OAZ3 cDNA ORF clone, Macaca mulatta(Rhesus monkey)

Gene
Clones
gRNAs

Summary

Gene Symbol	OAZ3
Entrez Gene ID	711313
Full Name	ornithine decarboxylase antizyme 3
Gene Type	protein-coding
Organism	Macaca mulatta(Rhesus monkey)
Summary	The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake, however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies in mice showed that homozygous mutant male mice were infertile, and indicated the likely role of this antizyme in the formation of a rigid connection between the sperm head and tail during spermatogenesis. This transcript initiates translation from a non-AUG (CUG) start codon that is highly conserved amongst the antizyme 3 orthologs. [provided by RefSeq, Aug 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001128630.1	NP_001122102.1	ornithine decarboxylase antizyme 3

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	OAZ3	NP_001166042.1
	OAZ3	NP_001122102.1
Canis lupus familiaris (dog)	OAZ3	NP_001128423.1
Mus musculus (house mouse)	Oaz3	NP_058597.2
Homo sapiens (human)	OAZ3	NP_057262.2
Bos taurus (cattle)	OAZ3	NP_001166179.1
Rattus norvegicus (Norway rat)	Oaz3	NP_001094488.1

Gene Ontology
Bibliography

Related articles in PubMed

A new rhesus macaque assembly and annotation for next-generation sequencing analyses.
Zimin AV, Cornish AS, Maudhoo MD, Gibbs RM, Zhang X, Pandey S, Meehan DT, Wipfler K, Bosinger SE, Johnson ZP, Tharp GK, Mar?ais G, Roberts M, Ferguson B, Fox HS, Treangen T, Salzberg SL, Yorke JA, Norgren RB Jr
Biology direct9(1)20(2014 Oct)

Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation.
Ivanov IP, Atkins JF
Nucleic acids research35(6)1842-58(2007)

Polyamines in spermiogenesis: not now, darling.
Coffino P
Proceedings of the National Academy of Sciences of the United States of America97(9)4421-3(2000 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following OAZ3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OAZ3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMb57571	NM_001128630.1 Latest version!	Macaca mulatta ornithine decarboxylase antizyme 3 (OAZ3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$174.30 $249.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OAZ3 ( NM_001128630.1 ) cDNA ORF clone, Macaca mulatta(Rhesus monkey) -> NP_001122102.1 Macaca mulatta ornithine decarboxylase antizyme 3 (OAZ3), mRNA.

Price & Availability↑

CloneID	OMb57571
Clone ID Related Accession (Same CDS sequence)	NM_001128630.1
Accession Version	NM_001128630.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 708bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-11
Organism	Macaca mulatta(Rhesus monkey)
Product	ornithine decarboxylase antizyme 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from QNVO02000011.1. On Jun 22, 2008 this sequence version replaced XR_013611.1. Sequence Note: This RefSeq record was created using reference genomic sequence. The genomic coordinates used for the transcript were based on alignment to the orthologous human transcript. The encoded protein is highly conserved in many organisms, including human, mouse and rat. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA4688315, SAMEA4688318 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: inferred from conservation ribosomal slippage :: inferred from conservation ##RefSeq-Attributes-END##

CTGCCTTGTA ACAGGTGTCG CCCCTCTGTC TACTCCCTTT CTTATATCAA GAGGGGAAAA 
ACACGTAACT ACCTCTACCC GATCTGGTCA CCATACGCCT ATTACCTTTA CTGTTACAAG 
TACCGGATCA CCCTCCGGGA GAAGATGCTG CCTCGTTGTT ATAAAAGCAT CACTTATAAG 
GAAGAGGAGG ACTTGACACT CCAGCCCCGT TCCTGCCTCC AGTGCTCCGA GTCCCTAGTA 
GGCCTCCAGG TGGGCAAAAG CACCGAGCAG GGTAACCACG ACCAGCTTAA AGAACTGTAT 
TCGGCTGGGA ACTTGACGGT GCTAGCTACT GATCCCCTGC TCCACCAGGA CCCAGTACAG 
TTAGACTTTC ACTTCCGCCT CACCCCCCAA ACCTCCGCCC ATTGGCACGG CCTTCTCTGT 
GACCGTCGAC TCTTCCTGGA TATCCCATAT CGGGCCTTGG ATCAAGGCAA CCGGGAAAGT 
TTGACTGCAA CGCTGGAGTA CGTGGAAGAG AAGACAAATG TGGACTCCGT GTTTGTGAAC 
TTCCAGAATG ATCGGAACGA CAGAGGTGCC CTGCTGCGGG CCTTCAGCTA CATGGGCTTT 
GAGGTGGTCA GACCAGGTCA CCCTGCCCTC CCTCCCTGGG ACAATGTCAT CTTTATGGTG 
TATCCCCTTG AAAGGGATGT TGGCCACCTG CCCAGTGAGC CTCCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001122102.1
CDS	join(68..295,297..776)
Translation	LPCNRCRPSVYSLSYIKRGKTRNYLYPIWSPYAYYLYCYKYRITLREKMLPRCYKSITYKEEEDLTLQPRSCLQCSESLVGLQVGKSTEQGNHDQLKELYSAGNLTVLATDPLLHQDPVQLDFHFRLTPQTSAHWHGLLCDRRLFLDIPYRALDQGNRESLTATLEYVEEKTNVDSVFVNFQNDRNDRGALLRAFSYMGFEVVRPGHPALPPWDNVIFMVYPLERDVGHLPSEPP

Target ORF information:

RefSeq Version	NM_001128630.1
Organism	Macaca mulatta(Rhesus monkey)
Definition	Macaca mulatta ornithine decarboxylase antizyme 3 (OAZ3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001128630.1

ORF Insert Sequence:

CTGCCTTGTA ACAGGTGTCG CCCCTCTGTC TACTCCCTTT CTTATATCAA GAGGGGAAAA 
ACACGTAACT ACCTCTACCC GATCTGGTCA CCATACGCCT ATTACCTTTA CTGTTACAAG 
TACCGGATCA CCCTCCGGGA GAAGATGCTG CCTCGTTGTT ATAAAAGCAT CACTTATAAG 
GAAGAGGAGG ACTTGACACT CCAGCCCCGT TCCTGCCTCC AGTGCTCCGA GTCCCTAGTA 
GGCCTCCAGG TGGGCAAAAG CACCGAGCAG GGTAACCACG ACCAGCTTAA AGAACTGTAT 
TCGGCTGGGA ACTTGACGGT GCTAGCTACT GATCCCCTGC TCCACCAGGA CCCAGTACAG 
TTAGACTTTC ACTTCCGCCT CACCCCCCAA ACCTCCGCCC ATTGGCACGG CCTTCTCTGT 
GACCGTCGAC TCTTCCTGGA TATCCCATAT CGGGCCTTGG ATCAAGGCAA CCGGGAAAGT 
TTGACTGCAA CGCTGGAGTA CGTGGAAGAG AAGACAAATG TGGACTCCGT GTTTGTGAAC 
TTCCAGAATG ATCGGAACGA CAGAGGTGCC CTGCTGCGGG CCTTCAGCTA CATGGGCTTT 
GAGGTGGTCA GACCAGGTCA CCCTGCCCTC CCTCCCTGGG ACAATGTCAT CTTTATGGTG 
TATCCCCTTG AAAGGGATGT TGGCCACCTG CCCAGTGAGC CTCCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A new rhesus macaque assembly and annotation for next-generation sequencing analyses.
Biology direct9(1)20(2014 Oct)
Zimin AV,Cornish AS,Maudhoo MD,Gibbs RM,Zhang X,Pandey S,Meehan DT,Wipfler K,Bosinger SE,Johnson ZP,Tharp GK,Mar?ais G,Roberts M,Ferguson B,Fox HS,Treangen T,Salzberg SL,Yorke JA,Norgren RB Jr

Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation.
Nucleic acids research35(6)1842-58(2007)
Ivanov IP,Atkins JF

Polyamines in spermiogenesis: not now, darling.
Proceedings of the National Academy of Sciences of the United States of America97(9)4421-3(2000 Apr)
Coffino P

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OAZ3 cDNA ORF clone, Macaca mulatta(Rhesus monkey)

Gene

Clones

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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