OAZ3 cDNA ORF clone, Canis lupus familiaris(dog)

Gene
Clones
gRNAs

Summary

Gene Symbol	OAZ3
Entrez Gene ID	475850
Full Name	ornithine decarboxylase antizyme 3
General protein information	Preferred Names ornithine decarboxylase antizyme 3 Names ornithine decarboxylase antizyme 3
Gene Type	protein-coding
Organism	Canis lupus familiaris(dog)
Summary	The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake, however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies in mice showed that homozygous mutant male mice were infertile, and indicated the likely role of this antizyme in the formation of a rigid connection between the sperm head and tail during spermatogenesis. This transcript initiates translation from a non-AUG (CUG) start codon that is highly conserved amongst the antizyme 3 orthologs. [provided by RefSeq, Aug 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001134951.2	NP_001128423.1	ornithine decarboxylase antizyme 3

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	OAZ3	NP_001166042.1
	OAZ3	NP_001122102.1
Canis lupus familiaris (dog)	OAZ3	NP_001128423.1
Mus musculus (house mouse)	Oaz3	NP_058597.2
Homo sapiens (human)	OAZ3	NP_057262.2
Bos taurus (cattle)	OAZ3	NP_001166179.1
Rattus norvegicus (Norway rat)	Oaz3	NP_001094488.1

Gene Ontology
Bibliography

Related articles in PubMed

Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation.
Ivanov IP, Atkins JF
Nucleic acids research35(6)1842-58(2007)

Polyamines in spermiogenesis: not now, darling.
Coffino P
Proceedings of the National Academy of Sciences of the United States of America97(9)4421-3(2000 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following OAZ3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OAZ3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OCe173668	NM_001134951.2 Latest version!	Canis lupus familiaris ornithine decarboxylase antizyme 3 (OAZ3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$174.30 $249.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OAZ3 ( NM_001134951.2 ) cDNA ORF clone, Canis lupus familiaris(dog) -> NP_001128423.1 Canis lupus familiaris ornithine decarboxylase antizyme 3 (OAZ3), mRNA.

Price & Availability↑

CloneID	OCe173668
Clone ID Related Accession (Same CDS sequence)	NM_001134951.2
Accession Version	NM_001134951.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 705bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-22
Organism	Canis lupus familiaris(dog)
Product	ornithine decarboxylase antizyme 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CX987856.1, CX991103.1 and CO609802.1. On Aug 16, 2014 this sequence version replaced NM_001134951.1. ##Evidence-Data-START## Transcript exon combination :: CX991103.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103936001, SAMEA103936002 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: inferred from conservation ribosomal slippage :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

CTGCCTTGTT ACAGGTCACG CCCCTCTGCC TTCTCCCTTT CTTACATCAA GAGGGGAAAA 
ACACGGAACT ACCTCTACCC GATCTGGTCA CCATACGCCT ATTACCTTTA CTGCTACAAA 
TACCGGATCA CCCTCCGGGA GAAGATGCTG CCTTGTTATA AAAGCATCAC TTATAAGGAA 
CGGGAGGACT TGACACTCCG GCCCCGTTCC TGCCTTCAGT GCTCCGAGTC CCTAGCAGGC 
CTTCAGGTGG TCAGAAGCAC TGAGCAGGGT GATCACAACC AGTTTAAAGA ATTATACTCG 
GTTGGGAAGC TGACGGTGCT GGCTACTGAC CCTCTGCTCC ACCAGGACCC AGTGCAGTTA 
GACTTCCATT TCCGCCTCAC CCCCCAGACC TCTACCCATT GGCACGGTCT TCTCTGTGAC 
CATCGACTCT TCCTGGATAT TCCATATCGG GCCTTGGATC AAGGCAACCG GGAAAGTTTG 
ACTGCAACAC TGGAGTATGT GGAGGAGAAG ACCAACGTGG ACTCCGTGTT TGTAAACTTC 
CAAAACAACC GGAATGACAG AGGTGCCCTG CTACGGGCTT TCAGCTACAT GGGGTTTGAG 
TTGGTCAGAC CAGATCACCC TGCCCTCCCT CCCTGGGACA ATGTCATCTT TATGGTGTAT 
CCCCTTGAAA GGGACCTTGG CCACCTGCCC AGTGAGCCTC CTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001128423.1
CDS	join(17..241,243..722)
Translation	LPCYRSRPSAFSLSYIKRGKTRNYLYPIWSPYAYYLYCYKYRITLREKMLPCYKSITYKEREDLTLRPRSCLQCSESLAGLQVVRSTEQGDHNQFKELYSVGKLTVLATDPLLHQDPVQLDFHFRLTPQTSTHWHGLLCDHRLFLDIPYRALDQGNRESLTATLEYVEEKTNVDSVFVNFQNNRNDRGALLRAFSYMGFELVRPDHPALPPWDNVIFMVYPLERDLGHLPSEPP

Target ORF information:

RefSeq Version	NM_001134951.2
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris ornithine decarboxylase antizyme 3 (OAZ3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001134951.2

ORF Insert Sequence:

CTGCCTTGTT ACAGGTCACG CCCCTCTGCC TTCTCCCTTT CTTACATCAA GAGGGGAAAA 
ACACGGAACT ACCTCTACCC GATCTGGTCA CCATACGCCT ATTACCTTTA CTGCTACAAA 
TACCGGATCA CCCTCCGGGA GAAGATGCTG CCTTGTTATA AAAGCATCAC TTATAAGGAA 
CGGGAGGACT TGACACTCCG GCCCCGTTCC TGCCTTCAGT GCTCCGAGTC CCTAGCAGGC 
CTTCAGGTGG TCAGAAGCAC TGAGCAGGGT GATCACAACC AGTTTAAAGA ATTATACTCG 
GTTGGGAAGC TGACGGTGCT GGCTACTGAC CCTCTGCTCC ACCAGGACCC AGTGCAGTTA 
GACTTCCATT TCCGCCTCAC CCCCCAGACC TCTACCCATT GGCACGGTCT TCTCTGTGAC 
CATCGACTCT TCCTGGATAT TCCATATCGG GCCTTGGATC AAGGCAACCG GGAAAGTTTG 
ACTGCAACAC TGGAGTATGT GGAGGAGAAG ACCAACGTGG ACTCCGTGTT TGTAAACTTC 
CAAAACAACC GGAATGACAG AGGTGCCCTG CTACGGGCTT TCAGCTACAT GGGGTTTGAG 
TTGGTCAGAC CAGATCACCC TGCCCTCCCT CCCTGGGACA ATGTCATCTT TATGGTGTAT 
CCCCTTGAAA GGGACCTTGG CCACCTGCCC AGTGAGCCTC CTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation.
Nucleic acids research35(6)1842-58(2007)
Ivanov IP,Atkins JF

Polyamines in spermiogenesis: not now, darling.
Proceedings of the National Academy of Sciences of the United States of America97(9)4421-3(2000 Apr)
Coffino P

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OAZ3 cDNA ORF clone, Canis lupus familiaris(dog)

Gene

Clones

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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