Slc15a1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc15a1
Entrez Gene ID	56643
Full Name	solute carrier family 15 (oligopeptide transporter), member 1
Synonyms	D630032F02,PECT1,PEPT1
General protein information	Preferred Names solute carrier family 15 (oligopeptide transporter), member 1 Names solute carrier family 15 member 1 intestinal H(+)/peptide cotransporter intestinal peptide transporter PEPT1 oligopeptide transporter, small intestine isoform peptide transporter 1 proton-coupled dipeptide cotransporter
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 14 Map Location: 14\|14 E5

mRNA and Protein(s)

mRNA	Protein	Name
NM_053079.2	NP_444309.2	solute carrier family 15 member 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	SLC15A1	XP_522705.3
Canis lupus familiaris (dog)	SLC15A1	NP_001003036.1
Schizosaccharomyces pombe (fission yeast)	SPBC13A2.04c	NP_596417.1
	SLC15A1	NP_001028071.1
Danio rerio (zebrafish)	slc15a1b	NP_932330.1
Saccharomyces cerevisiae (baker's yeast)	PTR2	NP_013019.1
Oryza sativa (rice)	Os03g0719900	NP_001051098.1
Rattus norvegicus (Norway rat)	Slc15a1	NP_476462.1
Gallus gallus (chicken)	SLC15A1	NP_989696.1
Danio rerio (zebrafish)	slc15a1a	XP_001919914.3
Caenorhabditis elegans (roundworm)	pept-1	NP_509087.1
Xenopus tropicalis (tropical clawed frog)	slc15a1	XP_002935692.2
Bos taurus (cattle)	SLC15A1	NP_001092848.1
Drosophila melanogaster (fruit fly)	CG2930	NP_788857.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010383	XP_311562.3
Kluyveromyces lactis	KLLA0E12915g	XP_454532.1
Homo sapiens (human)	SLC15A1	NP_005064.1
Mus musculus (house mouse)	Slc15a1	NP_444309.2
Caenorhabditis elegans (roundworm)	pept-2	NP_502002.1
Arabidopsis thaliana (thale cress)	PTR2	NP_178313.1

Gene Ontology
Bibliography

Related articles in PubMed

A Variant of Peptide Transporter 2 Predicts the Severity of Porphyria-Associated Kidney Disease.
Tchernitchko D, Tavernier Q, Lamoril J, Schmitt C, Talbi N, Lyoumi S, Robreau AM, Karim Z, Gouya L, Thervet E, Karras A, Puy H, Pallet N
Journal of the American Society of Nephrology : JASN28(6)1924-1932(2017 Jun)

Glycans in the intestinal peptide transporter PEPT1 contribute to function and protect from proteolysis.
Stelzl T, Geillinger-K?stle KE, Stolz J, Daniel H
American journal of physiology. Gastrointestinal and liver physiology312(6)G580-G591(2017 Jun)

The collagen derived dipeptide hydroxyprolyl-glycine promotes C2C12 myoblast differentiation and myotube hypertrophy.
Kitakaze T, Sakamoto T, Kitano T, Inoue N, Sugihara F, Harada N, Yamaji R
Biochemical and biophysical research communications478(3)1292-7(2016 09)

PepT1 Expression Helps Maintain Intestinal Homeostasis by Mediating the Differential Expression of miRNAs along the Crypt-Villus Axis.
Zhang Y, Viennois E, Zhang M, Xiao B, Han MK, Walter L, Garg P, Merlin D
Scientific reports627119(2016 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We tested the hypothesis that PEPT2 genotypes affect the severity and prognosis of porphyria-associated kidney disease
Title: A Variant of Peptide Transporter 2 Predicts the Severity of Porphyria-Associated Kidney Disease.

Glycosylation of PEPT1 confers resistance against proteolytic cleavage by proteinase K, whereas a remarkable intrinsic stability against trypsin, even in the absence of N-linked glycans, was detected.
Title: Glycans in the intestinal peptide transporter PEPT1 contribute to function and protect from proteolysis.

Data (including data from studies in transgenic/knockout mice) suggest human PEPT1 and mouse PepT1 exhibit different affinities for antibiotic cefadroxil; these differences may account for species differences in intestinal absorption of cefadroxil.
Title: Species differences in the pharmacokinetics of cefadroxil as determined in wildtype and humanized PepT1 mice.

findings suggested a major role of PEPT1 in the intestinal permeability and oral absorption of 5-aminolevulinic acid
Title: The proton-coupled oligopeptide transporter 1 plays a major role in the intestinal permeability and absorption of 5-aminolevulinic acid.

Crystal structures of the extracellular domain from PepT1 and PepT2 provide novel insights into mammalian peptide transport.
Title: Crystal Structures of the Extracellular Domain from PepT1 and PepT2 Provide Novel Insights into Mammalian Peptide Transport.

The following Slc15a1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc15a1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu22123	NM_053079.2 Latest version!	Mus musculus solute carrier family 15 (oligopeptide transporter), member 1 (Slc15a1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$419.30 $599.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc15a1 ( NM_053079.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_444309.2 Mus musculus solute carrier family 15 (oligopeptide transporter), member 1 (Slc15a1), mRNA.

Price & Availability↑

CloneID	OMu22123
Clone ID Related Accession (Same CDS sequence)	NM_053079.2
Accession Version	NM_053079.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2130bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Mus musculus(house mouse)
Product	solute carrier family 15 member 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK136428.1, BC116248.1 and AV237408.1. On Dec 14, 2006 this sequence version replaced NM_053079.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK136428.1, AF205540.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380 [ECO:0000348] ##Evidence-Data-END##

ATGGGGATGT CCAAGTCTCG GGGTTGCTTC GGTTACCCGT TGAGCATCTT CTTCATCGTG 
GTCAATGAAT TCTGTGAAAG ATTCTCCTAC TATGGCATGC GAGCACTCCT GGTTCTGTAC 
TTCAGGAACT TCCTCGGCTG GGACGACAAT CTCTCCACGG CCATTTACCA TACGTTCGTT 
GCCCTCTGCT ACCTGACTCC AATTCTTGGA GCTCTGATCG CAGACTCGTG GCTGGGGAAG 
TTCAAGACAA TTGTTTCACT ATCCATCGTC TACACGATTG GACAAGCAGT CATCTCGGTG 
AGCTCAATTA ATGACCTCAC AGACCACGAC CACAATGGCA GTCCTGACAG CCTTCCCGTG 
CACGTAGCAC TGTCCATGGT TGGCCTGGCC CTGATAGCCC TTGGTACAGG AGGAATCAAG 
CCCTGTGTGT CTGCGTTTGG TGGCGATCAG TTTGAAGAGG GTCAGGAAAA ACAGCGAAAC 
CGGTTCTTTT CCATCTTTTA TTTGGCTATC AACGGGGGAA GCCTGCTCTC CACGATCATC 
ACTCCCATAC TCAGAGTTCA ACAGTGCGGA ATCCACAGTC AACAAGCTTG TTACCCACTG 
GCCTTCGGGG TTCCAGCGGC TCTCATGGCT GTTGCCCTAA TTGTGTTTGT CCTTGGCAGT 
GGAATGTACA AGAAGTTCCA GCCCCAGGGC AACATCATGG GCAAAGTGGC CAAGTGCATT 
GGTTTTGCCA TCAAAAACAG GTTTCGGCAC CGAAGTAAGG CATATCCCAA GAGGGAGCAC 
TGGCTGGACT GGGCTAAAGA GAAATACGAC GAGCGGCTCA TCTCACAGAT TAAGATGGTC 
ACGAAGGTGA TGTTCCTGTA CATCCCACTC CCCATGTTCT GGGCCTTGTT TGACCAGCAG 
GGTTCCAGAT GGACACTGCA AGCAACGACC ATGAATGGGA AAATTGGAGC AATTGAAATT 
CAGCCGGACC AGATGCAGAC GGTGAATGCC ATCTTGATTG TCATCATGGT CCCCATTGTG 
GACGCTGTGG TGTACCCGCT CATTGCAAAA TGTGGTTTCA ACTTCACATC CCTGAAGAAG 
ATGACTGTTG GGATGTTCCT GGCGTCCATG GCCTTTGTGG TGGCTGCAAT TGTGCAGGTG 
GAAATCGATA AAACTCTTCC AGTCTTCCCT GGTGGAAATC AAGTCCAAAT TAAGGTCTTG 
AACATCGGAA ACAATAACAT GACCGTGCAT TTTCCTGGAA ATAGTGTGAC GCTTGCCCAA 
ATGTCTCAGA CAGACACGTT CATGACTTTC GATATAGACA AGCTGACAAG CATAAACATA 
TCTTCCTCTG GATCCCCAGG AGTCACCACA GTAGCTCATG ATTTTGAGCA GGGTCACCGG 
CACACCCTTC TAGTGTGGAA CCCCAGTCAA TACCGTGTGG TAAAAGATGG TCTTAACCAA 
AAGCCAGAGA AAGGGGAGAA CGGAATCAGG TTTGTCAACA CCCTTAACGA GATGGTCACC 
ATCAAAATGA GTGGGAAAGT ATATGAAAAT GTCACCAGTC ACAACGCCAG CGGCTACCAG 
TTCTTCCCTT CTGGCGAAAA GCAGTACACA ATAAACACCA CGGCGGTGGC ACCAACCTGT 
CTAACTGATT TTAAATCTTC CAACCTTGAC TTTGGCAGCG CGTATACCTA CGTGATCCGA 
AGGGCGAGTG ATGGCTGCCT GGAAGTGAAG GAATTTGAAG ACATCCCACC CAACACTGTG 
AACATGGCTC TGCAGATCCC ACAGTACTTC CTTCTCACCT GCGGCGAGGT GGTCTTCTCT 
GTCACAGGAC TGGAGTTCTC TTATTCCCAG GCTCCGTCTA ACATGAAGTC CGTGCTTCAG 
GCAGGCTGGC TTCTAACTGT GGCGGTCGGC AATATCATTG TGCTCATCGT GGCAGGGGCG 
GGGCACTTCC CCAAACAGTG GGCTGAGTAC ATTCTGTTTG CCTCATTGCT TCTGGTTGTC 
TGCGTGATAT TCGCCATCAT GGCTCGATTC TACACCTACA TCAACCCAGC AGAGATTGAA 
GCACAGTTTG ATGAGGATGA GAAGAAAAAG GGCATAGGAA AGGAAAACCC GTATTCTTCA 
TTGGAACCAG TCTCACAGAC AAATATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_444309.2
CDS	33..2162
Translation	MGMSKSRGCFGYPLSIFFIVVNEFCERFSYYGMRALLVLYFRNFLGWDDNLSTAIYHTFVALCYLTPILGALIADSWLGKFKTIVSLSIVYTIGQAVISVSSINDLTDHDHNGSPDSLPVHVALSMVGLALIALGTGGIKPCVSAFGGDQFEEGQEKQRNRFFSIFYLAINGGSLLSTIITPILRVQQCGIHSQQACYPLAFGVPAALMAVALIVFVLGSGMYKKFQPQGNIMGKVAKCIGFAIKNRFRHRSKAYPKREHWLDWAKEKYDERLISQIKMVTKVMFLYIPLPMFWALFDQQGSRWTLQATTMNGKIGAIEIQPDQMQTVNAILIVIMVPIVDAVVYPLIAKCGFNFTSLKKMTVGMFLASMAFVVAAIVQVEIDKTLPVFPGGNQVQIKVLNIGNNNMTVHFPGNSVTLAQMSQTDTFMTFDIDKLTSINISSSGSPGVTTVAHDFEQGHRHTLLVWNPSQYRVVKDGLNQKPEKGENGIRFVNTLNEMVTIKMSGKVYENVTSHNASGYQFFPSGEKQYTINTTAVAPTCLTDFKSSNLDFGSAYTYVIRRASDGCLEVKEFEDIPPNTVNMALQIPQYFLLTCGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIVAGAGHFPKQWAEYILFASLLLVVCVIFAIMARFYTYINPAEIEAQFDEDEKKKGIGKENPYSSLEPVSQTNM

Target ORF information:

RefSeq Version	NM_053079.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus solute carrier family 15 (oligopeptide transporter), member 1 (Slc15a1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053079.2

ORF Insert Sequence:

ATGGGGATGT CCAAGTCTCG GGGTTGCTTC GGTTACCCGT TGAGCATCTT CTTCATCGTG 
GTCAATGAAT TCTGTGAAAG ATTCTCCTAC TATGGCATGC GAGCACTCCT GGTTCTGTAC 
TTCAGGAACT TCCTCGGCTG GGACGACAAT CTCTCCACGG CCATTTACCA TACGTTCGTT 
GCCCTCTGCT ACCTGACTCC AATTCTTGGA GCTCTGATCG CAGACTCGTG GCTGGGGAAG 
TTCAAGACAA TTGTTTCACT ATCCATCGTC TACACGATTG GACAAGCAGT CATCTCGGTG 
AGCTCAATTA ATGACCTCAC AGACCACGAC CACAATGGCA GTCCTGACAG CCTTCCCGTG 
CACGTAGCAC TGTCCATGGT TGGCCTGGCC CTGATAGCCC TTGGTACAGG AGGAATCAAG 
CCCTGTGTGT CTGCGTTTGG TGGCGATCAG TTTGAAGAGG GTCAGGAAAA ACAGCGAAAC 
CGGTTCTTTT CCATCTTTTA TTTGGCTATC AACGGGGGAA GCCTGCTCTC CACGATCATC 
ACTCCCATAC TCAGAGTTCA ACAGTGCGGA ATCCACAGTC AACAAGCTTG TTACCCACTG 
GCCTTCGGGG TTCCAGCGGC TCTCATGGCT GTTGCCCTAA TTGTGTTTGT CCTTGGCAGT 
GGAATGTACA AGAAGTTCCA GCCCCAGGGC AACATCATGG GCAAAGTGGC CAAGTGCATT 
GGTTTTGCCA TCAAAAACAG GTTTCGGCAC CGAAGTAAGG CATATCCCAA GAGGGAGCAC 
TGGCTGGACT GGGCTAAAGA GAAATACGAC GAGCGGCTCA TCTCACAGAT TAAGATGGTC 
ACGAAGGTGA TGTTCCTGTA CATCCCACTC CCCATGTTCT GGGCCTTGTT TGACCAGCAG 
GGTTCCAGAT GGACACTGCA AGCAACGACC ATGAATGGGA AAATTGGAGC AATTGAAATT 
CAGCCGGACC AGATGCAGAC GGTGAATGCC ATCTTGATTG TCATCATGGT CCCCATTGTG 
GACGCTGTGG TGTACCCGCT CATTGCAAAA TGTGGTTTCA ACTTCACATC CCTGAAGAAG 
ATGACTGTTG GGATGTTCCT GGCGTCCATG GCCTTTGTGG TGGCTGCAAT TGTGCAGGTG 
GAAATCGATA AAACTCTTCC AGTCTTCCCT GGTGGAAATC AAGTCCAAAT TAAGGTCTTG 
AACATCGGAA ACAATAACAT GACCGTGCAT TTTCCTGGAA ATAGTGTGAC GCTTGCCCAA 
ATGTCTCAGA CAGACACGTT CATGACTTTC GATATAGACA AGCTGACAAG CATAAACATA 
TCTTCCTCTG GATCCCCAGG AGTCACCACA GTAGCTCATG ATTTTGAGCA GGGTCACCGG 
CACACCCTTC TAGTGTGGAA CCCCAGTCAA TACCGTGTGG TAAAAGATGG TCTTAACCAA 
AAGCCAGAGA AAGGGGAGAA CGGAATCAGG TTTGTCAACA CCCTTAACGA GATGGTCACC 
ATCAAAATGA GTGGGAAAGT ATATGAAAAT GTCACCAGTC ACAACGCCAG CGGCTACCAG 
TTCTTCCCTT CTGGCGAAAA GCAGTACACA ATAAACACCA CGGCGGTGGC ACCAACCTGT 
CTAACTGATT TTAAATCTTC CAACCTTGAC TTTGGCAGCG CGTATACCTA CGTGATCCGA 
AGGGCGAGTG ATGGCTGCCT GGAAGTGAAG GAATTTGAAG ACATCCCACC CAACACTGTG 
AACATGGCTC TGCAGATCCC ACAGTACTTC CTTCTCACCT GCGGCGAGGT GGTCTTCTCT 
GTCACAGGAC TGGAGTTCTC TTATTCCCAG GCTCCGTCTA ACATGAAGTC CGTGCTTCAG 
GCAGGCTGGC TTCTAACTGT GGCGGTCGGC AATATCATTG TGCTCATCGT GGCAGGGGCG 
GGGCACTTCC CCAAACAGTG GGCTGAGTAC ATTCTGTTTG CCTCATTGCT TCTGGTTGTC 
TGCGTGATAT TCGCCATCAT GGCTCGATTC TACACCTACA TCAACCCAGC AGAGATTGAA 
GCACAGTTTG ATGAGGATGA GAAGAAAAAG GGCATAGGAA AGGAAAACCC GTATTCTTCA 
TTGGAACCAG TCTCACAGAC AAATATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A Variant of Peptide Transporter 2 Predicts the Severity of Porphyria-Associated Kidney Disease.
Journal of the American Society of Nephrology : JASN28(6)1924-1932(2017 Jun)
Tchernitchko D,Tavernier Q,Lamoril J,Schmitt C,Talbi N,Lyoumi S,Robreau AM,Karim Z,Gouya L,Thervet E,Karras A,Puy H,Pallet N

Glycans in the intestinal peptide transporter PEPT1 contribute to function and protect from proteolysis.
American journal of physiology. Gastrointestinal and liver physiology312(6)G580-G591(2017 Jun)
Stelzl T,Geillinger-K?stle KE,Stolz J,Daniel H

The collagen derived dipeptide hydroxyprolyl-glycine promotes C2C12 myoblast differentiation and myotube hypertrophy.
Biochemical and biophysical research communications478(3)1292-7(2016 09)
Kitakaze T,Sakamoto T,Kitano T,Inoue N,Sugihara F,Harada N,Yamaji R

PepT1 Expression Helps Maintain Intestinal Homeostasis by Mediating the Differential Expression of miRNAs along the Crypt-Villus Axis.
Scientific reports627119(2016 Jun)
Zhang Y,Viennois E,Zhang M,Xiao B,Han MK,Walter L,Garg P,Merlin D

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Slc15a1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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