGTTCCTC 
GCCAACCTGC ACATCACAGC CCTGCTGAAT GTTTCCCGCC GGACCTCTGA GGCCTGCACA 
ACCCACCTAC ACTACAAGTG GATCCCTGTG GAGGACAGCC ACACCGCCGA CATTAGCTCC 
CACTTTCAAG AAGCAATAGA TTTTATTGAC TGTGTCAGGG AAGAGGGAGG CAAGGTCCTG 
GTTCACTGTG AAGCCGGGGT CTCCCGGTCG CCCACCATCT GCATGGCTTA CCTCATGAAG 
ACCAAGCAGT TCCGCCTGAA GGAGGCCTTC GAGTATATCA AGCAGAGGAG GAGCGTGGTC 
TCTCCCAACT TTGGCTTCAT GGGACAGCTC CTGCAGTATG AGTCTGAGAT CCTGCCCTCC 
ACACCCACCC CCCAACCTCC CTCCTGCCAA GGGGAGGCAG CCAGCTCCAC CTTTATAGGC 
CACTTACAGA CACTGAGCCC TGATATGCAG GGTGCCTACT GCACATTCCC TACCTCAGTG 
CTGGCACCGG TGCCCACCCA CGCCACCGTC GCAGAGCTCC ACAGGAGCCC CGTGGCCACA 
GCCACATCCT GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

miR-32-5p-mediated Dusp5 downregulation contributes to neuropathic pain.
Biochemical and biophysical research communications495(1)506-511(2018 01)
Yan T,Zhang F,Sun C,Sun J,Wang Y,Xu X,Shi J,Shi G

MeCP2 regulation of cardiac fibroblast proliferation and fibrosis by down-regulation of DUSP5.
International journal of biological macromolecules8268-75(2016 Jan)
Tao H,Yang JJ,Hu W,Shi KH,Deng ZY,Li J

The family-wide structure and function of human dual-specificity protein phosphatases.
Acta crystallographica. Section D, Biological crystallography70(Pt 2)421-35(2014 Feb)
Jeong DG,Wei CH,Ku B,Jeon TJ,Chien PN,Kim JK,Park SY,Hwang HS,Ryu SY,Park H,Kim DS,Kim SJ,Ryu SE

Zinc-finger nuclease knockout of dual-specificity protein phosphatase-5 enhances the myogenic response and autoregulation of cerebral blood flow in FHH.1BN rats.
PloS one9(11)e112878(2014)
Fan F,Geurts AM,Pabbidi MR,Smith SV,Harder DR,Jacob H,Roman RJ

Signal-dependent repression of DUSP5 by class I HDACs controls nuclear ERK activity and cardiomyocyte hypertrophy.
Proceedings of the National Academy of Sciences of the United States of America110(24)9806-11(2013 Jun)
Ferguson BS,Harrison BC,Jeong MY,Reid BG,Wempe MF,Wagner FF,Holson EB,McKinsey TA

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Dusp5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報