Bcs1l cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Bcs1l
Entrez Gene ID	66821
Full Name	BCS1-like (yeast)
Synonyms	9130022O19Rik
General protein information	Preferred Names BCS1-like (yeast) Names mitochondrial chaperone BCS1 BCS1-like protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1\|1 C3
Summary	The protein encoded by this gene is a chaperone protein that is involved in the assembly of complex III (CIII), one of the five protein complexes of the mitochondrial respiratory chain, and is necessary for the insertion of the Rieske iron-sulfur (RISP) and Qcr10p proteins into the precomplex. Studies from the yeast ortholog of this protein indicate that it is targeted to the inner membrane of the mitochondria, despite the absence of an N-terminal targeting sequence. Positively charged amino acids located C-terminal to the transmembrane domain are thought to act as an internal targeting signal (PMID:8599931). Mutations in the human ortholog of this gene have been associated with GRACILE syndrome, characterized by Growth retardation, Amino aciduria, Cholestasis, Iron overload, Lactic acidosis, and Early death. Mouse models with the corresponding mutation mimic the phenotype of GRACILE syndrome and display decreased complex III activity and decreased electron transport capacity (PMID:21274865). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001305652.1	NP_001292581.1	mitochondrial chaperone BCS1
NM_025784.5	NP_080060.1	mitochondrial chaperone BCS1

Pathways from BioSystems

Homologies

Homo sapiens (human)	BCS1L	NP_004319.1
Pan troglodytes (chimpanzee)	BCS1L	XP_516092.4
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004266	XP_313188.3
Schizosaccharomyces pombe (fission yeast)	SPAC644.07	NP_593875.1
Xenopus tropicalis (tropical clawed frog)	bcs1l	NP_001016865.1
Canis lupus familiaris (dog)	BCS1L	XP_536070.1
Gallus gallus (chicken)	BCS1L	NP_001006520.1
Danio rerio (zebrafish)	bcs1l	NP_957476.2
Drosophila melanogaster (fruit fly)	CG4908	NP_609358.1
	BCS1L	XP_001092421.1
Kluyveromyces lactis	KLLA0E02487g	XP_454059.1
Bos taurus (cattle)	BCS1L	NP_001015671.1
Mus musculus (house mouse)	Bcs1l	NP_080060.1
Rattus norvegicus (Norway rat)	Bcs1l	NP_001007667.1
Caenorhabditis elegans (roundworm)	bcs-1	NP_001022191.1
Saccharomyces cerevisiae (baker's yeast)	BCS1	NP_010663.1
Eremothecium gossypii	AGOS_ACR200C	NP_983602.1

Gene Ontology
Bibliography

Related articles in PubMed

Ketogenic diet attenuates hepatopathy in mouse model of respiratory chain complex III deficiency caused by a Bcs1l mutation.
Purhonen J, Rajendran J, M?rgelin M, Uusi-Rauva K, Katayama S, Krjutskov K, Einarsdottir E, Velagapudi V, Kere J, Jauhiainen M, Fellman V, Kallij?rvi J
Scientific reports7(1)957(2017 Apr)

COX7A2L/SCAFI and Pre-Complex III Modify Respiratory Chain Supercomplex Formation in Different Mouse Strains with a Bcs1l Mutation.
Davoudi M, Kotarsky H, Hansson E, Kallij?rvi J, Fellman V
PloS one11(12)e0168774(2016)

Complex I function and supercomplex formation are preserved in liver mitochondria despite progressive complex III deficiency.
Davoudi M, Kotarsky H, Hansson E, Fellman V
PloS one9(1)e86767(2014)

Metabolite profiles reveal energy failure and impaired beta-oxidation in liver of mice with complex III deficiency due to a BCS1L mutation.
Kotarsky H, Keller M, Davoudi M, Lev?en P, Karikoski R, Enot DP, Fellman V
PloS one7(7)e41156(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

COX7A2L/SCAFI and Pre-Complex III Modify Respiratory Chain Supercomplex Formation in Different Mouse Strains with a Bcs1l Mutation.
Title: COX7A2L/SCAFI and Pre-Complex III Modify Respiratory Chain Supercomplex Formation in Different Mouse Strains with a Bcs1l Mutation.

Metabolite profiles reveal energy failure and impaired beta-oxidation in liver of mice with complex III deficiency due to a BCS1L mutation.
Title: Metabolite profiles reveal energy failure and impaired beta-oxidation in liver of mice with complex III deficiency due to a BCS1L mutation.

The GRACILE mutation introduced into Bcs1l causes postnatal complex III deficiency and is a viable mouse model for mitochondrial hepatopathy.
Title: The GRACILE mutation introduced into Bcs1l causes postnatal complex III deficiency: a viable mouse model for mitochondrial hepatopathy.

The predominant expression of BCS1L in the floor plate of the neural tube region, together with its presence in peripheral ganglia from E13 onwards, indicates a role for BCS1L in the development of neural structures.
Title: BCS1L is expressed in critical regions for neural development during ontogenesis in mice.

Studies in the yeast BCS1 ortholog indicate that the Bcs1 protein is anchored in the mitochondrial inner membrane, despite the absence of an N-terminal targeting sequence. Targeting occurs via charged amino acids near the transmembrane domain that act as an internal targeting signal.
Title: Internal targeting signal of the BCS1 protein: a novel mechanism of import into mitochondria.

The following Bcs1l gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Bcs1l cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu13521	NM_025784.5 Latest version!	Mus musculus BCS1-like (yeast) (Bcs1l), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
OMu13521	NM_001305652.1 Latest version!	Mus musculus BCS1-like (yeast) (Bcs1l), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Bcs1l ( NM_001305652.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001292581.1 Mus musculus BCS1-like (yeast) (Bcs1l), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu13521
Clone ID Related Accession (Same CDS sequence)	NM_001305652.1 , NM_025784.5
Accession Version	NM_001305652.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1257bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-17
Organism	Mus musculus(house mouse)
Product	mitochondrial chaperone BCS1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY265931.1, AK079385.1 and AW489767.1. On Mar 26, 2015 this sequence version replaced XM_006496196.2. Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: BC019781.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCATTTT CAGACTTTGT TCTGGCCCTT AAAGACAATC CCTACTTTGG GGCTGGATTT 
GGGCTGGTAG GTGTGGGTAC GGCTCTGGCT ATGGCCCGGA AAGGAGCCCA GTTGGGTCTA 
GTGGCATTCC GGCGCCATTA CATGATCACA CTGGAAGTCC CTGCCAGAGA CAGAAGCTAT 
GCCTGGTTGC TTAGCTGGCT TACCCGACAC AGCACCCGCA CTCAGCACCT CAGTGTTGAA 
ACCTCATACC TTCAGCATGA AAGTGGCCGG ATCTCCACCA AGTTTGAATT TATCCCCAGC 
CCTGGAAACC ACTTCATTTG GTATCAGGGA AAATGGATCC GGGTAGAACG AAACCGAGAC 
ATGCAGATGG TAGACTTGCA AACAGGGACT CCTTGGGAAT CTGTCACCTT CACGGCCCTG 
GGCACTGACC GAAAGGTTTT CTTCAACATC CTGGAAGAAG CTCGAGCACT GGCCCTGCAG 
CAGGAGGAAG GGAAGACTGT GATGTACACA GCTGTGGGGT CTGAATGGCG TACCTTTGGT 
TATCCGCGCC GACGTCGGCC ACTGGATTCT GTAGTCCTAC AGCAGGGTCT GGCTGACCGA 
ATTGTCAAAG ATATCCGGGA ATTTATTGAT AACCCCAAGT GGTACATTGA CAGAGGCATT 
CCCTACAGAC GTGGCTACCT TCTTTATGGG CCCCCTGGTT GTGGAAAGAG CAGTTTTATA 
ACAGCCCTGG CTGGAGAACT GGAACACAGC ATCTGCCTGC TCAGCCTCAC AGACTCTAGC 
CTCTCAGATG ACCGGCTCAA CCATCTACTG AGTGTAGCAC CACAGCAGAG CTTGGTGCTC 
CTGGAAGATG TGGATGCTGC TTTTCTCAGT AGAGACTTGG CTGTGGAGAA CCCTATAAAG 
TACCAAGGAC TAGGCCGCCT CACCTTCAGT GGACTGCTTA ATGCTTTGGA TGGTGTAGCC 
TCCACTGAAG CACGAATTGT GTTCATGACC ACCAACTACA TTGACAGGCT GGATCCTGCC 
CTCATACGTC CCGGGCGAGT AGATCTGAAG GAGTATGTGG GCTACTGCTC ACACTGGCAG 
CTGACCCAGA TGTTCCAGAG GTTCTATCCA GGGCAAGCAC CTTCTTTGGC TGAGAACTTT 
GCTGAACATG TCCTTAAAGC TACATCTGAG ATTAGTCCTG CCCAGGTGCA AGGCTACTTC 
ATGCTGTATA AAAATGACCC CATGGGGGCT GTTCACAACA TTGAATCTCT GAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001292581.1
CDS	179..1435
Translation	MPFSDFVLALKDNPYFGAGFGLVGVGTALAMARKGAQLGLVAFRRHYMITLEVPARDRSYAWLLSWLTRHSTRTQHLSVETSYLQHESGRISTKFEFIPSPGNHFIWYQGKWIRVERNRDMQMVDLQTGTPWESVTFTALGTDRKVFFNILEEARALALQQEEGKTVMYTAVGSEWRTFGYPRRRRPLDSVVLQQGLADRIVKDIREFIDNPKWYIDRGIPYRRGYLLYGPPGCGKSSFITALAGELEHSICLLSLTDSSLSDDRLNHLLSVAPQQSLVLLEDVDAAFLSRDLAVENPIKYQGLGRLTFSGLLNALDGVASTEARIVFMTTNYIDRLDPALIRPGRVDLKEYVGYCSHWQLTQMFQRFYPGQAPSLAENFAEHVLKATSEISPAQVQGYFMLYKNDPMGAVHNIESLR

Target ORF information:

RefSeq Version	NM_001305652.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus BCS1-like (yeast) (Bcs1l), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001305652.1

ORF Insert Sequence:

ATGCCATTTT CAGACTTTGT TCTGGCCCTT AAAGACAATC CCTACTTTGG GGCTGGATTT 
GGGCTGGTAG GTGTGGGTAC GGCTCTGGCT ATGGCCCGGA AAGGAGCCCA GTTGGGTCTA 
GTGGCATTCC GGCGCCATTA CATGATCACA CTGGAAGTCC CTGCCAGAGA CAGAAGCTAT 
GCCTGGTTGC TTAGCTGGCT TACCCGACAC AGCACCCGCA CTCAGCACCT CAGTGTTGAA 
ACCTCATACC TTCAGCATGA AAGTGGCCGG ATCTCCACCA AGTTTGAATT TATCCCCAGC 
CCTGGAAACC ACTTCATTTG GTATCAGGGA AAATGGATCC GGGTAGAACG AAACCGAGAC 
ATGCAGATGG TAGACTTGCA AACAGGGACT CCTTGGGAAT CTGTCACCTT CACGGCCCTG 
GGCACTGACC GAAAGGTTTT CTTCAACATC CTGGAAGAAG CTCGAGCACT GGCCCTGCAG 
CAGGAGGAAG GGAAGACTGT GATGTACACA GCTGTGGGGT CTGAATGGCG TACCTTTGGT 
TATCCGCGCC GACGTCGGCC ACTGGATTCT GTAGTCCTAC AGCAGGGTCT GGCTGACCGA 
ATTGTCAAAG ATATCCGGGA ATTTATTGAT AACCCCAAGT GGTACATTGA CAGAGGCATT 
CCCTACAGAC GTGGCTACCT TCTTTATGGG CCCCCTGGTT GTGGAAAGAG CAGTTTTATA 
ACAGCCCTGG CTGGAGAACT GGAACACAGC ATCTGCCTGC TCAGCCTCAC AGACTCTAGC 
CTCTCAGATG ACCGGCTCAA CCATCTACTG AGTGTAGCAC CACAGCAGAG CTTGGTGCTC 
CTGGAAGATG TGGATGCTGC TTTTCTCAGT AGAGACTTGG CTGTGGAGAA CCCTATAAAG 
TACCAAGGAC TAGGCCGCCT CACCTTCAGT GGACTGCTTA ATGCTTTGGA TGGTGTAGCC 
TCCACTGAAG CACGAATTGT GTTCATGACC ACCAACTACA TTGACAGGCT GGATCCTGCC 
CTCATACGTC CCGGGCGAGT AGATCTGAAG GAGTATGTGG GCTACTGCTC ACACTGGCAG 
CTGACCCAGA TGTTCCAGAG GTTCTATCCA GGGCAAGCAC CTTCTTTGGC TGAGAACTTT 
GCTGAACATG TCCTTAAAGC TACATCTGAG ATTAGTCCTG CCCAGGTGCA AGGCTACTTC 
ATGCTGTATA AAAATGACCC CATGGGGGCT GTTCACAACA TTGAATCTCT GAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Bcs1l ( NM_025784.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080060.1 Mus musculus BCS1-like (yeast) (Bcs1l), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu13521
Clone ID Related Accession (Same CDS sequence)	NM_001305652.1 , NM_025784.5
Accession Version	NM_025784.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1257bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-17
Organism	Mus musculus(house mouse)
Product	mitochondrial chaperone BCS1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY265931.1, AK079385.1 and AW489767.1. On Mar 26, 2015 this sequence version replaced NM_025784.4. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Sequence Note:. ##Evidence-Data-START## Transcript exon combination :: AK079385.1, AK012324.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCATTTT CAGACTTTGT TCTGGCCCTT AAAGACAATC CCTACTTTGG GGCTGGATTT 
GGGCTGGTAG GTGTGGGTAC GGCTCTGGCT ATGGCCCGGA AAGGAGCCCA GTTGGGTCTA 
GTGGCATTCC GGCGCCATTA CATGATCACA CTGGAAGTCC CTGCCAGAGA CAGAAGCTAT 
GCCTGGTTGC TTAGCTGGCT TACCCGACAC AGCACCCGCA CTCAGCACCT CAGTGTTGAA 
ACCTCATACC TTCAGCATGA AAGTGGCCGG ATCTCCACCA AGTTTGAATT TATCCCCAGC 
CCTGGAAACC ACTTCATTTG GTATCAGGGA AAATGGATCC GGGTAGAACG AAACCGAGAC 
ATGCAGATGG TAGACTTGCA AACAGGGACT CCTTGGGAAT CTGTCACCTT CACGGCCCTG 
GGCACTGACC GAAAGGTTTT CTTCAACATC CTGGAAGAAG CTCGAGCACT GGCCCTGCAG 
CAGGAGGAAG GGAAGACTGT GATGTACACA GCTGTGGGGT CTGAATGGCG TACCTTTGGT 
TATCCGCGCC GACGTCGGCC ACTGGATTCT GTAGTCCTAC AGCAGGGTCT GGCTGACCGA 
ATTGTCAAAG ATATCCGGGA ATTTATTGAT AACCCCAAGT GGTACATTGA CAGAGGCATT 
CCCTACAGAC GTGGCTACCT TCTTTATGGG CCCCCTGGTT GTGGAAAGAG CAGTTTTATA 
ACAGCCCTGG CTGGAGAACT GGAACACAGC ATCTGCCTGC TCAGCCTCAC AGACTCTAGC 
CTCTCAGATG ACCGGCTCAA CCATCTACTG AGTGTAGCAC CACAGCAGAG CTTGGTGCTC 
CTGGAAGATG TGGATGCTGC TTTTCTCAGT AGAGACTTGG CTGTGGAGAA CCCTATAAAG 
TACCAAGGAC TAGGCCGCCT CACCTTCAGT GGACTGCTTA ATGCTTTGGA TGGTGTAGCC 
TCCACTGAAG CACGAATTGT GTTCATGACC ACCAACTACA TTGACAGGCT GGATCCTGCC 
CTCATACGTC CCGGGCGAGT AGATCTGAAG GAGTATGTGG GCTACTGCTC ACACTGGCAG 
CTGACCCAGA TGTTCCAGAG GTTCTATCCA GGGCAAGCAC CTTCTTTGGC TGAGAACTTT 
GCTGAACATG TCCTTAAAGC TACATCTGAG ATTAGTCCTG CCCAGGTGCA AGGCTACTTC 
ATGCTGTATA AAAATGACCC CATGGGGGCT GTTCACAACA TTGAATCTCT GAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080060.1
CDS	273..1529
Translation	MPFSDFVLALKDNPYFGAGFGLVGVGTALAMARKGAQLGLVAFRRHYMITLEVPARDRSYAWLLSWLTRHSTRTQHLSVETSYLQHESGRISTKFEFIPSPGNHFIWYQGKWIRVERNRDMQMVDLQTGTPWESVTFTALGTDRKVFFNILEEARALALQQEEGKTVMYTAVGSEWRTFGYPRRRRPLDSVVLQQGLADRIVKDIREFIDNPKWYIDRGIPYRRGYLLYGPPGCGKSSFITALAGELEHSICLLSLTDSSLSDDRLNHLLSVAPQQSLVLLEDVDAAFLSRDLAVENPIKYQGLGRLTFSGLLNALDGVASTEARIVFMTTNYIDRLDPALIRPGRVDLKEYVGYCSHWQLTQMFQRFYPGQAPSLAENFAEHVLKATSEISPAQVQGYFMLYKNDPMGAVHNIESLR

Target ORF information:

RefSeq Version	NM_025784.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus BCS1-like (yeast) (Bcs1l), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025784.5

ORF Insert Sequence:

ATGCCATTTT CAGACTTTGT TCTGGCCCTT AAAGACAATC CCTACTTTGG GGCTGGATTT 
GGGCTGGTAG GTGTGGGTAC GGCTCTGGCT ATGGCCCGGA AAGGAGCCCA GTTGGGTCTA 
GTGGCATTCC GGCGCCATTA CATGATCACA CTGGAAGTCC CTGCCAGAGA CAGAAGCTAT 
GCCTGGTTGC TTAGCTGGCT TACCCGACAC AGCACCCGCA CTCAGCACCT CAGTGTTGAA 
ACCTCATACC TTCAGCATGA AAGTGGCCGG ATCTCCACCA AGTTTGAATT TATCCCCAGC 
CCTGGAAACC ACTTCATTTG GTATCAGGGA AAATGGATCC GGGTAGAACG AAACCGAGAC 
ATGCAGATGG TAGACTTGCA AACAGGGACT CCTTGGGAAT CTGTCACCTT CACGGCCCTG 
GGCACTGACC GAAAGGTTTT CTTCAACATC CTGGAAGAAG CTCGAGCACT GGCCCTGCAG 
CAGGAGGAAG GGAAGACTGT GATGTACACA GCTGTGGGGT CTGAATGGCG TACCTTTGGT 
TATCCGCGCC GACGTCGGCC ACTGGATTCT GTAGTCCTAC AGCAGGGTCT GGCTGACCGA 
ATTGTCAAAG ATATCCGGGA ATTTATTGAT AACCCCAAGT GGTACATTGA CAGAGGCATT 
CCCTACAGAC GTGGCTACCT TCTTTATGGG CCCCCTGGTT GTGGAAAGAG CAGTTTTATA 
ACAGCCCTGG CTGGAGAACT GGAACACAGC ATCTGCCTGC TCAGCCTCAC AGACTCTAGC 
CTCTCAGATG ACCGGCTCAA CCATCTACTG AGTGTAGCAC CACAGCAGAG CTTGGTGCTC 
CTGGAAGATG TGGATGCTGC TTTTCTCAGT AGAGACTTGG CTGTGGAGAA CCCTATAAAG 
TACCAAGGAC TAGGCCGCCT CACCTTCAGT GGACTGCTTA ATGCTTTGGA TGGTGTAGCC 
TCCACTGAAG CACGAATTGT GTTCATGACC ACCAACTACA TTGACAGGCT GGATCCTGCC 
CTCATACGTC CCGGGCGAGT AGATCTGAAG GAGTATGTGG GCTACTGCTC ACACTGGCAG 
CTGACCCAGA TGTTCCAGAG GTTCTATCCA GGGCAAGCAC CTTCTTTGGC TGAGAACTTT 
GCTGAACATG TCCTTAAAGC TACATCTGAG ATTAGTCCTG CCCAGGTGCA AGGCTACTTC 
ATGCTGTATA AAAATGACCC CATGGGGGCT GTTCACAACA TTGAATCTCT GAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ketogenic diet attenuates hepatopathy in mouse model of respiratory chain complex III deficiency caused by a Bcs1l mutation.
Scientific reports7(1)957(2017 Apr)
Purhonen J,Rajendran J,M?rgelin M,Uusi-Rauva K,Katayama S,Krjutskov K,Einarsdottir E,Velagapudi V,Kere J,Jauhiainen M,Fellman V,Kallij?rvi J

COX7A2L/SCAFI and Pre-Complex III Modify Respiratory Chain Supercomplex Formation in Different Mouse Strains with a Bcs1l Mutation.
PloS one11(12)e0168774(2016)
Davoudi M,Kotarsky H,Hansson E,Kallij?rvi J,Fellman V

Complex I function and supercomplex formation are preserved in liver mitochondria despite progressive complex III deficiency.
PloS one9(1)e86767(2014)
Davoudi M,Kotarsky H,Hansson E,Fellman V

Metabolite profiles reveal energy failure and impaired beta-oxidation in liver of mice with complex III deficiency due to a BCS1L mutation.
PloS one7(7)e41156(2012)
Kotarsky H,Keller M,Davoudi M,Lev?en P,Karikoski R,Enot DP,Fellman V

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Bcs1l cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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