Esco2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Esco2
Entrez Gene ID	71988
Full Name	establishment of sister chromatid cohesion N-acetyltransferase 2
Synonyms	2410004I17Rik,D030072L07Rik
General protein information	Preferred Names establishment of sister chromatid cohesion N-acetyltransferase 2 Names N-acetyltransferase ESCO2 ECO1 homolog 2 establishment of cohesion 1 homolog 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 14 Map Location: 14\|14 D1

mRNA and Protein(s)

mRNA	Protein	Name
NM_028039.2	NP_082315.3	N-acetyltransferase ESCO2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ESCO2	XP_528296.2
Canis lupus familiaris (dog)	ESCO2	XP_543224.2
Mus musculus (house mouse)	Esco2	NP_082315.3
Rattus norvegicus (Norway rat)	Esco2	XP_006252234.1
Oryza sativa (rice)	Os04g0498900	NP_001053216.2
Xenopus tropicalis (tropical clawed frog)	esco2	NP_001121462.1
Homo sapiens (human)	ESCO2	NP_001017420.1
Bos taurus (cattle)	ESCO2	NP_001094652.1
Oryza sativa (rice)	Os05g0376300	NP_001055381.1
Gallus gallus (chicken)	ESCO2	XP_420012.3
Danio rerio (zebrafish)	esco2	NP_001003872.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011742	XP_320770.4
Arabidopsis thaliana (thale cress)	CTF7	NP_194868.2

Gene Ontology
Bibliography

Related articles in PubMed

ESCO2 knockdown inhibits cell proliferation and induces apoptosis in human gastric cancer cells.
Chen H, Zhang L, He W, Liu T, Zhao Y, Chen H, Li Y
Biochemical and biophysical research communications(2018 Jan)

BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions.
Fard MK, van der Meer F, S?nchez P, Cantuti-Castelvetri L, Mandad S, J?kel S, Fornasiero EF, Schmitt S, Ehrlich M, Starost L, Kuhlmann T, Sergiou C, Schultz V, Wrzos C, Br?ck W, Urlaub H, Dimou L, Stadelmann C, Simons M
Science translational medicine9(419)(2017 Dec)

Cohesin acetyltransferase Esco2 regulates SAC and kinetochore functions via maintaining H4K16 acetylation during mouse oocyte meiosis.
Lu Y, Dai X, Zhang M, Miao Y, Zhou C, Cui Z, Xiong B
Nucleic acids research45(16)9388-9397(2017 Sep)

Decrease in newly generated oligodendrocytes leads to motor dysfunctions and changed myelin structures that can be rescued by transplanted cells.
Schneider S, Gruart A, Grade S, Zhang Y, Kr?ger S, Kirchhoff F, Eichele G, Delgado Garc?a JM, Dimou L
Glia64(12)2201-2218(2016 Dec)

Adult NG2-Glia Are Required for Median Eminence-Mediated Leptin Sensing and Body Weight Control.
Djogo T, Robins SC, Schneider S, Kryzskaya D, Liu X, Mingay A, Gillon CJ, Kim JH, Storch KF, Boehm U, Bourque CW, Stroh T, Dimou L, Kokoeva MV
Cell metabolism23(5)797-810(2016 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the involvement of Esco2 in spindle assembly checkpoint and kinetochore functions is mediated by its binding to histone H4 and acetylation of H4K16 both in vivo and in vitro
Title: Cohesin acetyltransferase Esco2 regulates SAC and kinetochore functions via maintaining H4K16 acetylation during mouse oocyte meiosis.

ESCO2 may play a vital role in meiosis in both males and females.
Title: Localization and regulation of murine Esco2 during male and female meiosis.

To Roberts syndrome(RBS), mouse Esco2 turns out to be a cell viability factor, the absence of which results in severe chromosome segregation defects and apoptosis.
Title: The non-redundant function of cohesin acetyltransferase Esco2: some answers and new questions.

Esco2 is needed for cohesin acetylation in PCH and that this modification is required for the proper distribution of cohesin on mitotic chromosomes and for centromeric cohesion
Title: Cohesin acetyltransferase Esco2 is a cell viability factor and is required for cohesion in pericentric heterochromatin.

Esco2 promotes neuronal differentiation by repressing Notch signaling.
Title: Esco2 promotes neuronal differentiation by repressing Notch signaling.

The following Esco2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Esco2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu22509	NM_028039.2 Latest version!	Mus musculus establishment of sister chromatid cohesion N-acetyltransferase 2 (Esco2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$349.30 $499.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Esco2 ( NM_028039.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_082315.3 Mus musculus establishment of sister chromatid cohesion N-acetyltransferase 2 (Esco2), mRNA.

Price & Availability↑

CloneID	OMu22509
Clone ID Related Accession (Same CDS sequence)	NM_028039.2
Accession Version	NM_028039.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1779bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-10
Organism	Mus musculus(house mouse)
Product	N-acetyltransferase ESCO2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY029949.1, CF168369.1, CF730483.1, AA189671.1, AK010391.1, AA881675.1 and AV216701.1. On Mar 27, 2008 this sequence version replaced NM_028039.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK144685.1, BC071275.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134, SAMN01164142 [ECO:0000348] ##Evidence-Data-END##

ATGATGGCAA CTTGTACTCC AAGAAAGAGG AAGCGATATA CACTGAATGC TGATAATGAT 
GATAGCCTAT TAACAGATAT TTCATCAAGC AAATTAAGAT GTGCTGAAAA TCTATTTCCA 
TCACCTAATA AGAAACATAA TTATCAAAGC AGTGTTCAAA AGGAAGACAA GTCTTGCTCC 
CACCAACTCC ATTTCCCTTC AAGTCCACTC AAAACAACTG AAAATAGTAG GTTTTCATTT 
GCAAACCACA GCTCATTATT TAAACCAGCT ATGTCTACTG TATCTTTCTA CAGTAAAGAG 
AAATACTACC TCAATCCACT CGAGAGGAAG TTGATAAGAG AGTGTAGATC TATTTGTCTA 
GCAACTGAAA GTGGAGATAA ACCTATTCCC AGTGTGACAG AAAATATTCA GAGAAAACCA 
GTCTGTACCA AGAAGAATAA AAAAAAACAG AAGAGTTTAA CTGCCAAATA TCAACCAAAT 
TATAAGCACA TCAAGTCTAA ATCAAGAAAC CTGAAAAATT CCAAGCCAAA TCAAGTGACC 
TATAAGCCAG TTGTGGACCA AGAGAACAGT TGTTTTCCAG CAAAAAATTA TCCAAATTCT 
CCTCCTCGGG TTCTGAGCCA AAAAATAAAG CCTCAAGTTA CACTCCAAGG CGGAGCAGCA 
TTTTTCGTTA GGAAAAGAAA CTCTCTTAAA AAGTTACCTC TGGAAGATAA GCCCTTACTT 
TTGCAGAAAA ATTTACCAGA AGTCCCTGAA GGTGCTCCAG AGGCAAAGCA AATACCAAAG 
TCCTTGCTAG TGGATGAGAA ATCCAGTGTT AAAGTACAGA ATGCAAGAAG TAAAAATGAA 
GAGAAACTGA GAAAGAATCC CTCAGGTGCA GTAGTTTCTT CAAAGGAATG TAACCTTGAT 
AAACATGATT TTCCTTCAGA GAATTCACTT GATGAGAACA AGACAATTTC CCCAGAGTCT 
GTCTATCCCA TCTTCAATGT TTCTTCAGTG AACACAAAAA GACCTGAAGA ACAGTCTTCT 
GTGGGATCCA CTGCATGTAC TAACTTCTTG AAACAGACAA ATGTACCGAA AAATATTAAT 
TCCAGAGATA CAAATAAAGG AGGAAAAGAC CAGCTCGTCA TTGACGCAGG TCAGAAACAT 
TTTGGGACGA CTGTGTGTAA GTCTTGTGGC ATGATCTATA CTGCTTCCAA CCCTGAAGAC 
GAAATACAAC ATCTCCAACA TCACCACCGA TTTCTGGAAG GAATTAAATT CGTGGGCTGG 
AAAAGAGAAC GGGTAGTAGC AGAGTTTTGG GATGGGAAGA TTGTGTTGGT CCTGCCACGT 
GATCCAAGTT ATGCCATCAA AAAGGTAGAA GATGTCCAAG AACTTGTGGA TCTGGAATTA 
GGTTTCCAGC AGACTGTTCC CGTGTGTCCA GACAAAACCA AAACCTTCCT CTTTATTGAT 
GAGAAGAGAG TAGTTGGATG TTTAATTGCA GAACCCATCA AACAGGCCTT TCGGGTCCTG 
TCAGAACCAA GTGCCAGTAA AGAATGTTCT AGAGCTTGGC GGTGTTCAGA TGTACCAGAA 
CCTGCAATTT GTGGAATAAG TAGAATCTGG GTCTTCAGAC TAAAAAGAAG GAAGCGCATT 
GCAAGACGAC TGGTTGACAC TGTCAGGAAT TGCTTCATGT TTGGCTGTTT CCTCAGCACT 
AATGAAATTG CATTTTCTGA CCCAACACCA GATGGCAAAT TATTTGCAAC CAAGTACTGC 
AACACCCCAA ATTTCCTTGT ATATAATTTT CATAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_082315.3
CDS	182..1960
Translation	MMATCTPRKRKRYTLNADNDDSLLTDISSSKLRCAENLFPSPNKKHNYQSSVQKEDKSCSHQLHFPSSPLKTTENSRFSFANHSSLFKPAMSTVSFYSKEKYYLNPLERKLIRECRSICLATESGDKPIPSVTENIQRKPVCTKKNKKKQKSLTAKYQPNYKHIKSKSRNLKNSKPNQVTYKPVVDQENSCFPAKNYPNSPPRVLSQKIKPQVTLQGGAAFFVRKRNSLKKLPLEDKPLLLQKNLPEVPEGAPEAKQIPKSLLVDEKSSVKVQNARSKNEEKLRKNPSGAVVSSKECNLDKHDFPSENSLDENKTISPESVYPIFNVSSVNTKRPEEQSSVGSTACTNFLKQTNVPKNINSRDTNKGGKDQLVIDAGQKHFGTTVCKSCGMIYTASNPEDEIQHLQHHHRFLEGIKFVGWKRERVVAEFWDGKIVLVLPRDPSYAIKKVEDVQELVDLELGFQQTVPVCPDKTKTFLFIDEKRVVGCLIAEPIKQAFRVLSEPSASKECSRAWRCSDVPEPAICGISRIWVFRLKRRKRIARRLVDTVRNCFMFGCFLSTNEIAFSDPTPDGKLFATKYCNTPNFLVYNFHN

Target ORF information:

RefSeq Version	NM_028039.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus establishment of sister chromatid cohesion N-acetyltransferase 2 (Esco2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_028039.2

ORF Insert Sequence:

ATGATGGCAA CTTGTACTCC AAGAAAGAGG AAGCGATATA CACTGAATGC TGATAATGAT 
GATAGCCTAT TAACAGATAT TTCATCAAGC AAATTAAGAT GTGCTGAAAA TCTATTTCCA 
TCACCTAATA AGAAACATAA TTATCAAAGC AGTGTTCAAA AGGAAGACAA GTCTTGCTCC 
CACCAACTCC ATTTCCCTTC AAGTCCACTC AAAACAACTG AAAATAGTAG GTTTTCATTT 
GCAAACCACA GCTCATTATT TAAACCAGCT ATGTCTACTG TATCTTTCTA CAGTAAAGAG 
AAATACTACC TCAATCCACT CGAGAGGAAG TTGATAAGAG AGTGTAGATC TATTTGTCTA 
GCAACTGAAA GTGGAGATAA ACCTATTCCC AGTGTGACAG AAAATATTCA GAGAAAACCA 
GTCTGTACCA AGAAGAATAA AAAAAAACAG AAGAGTTTAA CTGCCAAATA TCAACCAAAT 
TATAAGCACA TCAAGTCTAA ATCAAGAAAC CTGAAAAATT CCAAGCCAAA TCAAGTGACC 
TATAAGCCAG TTGTGGACCA AGAGAACAGT TGTTTTCCAG CAAAAAATTA TCCAAATTCT 
CCTCCTCGGG TTCTGAGCCA AAAAATAAAG CCTCAAGTTA CACTCCAAGG CGGAGCAGCA 
TTTTTCGTTA GGAAAAGAAA CTCTCTTAAA AAGTTACCTC TGGAAGATAA GCCCTTACTT 
TTGCAGAAAA ATTTACCAGA AGTCCCTGAA GGTGCTCCAG AGGCAAAGCA AATACCAAAG 
TCCTTGCTAG TGGATGAGAA ATCCAGTGTT AAAGTACAGA ATGCAAGAAG TAAAAATGAA 
GAGAAACTGA GAAAGAATCC CTCAGGTGCA GTAGTTTCTT CAAAGGAATG TAACCTTGAT 
AAACATGATT TTCCTTCAGA GAATTCACTT GATGAGAACA AGACAATTTC CCCAGAGTCT 
GTCTATCCCA TCTTCAATGT TTCTTCAGTG AACACAAAAA GACCTGAAGA ACAGTCTTCT 
GTGGGATCCA CTGCATGTAC TAACTTCTTG AAACAGACAA ATGTACCGAA AAATATTAAT 
TCCAGAGATA CAAATAAAGG AGGAAAAGAC CAGCTCGTCA TTGACGCAGG TCAGAAACAT 
TTTGGGACGA CTGTGTGTAA GTCTTGTGGC ATGATCTATA CTGCTTCCAA CCCTGAAGAC 
GAAATACAAC ATCTCCAACA TCACCACCGA TTTCTGGAAG GAATTAAATT CGTGGGCTGG 
AAAAGAGAAC GGGTAGTAGC AGAGTTTTGG GATGGGAAGA TTGTGTTGGT CCTGCCACGT 
GATCCAAGTT ATGCCATCAA AAAGGTAGAA GATGTCCAAG AACTTGTGGA TCTGGAATTA 
GGTTTCCAGC AGACTGTTCC CGTGTGTCCA GACAAAACCA AAACCTTCCT CTTTATTGAT 
GAGAAGAGAG TAGTTGGATG TTTAATTGCA GAACCCATCA AACAGGCCTT TCGGGTCCTG 
TCAGAACCAA GTGCCAGTAA AGAATGTTCT AGAGCTTGGC GGTGTTCAGA TGTACCAGAA 
CCTGCAATTT GTGGAATAAG TAGAATCTGG GTCTTCAGAC TAAAAAGAAG GAAGCGCATT 
GCAAGACGAC TGGTTGACAC TGTCAGGAAT TGCTTCATGT TTGGCTGTTT CCTCAGCACT 
AATGAAATTG CATTTTCTGA CCCAACACCA GATGGCAAAT TATTTGCAAC CAAGTACTGC 
AACACCCCAA ATTTCCTTGT ATATAATTTT CATAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ESCO2 knockdown inhibits cell proliferation and induces apoptosis in human gastric cancer cells.
Biochemical and biophysical research communications(2018 Jan)
Chen H,Zhang L,He W,Liu T,Zhao Y,Chen H,Li Y

BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions.
Science translational medicine9(419)(2017 Dec)
Fard MK,van der Meer F,S?nchez P,Cantuti-Castelvetri L,Mandad S,J?kel S,Fornasiero EF,Schmitt S,Ehrlich M,Starost L,Kuhlmann T,Sergiou C,Schultz V,Wrzos C,Br?ck W,Urlaub H,Dimou L,Stadelmann C,Simons M

Cohesin acetyltransferase Esco2 regulates SAC and kinetochore functions via maintaining H4K16 acetylation during mouse oocyte meiosis.
Nucleic acids research45(16)9388-9397(2017 Sep)
Lu Y,Dai X,Zhang M,Miao Y,Zhou C,Cui Z,Xiong B

Decrease in newly generated oligodendrocytes leads to motor dysfunctions and changed myelin structures that can be rescued by transplanted cells.
Glia64(12)2201-2218(2016 Dec)
Schneider S,Gruart A,Grade S,Zhang Y,Kr?ger S,Kirchhoff F,Eichele G,Delgado Garc?a JM,Dimou L

Adult NG2-Glia Are Required for Median Eminence-Mediated Leptin Sensing and Body Weight Control.
Cell metabolism23(5)797-810(2016 May)
Djogo T,Robins SC,Schneider S,Kryzskaya D,Liu X,Mingay A,Gillon CJ,Kim JH,Storch KF,Boehm U,Bourque CW,Stroh T,Dimou L,Kokoeva MV

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Esco2 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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