Pak1ip1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pak1ip1
Entrez Gene ID	68083
Full Name	PAK1 interacting protein 1
Synonyms	5830431I15Rik,5930415H02Rik,AA419825,AI314040,AW556169,Gdpd1,PIP1
General protein information	Preferred Names PAK1 interacting protein 1 Names p21-activated protein kinase-interacting protein 1 glycerophosphodiester phosphodiesterase domain containing 1 putative PAK inhibitor Skb15
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 13 Map Location: 13\|13 A3.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_026550.3	NP_080826.2	p21-activated protein kinase-interacting protein 1

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	CG9123	NP_573018.1
Kluyveromyces lactis	KLLA0E07965g	XP_454309.1
Eremothecium gossypii	AGOS_ACR166W	NP_983568.2
Arabidopsis thaliana (thale cress)	AT1G65030	NP_176683.1
Xenopus tropicalis (tropical clawed frog)	pak1ip1	NP_001017054.2
	PAK1IP1	XP_001087458.1
Bos taurus (cattle)	PAK1IP1	NP_001014852.1
Mus musculus (house mouse)	Pak1ip1	NP_080826.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001149	XP_322011.5
Oryza sativa (rice)	Os12g0615900	NP_001067278.1
Homo sapiens (human)	PAK1IP1	NP_060376.2
Rattus norvegicus (Norway rat)	Pak1ip1	NP_001032433.1
Drosophila melanogaster (fruit fly)	CG12608	NP_573019.1
Neurospora crassa	NCU07864	XP_963125.1
Pan troglodytes (chimpanzee)	PAK1IP1	XP_518863.3
Canis lupus familiaris (dog)	PAK1IP1	XP_535884.1
Gallus gallus (chicken)	PAK1IP1	NP_001026170.1
Danio rerio (zebrafish)	pak1ip1	NP_957239.2
Saccharomyces cerevisiae (baker's yeast)	MAK11	NP_012904.3
Magnaporthe oryzae (rice blast fungus)	MGG_06429	XP_003717138.1

Gene Ontology
Bibliography

Related articles in PubMed

A mutation in mouse Pak1ip1 causes orofacial clefting while human PAK1IP1 maps to 6p24 translocation breaking points associated with orofacial clefting.
Ross AP, Mansilla MA, Choe Y, Helminski S, Sturm R, Maute RL, May SR, Hozyasz KK, W?jcicki P, Mostowska A, Davidson B, Adamopoulos IE, Pleasure SJ, Murray JC, Zarbalis KS
PloS one8(7)e69333(2013)

Induction of vascular permeability: beta PIX and GIT1 scaffold the activation of extracellular signal-regulated kinase by PAK.
Stockton R, Reutershan J, Scott D, Sanders J, Ley K, Schwartz MA
Molecular biology of the cell18(6)2346-55(2007 Jun)

A global genomic transcriptional code associated with CNS-expressed genes.
Bailey PJ, Klos JM, Andersson E, Karl?n M, K?llstr?m M, Ponjavic J, Muhr J, Lenhard B, Sandelin A, Ericson J
Experimental cell research312(16)3108-19(2006 Oct)

Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia.
Carninci P, Waki K, Shiraki T, Konno H, Shibata K, Itoh M, Aizawa K, Arakawa T, Ishii Y, Sasaki D, Bono H, Kondo S, Sugahara Y, Saito R, Osato N, Fukuda S, Sato K, Watahiki A, Hirozane-Kishikawa T, Nakamura M, Shibata Y, Yasunishi A, Kikuchi N, Yoshiki A, Kusakabe M, Gustincich S, Beisel K, Pavan W, Aidinis V, Nakagawara A, Held WA, Iwata H, Kono T, Nakauchi H, Lyons P, Wells C, Hume DA, Fagiolini M, Hensch TK, Brinkmeier M, Camper S, Hirota J, Mombaerts P, Muramatsu M, Okazaki Y, Kawai J, Hayashizaki Y
Genome research13(6B)1273-89(2003 Jun)

Genetic and molecular characterization of Skb15, a highly conserved inhibitor of the fission yeast PAK, Shk1.
Kim HW, Yang P, Qyang Y, Lai H, Du H, Henkel JS, Kumar K, Bao S, Liu M, Marcus S
Molecular cell7(5)1095-101(2001 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A mutation in mouse Pak1ip1 causes orofacial clefting while human PAK1IP1 maps to 6p24 translocation breaking points associated with orofacial clefting.
Title: A mutation in mouse Pak1ip1 causes orofacial clefting while human PAK1IP1 maps to 6p24 translocation breaking points associated with orofacial clefting.

Results suggest that the PAK-PIX-GIT1 complex is critical for Erk-dependent myosin phosphorylation and vascular permeability.
Title: Induction of vascular permeability: beta PIX and GIT1 scaffold the activation of extracellular signal-regulated kinase by PAK.

The following Pak1ip1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pak1ip1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu14144	NM_026550.3 Latest version!	Mus musculus PAK1 interacting protein 1 (Pak1ip1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pak1ip1 ( NM_026550.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080826.2 Mus musculus PAK1 interacting protein 1 (Pak1ip1), mRNA.

Price & Availability↑

CloneID	OMu14144
Clone ID Related Accession (Same CDS sequence)	NM_026550.3
Accession Version	NM_026550.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1149bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	p21-activated protein kinase-interacting protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY055321.1, BY788898.1, AK150919.1 and AV225950.1. On Mar 11, 2009 this sequence version replaced NM_026550.2. ##Evidence-Data-START## Transcript exon combination :: AF386076.1, BC043461.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849376 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCTGG TCGCCGGCAG CTACGAGCAG GTCCTGTTTG GGTTCACGGT ACAGCGCGGG 
CCCGCGAAGA GTGGCCATCA GGAGACATGG ACTCCTGTGG CTGATTTCAC TCACCACTCG 
CACACTGCCT CCCTGTCGGT GCTGGCCTCC AACAGTCGCT ATGTAGTCTC TGGCAGCAAA 
GATGAGACGA TTCACATTTA TGACATGAAA AGGAAGGTGG AGCATGGGGC TCTGGTGCAT 
CACGCTGGCA CAGTAACTTG CCTGAAATTC CATGGCAACC AGCACTTAAT CAGTGGGGCA 
GAAGACGGCC ACATCTGCAT CTGGGATGTG AAGAGATGGA AGTGCCTGAA GACCTTTAAA 
GCTCACAGGG GACATGTCAC TTTCCTTTCT ATCCACCCGT CTGGCAAGTT GGCTCTGTCT 
GTTGGCACCG ATAAAACATT AAGAACATGG AATCTTATAG AGGGAAGATC AGCTTTCATA 
AAAAATATAA AGGAAAATGC TCACATAGTG GAGTGGTCCC CAAGTGGAGG GAAGTACATA 
GTTGTTGTGC AGAATAAAGT GGATGTCTAT CGGCTGGGCA CGGCGTCTGT GAGCGGCACC 
ATCACAAACG GAAAGAGGAT CTCTTCTGTT ACCTTTCTCT CAGACTCTGT CCTTGCAGTG 
GCTGGAGATG AAGAAGTTGT GAGGATTTTT GACTGTGATT CCCTAGAGTG CCTCTGTGAA 
TTCAGAGCTC ATGAGAACAG GGTAAAAGAC ATGGTCAGTT TTGAAGTCCC AGACCATCAC 
GTTCTTGTCA CAGCATCAAA TGATGGCTTC ATCAAAATGT GGACGCTTCC ACAGGATAAG 
AAAGTTCCTC CATCTTTGCT GTGTGAGGCC AAAACTGGTG CCAGGCTGAC ATGTCTTACT 
GTGTGGTTAG ACAGAGCAGC AAATGGAATG GCGAGCCTTC CTCCAGCAGC AGAGCCCTGC 
CCTGACCAAC CTAAGACAAT CGAAAAGGAA TCTGGTGACA CAGTTCAGGA AGAAACATCA 
GAACCTAACT CGGAGAAATC TGATGTAAGT GGTGACAGCA AGCAGCCAAC AAAAGGAAAT 
AGCCCAGTGA CAGCCAAGAA GAGGAAAATG GCAACCATGT CGGAAAAGAA GAGAAAGAAG 
AAAATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080826.2
CDS	321..1469
Translation	MELVAGSYEQVLFGFTVQRGPAKSGHQETWTPVADFTHHSHTASLSVLASNSRYVVSGSKDETIHIYDMKRKVEHGALVHHAGTVTCLKFHGNQHLISGAEDGHICIWDVKRWKCLKTFKAHRGHVTFLSIHPSGKLALSVGTDKTLRTWNLIEGRSAFIKNIKENAHIVEWSPSGGKYIVVVQNKVDVYRLGTASVSGTITNGKRISSVTFLSDSVLAVAGDEEVVRIFDCDSLECLCEFRAHENRVKDMVSFEVPDHHVLVTASNDGFIKMWTLPQDKKVPPSLLCEAKTGARLTCLTVWLDRAANGMASLPPAAEPCPDQPKTIEKESGDTVQEETSEPNSEKSDVSGDSKQPTKGNSPVTAKKRKMATMSEKKRKKKM

Target ORF information:

RefSeq Version	NM_026550.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus PAK1 interacting protein 1 (Pak1ip1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_026550.3

ORF Insert Sequence:

ATGGAGCTGG TCGCCGGCAG CTACGAGCAG GTCCTGTTTG GGTTCACGGT ACAGCGCGGG 
CCCGCGAAGA GTGGCCATCA GGAGACATGG ACTCCTGTGG CTGATTTCAC TCACCACTCG 
CACACTGCCT CCCTGTCGGT GCTGGCCTCC AACAGTCGCT ATGTAGTCTC TGGCAGCAAA 
GATGAGACGA TTCACATTTA TGACATGAAA AGGAAGGTGG AGCATGGGGC TCTGGTGCAT 
CACGCTGGCA CAGTAACTTG CCTGAAATTC CATGGCAACC AGCACTTAAT CAGTGGGGCA 
GAAGACGGCC ACATCTGCAT CTGGGATGTG AAGAGATGGA AGTGCCTGAA GACCTTTAAA 
GCTCACAGGG GACATGTCAC TTTCCTTTCT ATCCACCCGT CTGGCAAGTT GGCTCTGTCT 
GTTGGCACCG ATAAAACATT AAGAACATGG AATCTTATAG AGGGAAGATC AGCTTTCATA 
AAAAATATAA AGGAAAATGC TCACATAGTG GAGTGGTCCC CAAGTGGAGG GAAGTACATA 
GTTGTTGTGC AGAATAAAGT GGATGTCTAT CGGCTGGGCA CGGCGTCTGT GAGCGGCACC 
ATCACAAACG GAAAGAGGAT CTCTTCTGTT ACCTTTCTCT CAGACTCTGT CCTTGCAGTG 
GCTGGAGATG AAGAAGTTGT GAGGATTTTT GACTGTGATT CCCTAGAGTG CCTCTGTGAA 
TTCAGAGCTC ATGAGAACAG GGTAAAAGAC ATGGTCAGTT TTGAAGTCCC AGACCATCAC 
GTTCTTGTCA CAGCATCAAA TGATGGCTTC ATCAAAATGT GGACGCTTCC ACAGGATAAG 
AAAGTTCCTC CATCTTTGCT GTGTGAGGCC AAAACTGGTG CCAGGCTGAC ATGTCTTACT 
GTGTGGTTAG ACAGAGCAGC AAATGGAATG GCGAGCCTTC CTCCAGCAGC AGAGCCCTGC 
CCTGACCAAC CTAAGACAAT CGAAAAGGAA TCTGGTGACA CAGTTCAGGA AGAAACATCA 
GAACCTAACT CGGAGAAATC TGATGTAAGT GGTGACAGCA AGCAGCCAAC AAAAGGAAAT 
AGCCCAGTGA CAGCCAAGAA GAGGAAAATG GCAACCATGT CGGAAAAGAA GAGAAAGAAG 
AAAATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A mutation in mouse Pak1ip1 causes orofacial clefting while human PAK1IP1 maps to 6p24 translocation breaking points associated with orofacial clefting.
PloS one8(7)e69333(2013)
Ross AP,Mansilla MA,Choe Y,Helminski S,Sturm R,Maute RL,May SR,Hozyasz KK,W?jcicki P,Mostowska A,Davidson B,Adamopoulos IE,Pleasure SJ,Murray JC,Zarbalis KS

Induction of vascular permeability: beta PIX and GIT1 scaffold the activation of extracellular signal-regulated kinase by PAK.
Molecular biology of the cell18(6)2346-55(2007 Jun)
Stockton R,Reutershan J,Scott D,Sanders J,Ley K,Schwartz MA

A global genomic transcriptional code associated with CNS-expressed genes.
Experimental cell research312(16)3108-19(2006 Oct)
Bailey PJ,Klos JM,Andersson E,Karl?n M,K?llstr?m M,Ponjavic J,Muhr J,Lenhard B,Sandelin A,Ericson J

Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia.
Genome research13(6B)1273-89(2003 Jun)
Carninci P,Waki K,Shiraki T,Konno H,Shibata K,Itoh M,Aizawa K,Arakawa T,Ishii Y,Sasaki D,Bono H,Kondo S,Sugahara Y,Saito R,Osato N,Fukuda S,Sato K,Watahiki A,Hirozane-Kishikawa T,Nakamura M,Shibata Y,Yasunishi A,Kikuchi N,Yoshiki A,Kusakabe M,Gustincich S,Beisel K,Pavan W,Aidinis V,Nakagawara A,Held WA,Iwata H,Kono T,Nakauchi H,Lyons P,Wells C,Hume DA,Fagiolini M,Hensch TK,Brinkmeier M,Camper S,Hirota J,Mombaerts P,Muramatsu M,Okazaki Y,Kawai J,Hayashizaki Y

Genetic and molecular characterization of Skb15, a highly conserved inhibitor of the fission yeast PAK, Shk1.
Molecular cell7(5)1095-101(2001 May)
Kim HW,Yang P,Qyang Y,Lai H,Du H,Henkel JS,Kumar K,Bao S,Liu M,Marcus S

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Pak1ip1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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