Gucy1b1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gucy1b1
Entrez Gene ID	54195
Full Name	guanylate cyclase 1, soluble, beta 1
Synonyms	GC-S-beta-1,GCbeta1,Gucy1b3
General protein information	Preferred Names guanylate cyclase 1, soluble, beta 1 Names guanylate cyclase soluble subunit beta-1 GCS-beta-1 GCS-beta-3 NO-sensitive guanylyl cyclase beta 1 subunit beta 1 sGC guanylate cyclase 1, soluble, beta 3 guanylate cyclase soluble subunit beta-3 soluble guanylate cyclase beta-1 subunit soluble guanylate cyclase small subunit
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3\|3 E3

mRNA and Protein(s)

mRNA	Protein	Name
NM_001161796.1	NP_001155268.1	guanylate cyclase soluble subunit beta-1 isoform 2
NM_017469.4	NP_059497.1	guanylate cyclase soluble subunit beta-1 isoform 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	GUCY1B3	NP_000848.1
	GUCY1B3	XP_002804282.1
Canis lupus familiaris (dog)	GUCY1B3	NP_001018044.1
Danio rerio (zebrafish)	gucy1b3	NP_001238874.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000214	XP_310920.4
Caenorhabditis elegans (roundworm)	gcy-36	NP_510557.3
Caenorhabditis elegans (roundworm)	gcy-37	NP_500171.2
Pan troglodytes (chimpanzee)	GUCY1B3	XP_003310602.1
Mus musculus (house mouse)	Gucy1b3	NP_059497.1
Rattus norvegicus (Norway rat)	Gucy1b3	NP_036901.2
Gallus gallus (chicken)	GUCY1B3	XP_420376.3
Drosophila melanogaster (fruit fly)	Gycbeta100B	NP_524603.2
Bos taurus (cattle)	GUCY1B3	NP_777066.1
Caenorhabditis elegans (roundworm)	gcy-32	NP_506452.5
Caenorhabditis elegans (roundworm)	gcy-35	NP_001252131.1
Caenorhabditis elegans (roundworm)	gcy-34	NP_506319.1
Xenopus tropicalis (tropical clawed frog)	gucy1b3	XP_002933520.1

Gene Ontology
Bibliography

Related articles in PubMed

Hypertension reduces soluble guanylyl cyclase expression in the mouse aorta via the Notch signaling pathway.
Rippe C, Zhu B, Krawczyk KK, Bavel EV, Albinsson S, Sj?lund J, Bakker ENTP, Sw?rd K
Scientific reports7(1)1334(2017 May)

Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice.
Thoonen R, Cauwels A, Decaluwe K, Geschka S, Tainsh RE, Delanghe J, Hochepied T, De Cauwer L, Rogge E, Voet S, Sips P, Karas RH, Bloch KD, Vuylsteke M, Stasch JP, Van de Voorde J, Buys ES, Brouckaert P
Nature communications68482(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Apo-sGC mice expressing haem-free sGC are viable and develop hypertension. The haemodynamic effects of NO are abolished, but those of the sGC activator cinaciguat are enhanced.
Title: Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice.

NO-GC has a role in growth and plasticity of hindlimb and retinal vasculature after ischemic/hypoxic insult
Title: Cell-specific impact of nitric oxide-dependent guanylyl cyclase on arteriogenesis and angiogenesis in mice.

sGC and cGMP-dependent signaling are necessary and sufficient for HNO-induced vasodilation in vivo but are not required for positive inotropic action.
Title: Soluble guanylate cyclase is required for systemic vasodilation but not positive inotropy induced by nitroxyl in the mouse.

The broad substrate-specificity of soluble guanylyl cyclase and the possible second messenger roles of cyclic nucleotides other than adenosine 3',5'-cyclic monophosphate and guanosine 3',5'-cyclic monophosphate.
Title: cCMP, cUMP, cTMP, cIMP and cXMP as possible second messengers: development of a hypothesis based on studies with soluble guanylyl cyclase ?(1)?(1).

Deletion of GCbeta1 specifically in smooth muscle cells abolishes NO-induced corpus cavernosum relaxation but does not lead to infertility.
Title: Preserved fertility despite erectile dysfunction in mice lacking the nitric oxide receptor.

The following Gucy1b1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gucy1b1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu08280	NM_001161796.1 Latest version!	Mus musculus guanylate cyclase 1, soluble, beta 1 (Gucy1b1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OMu10817	NM_017469.4 Latest version!	Mus musculus guanylate cyclase 1, soluble, beta 1 (Gucy1b1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$370.30 $529.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gucy1b1 ( NM_001161796.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001155268.1 Mus musculus guanylate cyclase 1, soluble, beta 1 (Gucy1b1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu08280
Clone ID Related Accession (Same CDS sequence)	NM_001161796.1
Accession Version	NM_001161796.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1830bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Mus musculus(house mouse)
Product	guanylate cyclase soluble subunit beta-1 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC121563.3, BC050945.1 and AC131757.3. Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region compared to variant 1 that results in a frameshift. It encodes isoform 2, which has a shorter and distinct C-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC050945.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164139 [ECO:0000348] ##Evidence-Data-END##

ATGTACGGTT TCGTGAACCA TGCCCTGGAG CTGCTGGTGA TCCGCAATTA TGGTCCCGAG 
GTGTGGGAAG ACATCAAAAA AGAGGCACAG CTGGATGAAG AAGGCCAGTT TCTTGTCAGA 
ATAATATACG ATGATTCCAA AACATATGAC CTGGTGGCTG CTGCAAGCAA AGTCCTCAAC 
CTCAATGCTG GCGAAATCCT GCAGATGTTT GGGAAGATGT TTTTCGTCTT CTGCCAGGAG 
TCTGGCTATG ATACCATCTT GCGTGTCCTG GGATCTAATG TCAGAGAGTT TTTGCAGAAC 
CTCGATGCCC TGCATGACCA CCTCGCCACC ATTTACCCAG GGATGCGCGC GCCTTCCTTC 
AGGTGCACCG ATGCGGAGAA AGGCAAAGGG CTCATCCTGC ACTACTACTC GGAAAGAGAG 
GGGCTTCAGG ACATCGTGAT CGGGATTATC AAGACTGTTG CTCAACAGAT ACACGGCACT 
GAGATAGACA TGAAGGTGAT TCAGCAAAGA AATGAAGAAT GTGATCACAC CCAGTTTTTA 
ATTGAAGAAA AGGAATCAAA AGAAGAGGAT TTTTATGAAG ATCTGGATAG GTTTGAAGAG 
AATGGTACCC AGGAATCACG TATCAGCCCT TACACCTTCT GCAAAGCATT TCCTTTTCAC 
ATCATATTTG ACCGGAACCT AGTGGTCACT CAGTGTGGCA ATGCCATCTA CAGAGTGCTC 
CCCCAGCTCC AGCCTGGGAA CTGCAGCCTT CTGTCTGTCT TCTCTCTGGT CCGCCCTCAC 
ATCGACATCA GTTTCCATGG GATTCTTTCA CACATCAATA CAGTCTTTGT ACTGAGAAGC 
AAGGAAGGGT TGCTGGATGT GGAGAAACTT GAGTGTGAGG ATGAACTGAC TGGAGCAGAG 
ATTAGCTGCT TACGTCTCAA AGGCCAAATG ATCTACTTAC CAGAAGCAGA TAGCATCCTC 
TTCCTCTGTT CACCAAGTGT GATGAACCTG GACGACCTAA CAAGAAGAGG CCTGTATCTG 
AGTGACATCC CTCTCCACGA TGCTACCCGA GACCTGGTTC TTTTGGGAGA ACAGTTCCGG 
GAGGAGTACA AACTGACACA AGAGCTGGAA ATCCTCACCG ACAGGCTGCA GCTCACACTG 
AGAGCCTTGG AGGATGAGAA GAAAAAGACA GACACATTGC TGTATTCTGT CCTTCCTCCA 
TCTGTTGCCA ATGAGCTGAG ACACAAGCGC CCAGTGCCTG CCAAAAGATA CGACAATGTG 
ACCATCCTCT TCAGCGGCAT TGTGGGCTTC AATGCTTTCT GTAGCAAGCA TGCATCTGGA 
GAAGGGGCCA TGAAGATTGT CAATCTCCTC AACGATCTCT ACACCCGATT TGACACACTG 
ACTGATTCAC GAAAAAACCC ATTTGTTTAC AAGGTGGAAA CAGTTGGTGA CAAGTATATG 
ACAGTGAGTG GCTTGCCAGA ACCTTGTATC CACCATGCAC GGTCCATTTG CCACCTGGCT 
TTAGACATGA TGGAAATTGC TGGTCAAGTT CAAGTAGATG GTGAATCTGT TCAGATAACA 
ATCGGGATCC ATACCGGGGA GGTGGTGACA GGTGTGATTG GACAGCGGAT GCCTCGGTAT 
TGTCTCTTTG GGAATACCGT CAACCTCACA AGCAGGACAG AAACCACAGG AGAAAAGGGA 
AAGATAAATG TTTCCGAATA TACATACAGA AAACTCGGAT CCACTGTTCC ATTTGGAGCA 
CAGAGGCCCA GTGTCTATGA AGGGCAAGAA GGAACCAATG CAAGTCTGGT TCCTATCCAG 
GAAAAATACA GGCACGGAGG AAACAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001155268.1
CDS	138..1967
Translation	MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLNLNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSFRCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFLIEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFPFHIIFDRNLVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGAEISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRKLGSTVPFGAQRPSVYEGQEGTNASLVPIQEKYRHGGNK

Target ORF information:

RefSeq Version	NM_001161796.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus guanylate cyclase 1, soluble, beta 1 (Gucy1b1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001161796.1

ORF Insert Sequence:

ATGTACGGTT TCGTGAACCA TGCCCTGGAG CTGCTGGTGA TCCGCAATTA TGGTCCCGAG 
GTGTGGGAAG ACATCAAAAA AGAGGCACAG CTGGATGAAG AAGGCCAGTT TCTTGTCAGA 
ATAATATACG ATGATTCCAA AACATATGAC CTGGTGGCTG CTGCAAGCAA AGTCCTCAAC 
CTCAATGCTG GCGAAATCCT GCAGATGTTT GGGAAGATGT TTTTCGTCTT CTGCCAGGAG 
TCTGGCTATG ATACCATCTT GCGTGTCCTG GGATCTAATG TCAGAGAGTT TTTGCAGAAC 
CTCGATGCCC TGCATGACCA CCTCGCCACC ATTTACCCAG GGATGCGCGC GCCTTCCTTC 
AGGTGCACCG ATGCGGAGAA AGGCAAAGGG CTCATCCTGC ACTACTACTC GGAAAGAGAG 
GGGCTTCAGG ACATCGTGAT CGGGATTATC AAGACTGTTG CTCAACAGAT ACACGGCACT 
GAGATAGACA TGAAGGTGAT TCAGCAAAGA AATGAAGAAT GTGATCACAC CCAGTTTTTA 
ATTGAAGAAA AGGAATCAAA AGAAGAGGAT TTTTATGAAG ATCTGGATAG GTTTGAAGAG 
AATGGTACCC AGGAATCACG TATCAGCCCT TACACCTTCT GCAAAGCATT TCCTTTTCAC 
ATCATATTTG ACCGGAACCT AGTGGTCACT CAGTGTGGCA ATGCCATCTA CAGAGTGCTC 
CCCCAGCTCC AGCCTGGGAA CTGCAGCCTT CTGTCTGTCT TCTCTCTGGT CCGCCCTCAC 
ATCGACATCA GTTTCCATGG GATTCTTTCA CACATCAATA CAGTCTTTGT ACTGAGAAGC 
AAGGAAGGGT TGCTGGATGT GGAGAAACTT GAGTGTGAGG ATGAACTGAC TGGAGCAGAG 
ATTAGCTGCT TACGTCTCAA AGGCCAAATG ATCTACTTAC CAGAAGCAGA TAGCATCCTC 
TTCCTCTGTT CACCAAGTGT GATGAACCTG GACGACCTAA CAAGAAGAGG CCTGTATCTG 
AGTGACATCC CTCTCCACGA TGCTACCCGA GACCTGGTTC TTTTGGGAGA ACAGTTCCGG 
GAGGAGTACA AACTGACACA AGAGCTGGAA ATCCTCACCG ACAGGCTGCA GCTCACACTG 
AGAGCCTTGG AGGATGAGAA GAAAAAGACA GACACATTGC TGTATTCTGT CCTTCCTCCA 
TCTGTTGCCA ATGAGCTGAG ACACAAGCGC CCAGTGCCTG CCAAAAGATA CGACAATGTG 
ACCATCCTCT TCAGCGGCAT TGTGGGCTTC AATGCTTTCT GTAGCAAGCA TGCATCTGGA 
GAAGGGGCCA TGAAGATTGT CAATCTCCTC AACGATCTCT ACACCCGATT TGACACACTG 
ACTGATTCAC GAAAAAACCC ATTTGTTTAC AAGGTGGAAA CAGTTGGTGA CAAGTATATG 
ACAGTGAGTG GCTTGCCAGA ACCTTGTATC CACCATGCAC GGTCCATTTG CCACCTGGCT 
TTAGACATGA TGGAAATTGC TGGTCAAGTT CAAGTAGATG GTGAATCTGT TCAGATAACA 
ATCGGGATCC ATACCGGGGA GGTGGTGACA GGTGTGATTG GACAGCGGAT GCCTCGGTAT 
TGTCTCTTTG GGAATACCGT CAACCTCACA AGCAGGACAG AAACCACAGG AGAAAAGGGA 
AAGATAAATG TTTCCGAATA TACATACAGA AAACTCGGAT CCACTGTTCC ATTTGGAGCA 
CAGAGGCCCA GTGTCTATGA AGGGCAAGAA GGAACCAATG CAAGTCTGGT TCCTATCCAG 
GAAAAATACA GGCACGGAGG AAACAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gucy1b1 ( NM_017469.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_059497.1 Mus musculus guanylate cyclase 1, soluble, beta 1 (Gucy1b1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu10817
Clone ID Related Accession (Same CDS sequence)	NM_017469.4
Accession Version	NM_017469.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1863bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Mus musculus(house mouse)
Product	guanylate cyclase soluble subunit beta-1 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC121563.3, AK139406.1, BC050945.1 and AC131757.3. On Jun 17, 2009 this sequence version replaced NM_017469.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF297083.1, AK147128.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164139 [ECO:0000348] ##Evidence-Data-END##

ATGTACGGTT TCGTGAACCA TGCCCTGGAG CTGCTGGTGA TCCGCAATTA TGGTCCCGAG 
GTGTGGGAAG ACATCAAAAA AGAGGCACAG CTGGATGAAG AAGGCCAGTT TCTTGTCAGA 
ATAATATACG ATGATTCCAA AACATATGAC CTGGTGGCTG CTGCAAGCAA AGTCCTCAAC 
CTCAATGCTG GCGAAATCCT GCAGATGTTT GGGAAGATGT TTTTCGTCTT CTGCCAGGAG 
TCTGGCTATG ATACCATCTT GCGTGTCCTG GGATCTAATG TCAGAGAGTT TTTGCAGAAC 
CTCGATGCCC TGCATGACCA CCTCGCCACC ATTTACCCAG GGATGCGCGC GCCTTCCTTC 
AGGTGCACCG ATGCGGAGAA AGGCAAAGGG CTCATCCTGC ACTACTACTC GGAAAGAGAG 
GGGCTTCAGG ACATCGTGAT CGGGATTATC AAGACTGTTG CTCAACAGAT ACACGGCACT 
GAGATAGACA TGAAGGTGAT TCAGCAAAGA AATGAAGAAT GTGATCACAC CCAGTTTTTA 
ATTGAAGAAA AGGAATCAAA AGAAGAGGAT TTTTATGAAG ATCTGGATAG GTTTGAAGAG 
AATGGTACCC AGGAATCACG TATCAGCCCT TACACCTTCT GCAAAGCATT TCCTTTTCAC 
ATCATATTTG ACCGGAACCT AGTGGTCACT CAGTGTGGCA ATGCCATCTA CAGAGTGCTC 
CCCCAGCTCC AGCCTGGGAA CTGCAGCCTT CTGTCTGTCT TCTCTCTGGT CCGCCCTCAC 
ATCGACATCA GTTTCCATGG GATTCTTTCA CACATCAATA CAGTCTTTGT ACTGAGAAGC 
AAGGAAGGGT TGCTGGATGT GGAGAAACTT GAGTGTGAGG ATGAACTGAC TGGAGCAGAG 
ATTAGCTGCT TACGTCTCAA AGGCCAAATG ATCTACTTAC CAGAAGCAGA TAGCATCCTC 
TTCCTCTGTT CACCAAGTGT GATGAACCTG GACGACCTAA CAAGAAGAGG CCTGTATCTG 
AGTGACATCC CTCTCCACGA TGCTACCCGA GACCTGGTTC TTTTGGGAGA ACAGTTCCGG 
GAGGAGTACA AACTGACACA AGAGCTGGAA ATCCTCACCG ACAGGCTGCA GCTCACACTG 
AGAGCCTTGG AGGATGAGAA GAAAAAGACA GACACATTGC TGTATTCTGT CCTTCCTCCA 
TCTGTTGCCA ATGAGCTGAG ACACAAGCGC CCAGTGCCTG CCAAAAGATA CGACAATGTG 
ACCATCCTCT TCAGCGGCAT TGTGGGCTTC AATGCTTTCT GTAGCAAGCA TGCATCTGGA 
GAAGGGGCCA TGAAGATTGT CAATCTCCTC AACGATCTCT ACACCCGATT TGACACACTG 
ACTGATTCAC GAAAAAACCC ATTTGTTTAC AAGGTGGAAA CAGTTGGTGA CAAGTATATG 
ACAGTGAGTG GCTTGCCAGA ACCTTGTATC CACCATGCAC GGTCCATTTG CCACCTGGCT 
TTAGACATGA TGGAAATTGC TGGTCAAGTT CAAGTAGATG GTGAATCTGT TCAGATAACA 
ATCGGGATCC ATACCGGGGA GGTGGTGACA GGTGTGATTG GACAGCGGAT GCCTCGGTAT 
TGTCTCTTTG GGAATACCGT CAACCTCACA AGCAGGACAG AAACCACAGG AGAAAAGGGA 
AAGATAAATG TTTCCGAATA TACATACAGG TGTCTCATGT CTCCAGAAAA CTCGGATCCA 
CTGTTCCATT TGGAGCACAG AGGCCCAGTG TCTATGAAGG GCAAGAAGGA ACCAATGCAA 
GTCTGGTTCC TATCCAGGAA AAATACAGGC ACGGAGGAAA CAAATGAGGA GGATGAAAAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_059497.1
CDS	138..2000
Translation	MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLNLNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSFRCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFLIEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFPFHIIFDRNLVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGAEISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPLFHLEHRGPVSMKGKKEPMQVWFLSRKNTGTEETNEEDEN

Target ORF information:

RefSeq Version	NM_017469.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus guanylate cyclase 1, soluble, beta 1 (Gucy1b1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017469.4

ORF Insert Sequence:

ATGTACGGTT TCGTGAACCA TGCCCTGGAG CTGCTGGTGA TCCGCAATTA TGGTCCCGAG 
GTGTGGGAAG ACATCAAAAA AGAGGCACAG CTGGATGAAG AAGGCCAGTT TCTTGTCAGA 
ATAATATACG ATGATTCCAA AACATATGAC CTGGTGGCTG CTGCAAGCAA AGTCCTCAAC 
CTCAATGCTG GCGAAATCCT GCAGATGTTT GGGAAGATGT TTTTCGTCTT CTGCCAGGAG 
TCTGGCTATG ATACCATCTT GCGTGTCCTG GGATCTAATG TCAGAGAGTT TTTGCAGAAC 
CTCGATGCCC TGCATGACCA CCTCGCCACC ATTTACCCAG GGATGCGCGC GCCTTCCTTC 
AGGTGCACCG ATGCGGAGAA AGGCAAAGGG CTCATCCTGC ACTACTACTC GGAAAGAGAG 
GGGCTTCAGG ACATCGTGAT CGGGATTATC AAGACTGTTG CTCAACAGAT ACACGGCACT 
GAGATAGACA TGAAGGTGAT TCAGCAAAGA AATGAAGAAT GTGATCACAC CCAGTTTTTA 
ATTGAAGAAA AGGAATCAAA AGAAGAGGAT TTTTATGAAG ATCTGGATAG GTTTGAAGAG 
AATGGTACCC AGGAATCACG TATCAGCCCT TACACCTTCT GCAAAGCATT TCCTTTTCAC 
ATCATATTTG ACCGGAACCT AGTGGTCACT CAGTGTGGCA ATGCCATCTA CAGAGTGCTC 
CCCCAGCTCC AGCCTGGGAA CTGCAGCCTT CTGTCTGTCT TCTCTCTGGT CCGCCCTCAC 
ATCGACATCA GTTTCCATGG GATTCTTTCA CACATCAATA CAGTCTTTGT ACTGAGAAGC 
AAGGAAGGGT TGCTGGATGT GGAGAAACTT GAGTGTGAGG ATGAACTGAC TGGAGCAGAG 
ATTAGCTGCT TACGTCTCAA AGGCCAAATG ATCTACTTAC CAGAAGCAGA TAGCATCCTC 
TTCCTCTGTT CACCAAGTGT GATGAACCTG GACGACCTAA CAAGAAGAGG CCTGTATCTG 
AGTGACATCC CTCTCCACGA TGCTACCCGA GACCTGGTTC TTTTGGGAGA ACAGTTCCGG 
GAGGAGTACA AACTGACACA AGAGCTGGAA ATCCTCACCG ACAGGCTGCA GCTCACACTG 
AGAGCCTTGG AGGATGAGAA GAAAAAGACA GACACATTGC TGTATTCTGT CCTTCCTCCA 
TCTGTTGCCA ATGAGCTGAG ACACAAGCGC CCAGTGCCTG CCAAAAGATA CGACAATGTG 
ACCATCCTCT TCAGCGGCAT TGTGGGCTTC AATGCTTTCT GTAGCAAGCA TGCATCTGGA 
GAAGGGGCCA TGAAGATTGT CAATCTCCTC AACGATCTCT ACACCCGATT TGACACACTG 
ACTGATTCAC GAAAAAACCC ATTTGTTTAC AAGGTGGAAA CAGTTGGTGA CAAGTATATG 
ACAGTGAGTG GCTTGCCAGA ACCTTGTATC CACCATGCAC GGTCCATTTG CCACCTGGCT 
TTAGACATGA TGGAAATTGC TGGTCAAGTT CAAGTAGATG GTGAATCTGT TCAGATAACA 
ATCGGGATCC ATACCGGGGA GGTGGTGACA GGTGTGATTG GACAGCGGAT GCCTCGGTAT 
TGTCTCTTTG GGAATACCGT CAACCTCACA AGCAGGACAG AAACCACAGG AGAAAAGGGA 
AAGATAAATG TTTCCGAATA TACATACAGG TGTCTCATGT CTCCAGAAAA CTCGGATCCA 
CTGTTCCATT TGGAGCACAG AGGCCCAGTG TCTATGAAGG GCAAGAAGGA ACCAATGCAA 
GTCTGGTTCC TATCCAGGAA AAATACAGGC ACGGAGGAAA CAAATGAGGA GGATGAAAAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hypertension reduces soluble guanylyl cyclase expression in the mouse aorta via the Notch signaling pathway.
Scientific reports7(1)1334(2017 May)
Rippe C,Zhu B,Krawczyk KK,Bavel EV,Albinsson S,Sj?lund J,Bakker ENTP,Sw?rd K

Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice.
Nature communications68482(2015 Oct)
Thoonen R,Cauwels A,Decaluwe K,Geschka S,Tainsh RE,Delanghe J,Hochepied T,De Cauwer L,Rogge E,Voet S,Sips P,Karas RH,Bloch KD,Vuylsteke M,Stasch JP,Van de Voorde J,Buys ES,Brouckaert P

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Gucy1b1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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