Trim35 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Trim35
Entrez Gene ID	66854
Full Name	tripartite motif-containing 35
Synonyms	0710005M05Rik,A430106H13Rik,AW046487,HLS5,Mair,NC8,mKIAA1098
General protein information	Preferred Names tripartite motif-containing 35 Names tripartite motif-containing protein 35 hemopoietic lineage switch protein 5 macrophage-derived apoptosis-inducing RBCC protein protein Nc8
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 14 Map Location: 14\|14 D1

mRNA and Protein(s)

mRNA	Protein	Name
NM_029979.3	NP_084255.2	tripartite motif-containing protein 35

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	TRIM35	XP_001234476.2
Homo sapiens (human)	TRIM35	NP_741983.2
Pan troglodytes (chimpanzee)	TRIM35	XP_519674.2
	TRIM35	XP_001108814.1
Rattus norvegicus (Norway rat)	Trim35	NP_001020313.2
Canis lupus familiaris (dog)	TRIM35	XP_543229.3
Bos taurus (cattle)	TRIM35	XP_002689839.1
Mus musculus (house mouse)	Trim35	NP_084255.2

Gene Ontology
Bibliography

Related articles in PubMed

TRIM35 negatively regulates TLR7- and TLR9-mediated type I interferon production by targeting IRF7.
Wang Y, Yan S, Yang B, Wang Y, Zhou H, Lian Q, Sun B
FEBS letters589(12)1322-30(2015 May)

A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions.
Xue W, Kitzing T, Roessler S, Zuber J, Krasnitz A, Schultz N, Revill K, Weissmueller S, Rappaport AR, Simon J, Zhang J, Luo W, Hicks J, Zender L, Wang XW, Powers S, Wigler M, Lowe SW
Proceedings of the National Academy of Sciences of the United States of America109(21)8212-7(2012 May)

Identification and validation of novel C/EBPbeta-regulated genes in preadipocyte proliferation.
Liu M, Huang HY
Chinese medical journal123(9)1190-4(2010 May)

Hls5 regulated erythroid differentiation by modulating GATA-1 activity.
Endersby R, Majewski IJ, Winteringham L, Beaumont JG, Samuels A, Scaife R, Lim E, Crossley M, Klinken SP, Lalonde JP
Blood111(4)1946-50(2008 Feb)

Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization.
Powles N, Babbs C, Ficker M, Schimmang T, Maconochie M
Developmental biology268(1)24-38(2004 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that Trim35 (tripartite motif-containing 35) down-regulates type I interferon production in dendritic cells via toll-like receptors 7/9 and down-regulates stability of Irf7 (interferon regulatory factor 7) via ubiquitination/proteasomes.
Title: TRIM35 negatively regulates TLR7- and TLR9-mediated type I interferon production by targeting IRF7.

C/EBPbeta may regulate preadipocyte proliferation through activation of banp and trim35.
Title: Identification and validation of novel C/EBPbeta-regulated genes in preadipocyte proliferation.

isolated from monocytoid variant, but not parental J2E erythroleukemia cells; expressed in wide range of adult tissues; at different stages of embryogenesis, Hls5 was detected in the branchial arches, spinal cord, dorsal root ganglia, limb buds, and brain
Title: HLS5, a novel RBCC (ring finger, B box, coiled-coil) family member isolated from a hemopoietic lineage switch, is a candidate tumor suppressor.

a novel RING-B-box-coiled-coil (RBCC) protein that consists of an N-terminal RING finger, followed by a B-box zinc finger, a coiled-coil domain, and a B30.2 domain; cloning and characterization
Title: Cloning and characterization of a novel RING-B-box-coiled-coil protein with apoptotic function.

The following Trim35 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Trim35 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu07773	NM_029979.3 Latest version!	Mus musculus tripartite motif-containing 35 (Trim35), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$300.30 $429.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Trim35 ( NM_029979.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_084255.2 Mus musculus tripartite motif-containing 35 (Trim35), mRNA.

Price & Availability↑

CloneID	OMu07773
Clone ID Related Accession (Same CDS sequence)	NM_029979.3
Accession Version	NM_029979.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1551bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	tripartite motif-containing protein 35
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC140329.3 and AF145374.1. On Mar 16, 2007 this sequence version replaced NM_029979.2. Sequence Note: The translation start codon selected for this RefSeq is conserved in rodent species. A possible downstream start codon, which shows better cross-species conservation, would shorten the protein by 15 aa. The shorter protein is described in the literature, including PMIDs:12692137 and 14662771. No experimental evidence exists to show which start codon is used in vivo. CCDS Note: The coding region has been updated to extend the N-terminus based on the presence of an upstream translation start codon, which is conserved in rodent species and is supported by available transcript data. A possible downstream start codon, which shows better cross-species conservation, would shorten the protein by 15 aa. The shorter protein is described in the literature, including PMIDs:12692137 and 14662771. No experimental evidence exists to show which start codon is used in vivo. ##Evidence-Data-START## Transcript exon combination :: AF145374.1, AK075877.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGGCGG CGACACCGGT GGTGGTGACG GCGGCTGCTC CTGCGATGGA GCCGGGCCCT 
TCTGTGTCCC CGGGGCCTTC GCGCTCCTTC AAAGAGGAGC TGCTGTGTGC CGTGTGCTAC 
GACCCGTTCC GCGACGCAGT AACTCTGCGC TGTGGCCACA ACTTCTGCCG CCGGTGCGTG 
AGCGGCTGCT GGGAGGTGCA GACGACGCCC TCGTGTCCGG TGTGCAAGGA ACGAGCGGTG 
CCCGGGGAGC TGCGCACCAA CCACACGCTC AACAACCTGG TGGAGACCTT GCTGCGCGAG 
GAGGCTGAGG GCGCGCGCTG GACCGGTCGC CGGTCCCCGC GCCCCTGCCG TGCGCACCGT 
GCCCCGCTCA CGCTCTTCTG CCTGGAGGAC AAGGAGCTGC TGTGCTGTGC TTGCCAGGCC 
GACGCCCGGC ACCAAGAGCA TCGTGTGCAG CCCATCAAGG ACACTGCGCA AGACTTCCGG 
GCCAAGTGTA AGAACATGGA GCATGTATTG CGAGAGAAAG CCAAGGCCTT CTGGGCCCTG 
AGGCGCACCT ATGAGGCCAT TGCCAAGCAC AATGAGGTGC AAACGACTTG GCTGGAAGGC 
CGCATCCGGG ATGAGTTTGA CAAGCTCCGT GATTTCCTGA GGGTGGAGGA ACAGGCCACC 
TTGGATGCCA TGAAGGAAGA GAGCAGAAAG AAGCACCTGC AGGCTGAGGA GAAGATGAAG 
CAGCTAGCAG AACAGACCGA GGCGCTGGCT CGGGAGATTG AGCGTCTGCA GATGGAGATG 
AAGGAAGATG ACATGACCTT CCTCATGAAA CACAAGAGCC GAAAACGCCG GCTCTTCTGC 
ACCGTGGAGC CAGCTCCTCT CCAGCCTGGC TTGCTAATGG ATGCATGCAA GTATCTGGAG 
TCCCTGCAGT ACCGAGTCTG GAAGAAGATG CTTGGATCCG TTGAGTCTGT GCCCTTCAGC 
TTGGATCCCA ACACAGCTGC TGGCTGGCTC AAAGTGGCTG ATGACCTCAC GAGTGTCATC 
AACCATGGCT ACCGCGTGCA AGTGGAGAAT CCAGAGCGCT TCTCCTCGGC ACCCTGCCTG 
CTAGGCTCTC AAGTGTTCTC CAAGGGCTCC CACTCTTGGG AGGTGGATGT GGGTGGCCTG 
CCAACCTGGC GAGTGGGTGT GGTTCGGGTG CAGGCACATG CACAGGCGCA GGCTCAGGCT 
GACGTAGGTG GTGAAGGCCA CTCACACAGC TGCTACCATG ATACACGCTC AGGCTTCTGG 
TACCTGTGCC GCACGCAGGG TGTGGATGGA GACCACTGCA TGACTTCCGA CACTGCCACA 
GCCCCTCTGG TCCAGGCCAT GCCGCGCCGT CTGCGTGTGG AGCTGGAGTG TGAGGAGGGT 
GAGCTATCCT TCTATGACTC TGAGCGCCAC TGCCATCTGT ATACCTTCCA TGCCCACTTT 
GGGGAGGTGA GGCCCTACTT CTACCTGGGA GCCTCTCGAG GTGACGGTCC CCCGGAACCT 
CTGCGTATCT GCCACCTGCG TGTCTCCATC AAAGAAGAGC TGGACATCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_084255.2
CDS	46..1596
Translation	MKAATPVVVTAAAPAMEPGPSVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRRCVSGCWEVQTTPSCPVCKERAVPGELRTNHTLNNLVETLLREEAEGARWTGRRSPRPCRAHRAPLTLFCLEDKELLCCACQADARHQEHRVQPIKDTAQDFRAKCKNMEHVLREKAKAFWALRRTYEAIAKHNEVQTTWLEGRIRDEFDKLRDFLRVEEQATLDAMKEESRKKHLQAEEKMKQLAEQTEALAREIERLQMEMKEDDMTFLMKHKSRKRRLFCTVEPAPLQPGLLMDACKYLESLQYRVWKKMLGSVESVPFSLDPNTAAGWLKVADDLTSVINHGYRVQVENPERFSSAPCLLGSQVFSKGSHSWEVDVGGLPTWRVGVVRVQAHAQAQAQADVGGEGHSHSCYHDTRSGFWYLCRTQGVDGDHCMTSDTATAPLVQAMPRRLRVELECEEGELSFYDSERHCHLYTFHAHFGEVRPYFYLGASRGDGPPEPLRICHLRVSIKEELDI

Target ORF information:

RefSeq Version	NM_029979.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus tripartite motif-containing 35 (Trim35), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_029979.3

ORF Insert Sequence:

ATGAAGGCGG CGACACCGGT GGTGGTGACG GCGGCTGCTC CTGCGATGGA GCCGGGCCCT 
TCTGTGTCCC CGGGGCCTTC GCGCTCCTTC AAAGAGGAGC TGCTGTGTGC CGTGTGCTAC 
GACCCGTTCC GCGACGCAGT AACTCTGCGC TGTGGCCACA ACTTCTGCCG CCGGTGCGTG 
AGCGGCTGCT GGGAGGTGCA GACGACGCCC TCGTGTCCGG TGTGCAAGGA ACGAGCGGTG 
CCCGGGGAGC TGCGCACCAA CCACACGCTC AACAACCTGG TGGAGACCTT GCTGCGCGAG 
GAGGCTGAGG GCGCGCGCTG GACCGGTCGC CGGTCCCCGC GCCCCTGCCG TGCGCACCGT 
GCCCCGCTCA CGCTCTTCTG CCTGGAGGAC AAGGAGCTGC TGTGCTGTGC TTGCCAGGCC 
GACGCCCGGC ACCAAGAGCA TCGTGTGCAG CCCATCAAGG ACACTGCGCA AGACTTCCGG 
GCCAAGTGTA AGAACATGGA GCATGTATTG CGAGAGAAAG CCAAGGCCTT CTGGGCCCTG 
AGGCGCACCT ATGAGGCCAT TGCCAAGCAC AATGAGGTGC AAACGACTTG GCTGGAAGGC 
CGCATCCGGG ATGAGTTTGA CAAGCTCCGT GATTTCCTGA GGGTGGAGGA ACAGGCCACC 
TTGGATGCCA TGAAGGAAGA GAGCAGAAAG AAGCACCTGC AGGCTGAGGA GAAGATGAAG 
CAGCTAGCAG AACAGACCGA GGCGCTGGCT CGGGAGATTG AGCGTCTGCA GATGGAGATG 
AAGGAAGATG ACATGACCTT CCTCATGAAA CACAAGAGCC GAAAACGCCG GCTCTTCTGC 
ACCGTGGAGC CAGCTCCTCT CCAGCCTGGC TTGCTAATGG ATGCATGCAA GTATCTGGAG 
TCCCTGCAGT ACCGAGTCTG GAAGAAGATG CTTGGATCCG TTGAGTCTGT GCCCTTCAGC 
TTGGATCCCA ACACAGCTGC TGGCTGGCTC AAAGTGGCTG ATGACCTCAC GAGTGTCATC 
AACCATGGCT ACCGCGTGCA AGTGGAGAAT CCAGAGCGCT TCTCCTCGGC ACCCTGCCTG 
CTAGGCTCTC AAGTGTTCTC CAAGGGCTCC CACTCTTGGG AGGTGGATGT GGGTGGCCTG 
CCAACCTGGC GAGTGGGTGT GGTTCGGGTG CAGGCACATG CACAGGCGCA GGCTCAGGCT 
GACGTAGGTG GTGAAGGCCA CTCACACAGC TGCTACCATG ATACACGCTC AGGCTTCTGG 
TACCTGTGCC GCACGCAGGG TGTGGATGGA GACCACTGCA TGACTTCCGA CACTGCCACA 
GCCCCTCTGG TCCAGGCCAT GCCGCGCCGT CTGCGTGTGG AGCTGGAGTG TGAGGAGGGT 
GAGCTATCCT TCTATGACTC TGAGCGCCAC TGCCATCTGT ATACCTTCCA TGCCCACTTT 
GGGGAGGTGA GGCCCTACTT CTACCTGGGA GCCTCTCGAG GTGACGGTCC CCCGGAACCT 
CTGCGTATCT GCCACCTGCG TGTCTCCATC AAAGAAGAGC TGGACATCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TRIM35 negatively regulates TLR7- and TLR9-mediated type I interferon production by targeting IRF7.
FEBS letters589(12)1322-30(2015 May)
Wang Y,Yan S,Yang B,Wang Y,Zhou H,Lian Q,Sun B

A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions.
Proceedings of the National Academy of Sciences of the United States of America109(21)8212-7(2012 May)
Xue W,Kitzing T,Roessler S,Zuber J,Krasnitz A,Schultz N,Revill K,Weissmueller S,Rappaport AR,Simon J,Zhang J,Luo W,Hicks J,Zender L,Wang XW,Powers S,Wigler M,Lowe SW

Identification and validation of novel C/EBPbeta-regulated genes in preadipocyte proliferation.
Chinese medical journal123(9)1190-4(2010 May)
Liu M,Huang HY

Hls5 regulated erythroid differentiation by modulating GATA-1 activity.
Blood111(4)1946-50(2008 Feb)
Endersby R,Majewski IJ,Winteringham L,Beaumont JG,Samuels A,Scaife R,Lim E,Crossley M,Klinken SP,Lalonde JP

Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization.
Developmental biology268(1)24-38(2004 Apr)
Powles N,Babbs C,Ficker M,Schimmang T,Maconochie M

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Trim35 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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