Dusp5 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dusp5
Entrez Gene ID	240672
Full Name	dual specificity phosphatase 5
Synonyms	Gm337
General protein information	Preferred Names dual specificity phosphatase 5 Names dual specificity protein phosphatase 5
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 19 Map Location: 19\|19 D2

mRNA and Protein(s)

mRNA	Protein	Name
NM_001085390.1	NP_001078859.1	dual specificity protein phosphatase 5
NM_001085390.2	NP_001078859.1	dual specificity protein phosphatase 5

Pathways from BioSystems

Homologies

Bos taurus (cattle)	DUSP5	XP_003587938.2
Danio rerio (zebrafish)	dusp5	NP_997730.1
Xenopus tropicalis (tropical clawed frog)	dusp5	NP_001015856.1
Canis lupus familiaris (dog)	DUSP5	XP_544014.2
	DUSP5	XP_001086701.2
Mus musculus (house mouse)	Dusp5	NP_001078859.1
Homo sapiens (human)	DUSP5	NP_004410.3
Rattus norvegicus (Norway rat)	Dusp5	NP_598262.1
Gallus gallus (chicken)	DUSP5	XP_421754.2

Gene Ontology
Bibliography

Related articles in PubMed

DUSP5 functions as a feedback regulator of TNF?-induced ERK1/2 dephosphorylation and inflammatory gene expression in adipocytes.
Habibian JS, Jefic M, Bagchi RA, Lane RH, McKnight RA, McKinsey TA, Morrison RF, Ferguson BS
Scientific reports7(1)12879(2017 Oct)

Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling.
Kidger AM, Rushworth LK, Stellzig J, Davidson J, Bryant CJ, Bayley C, Caddye E, Rogers T, Keyse SM, Caunt CJ
Proceedings of the National Academy of Sciences of the United States of America114(3)E317-E326(2017 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study shown that the Dusp15 promoter is sufficient for oligodendroglial expression and jointly activated by Sox10 and Myrf in an oligodendroglial cell line.
Title: The Dual-specificity phosphatase Dusp15 is regulated by Sox10 and Myrf in Myelinating Oligodendrocytes.

Dual specificity phosphatase 5 knockout (Dusp5-/- ) T cells display increased proliferation, increased apoptosis, and altered metabolic profiles, suggesting that DUSP5 is a pro-survival protein in T cells.
Title: Dual Specificity Phosphatase 5 Is Essential for T Cell Survival.

DUSP5 phosphatase is regulated at the transcriptional level by the MAPK pathway and that serum responsive element is involved in the regulation of this early response gene.
Title: Dual Specificity Phosphatase 5, a Specific Negative Regulator of ERK Signaling, Is Induced by Serum Response Factor and Elk-1 Transcription Factor.

results suggest an in vivo role for DUSP5 as a tumor suppressor by modulating the oncogenic potential of activated Ras in the epidermis
Title: Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRasQ61L)-driven SerpinB2 expression.

After SSH between cDNA libraries from FD-Fms cells stimulated by M-CSF in the presence or the absence of U0126, we isolated DUSP5. DUSP5 expression is induced by M-CSF in various myeloid cells & acts as a specific negative-feedback regulator of ERK1/2.
Title: Macrophage differentiation of myeloid progenitor cells in response to M-CSF is regulated by the dual-specificity phosphatase DUSP5.

The following Dusp5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dusp5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu02927	NM_001085390.2 Latest version!	Mus musculus dual specificity phosphatase 5 (Dusp5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00
View Old Accession Versions >>
OMu02927	NM_001085390.1	Mus musculus dual specificity phosphatase 5 (Dusp5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dusp5 ( NM_001085390.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001078859.1 Mus musculus dual specificity phosphatase 5 (Dusp5), mRNA.

Price & Availability↑

CloneID	OMu02927
Clone ID Related Accession (Same CDS sequence)	NM_001085390.1 , NM_001085390.2
Accession Version	NM_001085390.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1155bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-10-13
Organism	Mus musculus(house mouse)
Product	dual specificity protein phosphatase 5
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ479917.1. On or before Jul 25, 2007 this sequence version replaced XM_904896.3, XM_140740.8. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BI691840.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGAAGGTCA CGTCGCTCGA CGGGCGCCAG CTGCGCAAGA TGCTCCGCAA GGAGGCGGAG 
GCGCGCTGCG TGGTGCTCGA CTGCCGGCCC TACCTGGCCT TCGCCGCGTC GAGCGTGCGC 
GGCTCGCTCA ACGTCAACCT CAACTCGGTG GTGCTGCGGC GGGCCCGGGG CGGCGCGGTG 
TCGGCGCGCT ACGTGCTGCC CGACGAGGCG GCCCGCGCTC GGCTGCTGCA GGAGGGCGGC 
GGCGGTGTGG CGGCGGTGGT CGTGCTGGAC CAGGGTAGCC GCCACTGGCA GAAGCTGCGG 
GAGGAGAGCG CCGCGCGCGT CGTGCTCACC TCGCTGCTGG CCTGCCTGCC CGCCGGCCCG 
CGGGTCTACT TCCTTAAAGG GGGGTATGAG ACCTTCTACT CACAGTATCC TGAGTGCTGT 
GTGGATGTGA AGCCCACCTC ACAAGAGAAG ATCGAAGGCG AGAGAAGCCT CCTCAGCCAG 
TGTGGAAAGC CCGTTCTCAG CGTCGCCTAC AGACCAGCCT ATGACCAGGG TGGCCCGGTT 
GAAATCCTTC CCTTCCTCTA CCTTGGAAGT GCCTACCACG CATCCAAGTG CGAGTTCCTC 
GCCAACCTGC ACATCACAGC CCTGCTGAAT GTTTCCCGCC GGACCTCCGA GGCCTGCACC 
ACCCACCTAC ACTACAAGTG GATCCCCGTG GAGGACAGCC ACACTGCTGA CATTAGCTCC 
CACTTTCAAG AAGCAATAGA TTTTATTGAC TGTGTCAGGG AAGAAGGAGG CAAGGTCCTG 
GTCCACTGCG AAGCTGGGGT TTCCCGGTCG CCCACCATCT GCATGGCTTA CCTCATGAAG 
ACCAAGCAGT TCCGGCTGAA GGAGGCCTTC GATTACGTCA AGCAGAGGAG GAGCGTGGTC 
TCTCCCAACT TTGGCTTCAT GGGACAGCTC CTTCAGTATG AATCTGAGAT CCTGCCCTCC 
ACACCCACCC TCCAGCCGCC CTCCTGCCAA GGGGAGGCAG CCAGCTCCAC GTTTATAGGC 
CATTTACAGA CACTGAGCCC TGATATGCAG GGCACCTACT GCACATTCCG TACCTCAGTG 
CTGGCACCGG TGCCCACCCA CTCCACAGTC CCAGAGCTCC ACAGGAGCCC CGTGGCCACA 
GCCACATCCT GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001078859.1
CDS	1..1155
Translation	MKVTSLDGRQLRKMLRKEAEARCVVLDCRPYLAFAASSVRGSLNVNLNSVVLRRARGGAVSARYVLPDEAARARLLQEGGGGVAAVVVLDQGSRHWQKLREESAARVVLTSLLACLPAGPRVYFLKGGYETFYSQYPECCVDVKPTSQEKIEGERSLLSQCGKPVLSVAYRPAYDQGGPVEILPFLYLGSAYHASKCEFLANLHITALLNVSRRTSEACTTHLHYKWIPVEDSHTADISSHFQEAIDFIDCVREEGGKVLVHCEAGVSRSPTICMAYLMKTKQFRLKEAFDYVKQRRSVVSPNFGFMGQLLQYESEILPSTPTLQPPSCQGEAASSTFIGHLQTLSPDMQGTYCTFRTSVLAPVPTHSTVPELHRSPVATATSC

Target ORF information:

RefSeq Version	NM_001085390.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus dual specificity phosphatase 5 (Dusp5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001085390.1

ORF Insert Sequence:

ATGAAGGTCA CGTCGCTCGA CGGGCGCCAG CTGCGCAAGA TGCTCCGCAA GGAGGCGGAG 
GCGCGCTGCG TGGTGCTCGA CTGCCGGCCC TACCTGGCCT TCGCCGCGTC GAGCGTGCGC 
GGCTCGCTCA ACGTCAACCT CAACTCGGTG GTGCTGCGGC GGGCCCGGGG CGGCGCGGTG 
TCGGCGCGCT ACGTGCTGCC CGACGAGGCG GCCCGCGCTC GGCTGCTGCA GGAGGGCGGC 
GGCGGTGTGG CGGCGGTGGT CGTGCTGGAC CAGGGTAGCC GCCACTGGCA GAAGCTGCGG 
GAGGAGAGCG CCGCGCGCGT CGTGCTCACC TCGCTGCTGG CCTGCCTGCC CGCCGGCCCG 
CGGGTCTACT TCCTTAAAGG GGGGTATGAG ACCTTCTACT CACAGTATCC TGAGTGCTGT 
GTGGATGTGA AGCCCACCTC ACAAGAGAAG ATCGAAGGCG AGAGAAGCCT CCTCAGCCAG 
TGTGGAAAGC CCGTTCTCAG CGTCGCCTAC AGACCAGCCT ATGACCAGGG TGGCCCGGTT 
GAAATCCTTC CCTTCCTCTA CCTTGGAAGT GCCTACCACG CATCCAAGTG CGAGTTCCTC 
GCCAACCTGC ACATCACAGC CCTGCTGAAT GTTTCCCGCC GGACCTCCGA GGCCTGCACC 
ACCCACCTAC ACTACAAGTG GATCCCCGTG GAGGACAGCC ACACTGCTGA CATTAGCTCC 
CACTTTCAAG AAGCAATAGA TTTTATTGAC TGTGTCAGGG AAGAAGGAGG CAAGGTCCTG 
GTCCACTGCG AAGCTGGGGT TTCCCGGTCG CCCACCATCT GCATGGCTTA CCTCATGAAG 
ACCAAGCAGT TCCGGCTGAA GGAGGCCTTC GATTACGTCA AGCAGAGGAG GAGCGTGGTC 
TCTCCCAACT TTGGCTTCAT GGGACAGCTC CTTCAGTATG AATCTGAGAT CCTGCCCTCC 
ACACCCACCC TCCAGCCGCC CTCCTGCCAA GGGGAGGCAG CCAGCTCCAC GTTTATAGGC 
CATTTACAGA CACTGAGCCC TGATATGCAG GGCACCTACT GCACATTCCG TACCTCAGTG 
CTGGCACCGG TGCCCACCCA CTCCACAGTC CCAGAGCTCC ACAGGAGCCC CGTGGCCACA 
GCCACATCCT GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dusp5 ( NM_001085390.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001078859.1 Mus musculus dual specificity phosphatase 5 (Dusp5), mRNA.

Price & Availability↑

CloneID	OMu02927
Clone ID Related Accession (Same CDS sequence)	NM_001085390.1 , NM_001085390.2
Accession Version	NM_001085390.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1155bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Mus musculus(house mouse)
Product	dual specificity protein phosphatase 5
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC137853.21. On Feb 8, 2019 this sequence version replaced NM_001085390.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7345562.1318286.1, SRR7345562.4749197.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGAAGGTCA CGTCGCTCGA CGGGCGCCAG CTGCGCAAGA TGCTCCGCAA GGAGGCGGAG 
GCGCGCTGCG TGGTGCTCGA CTGCCGGCCC TACCTGGCCT TCGCCGCGTC GAGCGTGCGC 
GGCTCGCTCA ACGTCAACCT CAACTCGGTG GTGCTGCGGC GGGCCCGGGG CGGCGCGGTG 
TCGGCGCGCT ACGTGCTGCC CGACGAGGCG GCCCGCGCTC GGCTGCTGCA GGAGGGCGGC 
GGCGGTGTGG CGGCGGTGGT CGTGCTGGAC CAGGGTAGCC GCCACTGGCA GAAGCTGCGG 
GAGGAGAGCG CCGCGCGCGT CGTGCTCACC TCGCTGCTGG CCTGCCTGCC CGCCGGCCCG 
CGGGTCTACT TCCTTAAAGG GGGGTATGAG ACCTTCTACT CACAGTATCC TGAGTGCTGT 
GTGGATGTGA AGCCCACCTC ACAAGAGAAG ATCGAAGGCG AGAGAAGCCT CCTCAGCCAG 
TGTGGAAAGC CCGTTCTCAG CGTCGCCTAC AGACCAGCCT ATGACCAGGG TGGCCCGGTT 
GAAATCCTTC CCTTCCTCTA CCTTGGAAGT GCCTACCACG CATCCAAGTG CGAGTTCCTC 
GCCAACCTGC ACATCACAGC CCTGCTGAAT GTTTCCCGCC GGACCTCCGA GGCCTGCACC 
ACCCACCTAC ACTACAAGTG GATCCCCGTG GAGGACAGCC ACACTGCTGA CATTAGCTCC 
CACTTTCAAG AAGCAATAGA TTTTATTGAC TGTGTCAGGG AAGAAGGAGG CAAGGTCCTG 
GTCCACTGCG AAGCTGGGGT TTCCCGGTCG CCCACCATCT GCATGGCTTA CCTCATGAAG 
ACCAAGCAGT TCCGGCTGAA GGAGGCCTTC GATTACGTCA AGCAGAGGAG GAGCGTGGTC 
TCTCCCAACT TTGGCTTCAT GGGACAGCTC CTTCAGTATG AATCTGAGAT CCTGCCCTCC 
ACACCCACCC TCCAGCCGCC CTCCTGCCAA GGGGAGGCAG CCAGCTCCAC GTTTATAGGC 
CATTTACAGA CACTGAGCCC TGATATGCAG GGCACCTACT GCACATTCCG TACCTCAGTG 
CTGGCACCGG TGCCCACCCA CTCCACAGTC CCAGAGCTCC ACAGGAGCCC CGTGGCCACA 
GCCACATCCT GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001078859.1
CDS	174..1328
Translation	MKVTSLDGRQLRKMLRKEAEARCVVLDCRPYLAFAASSVRGSLNVNLNSVVLRRARGGAVSARYVLPDEAARARLLQEGGGGVAAVVVLDQGSRHWQKLREESAARVVLTSLLACLPAGPRVYFLKGGYETFYSQYPECCVDVKPTSQEKIEGERSLLSQCGKPVLSVAYRPAYDQGGPVEILPFLYLGSAYHASKCEFLANLHITALLNVSRRTSEACTTHLHYKWIPVEDSHTADISSHFQEAIDFIDCVREEGGKVLVHCEAGVSRSPTICMAYLMKTKQFRLKEAFDYVKQRRSVVSPNFGFMGQLLQYESEILPSTPTLQPPSCQGEAASSTFIGHLQTLSPDMQGTYCTFRTSVLAPVPTHSTVPELHRSPVATATSC

Target ORF information:

RefSeq Version	NM_001085390.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus dual specificity phosphatase 5 (Dusp5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001085390.2

ORF Insert Sequence:

ATGAAGGTCA CGTCGCTCGA CGGGCGCCAG CTGCGCAAGA TGCTCCGCAA GGAGGCGGAG 
GCGCGCTGCG TGGTGCTCGA CTGCCGGCCC TACCTGGCCT TCGCCGCGTC GAGCGTGCGC 
GGCTCGCTCA ACGTCAACCT CAACTCGGTG GTGCTGCGGC GGGCCCGGGG CGGCGCGGTG 
TCGGCGCGCT ACGTGCTGCC CGACGAGGCG GCCCGCGCTC GGCTGCTGCA GGAGGGCGGC 
GGCGGTGTGG CGGCGGTGGT CGTGCTGGAC CAGGGTAGCC GCCACTGGCA GAAGCTGCGG 
GAGGAGAGCG CCGCGCGCGT CGTGCTCACC TCGCTGCTGG CCTGCCTGCC CGCCGGCCCG 
CGGGTCTACT TCCTTAAAGG GGGGTATGAG ACCTTCTACT CACAGTATCC TGAGTGCTGT 
GTGGATGTGA AGCCCACCTC ACAAGAGAAG ATCGAAGGCG AGAGAAGCCT CCTCAGCCAG 
TGTGGAAAGC CCGTTCTCAG CGTCGCCTAC AGACCAGCCT ATGACCAGGG TGGCCCGGTT 
GAAATCCTTC CCTTCCTCTA CCTTGGAAGT GCCTACCACG CATCCAAGTG CGAGTTCCTC 
GCCAACCTGC ACATCACAGC CCTGCTGAAT GTTTCCCGCC GGACCTCCGA GGCCTGCACC 
ACCCACCTAC ACTACAAGTG GATCCCCGTG GAGGACAGCC ACACTGCTGA CATTAGCTCC 
CACTTTCAAG AAGCAATAGA TTTTATTGAC TGTGTCAGGG AAGAAGGAGG CAAGGTCCTG 
GTCCACTGCG AAGCTGGGGT TTCCCGGTCG CCCACCATCT GCATGGCTTA CCTCATGAAG 
ACCAAGCAGT TCCGGCTGAA GGAGGCCTTC GATTACGTCA AGCAGAGGAG GAGCGTGGTC 
TCTCCCAACT TTGGCTTCAT GGGACAGCTC CTTCAGTATG AATCTGAGAT CCTGCCCTCC 
ACACCCACCC TCCAGCCGCC CTCCTGCCAA GGGGAGGCAG CCAGCTCCAC GTTTATAGGC 
CATTTACAGA CACTGAGCCC TGATATGCAG GGCACCTACT GCACATTCCG TACCTCAGTG 
CTGGCACCGG TGCCCACCCA CTCCACAGTC CCAGAGCTCC ACAGGAGCCC CGTGGCCACA 
GCCACATCCT GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

DUSP5 functions as a feedback regulator of TNF?-induced ERK1/2 dephosphorylation and inflammatory gene expression in adipocytes.
Scientific reports7(1)12879(2017 Oct)
Habibian JS,Jefic M,Bagchi RA,Lane RH,McKnight RA,McKinsey TA,Morrison RF,Ferguson BS

Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling.
Proceedings of the National Academy of Sciences of the United States of America114(3)E317-E326(2017 Jan)
Kidger AM,Rushworth LK,Stellzig J,Davidson J,Bryant CJ,Bayley C,Caddye E,Rogers T,Keyse SM,Caunt CJ

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Dusp5 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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